Clinical trials: Chest Pains
Acute Coronary Syndrome, Acute Myocardial Infarction
Coronary Computed Tomographic Angiography in Emergency Department Chest Pain Patients at Intermediate Risk of Acute Coronary Syndrome
The purpose of this study is to determine whether Coronary Computed Tomographic Angiography (CCTA) will increase patient safety by decreasing the rate of missed ACS and adverse events in patients who receive standard care plus…
- Conditions
- Acute Coronary Syndrome, Acute Myocardial Infarction, Unstable Angina, Coronary Disease
- Trial name
- CCTA (NCT00473863)
- Testing
- Coronary Computed Tomographic Angiography
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Vancouver General Hospital
Chest Pain
Impact of General Practice Follow-up on Emergency Hospitalization of Patients Admitted for Chest Pain
This is a prospective observational study carried out in the emergency department of Emile Roux Hospital. Its aim is to compare the medical, psychological and social characteristics of patients followed up by a general…
- Trial name
- NCT06693063
- Testing
- Data collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Emile Roux
Coronary Artery Disease, Atherosclerosis
Coronary Artery Geometry and the Severity of Coronary Atherosclerosis
The purpose of this study is to investigate the potential association of coronary artery geometry, based on coronary CT angiography (CCTA), with the complexity and the severity of coronary atherosclerosis.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Atherosclerotic Plaque, Stable Angina
- Trial name
- GEOMETRY-CTA (NCT04185493)
- Testing
- CCTA
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Nicotine Dependence, Thoracic Diseases
Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco Smokers Undergoing Thoracic Surgery: A Randomized Controlled Pilot Study
Globally, approximately 230 million adults undergo surgical procedures each year, with around 30% of patients maintaining smoking habits prior to surgery.
- Conditions
- Nicotine Dependence, Thoracic Diseases, Analgesia
- Trial name
- NCT07250230
- Testing
- Nicotine patch
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Henan Provincial People's Hospital
Chronic Pain
Efficacy of Compound Betamethasone Injection Combined With Ropivacaine in Ultrasound-guided Thoracic Paravertebral Nerve Block for Chronic Post-thoracotomy Pain
Chronic post-thoracotomy pain（CPTP）will not only have a negative impact on patients' physiology and psychology, but also affect postoperative recovery.A number of researches have demonstrated that Injury to the intercostal nerve…
- Trial name
- NCT05175001
- Testing
- Diprospan, Ropivacaine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Affiliated Hospital of Nantong University
Non-Cardiac Chest Pain
Effect of GABAB Agonist on Visceral Hyperalgesia in NCCP patientsChinese?
The effect of baclofen (GABAB agonist), diltiazem (muscle relaxant) and placebo will be compared in a double-blinded randomized study for the treatment of NCCP.
- Trial name
- NCT00164801
- Testing
- Baclofen, Diltiazem
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Cardiovascular Diseases
NITRATE-OCT-CIN (Sub-Study of NITRATE-OCT)
The NITRATE-OCT:- Contrast Nephropathy Sub-study is a proof-of concept single center, randomized, clinical trial designed to ascertain whether a dietary NO3- approach might prove useful adjunctive therapy improving renal function…
- Trial name
- NIT-OCT-CIN (NCT05544981)
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Queen Mary University of London
Gastroesophageal Reflux Disease
Study Using Esomeprazole as a Diagnostic Test for GERD in Patients With NCCP
Gastroesophageal reflux disease (GERD), with its cardinal symptom, heartburn, is the most common disorder of the esophagus in the West.
- Trial name
- ECP (NCT00786695)
- Testing
- esomeprazole
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- National University Hospital, Singapore
Acute Coronary Syndrome
Impact of a Decision Aid on Patient Decision Making in Emergency Department Chest Pain Patients
We are doing a study to assess the impact of including patients in making decision regarding their own medical care in the emergency department. We will randomly assign them to either receive a decision aid or usual care.
- Trial name
- NCT01077037
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Mayo Clinic
Angina Pectoris, Coronary Artery Disease
Utility of a Molecular Personalized Coronary Gene Expression Test (Corus CAD or ASGES) on Cardiology Practice Pattern
To investigate whether the use of Corus CAD (Age/Sex/Gene Expression score - ASGES) blood assay changes the diagnostic testing pattern in patients referred to a cardiologist for the evaluation of chest pain or anginal equivalent…
- Conditions
- Angina Pectoris, Coronary Artery Disease, Chest Pain, Cardiovascular Diseases
- Trial name
- IMPACT-CARD (NCT01251302)
- Testing
- Corus CAD (ASGES)
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- CardioDx
Coronary Artery Disease
Prognostic Assessment of Contrast Echocardiography (PACE Study)
This study will demonstrate whether patients with prognostically-significant myocardial abnormalities detected with AI-700 contrast ECHO have a rate of cardiac death or MI that is higher than that of patients with normal AI-700…
- Trial name
- PACE (NCT00670332)
- Where
- United States
- Volunteers
- 773 people
- Sponsor
- Acusphere
Postoperative Pain, Thoracic Surgery
RISS Block for Enhanced Recovery After Video-Assisted Thoracoscopic Surgery
This prospective randomized controlled trial evaluates the efficacy and safety of ultrasound-guided rhomboid intercostal and subserratus plane (RISS) block for postoperative analgesia in patients undergoing video-assisted…
- Conditions
- Postoperative Pain, Thoracic Surgery, Video-Assisted Thoracic Surgery
- Trial name
- NCT07462273
- Testing
- Rhomboid Intercostal and Subserratus Plane Block with local anesthetic, Intercostal nerve block
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Ningbo University
Stable Angina Pectoris, Atherosclerosis
Effect of Molsidomine on the Endothelial (Internal Layer of Blood Vessels) Dysfunction in Patients With Angina Pectoris
Molsidomine used as an add-on treatment on standard care therapy should be superior to placebo used also as an add-on treatment on standard care therapy on improving the endothelial function (endothelium score measured by…
- Trial name
- MEDCOR (NCT01363661)
- Testing
- Coruno
- Where
- Belgium
- Volunteers
- 165 people
- Sponsor
- Therabel Pharma SA/NV
Postoperative Pain After Thoracic Surgery, Coronary Artery Bypass Graft (CABG)
Comparison of Erector Spinae Plane Block and Serratus Posterior Superior Intercostal Plane Block in Postoperative Pain Management After Coronary Artery Bypass Grafting
Coronary Artery Bypass Grafting (CABG) is a common surgical procedure for ischemic heart disease, but it often leads to severe acute and chronic postoperative pain, which can delay recovery and reduce patient comfort.
- Trial name
- NCT07287761
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Ankara Education and Research Hospital
Pain, Postoperative, Chronic Pain
The Effect of Choice of Intraoperative Opioid on Postoperative Pain
The primary aim of this randomized, double-blind study is to examine the effect of a single intraoperative dose of methadone on postoperative pain and analgesic requirements in patients undergoing cardiac surgery with…
- Trial name
- NCT01542645
- Testing
- Methadone, Fentanyl
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Endeavor Health
Coronary Artery Disease
Diagnostic Accuracy of On-line Quantitative Flow Ratio (QFR). FAVOR II Europe-Japan
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. QFR is assessed by calculation of the pressure in the vessel based on two angiographic projections.
- Trial name
- FAVOR II EJ (NCT02959814)
- Testing
- QFR (observational)
- Where
- 10 sites in Denmark, France and 5 more
- Volunteers
- 329 people
- Sponsor
- Aarhus University Hospital Skejby
Chest Pain
Evaluation of hsTnI in the Management of Patients With Chest Pain in the Emergency Department
Current standard of care algorithm using high sensitivity troponin T (hsTnT) requires up to 6.5 hours to diagnose an ACS. Data will be stratified based upon time of symptom onset and gender.
- Trial name
- hsTnI (NCT02789904)
- Testing
- blood taking
- Where
- Singapore
- Volunteers
- 1,200 people
- Sponsor
- National Heart Centre Singapore
Myocardial Infarction, Unstable Angina Pectoris
Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction
A three months, double-blind, randomised, parallel-group study evaluating the efficacy of sitagliptin (Januvia™) versus placebo on beta-cell function in patients with newly detected glucose abnormalities and acute myocardial…
- Conditions
- Myocardial Infarction, Unstable Angina Pectoris, Diabetes Mellitus, Impaired Glucose Tolerance
- Trial name
- BEGAMI (NCT00627744)
- Testing
- Sitagliptin
- Where
- 2 sites in Sweden
- Volunteers
- 85 people
- Sponsor
- Karolinska Institutet
Chest Pain
Stripping Massage After Thoracoscopy
This study investigated the effects of stripping massage (SM) on myofascial trigger points in the rhomboid after thoracoscopic surgery.
- Trial name
- SMAT (NCT04716816)
- Testing
- Stripping massage
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Rib Fractures, Pain, Chest
Kinesiotaping Method for Rib Fractures
Kinesiotaping is used as a physiotherapy method to reduce muscle pain. In this technique, kinesiotaping tapes are attached to the relevant parts of the body. Patients experience serious pain in rib fractures.
- Trial name
- NCT06222320
- Testing
- Kinesiotaping, Painkillers
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Kastamonu University