Clinical trials: Chemotherapy-Related Nausea and/or Vomiting
Chemotherapy-induced Neutropenia, Chemotherapy-induced Nausea and Vomiting
Community-Led Action Research in Oncology: Improving Symptom Management
This study will be conducted at La Liga Contra el Cancer in San Pedro Sula, Honduras. The overall objective of this project is to improve symptom management for patients undergoing chemotherapy in Honduras.
- Conditions
- Chemotherapy-induced Neutropenia, Chemotherapy-induced Nausea and Vomiting, Anxiety, Depression
- Trial name
- CLARO (NCT03208816)
- Testing
- symptom management program for chemotherapy patients
- Where
- 2 sites in United States, Honduras
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chemotherapy-Induced Nausea and Vomiting
Fosaprepitant + 5HT3 Receptor Antagonists + Dexamethasone in Germ Cell Tumors
The hypothesis is that the substitution of multi-day oral aprepitant with (intravenous) IV fosaprepitant, in combination with a 5-HT3 receptor antagonists (5HT3RA) + dexamethasone will provide comparable protection from 5 day…
- Trial name
- NCT01736917
- Testing
- Fosaprepitant, Dexamethasone, 5HT3
- Where
- 4 sites in United States
- Volunteers
- 65 people
- Sponsor
- Lawrence Einhorn
Chemotherapy-induced Nausea and Vomiting
Capsaicin to Prevent Delayed Chemotherapy Induced Nausea and Vomiting (CapCIN)
Chemotherapy-induced nausea and vomiting (CINV) is one of the few most severe adverse effects of chemotherapy, which often panic patients undergoing cancer treatment.
- Trial name
- CapCIN (NCT04918069)
- Testing
- Capsaicin
- Where
- India
- Volunteers
- 160 people
- Sponsor
- Christian Medical College, Vellore, India
Neoplasms, Chemotherapy-induced Nausea and Vomiting
Promoting Cancer Symptom Management in Older Adults
The purpose of the project is to estimate the effect size of a technology based intervention for older adults with cancer for nausea and vomiting. Participants will be randomized to either an intervention or a wait control group.
- Trial name
- NCT03143829
- Testing
- eSSET-CINV
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Central Florida
Chemotherapy-induced Nausea and Vomiting
Olanzapine and 5-HT3 With or Without Dexamethasone to Prevent CINV
Nausea and vomiting caused by chemotherapy are considered by patients as the main side effects of cancer treatment, which affect the quality of treatment and life.At present, NCCN guidelines have recommended three or four drug…
- Trial name
- NCT05805800
- Testing
- 5HT3RA+Olanzapine, 5HT3RA+Olanzapine+Dexamethasone
- Where
- China
- Volunteers
- 275 people
- Sponsor
- Xingchen Peng
Chemotherapy Induced Nausea and Vomiting
This Study Will Investigate the Effectiveness of Peppermint Oil Inhalation in Reducing the Intensity and Frequency of Acute Nausea and Vomiting Among Cancer Patients Undergoing Chemotherapy. Chemotherapy-induced Nausea and Vomiting (CINV) Are Among the Most Distressing Side Effects Experienced by pa
Cancer is a major cause of death and disability worldwide and in South Asian countries. Cancer treatment options include chemotherapy, radiation therapy, surgery, and adjuvant therapy (Additional treatments after primary cancer…
- Trial name
- NCT06950632
- Testing
- Pepppermint oil inhalation
- Where
- Pakistan
- Volunteers
- 106 people
- Sponsor
- University of Health Sciences Lahore
Chemotherapy-induced Nausea and Vomiting
Acupuncture for Chemical Therapy Induced Nausea and Vomiting: a Cross-over Trail
This is a randomized, controlled cross-over trial. The hypothesis of this study is that the differences in manual acupuncture manipulation can impact clinical effect though the acupuncturists follow the same needling regimen.
- Trial name
- ACTIN (NCT02127255)
- Testing
- Manual acupuncture implemented by acupuncturist 1, Manual acupuncture implemented by acupuncturist 2
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Beijing University of Chinese Medicine
Chemotherapy-Induced Nausea and Vomiting (CINV), Nausea
HR20013 for the Prevention of Nausea and Vomiting in Patients With Cancer: A Real-World Study
HR20013 is a newly approved medicine in China to prevent nausea and vomiting from anticancer treatment. This prospective, observational, multicenter real-world study will enroll about 3,000 patients receiving this medicine as…
- Conditions
- Chemotherapy-Induced Nausea and Vomiting (CINV), Nausea, Vomiting, Neoplasms
- Trial name
- HR20013-RWS (NCT07874308)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-sen University
Breast Cancer, Aromatherapy
Aromatherapy Combined With Standard Antiemetic Therapy vs Standard Therapy Alone for Prevention of CINV in Breast Cancer Patients Receiving Highly Emetogenic Chemotherapy
This phase III, multicenter, randomized, open-label trial evaluates whether aromatherapy plus standard antiemetic therapy improves complete response (CR) of CINV compared with standard therapy alone in breast cancer patients…
- Conditions
- Breast Cancer, Aromatherapy, Chemotherapy, CINV
- Trial name
- NCT07761325
- Testing
- Aromatherapy, Standard triple antiemetic therapy
- Volunteers
- 374 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Nausea, Vomiting
Effect of Iranian Traditional Medicine Remedy on Chemotherapy Induced Nausea and Vomiting
The main objective of this research is the role of the Persumac(an Iranian traditional remedy) on refractory Chemotherapy Induced Nausea and Vomiting (CINV) in breast cancer patients.
- Trial name
- NCT02787707
- Testing
- Persumac, lactose
- Where
- Iran
- Volunteers
- 69 people
- Sponsor
- Mashhad University of Medical Sciences
Chemotherapy-induced Nausea and Vomiting
Aprepitant ,Olanzapine,Palonosetron and Dexamethasone for the Prevention of Chemotherapy-induced Nausea and Vomiting
The purpose of the study is to mainly evaluate the efficacy and safety of aprepitant in combination with olanzapine ,palonosetron and dexamethasone for the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients…
- Trial name
- AOPDPCINV (NCT02484911)
- Testing
- Olanzapine, Aprepitant, Palonosetron
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Chemotherapy Induced Nausea and Vomiting
Palonosetron Plus Aprepitant Versus Palonosetron in Preventing Nausea and Vomiting in Leukemic Patients
The aim of present study is to evaluate if the addition of Aprepitant to multiple doses of palonosetron IV enhances the efficacy of multiple doses of palonosetron IV alone, in preventing CINV in AML or High risk MDS patient…
- Trial name
- NCT02205164
- Testing
- Palonosetron + Aprepitant, Palonosetron
- Where
- 11 sites in Italy
- Volunteers
- 134 people
- Sponsor
- Associazione Salentina Angela Serra
Nausea, Vomiting
Safety and Efficacy of Palonosetron in Preventing Chemotherapy-induced Nausea and Vomiting
The purpose of this study is to determine whether palonosetron is tolerate and effective in preventing chemotherapy-induced nausea and vomiting in oriental population.
- Conditions
- Nausea, Vomiting, Chemotherapy
- Trial name
- NCT00503386
- Testing
- Palonosetron, Granisetron
- Where
- 6 sites in China
- Volunteers
- 144 people
- Sponsor
- Hangzhou Jiuyuan Gene Engineering Co. Ltd.,
Nausea, Vomiting
An Investigational Drug for the Prevention of Chemotherapy-Induced Nausea and Vomiting (MK-0869-071)
This protocol will study an investigational drug treatment plan against standard therapy in the prevention of chemotherapy-induced nausea and vomiting in patients diagnosed with breast cancer who are to be treated with up to 4…
- Conditions
- Nausea, Vomiting, Breast Neoplasms
- Trial name
- NCT00092183
- Testing
- MK0869, aprepitant / Duration of Treatment: 3 days, Comparator: ondansetron / Duration of Treatment: 3 days
- Volunteers
- 866 people
- Sponsor
- Merck Sharp & Dohme LLC
Nausea, Vomiting
A Multicenter, Randomized, Controlled Trial of SCH 619734 for the Treatment of Chemotherapy-Induced Nausea and Vomiting (Study P04351AM2)(COMPLETED)
This is a Phase 2, randomized, multicenter, parallel-group, double-blind, placebo-controlled study of various doses of SCH 619734 in subjects receiving cisplatin-based chemotherapy.
- Trial name
- NCT00394966
- Testing
- SCH 619734 Dose 1, SCH 619734 Dose 2, SCH 619734 Dose 3
- Volunteers
- 450 people
- Sponsor
- Schering-Plough
Neoplasms, Nausea
Palonosetron in Moderately and Highly Emetogenic Chemotherapy Induced Nausea and Vomiting (Study P04935)(COMPLETED)
The purpose of this study is to evaluate the efficacy and safety of single IV doses of Onicit® (Palonosetron) 0.25 mg in the prevention of acute and delayed nausea and vomiting associated with moderate and highly emetogenic…
- Conditions
- Neoplasms, Nausea, Vomiting
- Trial name
- NCT00684463
- Testing
- Palonosetron
- Volunteers
- 59 people
- Sponsor
- Merck Sharp & Dohme LLC
Chemotherapy-Induced Nausea and Vomiting (CINV)
Safety Study of Repeat Doses of SUSTOL in Adults
This is a repeat-dose, single-arm, open-label study that will evaluate the potential impact of subject-reported injection-site reactions (ISRs) on activities of daily living (ADL) in adult subjects with cancer receiving SUSTOL®…
- Trial name
- NCT05434663
- Testing
- SUSTOL
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Heron Therapeutics
Malignant Neoplasm
Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy
This randomized phase III trial studies how well olanzapine with or without fosaprepitant work in preventing chemotherapy induced nausea and vomiting in cancer patients receiving chemotherapy that causes vomiting.
- Trial name
- NCT03578081
- Testing
- Palonosetron Hydrochloride, Ondansetron Hydrochloride, Dexamethasone
- Where
- 566 sites in United States, Guam
- Volunteers
- 690 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Multiple Myeloma
Efficacy and Safety of Aprepitant in Subjects With Multiple Myeloma During and After High-dose Chemotherapy
1. Scientific background In patients with multiple myeloma high-dose chemotherapy followed by autologous stemcell transplantation is preferred to conventional therapy, since the superiority in respect to complete remission…
- Trial name
- EmNa (NCT00571168)
- Testing
- Emend
- Where
- Germany
- Volunteers
- 362 people
- Sponsor
- Heidelberg University
Nausea, Vomiting
The Effects of Inhaled Aromatherapy on Chemotherapy Induced Nausea (CINV) and Vomiting
This study is a three group, randomized, double blind, placebo-controlled trial with two repeated measurements. The same measurements will be collected for each participant during two consecutive chemotherapy treatment…
- Trial name
- CINV (NCT04478630)
- Testing
- Peppermint Essential Oil, Ginger Essential Oil, or Pure Vanilla Extract
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Milton S. Hershey Medical Center