Clinical trials: Chemotherapy Symptoms
Amphetamine Addiction, Pharmacotherapy
Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction
The investigators will conducted a randomized double-blind placebo-controlled study to investigate the treatment outcomes of add-on low dose dextromethorphan (DM), memantine (MM), or dextromethorphan and memantine combination…
- Trial name
- NCT04687566
- Testing
- Dextromethorphan, Memantine, Dextromethorphan and memantine
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng-Kung University Hospital
Metabolic Syndrome
Probiotics and Gut Health
This study evaluates the effects of probiotic consumption on inflammatory outcomes and measures of gut health. Participants will be given yogurt with probiotics for one period and yogurt without probiotics for another, with a…
- Trial name
- PRO (NCT03418857)
- Testing
- Yogurt smoothie with BB-12, Yogurt smoothie
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Penn State University
Frailty at Older Adults, Ovarian Cancer
The Better, Harder, Faster, Stronger Study
The purpose of this study is to evaluate changes in the electronic Frailty Index (eFI) score following 3-4 cycles of neoadjuvant chemotherapy (NACT) in participants with advanced ovarian and endometrial cancer.
- Conditions
- Frailty at Older Adults, Ovarian Cancer, Endometrial Cancer, Cognitive Dysfunction
- Trial name
- NCT07220512
- Testing
- data collection
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer
A Phase-3, Open-Label, Randomized Study of Dato-DXd Versus Investigator's Choice of Chemotherapy (ICC) in Participants With Inoperable or Metastatic HR-Positive, HER2-Negative Breast Cancer Who Have Been Treated With One or Two Prior Lines of Systemic Chemotherapy (TROPION-Breast01)
The study will evaluate the safety and efficacy of datopotamab deruxtecan (also known as Dato-DXd, DS-1062a), when compared with Investigator's choice of standard of care single-agent chemotherapy (eribulin, capecitabine…
- Trial name
- NCT05104866
- Testing
- Dato-DXd, Capecitabine, Gemcitabine
- Where
- 167 sites in United States, Argentina and 18 more
- Volunteers
- 732 people
- Sponsor
- AstraZeneca
Obesity
Individualized Obesity Pharmacotherapy
The researchers are trying to identify the specific characteristics (phenotypes) that may be useful to help select the right medication for weight loss.
- Trial name
- NCT03374956
- Testing
- Phentermine-Topiramate, Liraglutide, Naltrexone/bupropion
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- Mayo Clinic
Advanced Cancer, Advanced Solid Tumor
NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours
This study is an open-label, multi-arm, parallel cohort, dose validation and expansion design. The study is modular in design, allowing evaluation of the safety, efficacy and pharmacokinetics (PK) of NUC-3373 in combination with…
- Conditions
- Advanced Cancer, Advanced Solid Tumor, Neoplasm Malignant, Metastatic Cancer
- Trial name
- NCT05714553
- Testing
- Fosifloxuridine Nafalbenamide, Leucovorin, Pembrolizumab
- Where
- 4 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- NuCana plc
Melanoma, Metastases
Volociximab in Combination With DTIC in Patients With Metastatic Melanoma Not Previously Treated With Chemotherapy
This clinical trial is being conducted to determine tumor response and preliminary safety of a monoclonal antibody that specifically binds to a cell surface receptor (α5β1 integrin) that is required for the establishment of new…
- Trial name
- NCT00099970
- Testing
- M200 (volociximab) in Combination with Dacarbazine (DTIC)
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- PDL BioPharma, Inc.
Geriatric Oncology, Oncology
G8, CARG, Frailty, and Nutritional Markers in Predicting Chemotoxicity
This study aims to evaluate the ability of G8, CARG, and Frailty scales to predict chemotherapy-related toxicity and the need for G-CSF in elderly cancer patients.
- Conditions
- Geriatric Oncology, Oncology, Nutrition, Nutrition Assessment
- Trial name
- NCT07151794
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Çanakkale Onsekiz Mart University
Cancer, Neoplams
Effect of Pecha Kucha-Based Education on Symptom Management and Quality of Life in Patients Receiving Chemotherapy
This randomized controlled study aims to evaluate the effect of education delivered using the PechaKucha method on symptom management and quality of life in patients receiving chemotherapy.
- Trial name
- NCT07769931
- Testing
- PechaKucha-Based Symptom Management Education, Routine/Standard Patient Education
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Istanbul Aydın University
Pediatric Acute Myeloblastic Leukemia, Relapsed, Pediatric Acute Lymphoblastic Leukemia, Relapsed
AMD3100 for Sensitizing in Allogeneic Blood or Marrow Transplant for Chemotherapy Resistant Pediatric Acute Leukemia
This study is for patients 2-21 years old who have acute leukemia that has not responded well to chemotherapy and will have a bone marrow transplant. This is a pilot (phase 1) study of AMD3100(also called Plerixafor, Mozobil).
- Trial name
- BMTAMD3100 (NCT01655875)
- Testing
- AMD3100
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Emory University
Obesity & Overweight
Changes in Body Composition Including Muscle With Anti-Obesity Medications, Both With and Without Exercise
The goal of this clinical trial is to learn whether adding either cardiovascular exercise or resistance exercise to pharmacotherapy treatment for obesity improves the retention of lean mass compared to pharmacotherapy alone in…
- Trial name
- M3-E (NCT07698145)
- Testing
- Standard Medical Care with an Obesity Management Medication, Cardiovascular Exercise Training, Resistance Exercise Training
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- University of Kansas Medical Center
Solid Tumors, Ototoxicity
Statins Effect on Incidence of Side Effects of Platinum Based Chemotherapy
Platinum based chemotherapy (mainly Cisplatin) is known to cause a variety of adverse effects, including Ototoxicity and nephrotoxicity.
- Trial name
- NCT06553157
- Testing
- Statin
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Minia University
Cardiac Toxicity, Lung Cancer Stage III
COr Loco-regional Advanced Lung Cancer Treated With Chemo-radiotherapy (COLA)
Patients with loco-regional NSCLC planned for curative treatment with chemoradiotherapy will be invited to participate in a prospective study; besides routine treatment, the patients will be followed with an ECG and cardiac MR…
- Conditions
- Cardiac Toxicity, Lung Cancer Stage III, Lung Cancer Stage II, Radiation Toxicity
- Trial name
- COLA (NCT05258448)
- Testing
- Chemoradiotherapy
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Chronic Pain, Opioid Use Disorder
Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine
This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use…
- Trial name
- NCT07886606
- Testing
- 400 mg Cannabidiol, 800 mg Cannabidiol, 1200 mg Cannabidiol
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Obesity
Pharmacological and Behavioral Treatment After Bariatric Surgery
This study will compare the effectiveness of behavioral and pharmacologic treatment, alone and combined, for improvements in weight loss, cardiovascular risk factors, and psychosocial functioning following metabolic and bariatric…
- Trial name
- NCT05157698
- Testing
- Naltrexone and Bupropion Combination, Behavioral Weight Loss
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Yale University
Cholangiocarcinoma
Regorafenib Versus Placebo to Treat Cholangiocarcinoma
The study is a multicenter randomized (1:1) placebo-controlled, double-blinded phase II trial aiming to demonstrate an improvement of median PFS when treating locally advanced unresectable or metastatic patients suffering from an…
- Trial name
- REACHIN (NCT02162914)
- Testing
- Regorafenib/active
- Where
- 12 sites in Belgium
- Volunteers
- 66 people
- Sponsor
- Erasme University Hospital
Oral Mucositis
Study for the Prevention of Oral Mucositis (SPOM)
1. Study Design Prospective, Randomized, Questionnaire-Based Study Study Type: Phase 1/Phase 2 Interventional Clinical Trial Intervention Model: Parallel Assignment Masking: None (Open-label) Actual Enrollment: 100 participants…
- Trial name
- SPOM (NCT05338398)
- Testing
- Bocaliner, Benzydamine
- Where
- Armenia
- Volunteers
- 100 people
- Sponsor
- E2Bio Life Sciences, LLC
Gastroesophageal Reflux Disease, Erosive Esophagitis
Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets
The purpose of this study is to measure the in-vivo disintegration time of a single dexlansoprazole delayed-release orally disintegrating (OD) tablet.
- Conditions
- Gastroesophageal Reflux Disease, Erosive Esophagitis, Heartburn
- Trial name
- NCT02096458
- Testing
- Dexlansoprazole
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Takeda
Breast Cancer, Triple Negative Breast Cancer
Avoiding Sentinel Lymph Node Biopsy in Breast Cancer Patients After Neoadjuvant Chemotherapy
This study evaluates whether SLNB can safely be omitted in breast cancer patients with HER2+ or TN tumors who achieve a radiological complete response on MRI after neoadjuvant systemic therapy
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, HER2-positive Breast Cancer, Sentinel Lymph Node
- Trial name
- ASICS (NCT04225858)
- Testing
- Omission of sentinel lymph node biopsy
- Volunteers
- 340 people
- Sponsor
- The Netherlands Cancer Institute
Sleep Disorders, Circadian Rhythm, Depression
Melatonin as a Circadian Clock Regulator, Neuromodulator and Myelo-protector in Adjuvant Breast Cancer Chemotherapy
Breast cancer is the second most common cancer in the world, the most common in women, representing the leading cause of death in Brazil.
- Conditions
- Sleep Disorders, Circadian Rhythm, Depression, Genotoxicity, Pain
- Trial name
- NCT03205033
- Testing
- Melatonin 20 MG Oral Capsule
- Volunteers
- 36 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.