Clinical trials: Chemotherapy-Related Cognitive Impairment
Cancer-related Problem/Condition, Cognitive Impairment
Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase II
Cancer-related cognitive dysfunction (CRCD) affects up to 75% of patients receiving chemotherapy and older adults are at greater risk of developing CRCD, which can negatively affect their functional independence and quality of…
- Trial name
- NCT04669301
- Testing
- MAAT-G, Supportive therapy (time and attention control)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Rochester
Survivors of Childhood Cancer
Technological Gaming in Cancer Survivors (WINNERS)
HYPOTHESIS 1. Neurocognitive deficits in cancer survivors are underestimated. They represent a very limiting long-term side effect in this group of patients. 2.
- Trial name
- WINNERS (NCT06312969)
- Testing
- Video game based training
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Antonio Pérez Martínez
Chemo Brain
Edaravone and Dexborneol Sublingual Tablet for Treating Chemotherapy- Induced Cognitive Impairment Study
Chemotherapy-induced cognitive impairment (CICI), also known as "chemobrain," is a range of neurocognitive deficits experienced during and after cancer chemotherapy.
- Trial name
- EDS-CICI (NCT07454473)
- Testing
- Edaravone Dexborneol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chuansheng Zhao
Chronic Pain, Neuropathic Pain
Transcranial Direct Current Stimulation for Chemotherapy-Related Chronic Pain in Cancer Survivors
The goal of this clinical trial is to learn if transcranial direct current stimulation (tDCS) combined with a working-memory task can treat chronic pain and related emotional and cognitive problems after chemotherapy in adult…
- Conditions
- Chronic Pain, Neuropathic Pain, Cancer Survivors, Anxiety
- Trial name
- ONCOSTIM (NCT07912775)
- Testing
- Active tDCS with Sternberg task
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Instituto de investigación e innovación biomédica de Cádiz
Chemotherapy-induced Cognitive Impairment
Chemotherapy-Induced Cognitive Impairment in Ovarian Cancer Patients
Chemotherapy-induced cognitive impairment (CICI), also known as "chemobrain," is a spectrum of neurocognitive deficits experienced during and after the administration of chemotherapy for cancer.
- Trial name
- NCT03324945
- Testing
- Neurocognitive assessments
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Rachel Miller
Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity
Investigating Cognitive Impairment in Young Patients With Cancer Prospectively
The MyBrain study investigates the brain function of children, adolescents and young adults during and after chemo treatment for cancer.
- Conditions
- Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity, Chemo-brain, Cancer
- Trial name
- MyBrain (NCT05840575)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myelodysplastic Syndrome, Effects of Chemotherapy
Electrophysiological Biomarkers of Chemotherapy-related Cognitive Impairment and Recovery
Broadly speaking, the goal of this study is to better understand the influence of chemotherapy treatment on the cognitive and neural mechanisms underlying human behavior.
- Conditions
- Myelodysplastic Syndrome, Effects of Chemotherapy, Mild Cognitive Impairment, Multiple Myeloma
- Trial name
- Chemobrain (NCT02767388)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Breast Cancer, Peripheral Neuropathy
Role of Silymarin in Chemotherapy Toxicity and Cognition Improvement in Breast Cancer Patients
Aim of the work This study aims to evaluate the possible beneficial role of silymarin in attenuating both doxorubicin related cardiac and hepatic toxicities and paclitaxel associated peripheral neuropathy and improving cognitive…
- Conditions
- Breast Cancer, Peripheral Neuropathy, Cardiac Toxicities, Hepatic Toxicity
- Trial name
- NCT05595109
- Testing
- Silymarin
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Tanta University
1- Cancer Patients During Chemotherapy Treatment, 2- Use of Cannabis Comparing to Control Without Cannabis Use
Evaluation Prospectively the Level of Reduction in Cognitive Functions of Cancer Patients Who Are on Active Oncology Treatments and Use Cannabis. The Second Goal is to Identify High-risk Groups for Cognitive Impairment Due to Cannabis Use.
Cannabis sativa is one of the most ancient psychotropic drugs known to humanity. Although most Western countries have outlawed the use of cannabis according to the UN Convention of Psychotropic Substances, an increasing number of…
- Trial name
- NCT01983267
- Testing
- cannabis
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Breast Cancer
Chemotherapy Effect on Brain Structure, Neurophysiology and Psychomotor Behavior in Breast Cancer Patients
Some cancer patients report experiencing mild problems with thinking during or following chemotherapy. Symptoms include problems concentrating, slow thinking, some gaps in memory and difficulty performing complex or multi-tasks.
- Trial name
- NCT02896504
- Testing
- Exposure: Adjuvant chemotherapy treatment, Exposure: Adjuvant hormonal therapy treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Neoplasm, Colorectal, Cognitive Impairment
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute.
- Conditions
- Neoplasm, Colorectal, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change
- Trial name
- Chemo Brain (NCT05014399)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joseph McCollom
Breast Cancer
CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)
An interventional, non-pharmacological, monocentric study evaluating the effectiveness of cognitive rehabilitation in counteracting chemotherapy-induced cognitive impairment (CRCI) in women with operable breast cancer treated…
- Trial name
- CHEMOFOG (NCT06435559)
- Testing
- Neurotablet® and Neuropsychological evaluations, Neuropsychological evaluations
- Volunteers
- 128 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Oncology, Support Care
Breast Cancer and Chemobrain : Effects of Photobiomodulation on the Improvement of Perceived Cognitive Impairment
Breast cancer is one of the most common cancers in metropolitan France, with over 60,000 new cases in 2023. Mostly a female cancer, it can affect a young population, with around 20% of breast cancers occurring in women under 50.
- Conditions
- Oncology, Support Care, Cognitive Disorders
- Trial name
- REGAIN (NCT06995443)
- Testing
- Photobiomodulation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier de Valenciennes
Chemo-brain, Chemotherapy-Related Cognitive Impairment
nCCR for Chemotherapy Related Cognitive Impairment Randomized Study
The investigators propose to apply neuroplasticity-based computerized cognitive remediation (nCCR) to treat chemotherapy-related cognitive impairment (CRCI).
- Trial name
- NCT05283629
- Testing
- Neuroplasticity-based Computerized Cognitive Remediation, Active Control Condition
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Chemotherapy-related Cognitive Dysfunction
Telehealth and Memory Study
The overall purpose of this trial is to confirm the efficacy of Memory and Attention Adaptation Training (MAAT), a cognitive-behavioral therapy (CBT) for treatment of chemotherapy-related cognitive dysfunction among (female or…
- Trial name
- TAMS (NCT04586530)
- Testing
- Memory and Attention Adaptation Training (MAAT), Supportive Therapy (ST)
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- University of Pittsburgh
Breast Neoplasms
Telehealth Program to Prevent Cancer and Chemotherapy-related Cognitive Impairment.
The present randomized controlled trial has the main objective to study the effects of a videoconferenced occupational therapy program in preventing cancer and chemotherapy-related cognitive impairment and other health outcomes…
- Trial name
- NCT04783402
- Testing
- e-OTCAT program, Educational handbook and standard care
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Universidad de Granada
Chemo-brain, Drug-Related Side Effects and Adverse Reactions
Acupuncture Prevents Chemobrain in Breast Cancer Patients
Chemobrain is an expression used to describe a cluster of chemotherapy-induced cognitive impairment symptoms, including problems with visual and verbal memory, forgetfulness, difficulty in learning, attention, concentration and…
- Conditions
- Chemo-brain, Drug-Related Side Effects and Adverse Reactions, Mild Cognitive Impairment, Breast Cancer
- Trial name
- NCT02457039
- Testing
- Dense cranial electroacupuncture stimulation, Body acupuncture, Least acupuncture stimulation
- Where
- 6 sites in China, Hong Kong
- Volunteers
- 93 people
- Sponsor
- The University of Hong Kong
Diffuse Large B-Cell Lymphoma
Cognitive Impairment in Patients With Diffuse Large B-Cell Lymphoma
This prospective, non-randomized diagnostic interventional study evaluates cognitive impairment in patients with diffuse large B-cell lymphoma (DLBCL) treated at the Institute of Oncology Ljubljana.
- Trial name
- NCT07443514
- Testing
- Structured Neurocognitive Assessment Battery, Psychometric Questionnaires, CSF Biomarker Analysis
- Where
- Slovenia
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Institute of Oncology Ljubljana
Breast Cancer, Cognitive Symptoms
Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment
The investigators hypothesize that continuous active interaction with environments that are demanding to sensory, cognitive, and motor systems, together with imbedded rewards for successful performance, will help improve memory…
- Conditions
- Breast Cancer, Cognitive Symptoms, Memory Disorders
- Trial name
- NCT00387062
- Testing
- Computer-based Cognitive Training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Posit Science Corporation
Cancer
A Multi-modality Imaging Assessment of Chemobrain
Patients must have had their breast cancer treated at the Huntsman Cancer Institute to be eligible for this trial. OBJECTIVES: To use quantitative FDG-positron emission tomography (PET), functional MRI (fMRI) and co-registered…
- Trial name
- Chemobrain (NCT00708045)
- Testing
- [18F]fluoro-2-deoxy-D-glucose (FDG)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Utah