Clinical trials: Chemoradiotherapy
Nasopharyngeal Carcinoma
Chemoradiotherapy for Patients With Locally Advanced Nasopharyngeal Carcinoma Using Raltitrexed-Cisplatin
The purpose of this study is to evaluate the efficacy and safety of raltitrexed and cisplatin neoadjuvant chemotherapy followed by concurrent radiotherapy with raltitrexed and cisplatin in patients with locally advanced…
- Trial name
- NCT02562599
- Testing
- raltitrexed-cisplatin, Intensity-modulated radiotherapy (IMRT)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hubei Cancer Hospital
Head and Neck Cancer
Topical/Oral Melatonin for Preventing Concurrent Radiochemotherapy Induced Oral Mucositis/Xerostomia Cancer Patients
The study evaluates the effect of melatonin for preventing concurrent radiochemotherapy induced oral mucositis and xerostomia and improving quality of life in head and neck cancer patients.
- Trial name
- NCT02430298
- Testing
- Melatonin
- Where
- Thailand
- Volunteers
- 39 people
- Sponsor
- Khon Kaen University
PD-1, Chemoradiotherapy
Toripalimab With Preoperative Chemoradiotherapy for LA-EGJ
This study aims to investigate the safety and efficacy of radiotherapy combined with Toripalimab (PD-1 inhibitor) in the treatment of locally advanced adenocarcinoma of the gastroesophageal junction.
- Conditions
- PD-1, Chemoradiotherapy, Gastroesophageal Junction Cancer
- Trial name
- NCT04061928
- Testing
- PD-1
- Volunteers
- 45 people
- Sponsor
- Peking University
Head and Neck Squamous Cell Cancer
Intensive Nutrition Counselling in Patients With Head and Neck Cancer
The purpose of this study is to assess the effect of a pre-planned patient-adjusted intensive nutritional counselling given by a dietitian several times during (chemo)radiotherapy vs.
- Trial name
- NCT02159508
- Testing
- Nutritional counselling
- Where
- Finland
- Volunteers
- 65 people
- Sponsor
- Helsinki University Central Hospital
Rectal Cancer
Leucine Plus Radiochemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cancer
Colorectal cancer (CRC), a prevalent gastrointestinal malignancy, is experiencing a rising incidence in China. Rectal cancer constitutes nearly half of all new CRC cases, with over half of these patients diagnosed at a locally…
- Trial name
- NCT07359989
- Testing
- Oral administration of Leucine
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Head and Neck Cancer
Clinical Trial on the Efficacy and Safety of Chining Decoction in the Treatment of Radiation Stomatitis
This study evaluates the efficiency and safety of ChiNing decoction to head and neck cancer patients with radioactive stomatitis.
- Trial name
- NCT02303197
- Testing
- ChiNing decoction
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Mucinous Adenocarcinoma of the Rectum, Recurrent Rectal Cancer
Genetic Mutations in Blood and Tissue Samples in Predicting Response to Treatment in Patients With Locally Advanced Rectal Cancer Undergoing Chemoradiation
This research trial studies genetic mutations in blood and tissue samples to see if they can be used to predict treatment response in patients with locally advanced rectal cancer undergoing chemoradiation.
- Conditions
- Mucinous Adenocarcinoma of the Rectum, Recurrent Rectal Cancer, Signet Ring Adenocarcinoma of the Rectum, Stage IIA Rectal Cancer
- Trial name
- NCT02132858
- Testing
- cytology specimen collection procedure, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Fox Chase Cancer Center
Head and Neck Cancer
Observational Study on Biomarkers in Head and Neck Cancer (HNprädBio)
The aim of this clinical research project is to validate the prognostic impact of potential biomarkers on loco-regional control of locally advanced head and neck cancer after definitive or adjuvant radiochemotherapy.
- Trial name
- HNprädBio (NCT02059668)
- Testing
- Biomarker analyses head & neck cancer tissue, blood specimen
- Where
- 10 sites in Germany
- Volunteers
- 588 people
- Sponsor
- Technische Universität Dresden
Locally Advanced Esophageal Squamous Cell Carcinoma
Consolidation of Toripalimab After Chemoradiotherapy in Elderly Esophageal Cancer (EC-CRT-007)
Although definitive chemoradiotherapy (CRT) is the standard treatment option for unresectable locally advanced esophageal cancer, elderly patients tolerate intravenous concurrent CRT less well with age and comorbidities.
- Trial name
- EC-CRT-007 (NCT06187597)
- Testing
- S-1, Toripalimab, Intensity-modulated radiotherapy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sun Yat-sen University
Cervical Cancer
Identification of a MOLecuLar Signature in Locally Advanced Cervical Cancer Patients
The importance of radioresistance in cervical cancer treatment failure indicates that certain biomarkers may be useful for cervical cancer treatment individualization.
- Trial name
- MOLLY (NCT06016868)
- Testing
- Tumor tissue, Blood sample
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gastric Cancer, Chemoradiation
Feasibility Trial of Neoadjuvant Chemoradiotherapy for Locally Advanced Gastric Cancer
Because locally far-advanced gastric cancer combined with adjacent tissue invasion has a poor prognosis, some phase 2 and 3 clinical trials of neoadjuvant chemotherapy (NAC) are performed in Japan.
- Trial name
- NCT01381913
- Where
- Japan
- Volunteers
- 12 people
- Sponsor
- Kagawa University
Cervical Cancer
Radiotherapy With Single-Agent Cisplatin or Combination Chemotherapy in Defined Poor-Prognostic Cervical Cancer
Concurrent radiotherapy with cisplatin-based chemotherapy has become the standard treatment for patients with cervical cancer. However, in patients with advanced cervical cancer, half of them treated with contemporary…
- Trial name
- NCT00842660
- Testing
- Gemzar (gemcitabine)
- Where
- 2 sites in Taiwan
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Radiation Therapy Complication, Chemotherapeutic Toxicity
System for High-Intensity Evaluation During Radiotherapy
This quality improvement project will evaluate the implementation of a previously described intervention (twice per week on-treatment clinical evaluations) in a feasible fashion using a previously described machine learning…
- Trial name
- SHIELD-RT (NCT04277650)
- Testing
- Machine learning algorithm
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- Duke University
Bladder Cancer
Chemotherapy and Radiation Therapy in Treating Patients With Stage II or Stage III Bladder Cancer That Was Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, cisplatin, and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00777491
- Testing
- induction cisplatin, induction 5-fluorouracil, induction gemcitabine
- Where
- 11 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- Radiation Therapy Oncology Group
Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer
This phase III trial compares the effect of adding stereotactic body radiation therapy (SBRT) to the usual treatment (conventional image guided radiation therapy [IGRT] and chemotherapy followed by immunotherapy with durvalumab…
- Conditions
- Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8
- Trial name
- NCT05624996
- Testing
- Carboplatin, Cisplatin, Computed Tomography
- Where
- 477 sites in United States, Canada
- Volunteers
- 474 people
- Sponsor
- NRG Oncology
Cervical Cancer, Neoplasm Recurrence, Local
Iparomlimab and Tuvonralimab With Chemoradiation for the Treatment of Locally Recurrent and Oligometastatic Cervical Cancer
The goal of this clinical trial is to evaluation the efficacy and safety of iparomlimab and tuvonralimab, paclitaxel + cisplatin/carboplatin combined with radiotherapy of locally recurrent and oligometastatic cervical cancer.The…
- Conditions
- Cervical Cancer, Neoplasm Recurrence, Local, Oligometastatic
- Trial name
- NCT06942416
- Testing
- Paclitaxel and Cisplatin/ Carboplatin, Iparomlimab and Tuvonralimab, Radiotherapy
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shandong Cancer Hospital and Institute
Non-small Cell Lung Cancer
Study of Split-course Chemoradiotherapy For Locally Advanced None-small Cell Lung Cancer
This Phase II study is to determine the efficacy of split-course irradiation with concurrent chemotherapy in locally advanced none-small cell lung cancer patients.
- Trial name
- NCT02573506
- Testing
- split-course radiotherapy, Concurrent chemotherapy
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Sun Yat-sen University
Head and Neck Squamous Cell Carcinoma
Efficacy of an Oral Immunomodulatory Nutrient on Survival During Postoperative Concomitant Chemoradiotherapy in Head and Neck Cancer
The investigators designed a prospective randomized double-blind trial to determine if the oral immunomodulating formula could improve the disease-free survival rate in high-risk locally-advanced head and neck Squamous Cell…
- Trial name
- SIMPA01 (NCT04001543)
- Testing
- Immunomodulating oral supplementation, Sip feed control
- Where
- 2 sites in France
- Volunteers
- 27 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Nasopharyngeal Carcinoma
The Effect of COX-2 Inhibitor on Radiosensitivity in Nasopharyngeal Carcinoma
The purpose of this study is to determine whether celecoxib is effective in the treatment of nasopharyngeal carcinoma by concurrent chemoradiation with weekly nedaplatin.
- Trial name
- NCT02537925
- Testing
- Celecoxib, Nedaplatin, Concurrent Radiotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changjie Huang
Nasopharyngeal Carcinoma, Malnutrition
Effect of Chemoradiotherapy on Nutritional Status in Advanced NPC Patients
This is an prospective，open-label, none-interventional, observational， multicenter phase II clinical trial. The purpose of this study is to observe the effect of neoadjuvant chemotherapy followed by concurrent chemoradiation…
- Trial name
- NCT02575547
- Testing
- cisplatin and docetaxel
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Zhao Chong