Clinical trials: Chemoradiotherapy
Locally Advanced Salivary Gland Carcinoma
Prospective Registry Study on the Implementation of Simultaneous Postoperative Radiochemotherapy for Salivary Gland Carcinomas of the Head and Neck Region
This is a prospective registry study based on a standard therapy concept for postoperative simultaneous radiochemotherapy established in Erlangen and elsewhere.
- Trial name
- NCT06464198
- Testing
- simultaneous postoperative radiochemotherapy
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Locally Advanced Non-small Cell Lung Cancer
The Predictive Biomarkers in Patients With Locally Advanced Non-small Cell Lung Cancer
This study is a prospective cohort study to evaluate the peripheral blood lymphocyte subsets as predicative biomarkers reflecting the efficacy and toxicity in patients with locally advanced non-small cell lung cancer (NSCLC)…
- Trial name
- NCT06287320
- Testing
- concurrent or sequential chemoradiotherapy, Immunotherapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma
Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study
This phase II trial studies how well lower-dose chemotherapy plus radiation (chemoradiation) therapy works in comparison to standard-dose chemoradiation in treating patients with early-stage anal cancer.
- Conditions
- Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma, Anal Canal Squamous Cell Carcinoma, Anal Margin Squamous Cell Carcinoma
- Trial name
- NCT04166318
- Testing
- Biopsy, Biospecimen Collection, Capecitabine
- Where
- 659 sites in United States
- Volunteers
- 252 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Head and Neck Neoplasms
Effectiveness of Manual Acupuncture for Head and Neck Cancer Patients Undergoing Chemoradiation
The goal of this clinical trial is to assess whether manual acupuncture (MA) is more effective than sham acupuncture in improving leukocyte count and reducing cancer-related fatigue (CRF) in head and neck cancer (HNC) patients…
- Trial name
- NCT07044414
- Testing
- Manual Acupuncture
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Universitas Indonesia
Muscle Invasive Bladder Cancer
Radical CystEctomy or RaDio-chEMotherapy as Preferred Treatment for invasivE blaDder Cancer
Your text is mostly clear and well-structured. Here's a slightly polished version for improved clarity and flow: This is a randomized, non-inferiority study comparing radiochemotherapy to radical cystectomy in patients with…
- Trial name
- REDEMPTED (NCT07008833)
- Testing
- Radiochemotherapy, Radical cystectomy
- Where
- Brazil
- Volunteers
- 336 people
- Sponsor
- Brazilian Clinical Research Institute
Lung Metastatic Nasopharyngeal Carcinoma
A Real-world Study of the Efficacy and Safety of PD-1 Inhibitors Combined With Chemoradiotherapy in Lung Metastatic Nasopharyngeal Carcinoma
This study is a retrospective real-world study. In this study, we plan to collect the clinical data of lung metastatic nasopharyngeal carcinoma patients who received PD-1 inhibitors and chemotherapy combined with or without…
- Trial name
- NCT07062484
- Testing
- Control: gemcitabine, cisplatin, tirelizumab, Experimental: gemcitabine, cisplatin, tirelizumab and radiotherapy
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Non-small Cell Lung Cancer
Hypofractionated Radiation Therapy Combined With Concurrent Chemotherapy for Patients With Non-small Cell Lung Cancer
The purpose of this study is to evaluate the safety of accelerated hypofractionated three-dimensional conformal radiation therapy (3 Gy/fraction) concurrent with chemotherapy for patients with unresectable stage III non-small…
- Trial name
- NCT02720614
- Testing
- Hypofractionated radiation/chemotherapy
- Volunteers
- 12 people
- Sponsor
- LIN QIANG
Head and Neck Cancer
Study Using Pharmacogenetics to Select Treatment for Head and Neck Cancer
This is a study for patients with head and neck cancer who will be receiving chemotherapy and radiation therapy for their disease.
- Trial name
- PGx-SELECT (NCT00881114)
- Testing
- Cisplatin, Cetuximab
- Sponsor
- Georgetown University
Head and Neck Neoplasms
Benefits of MPACT in Locally Advanced Head and Neck Cancer Patients Undergoing Chemoradiotherapy
The goal of this study is to test, in a randomized controlled trial among head and neck cancer patients, the short and longer term effects of the MPACT (Maintaining Physical Activity during Cancer Treatment) program (infused with…
- Trial name
- NCT02485470
- Testing
- MPACT
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan Rogel Cancer Center
Nasopharyngeal Cancinoma (NPC), Nasopharangeal Cancer
Phase III Trial of EBV-DNA-Guided Adaptive Immunotherapy for Advanced Nasopharyngeal Carcinoma
This trial evaluated the efficacy of two adjuvant regimens following identical induction and concurrent chemoradiotherapy (IC+CCRT) in locoregionally advanced nasopharyngeal carcinoma (LANPC) patients with persistent EBV DNA…
- Trial name
- NCT07238569
- Testing
- Adebrelimab (PD-L1 inhibitor), Cisplatin (100mg/m2), Intensity-modulated radiotherapy
- Volunteers
- 516 people
- Sponsor
- Sun Yat-sen University
Locally Advanced Nasopharyngeal Carcinoma, Envafolimab
Envafolimab Plus Chemoradiotherapy for Locally Advanced NPC, a Prospective, Single Armed Phase II Trial.
Patients diagnosed with locally advanced nasopharyngeal carcinoma will be recruited in this study. All the patients will get 3 cycles of GP+ Envafolimab for the induction chemotherapy.
- Conditions
- Locally Advanced Nasopharyngeal Carcinoma, Envafolimab, Induction Chemotherapy, PD-L1
- Trial name
- NCT05397769
- Testing
- Envafolimab Plus Chemoradiotherapy
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Sun Yat-sen University
Esophageal Malignant Neoplasm Primary
Prospective Phase II Clinical Study of Neoadjuvant Chemoradiotherapy Combined With PD-1/PD-L1 Inhibitors in the Treatment of Locally Advanced Resectable Esophageal Squamous Cell Carcinoma
A prospective trial design was used to evaluate the efficacy and safety of neoadjuvant chemoradiotherapy combined with PD-1/PD-L1 inhibitors in the treatment of locally advanced resectable esophageal squamous cell carcinoma.
- Trial name
- LA-ESCC (NCT06888531)
- Testing
- Neoadjuvant chemoradiotherapy combined with PD-1/PD-L1 inhibitors for the treatment of locally advanced resectable esophageal squamous cell carcinoma
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Henan Cancer Hospital
Esophageal Squamous Cell Carcinoma
Postoperative Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Patients With Locoregionally Advanced Esophageal Squamous Cell Carcinoma
The aim of this study is to investigate the effect of postoperative concurrent chemoradiotherapy versus radiotherapy alone for patients with locally advanced esophageal squamous cell carcinoma.
- Trial name
- NCT03600831
- Testing
- Docetaxel plus cisplatin, radiotherapy
- Where
- 4 sites in China
- Volunteers
- 434 people
- Sponsor
- Huai'an First People's Hospital
Rectal Cancer
Use of Positron Emission Tomography/Computed Tomography (PET/CT) to Assess Tumor Response to Neoadjuvant Treatment for Distal Rectal Cancer
Preoperative chemoradiation therapy is the preferred initial treatment option for distal rectal cancers. However, assessing tumor response to preoperative chemoradiation therapy remains a challenge to the colorectal surgeon…
- Trial name
- NCT00254683
- Testing
- PET/CT with FDG
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Colorectal Adenocarcinoma
Oncological Impact of Lateral Nodes in Rectal Cancer
The combination of neoadjuvant chemoradiotherapy (CRT) and total mesorectal excision (TME) is considered the standard treatment for locally advanced rectal cancer in the western world.
- Trial name
- I-ONARC (NCT05592873)
- Testing
- Neoadjuvant chemoradiotherapy (CRT)
- Volunteers
- 317 people
- Sponsor
- Niguarda Hospital
Pathologically Proven Gastrointestinal Malignancy, Plan of Care Must Include Chemoradiation
Effects of Chemoradiation and Surgery on Cardiopulmonary Fitness and Tumor Neoplastic Phenotype in Gastrointestinal Malignancies
There is growing evidence of the integral role of exercise following cancer treatment. Randomized trials show that exercise improves post treatment symptoms and quality of life in breast and prostate cancer patients.Regular…
- Trial name
- NCT02235441
- Testing
- Cardiopulmonary Exercise Test (CPET)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Rectal Cancer, Non Metastatic Cancer
Prospective Monocentric Study Evaluating the Circulating NK Cells Phenotype and the ImmunoScore® in Patients With Non Metastatic Rectal Cancer
Until 2020, the standard treatment for rectal cancer was a combination of radiotherapy and concomitant chemotherapy based on IV or oral 5FU, with a low complete response rate.
- Trial name
- IMMUNOREC (NCT06536127)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut Sainte Catherine
Esophageal Cancer, Chemoradiotherapy
Sintilimab After Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma
This trial is a prospective, randomized, controlled, multicenter, phase II clinical study to evaluate the efficacy and safety of sintilimab as consolidation therapy in elderly patients with esophageal cancer who did not progress…
- Conditions
- Esophageal Cancer, Chemoradiotherapy, Sintilimab, Immunotherapy
- Trial name
- NCT06413342
- Testing
- Sintilimab
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Zhejiang Cancer Hospital
Rectal Cancer, Rectal Cancer Stage II
TNT to Increase the Clinical Complete Response Rate for Distal LARC
This is a open-label, single-arm study to investigate the safety and efficacy of total neoadjuvant treatment (TNT) in patients with locally advanced resectable rectal cancer.
- Conditions
- Rectal Cancer, Rectal Cancer Stage II, Rectal Cancer Stage III, Chemoradiation
- Trial name
- TESS (NCT03840239)
- Testing
- Capecitabine, Oxaliplatin, External beam radiotherapy, Surgery
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Sun Yat-sen University
Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
Pembrolizumab, Chemotherapy, and Radiation Therapy With or Without Surgery in Treating Patients With Anaplastic Thyroid Cancer
This phase II trial studies how well pembrolizumab, chemotherapy, and radiation therapy work with or without surgery in treating patients with anaplastic thyroid cancer.
- Trial name
- NCT03211117
- Testing
- Docetaxel, Doxorubicin Hydrochloride, Intensity-Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
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