Clinical trials: Chemoradiotherapy
Solid Tumors
Combination of Hyperthermia and Concurrent Chemoradiotherapy (CCRT) in Treatment Failure Solid Tumors
The primary goals of hyperthermia combined with chemotherapy/radiotherapy on treatment failure solid tumors are tumor response rate, while secondary goals are rates of acute and late adverse effects, local control rate, distant…
- Trial name
- NCT02120118
- Testing
- Radiation, Hyperthermia, Cisplatin
- Where
- Taiwan
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Esophagus Adenocarcinoma
Organ Preservation With Durvalumab-based Immunotherapy in Combination With Chemoradiation as Definitive Therapy for Early Stage Esophageal Adenocarcinoma With Indication for Radical Surgery
The present clinical trial is a prospective, investigator-initiated, single-arm, open-label, multicenter phase II trial investigating whether a definite organ preservation therapy consisting of the combination of durvalumab with…
- Trial name
- NCT05713838
- Testing
- Durvalumab, FLOT, mFOLFOX-6
- Where
- 22 sites in Germany
- Volunteers
- 32 people
- Sponsor
- Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Head and Neck Squamous Cell Carcinoma
Predictive Value of Diffusion-weighted MRI Performed in Early Post-treatment in the Occurrence of Tumor Recurrence or Progression in Head and Neck Squamous Cell Carcinoma Treated With Chemoradiotherapy: a Pilot Study
Head and neck squamous cell carcinoma are frequent. The chemoradiotherapy protocols are part of the reference treatment of locally advanced stage tumors.
- Trial name
- ORODIFF (NCT02862678)
- Testing
- diffusion-weighted MRI
- Where
- France
- Volunteers
- 59 people
- Sponsor
- CHU de Reims
Epidermoid Carcinoma, Anus
Radiochemotherapy With Panitumumab in the Localised Epidermoid Carcinoma of the Anus
Treatment is based on radiochemotherapy for locally advanced tumours. The objective of treatment is to provide a cure without resorting to abdominoperineal amputation, while preserving sphincter function.
- Trial name
- NCT01581840
- Testing
- radiochemotherapy, Panitumumab
- Where
- 15 sites in France
- Volunteers
- 45 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Cervical Cancer Squamous Cell, Cervical Cancer
HYPOfractionated RadioTherapy in Cervical Cancer
The study is a prospective, randomized, non-inferiority clinical trial which will test whether a short course of radiation treatment (hypofractionation) for cervical cancer works as well as the standard longer course.
- Trial name
- HYPORT-CC (NCT07625943)
- Testing
- Hypofractionated Chemoradiation, Standard fractionated chemoradiation
- Where
- India
- Volunteers
- 396 people
- Sponsor
- All India Institute of Medical Sciences
Cachexia, Fatigue
Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced Non-Small Cell Lung Cancer Undergoing Chemoradiation
This randomized clinical trial studies pulmonary rehabilitation in improving lung function in patients with locally advanced non-small cell lung cancer undergoing chemoradiation.
- Conditions
- Cachexia, Fatigue, Pulmonary Complications, Radiation Toxicity
- Trial name
- NCT02017925
- Testing
- exercise intervention, pulmonary complications management/prevention, quality-of-life assessment
- Sponsor
- Ohio State University Comprehensive Cancer Center
Nasopharyngeal Neoplasms
Maintenance Therapy of Apatinib After Chemoradiotherapy in Metastatic Nasopharyngeal Carcinoma
The study is to evaluate the efficacy and safety of Apatinib as maintenace therapy for Nasopharyngeal Carcinoma With Metastasis after Chemoradiotherapy, including progress free survival(PFS)、overall survival (OS)、Quality of life…
- Trial name
- NCT03180476
- Testing
- Apatinib
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Neoplasms, Head and Neck
Study Of Adjuvant Lapatinib In High-Risk Head And Neck Cancer Subjects After Surgery
This is a randomised, double-blind, placebo-controlled, multicentre, global Phase III trial comparing the efficacy of adjuvant oral lapatinib versus placebo in high-risk subjects with head and neck cancer following surgery.
- Trial name
- NCT00424255
- Testing
- Lapatinib, Chemoradiation
- Where
- 117 sites in United States, Argentina and 20 more
- Volunteers
- 688 people
- Sponsor
- GlaxoSmithKline
Vaginal Neoplasms
Image-guided Brachytherapy for Vaginal Cancer (EMBRAVE)
The goal of this clinical study is to improve clinical outcomes of patients with vaginal cancer including vaginal recurrences who are treated with curative intent by primary radio(chemo)therapy and image-guided adaptive…
- Trial name
- EMBRAVE (NCT06514235)
- Testing
- Observational study (Non-interventional study)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Erasmus Medical Center
Pancreatic Cancer
Gemcitabine With or Without Capecitabine and/or Radiation Therapy or Gemcitabine With or Without Erlotinib in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed by Surgery
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00634725
- Testing
- capecitabine, erlotinib hydrochloride, gemcitabine hydrochloride
- Where
- 72 sites in France
- Volunteers
- 820 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Efficacy and Safety
Efficacy and Safety of Albumin Paclitaxel Combined With Cisplatin Chemoradiotherapy for Non-resectable Stage III NSCLC
Non-resectable stage III non-small cell lung cancer is recommended for concurrent chemoradiotherapy. Paclitaxel and platinum are commonly used in chemotherapy regimens.
- Trial name
- NCT04284215
- Testing
- Albumin paclitaxel combined with cisplatin
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Guizhou Medical University
Esophageal Neoplasms
A Trial of CMNa Combined With Preoperatie Concurrent Chemoradiotherapy for Locally Advanced ESCC
This is a perspective, multicenter,single arm, open label study to evaluate the efficacy and safety of treatment with CMNa combined with preoperatie concurrent chemoradiotherapy in patients with locally advanced squamous cell…
- Trial name
- NCT02721550
- Testing
- Sodium Glycididazole
- Where
- 9 sites in China
- Volunteers
- 2 people
- Sponsor
- Shandong Cancer Hospital and Institute
Thoracic Cancer
Patient-Generated Health Data Collection During Chemoradiotherapy for Lung Cancer
This is an observational study involving the collection of patient-generated health data using an Apple Watch, a home pulse oximeter, and a smartphone during a course of proton beam radiotherapy for lung cancer.
- Trial name
- PGHD (NCT06342284)
- Testing
- Proton Beam Radiation with or without concurrent chemotherapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The New York Proton Center
Nasopharyngeal Carcinoma
Induction and Concurrent Chemoradiotherapy With Cetuximab for Patients With Locally Advanced Nasopharyngeal Carcinoma
Standard of care for treatment of nasopharyngeal carcinoma is chemoradiation with concurrent cisplatin. Addition of a second agent, cetuximab, which targets nasopharyngeal carcinoma cells with high EGFR protein expression, may…
- Trial name
- NCT01230476
- Testing
- Cetuximab
- Where
- Malaysia
- Volunteers
- 3 people
- Sponsor
- University of Malaya
Malignant Head and Neck Neoplasm, Mucositis
Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy
This randomized phase III trial studies how well gabapentin plus standard of care work compares to standard of care without Gabapentin in preventing inflammation of the mucous membranes (mucositis) in patients with stage III-IV…
- Conditions
- Malignant Head and Neck Neoplasm, Mucositis, Radiation-Induced Disorder
- Trial name
- NCT02480114
- Testing
- Educational Intervention, Gabapentin, Pain Therapy
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
HNSCC
Chemo-radiotherapy Versus Radiotherapy in the Treatment of Salivary Glands and Nasal Tumors (IMRT or Protontherapy)
A phase III, multicenter, randomized, open-label, french study comparing: Arm A : Radiotherapy alone (66 to 70 Gy; 5 fractions/week; 1fraction/day; 2 Gy/fraction) (IMRT or protontherapy) Arm B: Radiotherapy (66 to 70 Gy; 5…
- Trial name
- SANTAL (NCT02998385)
- Testing
- Cisplatin, radiotherapy
- Where
- France
- Volunteers
- 342 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Rectal Cancer
Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients
This is a phase II, prospective, open label, one-center study for evaluation of the addition of nivolumab to the chemotherapy phase of the neoadjuvant treatment for locally advanced rectal cancer patients.
- Trial name
- NCT03921684
- Testing
- Capecitabine, Radiation therapy, mFOLFOX6
- Where
- Israel
- Volunteers
- 29 people
- Sponsor
- Baruch Brenner
Head and Neck (HNSCC)
HYperfractionated Radiation Therapy Versus Concurrent Chemoradiation for Head and Neck Cancer (HYTC)
This is an international multi-centre, non-inferiority phase III randomized controlled trial comparing concurrent chemoradiation with high dose cisplatin (Arm A) vs.
- Trial name
- NCT07801235
- Testing
- 70 gy 35 fractions/7weeks+high dose of cisplatin, 81.6 Gy /68 fractions BID FOR 7 WEEKS
- Where
- Jordan
- Volunteers
- 604 people
- Sponsor
- King Hussein Cancer Center
Non Small Cell Lung Carcinoma
Chemoradiotherapy in Patients With Localised Lung Cancer
The study compares 2 different methods of combined chemotherapy and radiotherapy for the treatment of localised lung cancer in patients not suitable for surgery. Hypothesis(es) to be tested: 1.
- Trial name
- NCT00193921
- Testing
- Vinorelbine, High dose Radiotherapy, Gemcitabine
- Where
- 8 sites in Australia
- Volunteers
- 82 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Locally Advanced Nasopharyngeal Carcinoma
Low-dose Radiotherapy and Neoadjuvant Chemotherapy Sequential Concurrent Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma#NPC#is common malignant tumor in China. The incidence of NPC in most parts of the world and the country is less than 1/10 million, but the incidence rate in China's Guangdong, Guangxi, Fujian and other…
- Trial name
- NCT05503914
- Testing
- low-dose radiotherapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
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