Clinical trials: Chest Wall Disease
ARDS, COVID-19
Paradoxical Response to Chest Wall Loading in Mechanically Ventilated Patients
The purposes of our study are to: 1) determine the incidence of paradoxical response to chest wall loading in mechanically ventilated patients; 2) identify sub-populations in which it is most likely to occur (e.g., severe ARDS)…
- Conditions
- ARDS, COVID-19, Mechanical Ventilation Pressure High, Ventilator-Induced Lung Injury
- Trial name
- NCT06093958
- Testing
- Manual loading of the chest wall
- Where
- United States
- Sponsor
- HealthPartners Institute
Atelectasis
The Effect of Oscillation and Lung Expansion (OLE) Therapy in Prolonged Mechanical Ventilated Patients With Atelectasis Evaluated in Multiple Methods
High frequency chest wall oscillation (HFCWO) is currently one of the most common and widespread mechanical airway clearance techniques (ACTs) in clinical practice in China.
- Trial name
- NCT07451405
- Testing
- High frequency chest wall oscillation or other airway clearance therapy, Oscillation and lung expansion
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Esophageal Cancer, Esophagectomy
Oesophagectomy and Chest Wall and Respiratory Function
Open surgery for esophageal cancer commonly involves large incisions in the chest, associated with a high rate of pulmonary complications (30-50%).
- Conditions
- Esophageal Cancer, Esophagectomy, Respiratory Function Loss
- Trial name
- NCT03835273
- Testing
- 3D motion capture system, Incentive spirometry, Questionnaires
- Where
- United Kingdom
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Bronchial Asthma, Asthma
HFCWO in Hospitalized Asthmatic Children
To determine whether or not high frequency chest wall oscillation (in the form of the VestTM) is superior to regular asthma therapy in the management of children hospitalized with moderate to severe asthma.
- Conditions
- Bronchial Asthma, Asthma, Status Asthmaticus
- Trial name
- NCT00722020
- Testing
- VEST
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Hill-Rom
Chronic Ischemic Heart Disease, Left Ventricular Dysfunction
Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study)
Coronary artery disease (CAD) is a common disorder that can lead to heart failure. Not all people with CAD are eligible for today's standard treatments.
- Conditions
- Chronic Ischemic Heart Disease, Left Ventricular Dysfunction, Angina, Ischemic Cardiomyopathy
- Trial name
- NCT00824005
- Testing
- Adult stem cells
- Where
- 5 sites in United States
- Volunteers
- 92 people
- Sponsor
- The University of Texas Health Science Center, Houston
Neuromuscular Diseases
Non-invasive Ventilation and Physical Activity
As fatigue and daytime sleepiness are typical symptoms of alveolar hypoventilation in patients with neuromuscular disorders and thoracic deformations, we hope, by starting non-invasive ventilation and improving these symptoms, to…
- Trial name
- NCT02951572
- Testing
- NIV
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Cancer, Lung Cancer
Dexmedetomidine and Hypoxic Pulmonary Vasoconstriction in Thoracic Surgical Procedures and One-Lung Ventilation
The purpose of this study is to evaluate the effects of Dexmedetomidine when used during thoracic surgery. The primary outcome will be changes in oxygenation as measured the PaO2 during one lung ventilation.
- Conditions
- Esophageal Cancer, Lung Cancer, Chest Wall Disorders
- Trial name
- Dex-One-Lung (NCT00839605)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Missouri-Columbia
Chronic Obstructive Pulmonary Disease
Effect of Portable NIV on Operational Chest Wall Volumes in COPD
The VitaBreath (Philips, Respironics) is a portable, handheld, battery powered, non-invasive ventilation device, that has been shown to reduce activity-related shortness of breath in patients with COPD.
- Trial name
- NCT03848819
- Testing
- VitaBreath device
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Northumbria University
Pectus Excavatum
Quantification of Chest Wall Changes After Nuss Bar Removal Utilizing Three-dimensional Optical Surface Scans
Pectus excavatum is the most common anterior chest wall deformity that affects up to 1:400 of newborns. If an operative correction is indicated, patients are often operated via the Ravitsch or Nuss bar procedure. The latter (i.e.
- Trial name
- CHEST (NCT04052321)
- Testing
- 3D optical surface scan
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Breast Neoplasms, Carcinoma, Ductal
Spect Analysis of Cardiac Perfusion Changes After Whole Breast/Chest Wall Radiation Therapy With ABC
Cardiac perfusion changes have been seen after whole breast / chest wall irradiation for breast cancer. The Active Breathing Coordinator (ABC) device theoretically decreases radiation exposure to the heart during radiation for…
- Conditions
- Breast Neoplasms, Carcinoma, Ductal, Adenocarcinoma
- Trial name
- NCT00321048
- Testing
- Active Breathing Coordinator
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Stroke
Dynamic Ventilatory and Asymmetry of the Chest Wall During Breath Stacking and Volume-oriented Incentive Spirometer
The purpose of the study was to analyze the effect of IS and BS on dynamics ventilatory and asymmetry of the chest wall in patients after stroke .
- Trial name
- NCT02088125
- Testing
- Breath Stacking, Incentive Spirometry
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Universidade Federal de Pernambuco
Non Cystic Fibrosis Bronchiectasis
HFCWO in Children With Non-CF Bronchiectasis
the study will concentrate on the effect of High Frequency Chest Wall Oscillation compared to conventional pulmonary physiotherapy on children with non cystic fibrosis bronchiectasis
- Trial name
- NCT07722364
- Testing
- High Frequency Chest Wall Oscillation, conventional physiotherapy program directed towards improvement of pulmonary functions and quality of life.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sphinx university
Respiratory System Abnormalities
Manual Diaphragm Release in Cleaning Laborer
This study intended to examine the effect of manual diaphragm release on pulmonary function, chest wall mobility, and functional ability in female occupational cleaners with respiratory hazards.
- Trial name
- NCT05802355
- Testing
- Manual Diaphragm Release, control group
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- Maged Basha
Esophageal Atresia, Oesophageal Atresia
Evaluation of the Respiratory Impact After Conventional or Minimally Invasive Esophageal Atresia Surgery
Right thoracotomy, conventional approach to esophageal atresia repair, leads to up to 60% radiological chest wall sequelae anomalies. The impact of these anomalies on the patient's respiratory function remains unknown.
- Conditions
- Esophageal Atresia, Oesophageal Atresia, Restrictive Lung Disease, Chest Wall Anomaly
- Trial name
- RestriMIS (NCT04136795)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Angers
Breast Cancer, Male Breast Cancer
Vorinostat and Trastuzumab in Treating Patients With Metastatic or Locally Recurrent Breast Cancer
This phase I/II trial is studying the side effects and best dose of vorinostat when given together with trastuzumab and to see how well they work in treating patients with metastatic breast canceror breast cancer that has…
- Conditions
- Breast Cancer, Male Breast Cancer, Recurrent Breast Cancer, Stage IIIB Breast Cancer
- Trial name
- NCT00258349
- Testing
- vorinostat, trastuzumab
- Where
- 25 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
Atelectasis
What is the Effective Pulmonary Physiotherapy Method in Critically Care Patients?
Effects of the high frequent chest wall oscillation technique applied on the patients who were intubated in intensive care unit were investigated.
- Trial name
- NCT02645695
- Testing
- routine pulmonary rehabilitation, chest wall vibration technique
- Volunteers
- 30 people
- Sponsor
- ILKE KUPELI
Pulmonary Neoplasm
Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors (JCOG 9806)
The purpose of this study is to evaluate the safety and efficacy of the trimodality (concurrent chemoradiotherapy followed by surgical resection) approach in superior sulcus tumors.
- Trial name
- NCT00128037
- Testing
- mitomycin C, vindesine, cisplatin and radiotherapy
- Where
- Japan
- Volunteers
- 75 people
- Sponsor
- Japan Clinical Oncology Group
Breast Carcinoma
A Correlational Study: Breast Cancer-related Chest Wall Lymphedema, Quality of Life, and Shoulder Function
This study evaluates how swelling in the chest following breast cancer treatment may affect patients' quality of life and shoulder function.
- Trial name
- NCT06285747
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Mayo Clinic
Late Effects of Hypofractionated Radiotherapy in Breast Cancer
Late-term Effects of Hypofractionated Chest Wall and Regional Nodal Irradiation in Patients With Breast Cancer
Survival of breast cancer patients has improved with multimodality treatment. Hypofractionated radiotherapy (RT) is rapidly emerging as one of the options for breast cancer patients after breast conservation surgery (BCS) but…
- Trial name
- LEHR (NCT04175821)
- Testing
- Hypofractionated radiotherapy
- Volunteers
- 1,770 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Lung Cancer
SRS Study in Patients With Non-Small Cell Lung Cancer
The goal of this clinical research study is to learn if stereotactic body radiotherapy (SBRT) can help to control NSCLC. The safety of SBRT will also be studied.
- Trial name
- NCT00489008
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- M.D. Anderson Cancer Center