Clinical trials: Chest Infection
Spondylodiscitis
Cytokine Profiles and suPAR in Spondylodiscitis
Spondylodiscitis is an infectious disease of the intervertebral discs and adjacent vertebral bodies, which often has a protracted progression.
- Trial name
- NCT02554227
- Testing
- Cytokine Profile and suPAR
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Cologne
Respiratory Distress Syndrome, Lower Respiratory Tract Infection
A Low-Resource Oxygen Blender Prototype for Use in Modified Bubble CPAP Circuits
Purpose: Using a novel oxygen blender prototype with modified bCPAP to manage children 1 month to 5 years of age hospitalized with respiratory distress due to lower respiratory tract infection (LRTI) in low-resource settings is…
- Trial name
- NCT04311320
- Testing
- Low-Resource Oxygen Blender
- Where
- Cambodia
- Volunteers
- 33 people
- Sponsor
- University of Minnesota
COVID-19 Lower Respiratory Infection
Phase I/II Study of COVID-19 DNA Vaccine (AG0302-COVID19 High-dose)
This study will assess the safety and immunogenicity of AG0302-COVID19 in healthy volunteers.
- Trial name
- NCT04993586
- Testing
- AG0302-COVID19 for Intramuscular Injection, AG0302-COVID19 for Intradermal Injection
- Where
- 6 sites in Japan
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- AnGes, Inc.
Lower Respiratory Tract Infection
The Effect of a Family-Centered Care Approach on Infants Receiving High-Flow Nasal Oxygen Therapy
This research is an experimental study of randomized control with pre-test - post-test control group. The aim of this study is to determine the effect of family-centered care approach on physiological parameters and follow-up…
- Trial name
- NCT07183553
- Testing
- maintenance training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Lower Respiratory Tract Infection, Parainfluenza
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.
- Conditions
- Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
- Trial name
- NCT03808922
- Testing
- DAS181, DAS181 COVID-19, DAS181 OL
- Where
- 28 sites in United States, Australia and 3 more
- Volunteers
- 274 people
- Sponsor
- Ansun Biopharma, Inc.
Acute Respiratory Failure, Pneumonia
HFCWO on Pneumonic Respiratory Failure
BACKGROUND: Endotracheal intubation and prolonged immobilization of patients receiving mechanical ventilation may reduce expectoration function.
- Trial name
- HFCWOonAFR (NCT02758106)
- Testing
- Vest Airway Clearance System Model 105
- Volunteers
- 73 people
- Sponsor
- Chung Shan Medical University
Lung Cancer, Lung Tuberculosis
68Ga-AlfatideII for the Differential Diagnosis of of Lung Cancer and Lung Tuberculosis by PET/CT
Comparison of 68Ga-AlfatideII and 18F-FDG in differential diagnosis effectiveness towards the solitary pulmonary nodules of lung cancer or tuberculosis.
- Trial name
- NCT02481726
- Testing
- 68Ga-labeled peptides of dimer RGD (Alfatide II) and 18F-FDG
- Volunteers
- 31 people
- Sponsor
- Xijing Hospital
Tuberculosis, Pulmonary
Comparative Efficacy of CUS, CXR and CAD in TB Diagnosis in LMIC
Pulmonary Tuberculosis (TB) remains a significant global health concern, particularly in low- and middle-income countries (LMIC), where resources for healthcare are often limited.
- Trial name
- CUSTB (NCT06409780)
- Testing
- Comparative analysis of CUS, CAD and CXR in pulmonary TB
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Bari
COVID-19, Lung Injury
Clinical Trial to Evaluate Methylprednisolone Pulses and Tacrolimus in Patients With COVID-19 Lung Injury
The primary objective of the study is to evaluate the days until reaching clinical stability after starting randomization in hospitalized patients with elevated inflammatory parameters and severe COVID-19 lung injury.
- Trial name
- TACROVID (NCT04341038)
- Testing
- Tacrolimus, Methylprednisolone
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Hospital Universitari de Bellvitge
COVID-19 Lower Respiratory Infection, Microbial Colonization
Oral Probiotics and Secondary Bacterial Pneumonia in Severe COVID-19
Background and aims: Patients with severe Coronavirus Disease 2019 (COVID-19) are prone to secondary bacterial pneumonia. The use of probiotics against oral pathogens might prevent lung colonization and progression to bacterial…
- Conditions
- COVID-19 Lower Respiratory Infection, Microbial Colonization, Severe COVID-19, Secondary Bacterial Pneumonia
- Trial name
- NCT05175833
- Testing
- Oral probiotics
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Universidade de Passo Fundo
Amyloidosis, Basal Cell Carcinoma
The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
This phase II trial studies whether providing cancer treatment in the home is preferred over the traditional clinic setting and if it improves treatment satisfaction in cancer patients living in the Florida Panhandle and…
- Conditions
- Amyloidosis, Basal Cell Carcinoma, Biliary Tract Carcinoma, Bladder Carcinoma
- Trial name
- NCT07285044
- Testing
- Cancer Therapeutic Procedure, Questionnaire Administration
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Mayo Clinic
Pneumonia; Pulmonary Infection
A Multicenter Randomized Trial of CT-Based AI Decision Support for Early Pneumonia Care
Adults hospitalized with pneumonia who need new or increased oxygen support or have defined immunocompromise will be assigned to usual care with or without access to a CT-based AI report.
- Trial name
- NCT07895290
- Testing
- CT-Based AI Decision Support for Pneumonia
- Where
- China
- Volunteers
- 4,800 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Lower Respiratory Tract Infection, Pneumonia
Fast Identification of Pathogen in the Setting of Pneumonia Using Multiplex PCR
With this study the investigators want to determine, if a fast identification of germs, causing infections of the lower respiratory tract, is possible through the use of Multiplex PCR technology - a method that allows on time…
- Trial name
- NCT01858974
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Göttingen
Pneumonia, Bacterial Pneumonia
Multiplex Polymerase Chain Reaction in Postoperative Pneumonia After Thoracic Surgery
Background: In thoracic surgery, postoperative pneumonia (POP) is the leading cause of postoperative morbidity and mortality. The clinical diagnosis of POP is difficult and conventional microbiological diagnostic tests perform…
- Trial name
- POP-PCR (NCT03752320)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Advanced Solid Tumors, MSI-H/dMMR Tumors
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors
The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of INCB099318 in select solid tumors.
- Conditions
- Advanced Solid Tumors, MSI-H/dMMR Tumors, Cutaneous Squamous Cell Carcinoma, Urothelial Carcinoma, HCC
- Trial name
- NCT04272034
- Testing
- INCB099318
- Where
- 24 sites in United States, Belgium and 5 more
- Volunteers
- 105 people
- Sponsor
- Incyte Corporation
Respiratory Syncytial Virus (RSV)
Safety, Pharmacokinetics, and Antiviral Activity of Remdesivir (VEKLURY®) in Hospitalized Children With RSV
THAI-CARES RSV Study is a Phase II, open-label, multicenter, randomized controlled trial with a two-arm, parallel-group design. The study aims to assess the safety, efficacy, and acceptability of a five-day course of Remdesivir…
- Trial name
- THAI-CARES RSV (NCT06873633)
- Testing
- Remdesivir
- Where
- 8 sites in Thailand
- Volunteers
- 120 people
- Sponsor
- PENTA Foundation
Diarrhea, Pneumonia
Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children
Zinc deficiency is common in developing country children, as food intakes are often low, foods from animal sources are infrequently used, the bioavailability of zinc from staple cereal-based diets is limited and zinc losses occur…
- Conditions
- Diarrhea, Pneumonia, Acute Respiratory Tract Infection
- Trial name
- NCT00272116
- Testing
- Zinc and vitamin A single dose at enrollment
- Where
- India
- Volunteers
- 2,482 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Cancer
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
- Trial name
- NCT00161187
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Fatal Outcome
Proadrenomedullin for Early Risk Assessment in the Emergency Department
The study ia aiming to the assessment of Mid-Regional proadrenomedullin (MR-proADM) as a novel biomarker that can provide accurate short-, mid- and long term prognostic information in the triage and multi-dimensional risk…
- Trial name
- ADRISK (NCT02823704)
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- University of Athens
Bronchiolitis
Assessment of Thoracic Echography for Pleuroparenchymatous Anomaly Diagnosis Complicating Bronchiolitis: BronchioIUS
The diagnosis of bronchiolitis, the most frequent lung infectious disease in infancy, is based on clinical examination. Chest X-ray is proposed when a lung parenchymal condensation is suspected.
- Trial name
- BronchioIUS (NCT02890797)
- Testing
- radiology
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Toulouse