Clinical trials: Chemoradiotherapy
Head and Neck Neoplasms, Carcinoma, Squamous
ctDNA and MRI Parameters in Head and Neck Cancer
Patients undergoing primary radiochhemotherapy for locally advanced head and neck squamous cell carcinomas are included in this study.
- Trial name
- NCT06215612
- Testing
- Blood draw, MRI
- Volunteers
- 50 people
- Sponsor
- Franziska Eckert
Rectal Cancer
Preoperative Hyperfractionated Radiotherapy or Radiochemotherapy in Locally Advanced Rectal Cancer.
Clinical objective of the study is to compare the rates of pathologic response, acute toxicity and sphincter preservation with two schedules of preoperative regiment in patients with locally advanced rectal cancer.
- Trial name
- NCT01814969
- Testing
- Hyperfractionated Radiochemotherapy, Hyperfractionated Radiotherapy
- Where
- Poland
- Volunteers
- 260 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Stomach Neoplasms
Perioperative Chemoradiotherapy for Potentially Resectable Gastric Cancer
Rationale: Adjuvant chemoradiation considered as standard of care after curative surgery for adenocarcinoma of stomach and gastroesophageal cancer.
- Trial name
- NCT00420394
- Testing
- Chemotherapy, surgery, radiotherapy
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Soroka University Medical Center
Lung Cancer
Chemotherapy and Radiation Therapy With or Without Panitumumab in Treating Patients With Stage IIIA Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy (CT), such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00979212
- Testing
- panitumumab, carboplatin, paclitaxel
- Where
- 31 sites in United States
- Volunteers
- 71 people
- Sponsor
- Radiation Therapy Oncology Group
Rectal Cancer, Adenocarcinoma, Neoadjuvant Chemoradiation
Multicenter, Prospective, RCT：Investigation of Combined Modality Therapy for Locally Advanced Mid/Low Rectal Cancer.
At present, the combined modality treatment of preoperative neoadjuvant chemoradiotherapy (NCRT) followed by radical surgery has become the standard of care for the locally advanced mid/low rectal cancer, having been proved to…
- Trial name
- NCT03042000
- Testing
- non-NCRT, NCRT, capecitabine with oxaliplatin
- Volunteers
- 1,200 people
- Sponsor
- Peking Union Medical College Hospital
Gastric Adenocarcinoma, Gastric Cancer
Study of 5-Fluorouracil and Leucovorin and Intra-abdominal Floxuridine Chemoradiation in Patients With Fully Resected Locally Advanced Gastric Adenocarcinoma
The purpose of this study is to evaluate the side effects of a new treatment for stomach cancer which may potentially improve the prognosis of this cancer.
- Trial name
- NCT00183911
- Testing
- floxuridine, 5-Fluorouracil, leucovorin, External Beam Radiotherapy, Surgery
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Southern California
Rectal Neoplasm Carcinoma in Situ Adenocarcinoma
Metformin With Neoadjuvant Chemoradiation to Improve Pathologic Responses in Rectal Cancer
This study is a phase II, single arm, controlled, open label internal pilot.
- Trial name
- NCT03053544
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
Esophageal Squamous Cell Carcinoma, Neoadjuvant Therapy
Surveillance of Peripheral Blood of Lymphocyte and Immunocyte in Neoadjuvant Therapy Patients With Esophageal Squamous Cell Carcinoma (pLINE)
Neoadjuvant chemoradiotherapy treatment represents the standard approach for resectable locally advanced esophageal squamous cell carcinoma.
- Conditions
- Esophageal Squamous Cell Carcinoma, Neoadjuvant Therapy, Surgery
- Trial name
- NCT04440332
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer
This phase I/Ib trial tests the safety and best dose of ipatasertib in combination with the usual treatment approach using chemotherapy together with radiation therapy ("chemo-radiation") in patients with head and neck cancer.
- Conditions
- Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Head and Neck Carcinoma of Unknown Primary, Locally Advanced Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT05172245
- Testing
- Biopsy Procedure, Biospecimen Collection, Cisplatin
- Where
- 18 sites in United States, Canada
- Volunteers
- 46 people
- Sponsor
- National Cancer Institute (NCI)
Oesophageal Cancer
Cytosponge™ for Post-Chemoradiation Surveillance of Oesophageal Cancer
This is a feasibility study testing the use of the Cytosponge™ device in patients with known oesophageal cancer treated with pre-operative or definitive chemoradiation.
- Trial name
- CYTOFLOC (NCT03529669)
- Testing
- Cytosponge™
- Where
- 11 sites in United Kingdom
- Volunteers
- 41 people
- Sponsor
- University of Oxford
Head and Neck Neoplasms
A Study of Concomitant Camrelizumab With Chemoradiation for Locally Advanced Head and Neck Cancer
The goal of this study is to determine the efficacy and safety of camrelizumab given concomitantly with chemoradiation in participants with unresectable, locally advanced head and neck squamous cell carcinoma (LA-HNSCC).
- Trial name
- NCT04405154
- Testing
- Camrelizumab, Cisplatin, IMRT or VMAT
- Volunteers
- 32 people
- Sponsor
- West China Hospital
Phase I: To Determine the Maximum Tolerated Dose (MTD), Phase II: To Assess the Pathologic CR Rate and Feasibility Following Neoadjuvant Chemoradiation Therapy With S1/Oxaliplatin
Phase I/II Study of Neoadjuvant Chemoradiotherapy With S-1/ Oxaliplatin in Patients With Gastric Cancer: Randomized Phase II Study of S-1/RT vs. S-1/Oxaliplatin/RT
To evaluate the efficacy of preoperative S-1/oxaliplatin/RT in locally advanced gastric cancer
- Trial name
- NCT01106066
- Testing
- Oxaliplatin, S-1, radiotherapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Oral Mucositis
RRx-001 for Reducing Oral Mucositis in Patients Receiving Chemotherapy and Radiation for Head and Neck Cancer
The purpose of this study is to determine if RRx-001, which is added on to the cisplatin and radiation treatment, reduces the incidence of severe oral mucositis in patients with head and neck cancers.
- Trial name
- KEVLARx (NCT05966194)
- Testing
- RRx-001, Intensity Modulated Radiation Therapy (IMRT), Cisplatin for injection 100 mg/m2
- Where
- 14 sites in United States
- Volunteers
- 216 people
- Sponsor
- EpicentRx, Inc.
Locally Advanced Cervical Cancer
Assessment of Prognosis Using Peripheral Blood Circulating Tumor DNA in Patients With Cervical Cancer
This observational study is conducted to assess the value of using peripheral blood ctDNA to detect dynamic changes in HPV and genetic variants in predicting the prognosis of patients with locally advanced cervical cancer, as…
- Trial name
- NCT05602831
- Testing
- detect HPV and genetic variants
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Fudan University
Locally Advanced Rectal Cancer
The Effect of Cancer Therapies and Exercise on Mitochondrial Energetics and Fitness
The present study is a randomised control trial investigating the effects of a short six week exercise training program in rectal cancer patients following neoadjuvant chemoradiotherapy prior to elective rectal cancer surgery.
- Trial name
- NCT01859442
- Testing
- Structured responsive interval exercise training programme
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Michelle Mossa
Nasopharyngeal Carcinoma
Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma (NPC)
The primary objective of this study is to determine the response rate, tolerance and overall survival in patients with stage III, IVa, IVb NPC treated with neoadjuvant chemotherapy (TPF regimen) and concurrent chemoradiation.
- Trial name
- TPF for NPC (NCT00817583)
- Testing
- docetaxel, cisplatin, fluorouracil, 3D-CRT (three-dimensional conformal radiation therapy) or IMRT (intensity-modulated radiation therapy)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Colorectal Cancer
Surgery With or Without Chemotherapy and Radiation Therapy in TreatingPatients With Stage I Rectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00023751
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 180 sites in United States, Canada and 1 more
- Volunteers
- 320 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Local Advanced Non-small Cell Lung Cancer
Study of Early Nutritional Intervention During Concurrent Chemoradiotherapy for Local Advanced Non-small Cell Lung Cancer
This single-arm phase II prospective study is to determine the efficacy of early nutritional intervention during concurrent chemoradiotherapy for local advanced non-small cell lung cancer.
- Trial name
- NCT03673657
- Testing
- Early Nutrition Intervention from the start of CCRT, Thoracic radiotherapy, Weekly DP chemotherapy concurrent with thoracic radiotherapy
- Where
- China
- Volunteers
- 67 people
- Sponsor
- Sun Yat-sen University
Uterine Cervical Neoplasms
Pelvic RT Versus Prophylactic Extended-field RT in Patients With Cervical Cancer
To investigate the value of prophylactic extended-field irradiation (EFI), we conduct a randomized clinical trial to compare the efficacy and toxicity of pelvic irradiation and prophylactic EFI in selected patients with cervical…
- Trial name
- NCT03955367
- Testing
- Prophylactic extended-field Irradiation, Pelvic irradiation, Intracavitary brachytherapy
- Where
- 2 sites in China
- Volunteers
- 638 people
- Sponsor
- Peking Union Medical College Hospital
Esophageal Neoplasms, Squamous Cell Carcinoma
Neoadjuvant Chemotherapy Followed by Preoperative Chemoradiation in Resectable Squamous-cell Esophageal Cancer
This study is conducted to evaluate efficacy and safety of neoadjuvant chemotherapy followed by preoperative chemoradiotherapy in patients with resectable esophageal squamous cell carcinoma
- Conditions
- Esophageal Neoplasms, Squamous Cell Carcinoma, Concurrent Chemoradiotherapy
- Trial name
- NCT03579004
- Testing
- Paclitaxel, Cisplatin, Fluorouracil
- Where
- 2 sites in Russia
- Volunteers
- 48 people
- Sponsor
- Mona Frolova
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.