Clinical trials: Chest Infection
Advanced Solid Tumors Cancer
A Study of the Safety, Tolerability and Pharmacokinetics of ABBV-368 as a Single Agent and Combination in Subjects With Locally Advanced or Metastatic Solid Tumors
The primary purpose of this Phase 1, open-label study is to evaluate the safety, pharmacokinetics, and preliminary efficacy of ABBV-368 as a monotherapy and in combination with ABBV-181 in participants with locally advanced or…
- Trial name
- NCT03071757
- Testing
- ABBV-368, ABBV-181
- Where
- 27 sites in United States, France and 4 more
- Volunteers
- 139 people
- Sponsor
- AbbVie
Tuberculosis
Early Risk Assessment in Household Contacts (≥10 Years) of TB Patients by New Diagnostic Tests in 3 African Countries
The ERASE - TB study will be conducted in order to fill a critical unmet need for tuberculosis control. Persons who are in contact with an infectious TB case may become infected themselves.
- Trial name
- ERASE-TB (NCT04781257)
- Testing
- New test candidates
- Where
- 3 sites in Mozambique, Tanzania and 1 more
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Michael Hoelscher
Lung Cancer, COVID
Study of the Immunity of Patients With Lung Cancer and COVID-19 Infection
Observational, retrospective data collection and prospective IgG analysis, and multicenter study. The main objective of the study is th description of the characteristics and evolution of patients with lung cancer who have…
- Conditions
- Lung Cancer, COVID, Corona Virus Infection
- Trial name
- SOLID (NCT04407143)
- Testing
- IgG test
- Where
- 68 sites in Spain
- Volunteers
- 1,980 people
- Sponsor
- Fundación GECP
Community-acquired Pneumonia
Community-Acquired Pneumonia - Study on the Initial Treatment With Antibiotics of Lower Respiratory Tract Infections
The purpose of this study is to compare the cost(effectiveness) of three existing antibiotic strategies for patients with community-acquired pneumonia admitted to the hospital, but not the ICU.
- Trial name
- CAP-START (NCT01660204)
- Testing
- Preferred empirical treatment
- Where
- 7 sites in Netherlands
- Volunteers
- 2,283 people
- Sponsor
- UMC Utrecht
Pleural Diseases, Pleural Mesothelioma
Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention
The PROSPECT study aims to look at the number of problems or side effects which occur after patients have had a procedure completed to remove fluid or air from the space between the lung and the chest wall.
- Conditions
- Pleural Diseases, Pleural Mesothelioma, Pneumothorax, Pleural Effusion
- Trial name
- PROSPECT (NCT05910112)
- Testing
- Pleural interventions
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Respiratory Tract Infections
Usefulness of C-reactive Protein Testing in Acute Cough
The aim of this study is to evaluate the usefulness in Russian general practice of C-reactive protein testing in patients with acute cough or lower respiratory tract infections.
- Trial name
- NCT01794819
- Testing
- C-reactive protein test
- Where
- Russia
- Volunteers
- 179 people
- Sponsor
- Northern State Medical University
Pneumonia, Pulmonary Edema
Chest U/S in Differentiating Lung Congestion & Pneumonia in Adult Critically-ill Patients and Its Prognostic Impact
This study aim will be to assess the effectiveness of chest ultrasound as a diagnostic and differentiating modality in cases of pneumonia and lung congestion .
- Trial name
- NCT05636631
- Testing
- Chest ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Lung Cancer Diagnosis
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
The PROACT LUNG study is a prospective multi-center observational study to validate a blood-based test for the early detection of lung cancer by collecting blood samples from high-risk participants who will undergo a routine…
- Trial name
- PROACT-LUNG (NCT06122077)
- Testing
- blood draw
- Where
- 36 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- Freenome Holdings Inc.
2019-nCoV (COVID-19), Interstitial Pneumonia
Interest of the Use of Pulmonary Ultrasound in the Referral of Patients With or Suspected COVID-19 +
The recent pandemic due to the SARS-CoV2 results in a pulmonary infection in major symptomatic patients. Because of the large number of patients and the risk of acute respiratory distress syndrome (which seems to occur in almost…
- Trial name
- eChoVid (NCT04335019)
- Testing
- Pulmonary ultrasound
- Where
- France
- Volunteers
- 328 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Urinary Catheterization, Thoracic Surgery
REduction of Post-Operative Urinary Retention With Tamsulosin Versus Placebo (REPOURT- P) Trial
The purpose of this study are to determine the efficacy of tamsulosin compared to placebo in reducing post-operative urinary retention and improving other clinical outcomes in people undergoing thoracic surgery.
- Conditions
- Urinary Catheterization, Thoracic Surgery, Thoracic Epidural Analgesia
- Trial name
- REPOURT-P (NCT04159077)
- Testing
- Tamsulosin Hydrochloride
- Volunteers
- 350 people
- Sponsor
- McMaster University
Lower Resp Tract Infection
An Algorithm to Decide on Antibiotic Prescription in Lower Respiratory Tract Infection in Primary Care
The study is randomized clustered pragmatic trial whose objective is to decrease unnecessary antibiotic prescription in adult patients with lower respiratory tract infection managed at primary care level in Switzerland, using a…
- Trial name
- UltraPro (NCT03191071)
- Testing
- UltraPro, Procalcitonin, Blood sampling
- Where
- Switzerland
- Volunteers
- 469 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Tuberculosis, Lung Cancer
Development of Tuberculosis Diagnostic Kit
Pulmonary tuberculosis is one of the most important infectious diseases in human with high mortality. Early diagnosis followed by antibiotic treatment is the only way for control of the disease.
- Conditions
- Tuberculosis, Lung Cancer, Pneumonia
- Trial name
- NCT00311207
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taichung Veterans General Hospital
Sepsis
Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation
Due to the failure of the respiratory system, many patients admitted to the Intensive Care Units (ICUs) require the institution of invasive mechanical ventilation (MV), aiming at maintaining gas exchange, reversing respiratory…
- Trial name
- NCT03464071
- Testing
- Hyperinflation with mechanical ventilator, Manual hyperinflation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Drug Effect, Rib Fractures
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures
Rib fractures represent a common injury pattern this is highly associated with patient morbidity and mortality, as pain control remains a challenge.
- Conditions
- Drug Effect, Rib Fractures, Rib Trauma, Surgical Procedure, Unspecified
- Trial name
- NCT03305666
- Testing
- Liposomal bupivacaine injection, Bupivacaine indwelling catheter
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Denver Health and Hospital Authority
Upper Respiratory Infection, Lower Resp Tract Infection
Holistic Approach Supporting the Uptake of Innovative Diagnostic Technologies for Respiratory Infections
This observational diagnostic validation study aims to evaluate the clinical performance of novel lateral flow and microfluidic-based technologies for the detection of upper and lower respiratory tract infections in children and…
- Trial name
- HOLICARE (NCT07651865)
- Where
- 3 sites in Ethiopia, Senegal and 1 more
- Volunteers
- 1,765 people
- Sponsor
- Karolinska Institutet
Acute Respiratory Infection, Asthma Exacerbations
Reusable Face Masks to Reduce Risk of Viral Respiratory Infections and Asthma Exacerbations
REMASK trial is a Trial within Cohort study (TwiCs), nested within the COVIDENCE UK longitudinal study. It has been designed to determine whether the offer of a free reusable, elastomeric face mask to adults with asthma and other…
- Trial name
- REMASK (NCT06885229)
- Testing
- FloMask - reuseable face mask
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Perioperative Complications, Perioperative/Postoperative Complications
Perioperative Database of Chinese Elderly Patients
The investigators aim to establish a prospective database of perioperative elderly patients from multiple regions and centers. Collected data involves postoperative complications of the central nervous system, cardiovascular…
- Conditions
- Perioperative Complications, Perioperative/Postoperative Complications, Perioperative Adverse Events
- Trial name
- PDCEP (NCT04911530)
- Testing
- no intervention
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Chinese PLA General Hospital
Covid-19, Lung Cancer
LunG and Melanoma canceR pAtients coVId19 Disease (GRAVID)
This is a multi-centre study on lung cancer patients which experienced COVID-19. Information on clinical features, clinical course, management and outcomes will be collected for both, thoracic cancers and COVID-19 infection.
- Trial name
- GRAVID (NCT04344002)
- Where
- 75 sites in Spain
- Volunteers
- 886 people
- Sponsor
- Spanish Lung Cancer Group
Graft Patency
Study of Feasibility for Surgical Patients Undergoing Heart Surgery With the Mammary Arteries: Reviewing Infection, Occlusion Rates and Pain Assessments.
The Pilot study for the COMFORT Trial is a single centre trial to determine the feasibility of the full COMFORT Trial. The main COMFORT Trial will be a multi-centre trial to investigate the coronary artery bypass grafting…
- Trial name
- COMFORT pilot (NCT07599553)
- Testing
- Skeletonized vs non-skeletonized harvesting of the left internal mammary artery
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Ottawa Heart Institute Research Corporation
COVID, SARS-CoV 2
Impact of Confinement and Preventive Measures in Period of SARS-COV2 Infection on Clinical Features, Diagnostic and Therapeutic Management and Prognosis of Patients With Lung Cancer
The unexpected onset of SARS-COV2 infection modified our practices, especially in routine medicine. In order to reverse the epidemic curve of severe cases and slow the spread of the infection, confinement was generalized in…
- Conditions
- COVID, SARS-CoV 2, Lung Cancer
- Trial name
- CBP-COVID (NCT04366219)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier le Mans