Clinical trials: Chemically-Induced Disorders
Metastatic Renal Cell Carcinoma ( mRCC), OligoProgressive Metastatic Disease
Radiotherapy in Combination With Checkpoint Inhibition for Patients With Metastatic Kidney Cancer
To evaluate the impact of combining innate immune system activation (with IMSA101) with antigen release (through SAbR/PULSAR) on limited progressing lesions during ongoing adaptive immune system activation (with maintenance Nivo).
- Trial name
- SPARK (NCT06601296)
- Testing
- IMSA101
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Texas Southwestern Medical Center
Drug-induced Liver Injury, Gut Microbiota
Alterations of Gut Microbiota and Serum Biochemical Markers in DILI Patients
Drug-induced liver injury is a leading cause of acute liver failure worldwide and one of the least understood areas in hepatology research.
- Conditions
- Drug-induced Liver Injury, Gut Microbiota, Biochemical Markers
- Trial name
- NCT05465642
- Testing
- Collect stool and blood samples from patients
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Substance Abuse, Suicide
Functional Connectivity Alterations in Suicidal Patients Among Opioid Users
Suicide is the 10th leading cause of death for Americans of all ages and more people in the United States now die from suicide than die from car accidents.
- Conditions
- Substance Abuse, Suicide, Depression
- Trial name
- NCT05489042
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Assessment of Potential Interactions Between GBR 12909 and Cocaine - 1
The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and 3 doses of GBR 12909.
- Trial name
- NCT00100113
- Testing
- GBR 12909
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Effects of Propranolol on Responses to Drug-Related Imagery Scripts
Background: Relapse to drug abuse is thought to result, in many cases, from exposure to cues that trigger drug-related memories or emotional associations for example, the association between the sight of a crack pipe and a set of…
- Trial name
- NCT00688805
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance-Related Disorders, Alcohol-Related Disorders
Conflict Between Maternal Autonomy and Child Health in Substance-use
Qualitative project, comprising open-ended semi-structured interviews with healthcare workers, who provide antenatal care to substance-using women.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Amphetamine-Related Disorders, Inhalant Abuse
- Trial name
- NCT02797990
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Fatigue, Malignant Ovarian Mixed Epithelial Tumor
Acetyl-L-Carnitine Hydrochloride in Preventing Peripheral Neuropathy in Patients With Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian Tube Cancer Undergoing Chemotherapy
This randomized phase III trial studies how well acetyl-L-carnitine hydrochloride works compared to a placebo in preventing peripheral neuropathy in patients with recurrent ovarian epithelial cancer, primary peritoneal cancer, or…
- Conditions
- Fatigue, Malignant Ovarian Mixed Epithelial Tumor, Neuropathy, Neurotoxicity Syndrome
- Trial name
- NCT01492920
- Testing
- Acetyl-L-Carnitine Hydrochloride, Questionnaire Administration, Quality-of-Life Assessment
- Sponsor
- Gynecologic Oncology Group
Breast Cancer
Acute Exercise Cardioprotection From Doxorubicin
In rodents, a single bout of exercise prior to injection of a chemotherapy agent used to treat breast cancer prevents or attenuates a number of markers of cardiac injury.
- Trial name
- NCT02006979
- Testing
- exercise
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of British Columbia
Substance Abuse, Substance Use
Enhancing Permanency in Children and Families
The Enhancing Permanency in Children and Families (EPIC) program is a collaborative effort between the Ohio State University College of Social Work, two county offices of the Ohio Department of Job and Family Services, two…
- Conditions
- Substance Abuse, Substance Use, Child Abuse, Neglect, Child
- Trial name
- EPIC (NCT04700696)
- Testing
- Peer Recovery Support, Family Treatment Drug Court with Medications for Opioid Use Disorders (MOUD), Relational Skill Building based on the Nurturing Parenting Program (NPP)
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Ohio State University
Drink Too Much, Drinking, Binge
Group-based Intervention for Club Patrons
The purpose of this study is to develop and test a group-based strategy for encouraging groups of young adults who are engaged in party behaviors at nightclubs to intervene with each other to reduce harms associated with overuse…
- Conditions
- Drink Too Much, Drinking, Binge, Drunk, Drug Use
- Trial name
- NCT03652688
- Testing
- Nightlife Safety Plans (NSP), Fire Safety
- Where
- 2 sites in United States
- Volunteers
- 959 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Adolescent, Substance Use
Martial Arts as Early Intervention for Teen Drug Abuse
This is a Stage 1A/1B behavioral therapy development project with the aim of developing and piloting an early intervention based upon traditional martial arts for adolescents who are in the early stages of substance use/misuse.
- Trial name
- NCT00956527
- Testing
- Modified traditional martial arts training
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Colorado, Denver
Cannabis Dependence
Effects of Chronic Intake of Cannabis on Contrast Sensitivity
Rates of driving under the influence of cannabis have risen in recent years. Cannabis is involved in 1/3 of motor vehicle collisions.
- Trial name
- NCT01793961
- Testing
- electroretinogram, contrast sensitivity tests
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Substance Use, Healthy
Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less…
- Trial name
- SIGN (NCT07094061)
- Testing
- fMRI, Questionnaires and surveys, Behavioral tasks and eye tracking
- Where
- 2 sites in United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Overdose
Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)
This study is designed to assess the impact of new approaches to therapy for paracetamol poisoning. Standard therapy is currently acetylcysteine by intravenous infusion over 20.25h.
- Trial name
- SNAP (NCT01050270)
- Testing
- Ondansetron, acetylcysteine
- Where
- 3 sites in United Kingdom
- Volunteers
- 222 people
- Sponsor
- University of Edinburgh
Alcohol or Other Drugs Use
Brief Substance Use Intervention for Youth in Teen Court
Youth involved in the juvenile justice system have multiple problems, including an earlier onset of alcohol and drug use and higher rates of alcohol and drug use than their peers in the general population.
- Trial name
- NCT01464554
- Testing
- Usual care, Project Free Talk
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- RAND
Chemotherapy-Related Cognitive Impairment, Healthy
Telerehabilitation Cognitive Impairments Following Chemotherapy Usability Study
Develop a game-based upper-extremity motor and cognitive rehabilitation system using custom and adaptable virtual reality simulations.
- Trial name
- TCIFCU (NCT04839588)
- Testing
- Usability study
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bright Cloud International Corp
Paediatric Thyrotoxicosis
Antithyroid Drug Treatment of Thyrotoxicosis in Young People
The investigators aim to establish whether biochemical control during anti-thyroid drug therapy in young people with thyrotoxicosis varies depending upon whether a 'block and replace' or 'dose titration' regimen is used.
- Trial name
- NCT01436994
- Testing
- Block and Replace, Dose Titration, carbimazole
- Where
- 18 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Alcohol Use Disorder
Developing a Novel Human Laboratory Paradigm for AUD Medication Screening
The intent of the study is to develop two versions of the 'ability to resist' drinking model designed to screen Alcohol Use Disorder (AUD) medications.
- Trial name
- NCT06489782
- Testing
- Model 1, Model 2
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Use Disorder
Child Healthcare at MATER - Pediatric Study
The objective of this project is to implement and evaluate a group model of well child care for mothers in treatment for opioid use disorder and their children that addresses the specific health needs and concerns of…
- Trial name
- CHAMPS (NCT05488379)
- Testing
- Group well child care
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Thomas Jefferson University
Opioid Use Disorder, Alcohol Use Disorder
Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis
The opioid epidemic has become one of America's deadliest crises, surpassing car crashes, firearms, and HIV/AIDS as a leading cause of death for Americans under fifty years of age.
- Conditions
- Opioid Use Disorder, Alcohol Use Disorder, Health Risk Behaviors, Criminal Behavior
- Trial name
- RB (NCT05665179)
- Testing
- Removing Barriers to Recovery
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- University of Michigan