Clinical trials: Chemotherapy-induced Neuropathy
Peripheral Neuropathy
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Purpose: The purpose of the study is to test a new way of measuring nerve damage in women with breast cancer receiving chemotherapy drug paclitaxel (Taxol).
- Trial name
- NCT02549534
- Testing
- Axon Reflexes, Axon Flares, Self-Reported Signs & Symptoms of CIPN
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Preliminary Effectiveness and Feasibility of Transcutaneous Acupoints Electrical Stimulation on Chemotherapy-induced Peripheral Neuropathy Among Children With Acute Lymphoblastic Leukemia
The first goal of this clinical trial is to assess the feasibility of transcutaneous acupoints electrical stimulation (TAES) on children with acute lymphoblastic leukemia (ALL).
- Trial name
- NCT07319481
- Testing
- Transcutaneous Acupoints Electrical Stimulation (TAES)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Breast Cancer
Omega-3 Fatty Acids and Chemotherapy-induced Neuropathy and Inflammation in Breast Cancer
The aim of this study is to assess the effects of n-3 fatty acids on taxane-induced neuropathy and neurotoxic inflammatory agents in patients suffering from invasive breast cancer.
- Trial name
- NCT01049295
- Testing
- oil fish, corn oil pearls
- Where
- Iran
- Volunteers
- 52 people
- Sponsor
- Tehran University of Medical Sciences
Advanced Colorectal Carcinoma, Metastatic Colorectal Carcinoma
Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab
This phase Ib trial studies side effects and best dose of dasatinib in preventing oxaliplatin-induced peripheral neuropathy in patients with gastrointestinal cancers who are receiving FOLFOX regimen with or without bevacizumab.
- Conditions
- Advanced Colorectal Carcinoma, Metastatic Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8
- Trial name
- NCT04164069
- Testing
- Bevacizumab, Dasatinib, Fluorouracil
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Anne Noonan
Chemotherapy-induced Peripheral Neuropathy
Effects of Massage Therapy on Peripheral Neuropathy and Quality of Life
The aim of this randomized controlled experimental study was to determine the effect of massage applied to colorectal cancer patients receiving chemotherapy on peripheral neuropathy and quality of life.
- Trial name
- NCT05433246
- Testing
- Massage therapy group
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Fatma Arikan
Chemotherapy-induced Peripheral Neuropathy, Colorectal Cancer Stage II
Effect of Hemp-CBD on Patients With CIPN
The purpose of this study is to assess the effect of a hemp-based cannabidiol (CBD) product, Ananda Hemp Spectrum Gelcaps, on the severity and duration of chemotherapy-induced neuropathy (CIPN) among non-metastatic breast…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Colorectal Cancer Stage II, Colorectal Cancer Stage III, Breast Cancer
- Trial name
- Coala-T-CBD (NCT04398446)
- Testing
- Hemp-based CBD
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Main Line Health
CIPN - Chemotherapy-Induced Peripheral Neuropathy
Biomarkers in Chemotherapy-Induced Peripheral Neurotoxicity
This pilot study will attempt to establish the feasibility of using tissue oxygen measurements and the protein, neurofilament light chain (NF-L), as potential biomarkers for chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- CIPN (NCT03348956)
- Testing
- EPR Oximetry
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chemotherapy-Induced Peripheral Neuropathy, Malignant Solid Neoplasm
Evaluating a Mobile Health Application Intervention for Caregiver Instruction in Manual Therapy for Chemotherapy-Induced Peripheral Neuropathy
This clinical trial assesses the impact of a family caregiver-delivered massage technique for use in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN).
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm
- Trial name
- NCT06945380
- Testing
- Best Practice, Comparator Program, Best Practice, Usual Care, Internet-Based Intervention
- Where
- United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chemotherapy-induced Peripheral Neuropathy
Efficacy and Safety of ATX01 in Adult Patients With CIPN (Chemotherapy-induced Peripheral Neuropathy)
The purpose of this clinical trial is to compare the efficacy of twice daily applications of ATX01 (10% \& 15%) versus placebo during a 12-week treatment period in treating chemotherapy-induced peripheral neuropathy (CIPN) in…
- Trial name
- ACT (NCT05593614)
- Testing
- ATX01 10%, ATX01 15%
- Where
- 43 sites in United States, Belgium and 5 more
- Volunteers
- 276 people
- Sponsor
- AlgoTherapeutix
Cancer, Adults
Cycling-Based Aerobic Exercise Intervention for Individuals With Chemotherapy-Induced Peripheral Neuropathy (CIPN)
CYCLE-CIPN is a proof-of-concept study designed to evaluate whether a prescribed aerobic exercise intervention has the potential to reduce the symptoms and functional impact of CIPN.
- Trial name
- CYCLE-CIPN (NCT07150117)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Multiple Myeloma, Chemotherapy-Induced Peripheral Neuropathy
Long Non-coding RNA (lncRNA) ZFAS1-Mediated Mechanism of Roasted Nux Vomica in Intervening Bortezomib-Induced Peripheral Neuropathy
This study aims to evaluate the efficacy and safety of Roasted Nux Vomica Capsules in the treatment of BIPN in patients with multiple myeloma.
- Trial name
- ZFAS1-BIPN (NCT07614243)
- Testing
- Roasted Nux Vomica Capsules
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Breast Cancer, Neuropathy;Peripheral
Efficacy and Safety of HILOTERM® Device for the Prevention of Peripheral Neuropathy
Taxol is a very effective drug in breast cancer, but it can cause peripheral neuropathy (PN). This toxicity is often dose-limiting.
- Trial name
- NCT06422949
- Testing
- Hilotherm® Cooling treatment
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- European Institute of Oncology
Breast Cancer
Identification of Chemotherapy-induced Peripheral Neuropathy
The main goal of this trial is to identify the optimal cut-off score of a Scoring System to discriminate between moderate to severe chemotherapy-induced peripheral neuropathy (CIPN) and no CIPN in breast cancer survivors…
- Trial name
- NEURO-BREAC (NCT07148336)
- Testing
- Symptom-based scoring system
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- University Hospital Schleswig-Holstein
Peripheral Neuropathy Due to Chemotherapy
Preventive Approach Using Venlafaxine
Peripheral and Motor neuropathy represent a main obstacle for a better quality of life for cancer patients, Venlafaxine is introduced in a new dosing regimen for treating of oxaliplatin and taxanes induced peripheral neuropathy…
- Trial name
- NCT05875610
- Testing
- Venlafaxine 75 MG, Gabapentin 400 mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mit Ghamr Oncology Center
CIPN - Chemotherapy-Induced Peripheral Neuropathy
Effect of Immersive Virtual Reality on Postural Control and Risk of Fall in Patients With Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of functional disability in cancer survivors. Patients with CIPN typically present with numbness, tingling, burning pain, and loss of proprioception, particularly…
- Trial name
- NCT07854574
- Testing
- The intervention will consist of conventional physical therapy exercise, Immersive Virtual Reality
- Volunteers
- 40 people
- Sponsor
- Cairo University
Peripheral Neuropathy Due to Chemotherapy, Peripheral Neuropathy, Chemotherapy-induced
Study on the Efficacy and Safety of Mecobalamin in Preventing Taxane-related Peripheral Neuropathy
Some patients receiving taxane-based chemotherapy experience numbness, tingling, or pain in their hands and feet, known as chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT07423390
- Testing
- Mecobalamin
- Where
- 4 sites in China
- Volunteers
- 326 people
- Sponsor
- Qinghai Red Cross Hospital
Chemotherapy-induced Neuropathy
Demonstrate the Value of Using Hypnosis in Chimiotherapy- Induced Chronic Neuropathies
Chimiotherapy produces neuropathies injuries to 30% to 70% cases. A third of those patients keeps suffering from this side effects disabilities and their quality of life is seriously affected.
- Trial name
- NHYP (NCT03156595)
- Testing
- Nurse interview, Hypnosis sessions
- Where
- France
- Volunteers
- 108 people
- Sponsor
- University Hospital, Strasbourg, France
Cancer
A Randomized Phase III Study of Vitamins B6 and B12 to Prevent Chemotherapy-Induced Neuropathy in Cancer Patients
Many types of chemotherapy may cause nerve damage as a side effect. This neurotoxicity can manifest as peripheral sensory neuropathy (characterized by numbness, tingling, or pain).
- Trial name
- NCT00659269
- Testing
- Multivitamin (MV), Multivitamin + Vitamin B12 + Vitamin B6, Chemotherapy
- Where
- 5 sites in United States
- Volunteers
- 319 people
- Sponsor
- New Mexico Cancer Research Alliance
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy
CIPN in Early Stage Breast Cancer Patients
Chemotherapy uses anti-cancer drugs to destroy cancer cells and is a common treatment for many cancers. Taxanes are the most widely used chemotherapy drugs given to breast cancer patients.
- Trial name
- NCT05441722
- Testing
- Exercise prehabilitation
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Northumbria University
Chemotherapy-induced Peripheral Neuropathy
Proof of Principle Study Evaluating Gonyautoxins NEURO SERUM, on Chemotherapy-induced Peripheral Neuropathy
Proof-of-concept study to assess the effects of gonyautoxins (PSP NEURO SERUM) on safety and tactile sensitivity on patients with chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT05052398
- Testing
- PSP NEURO SERUM
- Where
- 9 sites in Brazil
- Volunteers
- 52 people
- Sponsor
- Algenis SpA