Clinical trials: Chest Pains
Coronary Artery Disease
Safety and Cost-efficiëncy of New Imaging Techniques in Patients Suspected of Coronary Artery Disease
Yearly, 180 000 patients in the Netherlands are referred to a cardiologist with symptoms suspected of coronary artery disease (CAD). To assess this, multiple diagnostic tests are available.
- Trial name
- iCORONARY (NCT04939207)
- Testing
- CT-FFR, Angiography-derived FFR, Angiography with invasive FFR-measurements
- Where
- 4 sites in Netherlands
- Volunteers
- 825 people
- Sponsor
- St. Antonius Hospital
Spinal Manipulable Lesion, Somatic Dysfunction
Trigger Point Therapy Versus Manipulation Correcting Thoracic Manipulable Lesion
There will be no difference between trigger point therapy and spinal manipulation in correcting a spine joint dysfunction in the back
- Trial name
- NCT01123226
- Testing
- spinal manipulation, trigger point therapy
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Anglo-European College of Chiropractic
Breast Cancer Female, Pain, Postoperative
Analgesic Effect of Adding Thoracic Paravertebral Nerve Blocks to Modified PEC Block in Breast Cancer Surgery
To compare efficacy and safety of adding thoracic paravertebral nerve blocks to modified PEC block versus modified PEC block only in breast cancer surgery.
- Trial name
- NCT04056676
- Testing
- Thoracic paravertebral block under ultrasound guidance, Intraoperative modified PEC block, GA with ETT
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Mahidol University
Angina
The Addition of Cardiac CT to Exercise Treadmill Testing in the Evaluation of Angina
The current outpatient evaluation for angina in low and intermediate risk patients typically starts with a functional assessment for coronary ischemia.
- Trial name
- CT-EXTRA (NCT00491218)
- Where
- United States
- Sponsor
- Walter Reed Army Medical Center
Pain, Out-of-hospital Cardiac Arrest (OHCA)
Pain After Cardiac Arrest and Resuscitation (PAINCARE)
The PAINCARE substudy is an observational cohort substudy nested within the international STEPCARE trial, which evaluates sedation, temperature, and mean arterial pressure strategies after out-of-hospital cardiac arrest.
- Trial name
- PAINCARE (NCT07564778)
- Where
- 3 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Liver Cancer
Ultrasound Guided Thoracic Paravertebral Block for Hepatic Tumors Ablation
Patients undergo percutaneous radiofrequency ablation of hepatic tumors at Siriraj hospital normally receive only intravenous sedative drugs which sometimes can not provide effective pain control.
- Trial name
- NCT02271646
- Testing
- 0.5% marcaine 20ml
- Where
- Thailand
- Volunteers
- 35 people
- Sponsor
- Mahidol University
Rib Fractures, Pain
Analgesic Effect of Intranasal Calcitonin on Patients With Fractured Ribs
This study, which will be conducted at the emergency room of the Sacré-Cœur hospital, requires the recruitment of 60 subjects and involves some telephone follow-up.
- Trial name
- NCT00444808
- Testing
- Intranasal calcitonin
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Université de Montréal
Pain
Ultrasound Guided Bilateral Erector Spinae Plane Block in Caesarean Delivery
Erector Spinae plane block (ESPB) is a regional anesthesia technique described three years ago. Its use for many indications has been identified by case reports in the literature.
- Trial name
- NCT04118413
- Testing
- erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cigli Regional Training Hospital
Thoracostomy Pain Management, Pain Management
The Clinical Impact of Serratus Anterior VS. Erector Spinae Plane Block on Pain Management of Tube Thoracostomy in Emergency Department Patients.
In the emergency department, tube thoracostomy is a common critical procedure to manage symptomatic pleural issues such as pneumothorax and pleural effusion.[1] This technique employed to remove air or fluid from the pleural…
- Conditions
- Thoracostomy Pain Management, Pain Management, Chest Tube Insertion
- Trial name
- NCT07823920
- Testing
- serratus anterior plane blocks, Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Angina Pectoris, Myocardial Infarction
GLP-1 Loading During Elective Percutaneous Coronary Intervention
Angina is caused by narrowings or blockages within coronary arteries. Coronary angioplasty and stenting is performed for people with angina to improve the blood supply to the heart by placing metal tubes within the artery using…
- Conditions
- Angina Pectoris, Myocardial Infarction, Reperfusion Injury, Coronary Heart Disease
- Trial name
- GOLD-PCI (NCT02127996)
- Testing
- GLP-1
- Where
- United Kingdom
- Volunteers
- 193 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Lung Cancer, Esophageal Cancer
Perspectives of Receiving Open Versus Minimally Invasive Surgery
This study will examine the perspectives of patients' undergoing surgery for lung or esophageal cancer. It will examine both pre-op and post-op patient perspectives and opinions regarding pain and surgical complications.
- Trial name
- PROMIS (NCT01807390)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Coronary Artery Disease, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
First-in-Human Study Using the SiroMax™ Sirolimus-Coated Balloon Catheter as a Percutaneous Transluminal Coronary Angioplasty (PTCA) Balloon Catheter to Treat Subjects Who Have Coronary Artery Disease (CAD) Involving In-Stent Restenosis (ISR) or an Unstented Lesion in a Small Coronary Vessel (DNSV).
The goal of this clinical trial is to learn if the SiroMax™ drug-coated balloon catheter is safe and works to treat stenotic coronary lesions in adults.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), In-Stent Restenosis or De Novo Coronary Artery Lesions, In-Stent Stenosis (Restenosis) of Coronary Artery Stent
- Trial name
- SMART-I (NCT07811024)
- Testing
- Sirolimus-coated balloon catheter
- Where
- 2 sites in Uzbekistan
- Volunteers
- 60 people
- Sponsor
- Tonic Medical, Inc.
Abdominal Aortic Aneurysm, Coronary Heart Disease
Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study
Specific cardiovascular diseases, such as stroke and heart attack, have been shown to vary by ethnic group. However, less is known about differences between ethnic groups and a wider range of cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease, Sudden Cardiac Death, Intracerebral Haemorrhage
- Trial name
- NCT02176174
- Volunteers
- 1,068,318 people, healthy volunteers welcome
- Sponsor
- University College, London
Heart Diseases, Ischemic, Coronary Artery Disease
Power Walking in Cardiac Patients Who Underwent Post-coronary Angioplasty
The risk and prevalence of cardiovascular disease in United Arab Emirates (UAE) is high with ischemic heart disease ranks first in terms of major cause of mortality.
- Conditions
- Heart Diseases, Ischemic, Coronary Artery Disease, Coronary Arteriosclerosis, Coronary Syndrome
- Trial name
- PowerWalk (NCT04610060)
- Testing
- Power walking, Standardised outpatient cardiac rehabilitation
- Where
- United Arab Emirates
- Volunteers
- 24 people
- Sponsor
- Gulf Medical University
Atrial Fibrillation, Coronary Artery Disease
Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease
This study evaluates the efficacy and safety of Edoxaban with the combination of edoxaban and antiplatelet in patients with stable CAD (coronary artery stenosis ≥50% on medical treatment or revascularized stable CAD [≥ 12 months…
- Conditions
- Atrial Fibrillation, Coronary Artery Disease, Stable Angina, Stable Chronic Angina
- Trial name
- EPIC-CAD (NCT03718559)
- Testing
- Edoxaban Monotherapy, Edoxaban plus Single Antiplatelet Agent
- Where
- 18 sites in South Korea
- Volunteers
- 1,040 people
- Sponsor
- Gi-Byoung Nam
Pain, Postoperative, Thoracic Surgery, Video-Assisted
Postoperative Analgesic Effect of Hydromorphone on Partial Pulmonary Resection Under Video-assisted Thoracoscopy
Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Multimodal analgesia combines several agents and/or techniques to function on diverse nociceptive…
- Trial name
- NCT03648008
- Testing
- Hydromorphone, Morphine
- Where
- China
- Volunteers
- 171 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
CHD - Coronary Heart Disease, Angina, Stable
Coronary Microcirculatory and Bioresorbable Vascular Scaffolds
Angina and heart attacks are caused by narrowings in the coronary arteries (blood vessels) supplying the heart. These narrowings can be opened using a balloon and stent (angioplasty).
- Conditions
- CHD - Coronary Heart Disease, Angina, Stable, Myocardial Ischemia
- Trial name
- EMPIRE-BVS (NCT03076476)
- Testing
- Bioresorbable Vascular Scaffolds (BVS), Drug-Eluting Stent (DES) - slow, Drug-Eluting Stent (DES) - standard(std)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Acute Coronary Syndromes, Dyslipidemia
Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome
This randomized clinical trial will evaluate whether starting bempedoic acid in addition to high-intensity statin therapy and ezetimibe within 72 hours after percutaneous coronary intervention improves low-density lipoprotein…
- Trial name
- EARLY-BIRD ACS (NCT07824323)
- Testing
- bempedoic acid, Ezetimibe, High-Intensity Statin Therapy
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Medical University Hospital
Chronic Stable Angina
A Clinical Trial of a Self-Management Education Program for People With Chronic Stable Angina
The purpose of this clinical trial was to determine the effectiveness of a supportive and educational self-management program for improving health-related quality of life (HRQOL), angina symptoms, and self-efficacy and…
- Trial name
- NCT00350922
- Testing
- Psychoeducation
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- University of Toronto