Clinical trials: Change; Retina
Macular Edema, Retinal Vein Occlusion
Effect of Intravitreal Ranibizumab Injection With Retinal Vein Occlusion (RVO)
The purpose of this study is to evaluate the effects of intravitreal Lucentis® (Ranibizumab) and investigate the anatomical and functional improvement following this treatment in patients with macular edema due to retinal vein…
- Trial name
- NCT00942864
- Testing
- ranibizumab
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Novartis Korea Ltd.
Retinal Disease, Healthy Population
Multifocal Electroretinogram in Normal Egyptian Population
Studying normal subjects to create unique normal database for multifocal electroretinogram (mf-ERG) in specific population.
- Trial name
- NCT05323032
- Testing
- Multifocal electroretinogram (mf-ERG) by electroretinogram device
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Benha University
Central Retinal Artery Occlusion, Visual Field
Changes of Visual Field Defects After IAT for CRAO
Central retinal artery occlusion (CRAO) is an ophthalmic emergency which leads to devastating visual function defects and poor prognosis.
- Conditions
- Central Retinal Artery Occlusion, Visual Field, Intra-arterial Thrombolysis
- Trial name
- NCT05739487
- Testing
- selective intra-arterial thrombolysis
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Myopia
Red Light Therapy: Short-term Choroidal and Retinal Changes
This research project is a prospective, randomized controlled trial designed to assess the short-term effects of varied red light therapies on the choroidal and retinal structures in adult myopes.
- Trial name
- NCT06753773
- Testing
- Repeated Low-Level Red-Light
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Macular Holes
Macular Micro Vascular Changes Following Macular Hole Repair : Optical Coherence Tomography Angiography Study
The goal of this prospective interventional study is to to compare the micro vascular and structural changes between surgery with and without ILM flap to repair macular hole.
- Trial name
- NCT06233500
- Testing
- pars plana vitrectomy
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Fayoum University
Rhegmatogenous Retinal Detachments
Study of Vitreoretinal Molecular Changes During Rhegmatogenous Retinal Detachment
Retinal detachment is a condition with an estimated incidence of between 9.5 and 18.2 cases per 100,000 individuals. It is an ophthalmological emergency that threatens visual acuity and requires surgery.
- Trial name
- LIPIDRET (NCT06347302)
- Testing
- Blood sampling, vitreous sampling, Sub-retinal fluid sampling
- Where
- France
- Volunteers
- 137 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Choroideremia
The Dark-Adapted Retinal Function Response in Choroideremia (DARC) Study
Choroideremia (CHM) is an inherited retinal disorder that causes progressive vision loss, ultimately leading to complete blindness.
- Trial name
- DARC (NCT05045703)
- Testing
- Vitamin A palmitate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Amblyopia
Changes in Amblyopia Using Optical Coherence Tomography
There have been multiple trials to investigate the morphological changes in the macula and retinal nerve fiber layer of amblyopic eyes, due to the different published results and the lack of evident association between these…
- Trial name
- NCT04092361
- Testing
- optical coherence tomography
- Volunteers
- 28 people
- Sponsor
- Assiut University
Cognitive Change
Yoga Training and Retinal Vasculature
This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function.
- Trial name
- NCT06099405
- Testing
- High-speed, Cognitive Challenge Yoga, Traditional yoga
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Miami
Ocular Physiology, Retina
Is There a Difference in Flicker Induced Vasodilatation Between Smokers and Non-Smokers?
Habitual smoking is associated with an increased risk of coronary artery disease, cerebral and peripheral vascular disease, including ocular diseases like age-related macular degeneration or diabetic retinopathy.
- Conditions
- Ocular Physiology, Retina, Blood Flow Velocity
- Trial name
- NCT00431730
- Testing
- flicker light stimulation
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Retinitis Pigmentosa (RP)
Prospective, Randomized, Sham-controlled, Dose-finding I/II Trial of Safety and Efficacy of Modified Optogenetic Gene Therapy (ZM-02 Injection)
This is a Phase 1/2, multi-center, randomized, sham-controlled, dose-escalation study evaluating ZM-02 in patients with advanced retinitis pigmentosa (RP).
- Trial name
- PRISM (NCT07282457)
- Testing
- ZM-02 (low dose), ZM-02 (high dose), ZM-02 (selected dose)
- Volunteers
- 21 people
- Sponsor
- Augelux Therapeutics
Ocular Inflammation
PGE2 Levels in Patient Treated With NSAIDs
The aim of this study is to determine vitreous levels of nonsteroidal antinflammatory drugs (NSAIDs) and prostaglandinE2 (PGE2) in eyes scheduled for vitrectomy. All patients received the study drugs for 3 days before surgery.
- Trial name
- NCT03597867
- Testing
- Dicloftil, Nevanac, Indom
- Where
- Italy
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Healthy
Measurement of Retinal Venous Pressure Under Short-term Low-oxygen Environment
The hypothesis is that the pressure in the retinal veins increases under a short-term lack of oxygen and leads to a decreased blood circulation.
- Trial name
- NCT01771757
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Neovascular Age-related Macular Degeneration of All Subtypes
Assessment of Early Changes in SD-OCT After Initiation of a Treatment by Intravitreal Aflibercept (EYLEA®)START
Aflibercept (EYLEA®) induces a rapid reduction in central retinal thickness (CRT) for patients suffering from neovascular age-related-macular degeneration.1 This early dramatic reduction in CRT is already observed through week 4.
- Trial name
- START (NCT02246829)
- Testing
- Intravitreal injection
- Where
- 10 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
COPD Exacerbation, Physical Activity
Changes in Microcirculation and Functional Status During Exacerbation of COPD
This study investigates the influence of acute exacerbation of chronic obstructive pulmonary disease (COPD) on retinal microcirculation, on functional status and also investigates the prognostic value of retinal vessel caliber…
- Conditions
- COPD Exacerbation, Physical Activity, Retinal Vascular
- Trial name
- COPD-EX (NCT03250000)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Hasselt University
Thyroid Associated Orbitopathy
OCT Angiography Drived Alterations in Thyroid-associated Orbitopathy
The aim of this observational study is to evaluate retinal microvascular alterations in patients with thyroid-associated orbitopathy (TAO) using optical coherence tomography angiography (OCTA).
- Trial name
- TAO (NCT07341347)
- Where
- Croatia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Osijek University Hospital
Mild Cognitive Impairment
Lifestyle Intervention Program for Cognitive Impairment
The purpose of the Lifestyle Intervention Study is to investigate the influence of a micronutrient supplement in combination with a comprehensive lifestyle intervention program on retinal amyloid, among patients with Mild…
- Trial name
- NCT02741804
- Testing
- BBH-1001 Brain Health Supplement, Lifestyle Intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Cedars-Sinai Medical Center
Retinal Disease
Modified Soft Contact Lens During Vitrectomy
This study compared a modified soft contact lens with balanced salt solution irrigation during pars plana vitrectomy performed with a noncontact wide-angle viewing system.
- Trial name
- NCT07807436
- Testing
- Modified Soft Contact Lens, Balanced Salt Solution Irrigation
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Northwest University First Hospital (Xi'an No.1 Hospital)
Diabetes Mellitus, Diabetic Retinopathy
Study to Evaluate the Effectiveness of a Program Developed to Improve Eye Care for Veterans With Diabetes
The study's primary objective is to determine whether the PRSS improves the optimal timing of photocoagulation in diabetic patients in VA.
- Trial name
- NCT00119535
- Testing
- Implementation of Proactive Diabetes Eye Care Program
- Where
- 3 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- US Department of Veterans Affairs
Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration
Changes in Intraocular Pressure After Intravitreal Injection
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections introduce additional fluid volume into the eye, which can cause an acute, transient elevation in intraocular pressure (IOP).
- Conditions
- Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration, Retinal Vein Occlusion, Ocular Hypertension
- Trial name
- NCT07826286
- Volunteers
- 50 people
- Sponsor
- Assiut University