Clinical trials: Chemotherapy Symptoms
Fatigue, Cognitive Impairment
Cognitive Function After Stem Cell Transplantation
The trial will evaluate the effects of an exercise program on the physical and cognitive performance of patients with hematological neoplastic diseases after high dose chemotherapy with stem cell support.
- Conditions
- Fatigue, Cognitive Impairment, Stem Cell Transplantation
- Trial name
- NCT00884338
- Testing
- Endurance exercise, Counseling
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Cardiotoxicity, Breast Cancer
Early Detection of Cardiac Damage With CMR in Women With Breast Cancer
With this study the investigators will assess early cardiac damage by means of Global Longitudinal Strain (GLS) in newly diagnosed breast cancer (BC) patients treated with anthracycline-based chemotherapy, and to investigate…
- Conditions
- Cardiotoxicity, Breast Cancer, Chemotherapy Induced Systolic Dysfunction
- Trial name
- EARLY-CATCH (NCT04046315)
- Testing
- CMR
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- Radboud University Medical Center
Leukemia
Cord Blood Natural Killer (NK) Cells in Leukemia/Lymphoma
The goal of this clinical research study is to find the highest tolerable dose of immune cells called natural killer (NK) cells that can be given with chemotherapy to patients with CLL.
- Trial name
- NCT02280525
- Testing
- Lenalidomide, Rituximab, Fludarabine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer, Solid Tumor Cancer
Feasibility and Acceptability of the Remote Oncology Symptom Assessment Application
The goal of this study is to determine whether a mobile application that combines real-time sensor data and patient-reported symptoms to trigger care-team contact recommendations is feasible and beneficial for patients receiving…
- Conditions
- Cancer, Solid Tumor Cancer, Chemotherapy
- Trial name
- ROSA App (NCT07218874)
- Testing
- Mobile Symptom Monitoring and Alert App
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Pittsburgh
Breast Cancer, Lung Cancer
Nausea or Vomiting in Patients Who Are Receiving Chemotherapy for Breast Cancer or Lung Cancer
RATIONALE: Understanding how nausea or vomiting caused by chemotherapy effects a patient's treatment decisions may help doctors plan better cancer treatment and may help patients live more comfortably.
- Conditions
- Breast Cancer, Lung Cancer, Nausea and Vomiting
- Trial name
- NCT00416689
- Testing
- assessment of therapy complications, quality-of-life assessment
- Volunteers
- 99 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Primary Dysmenorrhea (PD)
Pelvic Floor and Diaphragmatic Breathing Exercises for Primary Dysmenorrhea
This study investigates whether combining pelvic floor muscle exercises with diaphragmatic breathing exercises can reduce menstrual pain in women with primary dysmenorrhea.
- Trial name
- PFDD (NCT07263516)
- Testing
- Pelvic Floor + Breathing Exercises, Diaphragmatic Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Gelisim University
Chronic Pain
Tailored Non-Pharmacotherapy Services for Chronic Pain
The RESOLVE study is a multicenter comparative effectiveness trial of two cognitive behavioral therapy-based chronic pain (CBT-CP) treatments delivered via telehealth modalities: 1) online program and 2) live, health coach-led…
- Trial name
- RESOLVE (NCT04523714)
- Testing
- Online CBT-CP based program, Virtual health coach-led CBT-CP based program
- Where
- 4 sites in United States
- Volunteers
- 2,333 people
- Sponsor
- Kaiser Permanente
Cancer, Heart Failure
Statins for the Primary Prevention of Heart Failure in Patients Receiving Anthracycline Pilot Study
Anthracycline (AC) chemotherapy has substantially reduced the mortality rate from several common cancers globally. Unfortunately, AC treatment is associated with up to 19% risk of heart failure (HF).
- Conditions
- Cancer, Heart Failure, Cardiotoxicity
- Trial name
- SPARE-HF (NCT03186404)
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- University Health Network, Toronto
Acute Myeloid Leukemia
Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML
This phase II clinical trial evaluates the efficacy and tolerability of the non-intensive treatment with venetoclax and the hypomethylating agent azacitidine as compared to the standard of care chemotherapy plus gemtuzumab…
- Trial name
- VINCENT (NCT05904106)
- Testing
- Venetoclax plus Azacitidine, standard of care chemotherapy plus gemtuzumab ozogamicin
- Where
- 18 sites in Germany
- Volunteers
- 146 people
- Sponsor
- Technische Universität Dresden
TNBC - Triple-Negative Breast Cancer, Breast Cancer
Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Gemcitabine and Carboplatin for Metastatic Triple-Negative Breast Cancer (TNBC)
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of trilaciclib versus placebo administered prior to gemcitabine and carboplatin in patients receiving first- or…
- Trial name
- PRESERVE 2 (NCT04799249)
- Testing
- Trilaciclib, Gemcitabine, Carboplatin
- Where
- 71 sites in United States, Australia and 9 more
- Volunteers
- 194 people
- Sponsor
- G1 Therapeutics, Inc.
Ovarian Cancer
Carboplatin-based Chemotherapy With or Without Panitumumab in Platinum-sensitive Recurrent Ovarian Cancer
The purpose of this trial is to estimate the therapeutic efficacy of the experimental targeted regimen including the EGFR antibody panitumumab (in combination with carboplatin and either pegylated liposomal doxorubicin or…
- Trial name
- PROVE (NCT01388621)
- Testing
- Panitumumab, pegylated liposomal doxorubicin (PLD), Carboplatin
- Where
- 18 sites in Germany
- Volunteers
- 140 people
- Sponsor
- WiSP Wissenschaftlicher Service Pharma GmbH
Quality of Life, Oral Mucositis
Efficacy of a Probiotic and Microbiological Analysis on Oral Complications in Patients With HNC
The study is a Clinical Trial and the main objective is to Evaluate the effects of probiotics on oral complications induced by antineoplastic therapies in patients with head and neck cancer, attended at the radiotherapy service…
- Conditions
- Quality of Life, Oral Mucositis, Dental Plaque, Periodontal Diseases
- Trial name
- HNC (NCT06122636)
- Testing
- The probiotic to be used in the intervention corresponds to PRODEFEN Plus manufactured by ITALFARMACO S.A. laboratory
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Barcelona
Chemotherapy Induced Peripheral Neuropathy (CIPN)
The Effect of Aerobic and Resistance Training With and Without Neurodynamic Exercises on Chemotherapy-induced Peripheral Neuropathy Symptoms and Associated Neuro-immune Mechanisms
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and potentially persistent side effect of neurotoxic chemotherapy, characterized by symptoms such as numbness, tingling, pain, and sensory dysfunction in the hands and…
- Trial name
- CIPN-NEXT (NCT07913958)
- Testing
- Exercise program 1: aerobic + resistance training, Exercise program 2: aerobic + resistance training combined with neurodynamic exercises
- Where
- 2 sites in Belgium
- Volunteers
- 87 people
- Sponsor
- Universiteit Antwerpen
Chemotherapy-Induced Nausea and Vomiting (CINV), Nausea
HR20013 for the Prevention of Nausea and Vomiting in Patients With Cancer: A Real-World Study
HR20013 is a newly approved medicine in China to prevent nausea and vomiting from anticancer treatment. This prospective, observational, multicenter real-world study will enroll about 3,000 patients receiving this medicine as…
- Conditions
- Chemotherapy-Induced Nausea and Vomiting (CINV), Nausea, Vomiting, Neoplasms
- Trial name
- HR20013-RWS (NCT07874308)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-sen University
Well Being
OptiTrain - Optimal Training Women With Breast Cancer
This study on women with breast cancer during and after chemo- and hormonal therapy compares the effect of different physical training programs on physical and mental well-being and systemic inflammation mechanisms in blood.
- Trial name
- OptiTrain (NCT02522260)
- Testing
- Resistance and aerobic training, Aerobic training, Standard supportive care
- Where
- Sweden
- Volunteers
- 240 people
- Sponsor
- Karolinska Institutet
Breast Cancer, Cognitive/Functional Effects
Fatigue Caused by Chemotherapy in Women Who Have Undergone Surgery for Breast Cancer and in Healthy Volunteers
RATIONALE: Gathering information over time from women undergoing chemotherapy for breast cancer may help doctors learn more about mental and physical fatigue caused by treatment.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Fatigue, Long-term Effects Secondary to Cancer Therapy in Adults
- Trial name
- NCT00909662
- Testing
- assessment of therapy complications, cognitive assessment, fatigue assessment and management
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Obesity (BMI Equal to or >30), Weight Regain After Bariatric Surgery
Changes in Body Composition Following Pharmacological Treatment for Obesity.
Background: Intentional weight loss via various treatments results in a loss of lean mass of approximately 10% for every 10 kg of total weight lost.
- Trial name
- NCT07908940
- Where
- Spain
- Volunteers
- 116 people
- Sponsor
- Hospital San Carlos, Madrid
Upper Gastrointestinal Disorders, Lower Gastrointestinal Disorders
Sarcopenia and Physiology Assessments in Cancer Patients
Primary Aim: To establish a reliable relationship between oxygen uptake (VO2) at estimated lactate threshold (AT) and CT-derived body composition measurments (e.g.
- Conditions
- Upper Gastrointestinal Disorders, Lower Gastrointestinal Disorders, Hepatobiliary Cancer
- Trial name
- NCT03641118
- Testing
- Cardiopulmonary exercise test
- Where
- United Kingdom
- Volunteers
- 639 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Leukemia, Myelodysplastic/Myeloproliferative Neoplasms
Donor Stem Cell Transplant With or Without Chemotherapy in Treating Children With Primary Myelodysplastic Syndrome
RATIONALE: Giving chemotherapy before a donor stem cell transplant helps stop the patient's immune system from rejecting the donor's stem cells.
- Trial name
- NCT00047268
- Testing
- cytarabine, mercaptopurine, laboratory biomarker analysis
- Where
- Germany
- Sponsor
- European Working Group of MDS in Childhood
Colorectal Cancer, Liver Metastases
ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer
The goal of this clinical trial is to compare in resectable colorectal cancer liver metastasis patients.The main question it aims to answer is whether the 3-year progression-free survival rate (PFS) of "watching and waiting" is…
- Conditions
- Colorectal Cancer, Liver Metastases, Circulating Tumor Cell, Chemotherapy Effect
- Trial name
- NCT05815082
- Testing
- Colorectal cancer resection combined with liver metastasis resection., FOLFOX chemotherapy regimen
- Where
- China
- Volunteers
- 490 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
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