Clinical trials: Change; Retina
Diabetes Mellitus, Type 2, Diabetic Retinopathy
Choroidal and Retinal Changes After RLRL Therapy in Diabetes and Diabetic Retinopathy
The choroidal thickness was found to be thinner in diabetic eyes without retinopathy compared to healthy eyes, thus choroidal thickness might be an important parameter for the development of diabetic retinopathy in diabetic eyes…
- Trial name
- NCT05773209
- Testing
- RLRL device
- Volunteers
- 58 people
- Sponsor
- The Second People's Hospital of Foshan
Graves' Ophthalmopathy
Retinal Oxygen Saturation in Patients With Graves' Ophthalmopathy and in Normal People
Find if the retinal function is affected in both the nonsevere and the severe stage of Graves' ophthalmopathy (GO) by comparing the retinal oxygen saturation of GO patients with that of normal people.
- Trial name
- NCT02290704
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Myopia
Pharmacological and Non-pharmacological Treatment Effects on Children With Different Predicted Myopia Progression Rate
The goal of this clinical trial is to compare pharmacological and non-pharmacological treatment effects on the children with different predicted myopia progression rate measured by modified multifocal electroretinogram.
- Trial name
- NCT06282848
- Testing
- Atropine 0.05%, DIMS lens
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Rhegmatogenous Macula-off Retinal Detachment
Corneal Endothelial Cell Changes In Silicon Filled Eye
The aim of this study is to evaluate corneal endothelial cell changes after pars plana vitrectomy in Rhegmatogenous Retinal detachment , compare the results using different silicon oil viscositites , and assess whether these…
- Trial name
- Endothelium (NCT07418606)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Diabetic Retinopathy
Effect of Panretinal Photocoagulation on Optic Nerve Head Topography
The purpose of this study is to evaluate the optic nerve head changes consequent to panretinal photocoagulation done for diabetic retinopathy.
- Trial name
- PRP (NCT00767884)
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- University of Nebraska
Telangiectasis
Effect of Avastin in Juxtafoveal Telangiectasias
Evaluation of efficacy of Intravitreal Injection of Bevacizumab in patients with Yuxtafoveal Telangiectasias
- Trial name
- NCT00406380
- Testing
- Bevacizumab, Intravitreal injection of Bevacizumab
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Eye Injury Trauma
Evaluation of Retinal Microvascular Change That May Develop in After Open Globe Injury
The aim of this study is to evaluate posterior segment changes in the non-traumatic eye after open globe injury.
- Trial name
- NCT05771467
- Testing
- Comprehensive Ophthalmologic Examination
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Safety
FDA Phase IV - Commitment - Retinal Function Study
Vardenafil (Levitra) and Sildenafil (Viagra) are drugs that are marketed for use in patients with erectile dysfunction. The purpose of this study is to find out if there are any changes in the eye after taking at least 15 doses…
- Trial name
- NCT00461565
- Testing
- Sildenafil, Vardenafil (Levitra, BAY38-9456)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Bayer
Age-related Macular Degeneration
Changes in Retinal Function After Intravitreal Ranibizumab for Age-related Macular Degeneration
Age-related macular degeneration, a leading cause of blindness, is caused by an abnormal growth of the vessels beneath the retina.
- Trial name
- NCT00539734
- Testing
- ranibizumab
- Where
- Thailand
- Volunteers
- 25 people
- Sponsor
- Prince of Songkla University
High Altitude Retinopathy
Retinal and Choroidal Circulation Changes Following Rapid Ascent to a High Altitude Environment
This is a prospective observational study. The purpose is to explore the effect of high altitude hypobaric hypoxia on retinal microcirculation and the change of the thickness of the retina and choroid by optical coherence…
- Trial name
- NCT04491500
- Testing
- High attitude environment
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Pediatric Disorder, Vitamin D Deficiency
Retinal Changes in Vitamin D Deficiency
Retinal tissue parameters of pediatric patients with vitamin D deficiency will be evaluated in this prospective case-control study. The patients will be divided into 2 groups according to the vitamin D level.
- Conditions
- Pediatric Disorder, Vitamin D Deficiency, Retinal Disease, Choroidal Disease
- Trial name
- VDD (NCT04891211)
- Testing
- Vitamin D deficiency
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Adiyaman University
Primary Open Angle Glaucoma
Retinal Vascular Changes in Primary Open Angle Glaucoma Patients
the study aims to detect ischemic changes in macula using OCT angiography in primary open angle glaucoma patients correlating with glaucoma staging system II by visual field.
- Trial name
- NCT05351307
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Age Related Macular Degeneration, Diabetic Macular Edema
Change in Ocular Perfusion After Intravitreal Anti-VEGF in Patients with Age-related Maculopathy or Diabetic Macula Edema
This prospective study will include patients with neovascular age-related macular degeneration or diabetic macular edema, scheduled for intravitreal aflibercept.
- Trial name
- NCT06878573
- Testing
- Intravitreal Aflibercept Injection, Laser speckle flowgraphy
- Where
- Austria
- Volunteers
- 36 people
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Flicker-induced Vasodilatation
Effect of Breathing a Mixture of 92% Oxygen (O2) + 8% Carbon Dioxide (CO2) on Flicker Induced Blood Flow Changes in Ocular Perfusion
It has been shown that diffuse luminance flicker increases retinal and optic nerve head blood flow. This indicates that a neuro-vascular coupling between neural activity and blood flow exists in the retina as described previously…
- Trial name
- NCT00719342
- Testing
- Oxygen + Carbondioxide, full field flickering light at 12.5 Hz
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 2 Diabetes Mellitus, Diabetic Retinopathy (DR)
Glycemic Velocity and Early Retinal Microvascular Change With GLP-1RA Versus SGLT2i Initiation in Type 2 Diabetes (GLIDE)
The GLIDE study looks at how the small blood vessels of the eye respond during the first months of a new diabetes medicine. Two widely used classes of glucose-lowering drugs, GLP-1 receptor agonists and SGLT2 inhibitors, are…
- Trial name
- GLIDE (NCT07723820)
- Testing
- GLP-1 Receptor Agonists, SGLT2 inhibitor
- Where
- Thailand
- Volunteers
- 126 people
- Sponsor
- Thammasat University Hospital
Healthy Participants, Retinal Oxygen Extraction
Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects
It has been found that several systemic and ocular diseases are associated with impaired retinal oxygen extraction. In the present study, retinal oxygen extraction will be measured in different age groups in order to identify age…
- Trial name
- NCT06643403
- Testing
- Oxygen 100% Gas for Inhalation
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Retinal Detachment, Refractive Errors
Refractive Changes Following Vitrectomy
We aimed o compare the refractive changes associated with pars plana vitrectomy with or without intraocular gas tamponade in pseudophakic eyes.
- Conditions
- Retinal Detachment, Refractive Errors, Vitreous Hemorrhage, Epiretinal Membrane
- Trial name
- NCT04712786
- Testing
- pars plana vitrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Bursa Retina Eye Hospital
Erectile Dysfunction Following Radical Prostatectomy
Study of Retinal and Choriocapillary Vascular Changes in Patients Undergoing Tadalafil 20mg for More Than 6 Months
This study evaluates the retinal and choriocapillary vascular features in patients under the effects of Tadalafil 20mg for more than 6 months, using optical coherence tomography angiography.
- Trial name
- NCT04491773
- Testing
- Tadalafil 20 MG
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Federico II University
Malignant Melanoma, Drug-Induced Retinopathy
Clinical and Functional Retinal Changes Associated With BRAF/MEK Inhibitor Therapy in Patients With Malignant Melanoma
Patients with malignant melanoma are increasingly treated with combined BRAF and MEK inhibitor therapy. Although this treatment has significantly improved survival outcomes, it has been associated with specific retinal changes…
- Trial name
- NCT07427953
- Where
- Slovenia
- Volunteers
- 14 people
- Sponsor
- Institute of Oncology Ljubljana
Age Related Macular Degeneration
Serial Retinal Thickness Changes And Scotoma Size Measured With Lucentis Therapy
The rationale for evaluating LucentisTM (a recombinant humanized anti-human Vascular Endothelial Growth Factor (VEGF) monoclonal antibody (Fab) in patients with neovascular (wet) Age related Macular Degeneration (AMD) is based on…
- Trial name
- FVF4193s (NCT01255774)
- Testing
- ranibizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The New York Eye & Ear Infirmary