Clinical trials: Chemotherapy Symptoms
Diabetes, Depression
Treatment of Diabetes and Depression in Hispanics and African Americans and Its Effect on A1c and Quality of Life.
This proposed study will test the following hypothesis: Treating depression in Hispanics and African Americans with diabetes will improve their HbA1c and quality of life while on intervention and six months after intervention.
- Trial name
- NCT00624013
- Testing
- sertraline
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Charles Drew University of Medicine and Science
Cancer
Topotecan Pharmacokinetic Characterization Study
A multi-center, open label, single dose Phase I pharmacokinetic (PK) characterization of weekly IV (intravenous) topotecan given at 4mg/m2. 15 patients will be evaluated.
- Trial name
- NCT00361803
- Testing
- topotecan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- GlaxoSmithKline
Chemotherapy-induced Nausea and Vomiting
Granisetron Transdermal Patch System for Prevention of CINV by CapeOX
This study aims to explore the prevention of delayed chemotherapy induced by CAPOX regimen with granisetron transdermal patch。
- Trial name
- NCT05325190
- Testing
- Granisetron Transdermal Patch System
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Chemotherapy-induced Nausea and Vomiting (CINV)
Aprepitant/MK0869 for Prevention of Chemotherapy Induced Nausea and Vomiting Associated With Cisplatin (0869-169)(COMPLETED)
This study will demonstrate and confirm the efficacy and safety of MK0869 for the treatment of chemotherapy-induced nausea and vomiting in Chinese patients.
- Trial name
- NCT00952341
- Testing
- aprepitant, dexamethasone, granisetron
- Volunteers
- 421 people
- Sponsor
- Merck Sharp & Dohme LLC
Carcinoma, Hepatocellular, Secondary
Study of SECOX Versus Sorafenib as First-Line Treatment in Patients With Advanced Hepatocellular Carcinoma (HCC)
The purpose of this study is to determine if sorafenib, capecitabine and oxaliplatin (SECOX) regimen is more effective than sorafenib alone in the treatment of advanced liver cancer.
- Trial name
- NCT02716766
- Testing
- Sorafenib, Capecitabine, Oxaliplatin
- Where
- Hong Kong
- Volunteers
- 46 people
- Sponsor
- The University of Hong Kong
Ovarian Cancer (OvCa), Fallopian Tube Cancers
Taste Alteration, Sarcopenia, and Malnutrition in Gynecologic Cancer Patients Receiving Carboplatin-Paclitaxel Chemotherapy
This observational study aims to evaluate chemotherapy-induced taste alterations, sarcopenia, and malnutrition in patients with gynecologic malignancies (ovarian, fallopian tube, and endometrial cancer) treated with standard…
- Conditions
- Ovarian Cancer (OvCa), Fallopian Tube Cancers, Endometrial Cancer, Chemotherapy-Induced Taste Alteration
- Trial name
- GYM-TASTE (NCT07154966)
- Testing
- Standard Chemotherapy (Carboplatin-Paclitaxel)
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Ankara Etlik City Hospital
Myalgia, Bruxism
Effectiveness of Botox, Dry Needling, Pharmacological Treatment, and Manual Therapy for Bruxism-Induced Myalgia
Eighty individuals (44 female, 36 male), which were randomly divided into 4 groups of 20 patients each, due to the treatment type: Botulinum toxin (BTX); Dry needling (DN); Pharmacological therapy (PT) and Manual therapy (MT).
- Conditions
- Myalgia, Bruxism, Quality of Life
- Trial name
- NCT06583551
- Testing
- Botulinum toxin, Dry needling, Myorel
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Squamous Non Small Cell Lung Cancer
A Randomized, Double-blind, Placebo Controlled Phase III Study to Investigate Efficacy and Safety of First-Line Treatment With HLX10 + Chemotherapy (Carboplatin-Nanoparticle Albumin Bound (Nab) Paclitaxel) in Patients With Stage IIIB/IIIC or IV NSCLC
This study is a randomized, double-blind, multicenter, phase III clinical study to compare the clinical efficacy and safety of HLX10 + chemotherapy vs chemotherapy in subjects with locally advanced or metastatic squamous NSCLC…
- Trial name
- NCT04033354
- Testing
- HLX10, carboplatin and nab paclitaxel
- Where
- 92 sites in United States, China and 5 more
- Volunteers
- 537 people
- Sponsor
- Shanghai Henlius Biotech
Metastatic Colorectal Cancer
Efficacy and Safety of Aflibercept in Combination With FOLFIRI Chemotherapy as 1st Line Treatment for Patients With Metastatic Colorectal Cancer
One of the treatments generally used to treat this disease is a chemotherapy called FOLFIRI. The purpose of this study is to improve the efficacy of the chemotherapy by adding a protein, similar to immunoglobulins, aflibercept…
- Trial name
- NCT02181556
- Testing
- FOLFIRI Protocol, Aflibercept Injection
- Where
- 8 sites in France
- Volunteers
- 41 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Fatigue, Peripheral Neuropathy
LevineConservationModelandColorectalPatients
Colorectal cancer is one of the most common types of cancer in the world, ranking 3rd among cancers that cause death in men and women.
- Conditions
- Fatigue, Peripheral Neuropathy, Anxiety
- Trial name
- NCT06499129
- Testing
- Sensory ball, progressive relaxation exercise, training
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- KTO Karatay University
Relapsed or Refractory Acute Myeloid Leukemia
Dexamethasone in Refractory or First Relapsed Acute Myeloid Leukemia
Recent preclinical and retrospective clinical data have suggested that dexamethasone might sensitize leukemic cells to chemotherapy-induced cell death and thus limit the risk of leukemic regrowth and relapse.
- Trial name
- DEXAML-03 (NCT03765541)
- Testing
- Dexamethasone, Amsacrine, Cytarabine
- Where
- 10 sites in France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Toulouse
Neoplasms, Chemotherapy-induced Nausea and Vomiting
Promoting Cancer Symptom Management in Older Adults
The purpose of the project is to estimate the effect size of a technology based intervention for older adults with cancer for nausea and vomiting. Participants will be randomized to either an intervention or a wait control group.
- Trial name
- NCT03143829
- Testing
- eSSET-CINV
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Central Florida
Constipation, Bowel Obstruction
Effect of Serotonin Level on Constipation Caused by Chemotherapy in Patients With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
RATIONALE: Gathering information about changes in serotonin levels in patients undergoing chemotherapy for ovarian cancer, fallopian tube cancer, or primary peritoneal cancer may help doctors learn more about constipation caused…
- Conditions
- Constipation, Bowel Obstruction, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00536523
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Minnesota
Chemotherapy-induced Neutropenia, Metastatic Tumors
Safety and Pharmacokinetic(PK) Study of GW003 to Metastatic Tumors
This study is designed to access the safety, tolerance and Pharmacokinetic/Pharmacodynamic(PK/PD) of single subcutaneous(SC) injection of GW003 in patients with metastatic tumors.
- Trial name
- NCT02156388
- Testing
- GW003
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Jiangsu T-Mab Biopharma Co.,Ltd
HIV Infections, Peripheral Nervous System Diseases
Study of NGX-4010 for Treatment of Painful HIV-Associated Neuropathy
The purpose of the study is to determine if an investigational drug, NGX-4010 (high-concentration capsaicin patch), is safe, tolerable and effective in treating painful HIV-associated neuropathy.
- Conditions
- HIV Infections, Peripheral Nervous System Diseases, Pain
- Trial name
- NCT00085761
- Testing
- Capsaicin Dermal Patch
- Where
- 2 sites in United States
- Sponsor
- NeurogesX
Urinary Incontinence
Effect Of Detrol LA With Behavioral Intervention In Overactive Bladder Subjects Dissatisfied With Recent OAB Medication.
To evaluate the effect of tolterodine ER in conjunction with behavioral intervention on subject satisfaction in OAB subjects who were dissatisfied with their most recent antimuscarinic OAB medication therapy.
- Trial name
- NCT00230789
- Testing
- Tolterodine ER 4 mg QD, OAB Patient Behavioral Training Material
- Where
- 51 sites in United States
- Volunteers
- 417 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Symptom Management, Quality of Life
The Effect of Mobile Application-Assisted Nursing Services on Symptom Control in Breast Cancer Patients
Breast cancer is the most common type of cancer in women, accounting for approximately one-quarter of all female cancers in Turkey.
- Trial name
- NCT07200791
- Testing
- Mobile Application, Usual Care Only
- Volunteers
- 74 people
- Sponsor
- Fenerbahce University
Cancer, Geriatric
The Effect of Walking on Fatigue After Chemotherapy in Patients 65 and Older
This study will look at the impact of a self-directed walking program on post-chemotherapy survivors experiencing fatigue. It is hypothesized that the walking program will help lessen fatigue.
- Conditions
- Cancer, Geriatric, Fatigue
- Trial name
- S-PACT (NCT02191982)
- Testing
- Walk With Ease
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Constipation
Study Intestinal Complaints During Chemotherapy.
Study intestinal complaints during chemotherapy. A prospective study into intestinal complaints in patients undergoing chemotherapy treatment.
- Trial name
- NCT05906186
- Testing
- kiwifruit
- Volunteers
- 80 people
- Sponsor
- Spaarne Gasthuis
Cancer, Nutrition Disorders
Co-designed Nutritional Training Program for Oncology Nurses in Vietnam
This study evaluates a co-designed nutritional training program for oncology nurses in Vietnam. The aim is to improve nurses' knowledge, confidence, and clinical practice in providing nutritional support for patients with cancer…
- Conditions
- Cancer, Nutrition Disorders, Chemotherapy-Related Symptoms
- Trial name
- NUTRI-NURSE-VN (NCT07566169)
- Testing
- Co-Designed Nutritional Training Program
- Where
- Vietnam
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VinUniversity
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