Clinical trials: Chest Infection
Stage IV Melanoma, Advanced Lung Cancer
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced Cancer
The purpose of this study is to refine and pilot test educational material developed to educate and support patients receiving immunotherapy for advanced cancer.
- Conditions
- Stage IV Melanoma, Advanced Lung Cancer, Stage IV Non-Small Cell Lung Cancer, Unresectable Non-Small Cell Lung Carcinoma
- Trial name
- UPLIFT (NCT04670445)
- Testing
- Educational Video and QPL List, Usual Care
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
LUNG CANCER
An Observational Study on the Impact of the 23-valent Pneumonia Vaccine on Lung Cancer Patients
To evaluate the impact of the 23-valent pneumonia vaccine on the incidence of pulmonary infection and survival in lung cancer patients, and to explore its preventive effect and safety in the lung cancer patients.
- Trial name
- NCT07142057
- Testing
- 23-valent pneumococcal vaccine
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Chronic Bronchitis
Early Mobilization With and Without Chest Physiotherapy in Chronic Bronchitis Patients.
It will be a randomized control trial study in which data are collected from hospital. A sample of 26 patients will divided into two group.
- Trial name
- NCT05646225
- Testing
- chest physiotherapy and early mobilization, early mobilization
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Pneumonia, Elderly Infection
CT Scan Compared to CXR and LUS in Pneumonia in the Elderly
Introduction: Pneumonia is a leading cause of mortality and a common indication for antibiotic in elderly patients. However, its diagnosis is often inaccurate.
- Trial name
- OCTOPLUS (NCT04978116)
- Testing
- Chest X-Ray (CXR), Low-dose CT scan (LDCT), Lung ultrasonography (LUS)
- Where
- 3 sites in Switzerland
- Volunteers
- 473 people
- Sponsor
- University Hospital, Geneva
Staphylococcus Aureus, Bacteremia
Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2)
This study will assess the efficacy of a single dose of V710 vaccine to prevent serious Staphylococcus aureus infections following elective cardiothoracic surgery.
- Conditions
- Staphylococcus Aureus, Bacteremia, Mediastinitis
- Trial name
- NCT00518687
- Testing
- V710
- Volunteers
- 8,031 people
- Sponsor
- Merck Sharp & Dohme LLC
Bronchiolitis, Pneumonia
National Observatory of Children Hospitalized for Acute Respiratory Distress or Lower Respiratory Tract Infections
This study is an observational, multicenter and prospective study for surveillance of case of hospitalised children acute respiratory distress or lower respiratory tract infections
- Conditions
- Bronchiolitis, Pneumonia, Asthma
- Trial name
- OVNI (NCT06112132)
- Where
- France
- Volunteers
- 1,827 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Bronchiolitis, Viral
Chest Physiotherapy in Infants Between 0 and 12 Months Old With Acute Bronchiolitis SRV(+)
The purpose of this research is to determine the effect of prolonged slow expiration techniques, provoked coughing and standard therapy compared to chest wall manual vibration and standard therapy in infants between 0 and 12…
- Trial name
- NCT02853838
- Testing
- Prolonged slow expiration+provoked coughing, Manual chest wall vibration, Standard Therapy
- Where
- Chile
- Volunteers
- 204 people
- Sponsor
- Universidad del Desarrollo
Advanced Solid Tumors, Genital Neoplasm, Female
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
This is an open label, multicenter, phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent and in combination with chemotherapy administered intravenously in participants…
- Conditions
- Advanced Solid Tumors, Genital Neoplasm, Female, Urogenital Neoplasms, Lung Neoplasm
- Trial name
- START-001 (NCT05592626)
- Testing
- STAR0602, Irinotecan (Camptosar), Docetaxel (Taxotere)
- Where
- 19 sites in United States, Canada and 2 more
- Volunteers
- 366 people
- Sponsor
- Marengo Therapeutics, Inc.
Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute
Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC
Lobectomy is a major, high-risk surgical procedure that in addition to one-lung ventilation (OLV) exerts a potent surgical stress response.
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic, Infections Postoperative
- Trial name
- NCT05172739
- Testing
- Opioid-Based Anesthesia-Analgesia Strategy, Opioid-free Anesthesia-Analgesia Strategy
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- University of Crete
Respiratory Syncytial Virus Lower Respiratory Tract Infection
Dose Ranging Study of ALX-0171 in Infants Hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection
The primary objective is to evaluate the anti-viral effect and safety of different doses of inhaled ALX-0171 in subjects hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection (RSV LRTI).
- Trial name
- Respire (NCT02979431)
- Testing
- ALX-0171 3.0 mg/kg, ALX-0171 6.0 mg/kg, ALX-0171 9.0 mg/kg
- Where
- 74 sites in Belgium, Bulgaria and 15 more
- Volunteers
- 180 people
- Sponsor
- Ablynx, a Sanofi company
Bladder Cancer, Brain and Central Nervous System Tumors
High-dose ICE With Amifostine
The purpose of the study is to evaluate the combination of amifostine and high dose chemotherapy with blood stem cell support. Amifostine is a druf developed to protect normal tissues against the toxicities of chemotherapy and…
- Conditions
- Bladder Cancer, Brain and Central Nervous System Tumors, Carcinoma of Unknown Primary, Extragonadal Germ Cell Tumor
- Trial name
- NCT00003657
- Testing
- filgrastim, Amifostine, Carboplatin
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Dana-Farber Cancer Institute
Sepsis, Septic Shock
Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock
In ICU, fluid challenge represents one of the cornerstones of hemodynamic care. However, fluid overload due to an excessive and/or inappropriate fluid administration could be associated with morbidity or mortality.
- Conditions
- Sepsis, Septic Shock, Hemodynamic Instability, Fluid Overload
- Trial name
- TFC-SEPSIS (NCT06572995)
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Pneumonia, Lung Cancer
Trial of Artificial Intelligence for Chest Radiography
Randomized Clinical Trial of the impact of Chest radiograph AI-assisted triage and report generation upon clinical outcomes and an economic analysis of impact of AI decision support on radiology service delivery.
- Trial name
- ACER (NCT06456203)
- Testing
- AI
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Lumbar Spondylitis
Thoracic Mobility Versus Hip Mobility Exercises to Core Stabilization in Lumbar Spondylitis
This study is conducted to determine the effect of thoracic mobility versus hip mobility exercises to core stabilization on pain severity (NPRS-Ar), functional disability (MODI-Ar), lumbar range of motion (BROM), spinal mobility…
- Trial name
- TME-HME (NCT07482527)
- Testing
- Group A : Core stabilization exercises (control group), Group B: Thoracic Mobility Exercises (1st experimental group only), Group C: Hip Mobility Exercises (2nd experimental group only)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Lower Resp Tract Infection, Ultrasound Therapy; Complications
Diagnostic of Lower Respiratory Tract Infection by Lung Ultrasonography in General Practice
Lower Respiratory Tract Infection (LRTI) is a frequent motive of consultation in General Practice. Cost, irradiation and availability of traditional imagery make it difficult to perform in every patient with suspected LRTI.
- Trial name
- AmbuLUS (NCT04602234)
- Testing
- Lung ultrasonography
- Where
- France
- Volunteers
- 151 people
- Sponsor
- University Hospital, Caen
Respiratory Syncytial Virus Lower Respiratory Tract Infection
Evaluation of ALX-0171 in Japanese Children Hospitalized for Respiratory Syncytial Virus Lower Respiratory Tract Infection
This was a randomized, double-blind, multicenter, Phase II study (NCT03418571) designed to support the selection of an optimal dose of inhaled ALX-0171 for further clinical development, taking ethnicity into consideration.
- Trial name
- NCT03418571
- Testing
- ALX-0171 1.5 mg/kg
- Where
- 25 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Ablynx, a Sanofi company
Unresectable Stage III NSCLC
Mobile Devices to Detect Early Pneumonitis in Stage III NSCLC Patients on Durvalumab.
A study of whether mobile devices can improve the detection of pulmonary AEs (including pneumonitis) in stage III NSCLC patients post-CRT, while on durvalumab.
- Trial name
- ON TRAX (NCT04381494)
- Testing
- Multiparametric Mobile Technology
- Where
- 18 sites in United States
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Pneumonia, Viral, Ventilator Associated Pneumonia
Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BAL
Almost 90 out of 100 people carry herpes simplex viruses (HSV). Once a person has been infected with the herpes viruses, he or she can't get rid of them for the rest of her/his life.
- Conditions
- Pneumonia, Viral, Ventilator Associated Pneumonia, Community-acquired Pneumonia, Herpes Simplex
- Trial name
- HerpMV (NCT06134492)
- Testing
- Acyclovir
- Where
- 28 sites in Germany
- Volunteers
- 616 people
- Sponsor
- Jena University Hospital
Heart Failure, Myocardial Infarction
INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure
INVESTED will test the hypothesis that high dose trivalent influenza vaccine will reduce cardiopulmonary events to a greater extent than standard dose quadrivalent influenza vaccine in high-risk cardiovascular patients with a…
- Trial name
- INVESTED (NCT02787044)
- Testing
- High Dose Trivalent Influenza Vaccine, Standard Dose Quadrivalent Influenza Vaccine
- Where
- 190 sites in United States, Canada and 1 more
- Volunteers
- 5,388 people
- Sponsor
- Brigham and Women's Hospital