Clinical trials: Chest Wall Disease
Lung Cancer
Efficacy Study of a Selective Chest Wall Restriction Belt in Postoperative of Lung Resection
The objective of this study is to evaluate the efficacy of a new medical device in post-surgery of lung resection. The principle of this new device is based on selective chest wall restriction.
- Trial name
- CTS-POP (NCT04369118)
- Testing
- Conventional follow-up, Conventional follow-up+chest wall restriction belt
- Where
- 3 sites in France
- Volunteers
- 94 people
- Sponsor
- University Hospital, Grenoble
Tumor of Bone, Chest Wall Tumor
3D Printed Implants for the Defect Reconstruction in Patients With Chest Wall Tumors
A patient with a tumor lesion of the chest wall undergoes CT scan with a step width of less than 1 mm, then engineers design an individual model to replace the defect.
- Conditions
- Tumor of Bone, Chest Wall Tumor, Chest Wall Sarcoma, Sarcoma of Bone
- Trial name
- NCT05057143
- Testing
- Implants, Plates
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Spinal Cord Injury
Chest Wall Kinematics and Respiratory Muscle Action During Supine Breathing in Individuals With and Without Spinal Cord Injury
Objective: To investigate the movement strategy of breathing based on three-compartment model measured by optoelectronic plethysmography (OEP) and electromyography (EMG ) among individuals with and without spinal cord injury in…
- Trial name
- SCI (NCT01084512)
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cystic Fibrosis
Airway Clearance Using High Frequency Chest Wall Oscillation
High frequency chest wall oscillation (HFCWO) has been shown to increase tracheal mucous clearance compared with control. These observations led to the development of 'The Vest' which is a non-stretchable jacket connected to an…
- Trial name
- NCT00817947
- Testing
- High frequency chest wall oscillation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Breast Cancer-Related Lymphedema, Breast Cancer
Pedicled Lateral Chest Wall Lymph-Adipofascial Flap to Prevent Arm Lymphedema After Breast Cancer Surgery
Breast cancer surgery that includes removal of lymph nodes from the armpit (axillary lymph node dissection) can disrupt normal lymphatic drainage and may lead to arm swelling, known as lymphedema.
- Conditions
- Breast Cancer-Related Lymphedema, Breast Cancer, Postoperative Complications
- Trial name
- LAF-ALND (NCT07415200)
- Testing
- Pedicled Lateral Chest Wall Lymph-Adipofascial Flap Axillary Reconstruction
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Desmoid, Desmoid Fibromatosis of Skin
Doxorubicin Eluting Intra-arterial Embolization for Aggressive Desmoid Fibromatosis
In this study Drug-eluting microbeads (DEB) loaded with Doxorubicin will be delivered into the target Desmoid Fibromatoses (DF) tissue via selective arterial embolization by angiographic technique.
- Conditions
- Desmoid, Desmoid Fibromatosis of Skin, Desmoid Neoplasm of Chest Wall, Desmoid Tumor Caused by Somatic Mutation
- Trial name
- NCT03966742
- Testing
- Drug Eluting Bead Embolization (DEB) for Desmoid Fibromatosis
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Rabin Medical Center
Pectus Excavatum
Multicenter Trial of Magnetic Mini-Mover for Pectus Excavatum
This study is a Phase 3, multicenter, non-randomized study to evaluate the safety and efficacy of the next-generation outpatient Magnetic Mini-Mover Procedure (3MP) in 15 patients aged 8-14 years for the correction of pectus…
- Trial name
- 3MP (NCT01327274)
- Testing
- Magnetic Mini-Mover Procedure (Magnimplant)
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Michael Harrison
Breast Cancer, Breast Cancer Female
Partial Chest Wall Radiation Therapy After Surgery for Lymph Node Negative Breast Cancer
The standard treatment for breast cancer when cancer cells were found near or within the margins of the tissue that is removed during breast surgery, is radiation of the entire chest wall.
- Conditions
- Breast Cancer, Breast Cancer Female, DCIS, Stage II Breast Cancer
- Trial name
- NCT05436808
- Testing
- Partial Chest Wall Radiation Therapy
- Where
- United States
- Sponsor
- Stony Brook University
Chronic Obstructive Pulmonary Disease
ACBT and High Frequency Chest Wall Oscillations in COPD Patients
Chronic obstructive pulmonary disease (COPD) patients with mucus hyper secretion tend to demonstrate increased frequency of infective exacerbations and a steeper slope of decline in lung function.
- Trial name
- NCT05424133
- Testing
- High frequency chest wall oscillation, Active cycle of breathing
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Breast Cancer, Metastatic Breast Cancer
Toll-like Receptor (TLR) 7 Agonist, Cyclophosphamide, and Radiotherapy for Breast Cancer With Skin Metastases
This study is to find an optimal dose of Imiquimod (IMQ) in the first part (Phase I) and test the effectiveness of the combination treatment of IMQ, cyclophosphamide (CTX), and radiotherapy (RT) in patients with skin metastases…
- Conditions
- Breast Cancer, Metastatic Breast Cancer, Recurrent Breast Cancer
- Trial name
- NCT01421017
- Testing
- Radiation, Imiquimod, Cyclophosphamide
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- NYU Langone Health
COPD
Effectiveness of Chest Wall Mobilization Program in Improving Respiratory Function for Patients With COPD
Patients with severe COPD will be recruited from the Respiratory Outpatient Clinic of Kowloon Hospital. Baseline (pre-intervention) assessment for all recruited subjects will be conducted by one physiotherapist assessor who is…
- Trial name
- NCT04122365
- Testing
- Chest Wall Mobilization Program, Control
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Fibromyalgia
Breathing and Chest Wall Mobility in People With Fibromyalgia.
The aim of this study is to examine differences between respiratory function in female fibromyalgia patients and healthy controls. The study will also examine differences in spine mobility and pain intensity.
- Trial name
- NCT03495687
- Where
- Sweden
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Bone Diseases, Obesity
Stereophotogrammetry of the Torso in Healthy Individuals and Patients With Scoliosis, Chest Wall Deformations, or Obesity
Background: Stereophotogrammetry (SP) uses four sets of digital cameras to generate a three-dimensional computer image. Unlike other types of evaluations which require radiation, SP only uses computer images to learn more about…
- Conditions
- Bone Diseases, Obesity, Healthy Volunteers
- Trial name
- NCT01352949
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cystic Fibrosis, Bronchiectasis
Effect of HFCWO Vests on Spirometry Measurements
The impact of high-frequency chest wall oscillation therapy on spirometry values (Forced Expiratory Volume, Forced Vital Capacity, Peak Expiratory Flow, Forced Expiratory Flow and Tidal Volume is investigated during use of…
- Trial name
- NCT03628456
- Testing
- International Biophysics AffloVest, Hill-Rom Monarch
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- International Biophysics Corporation
Chronic Obstructive Pulmonary Disease
Effect of Pursed Lips Breathing on Chest Wall, Mobility Diaphragmatic and Exercise Tolerance in Patients With Chronic Obstructive Pulmonary Disease
This study aimed to evaluate the acute effect of PLB technique on diaphragmatic mobility, the kinematics of the thoracoabdominal complex analysis of lung volumes and exercise tolerance in patients with Chronic Obstructive…
- Trial name
- NCT02424331
- Testing
- Pursed Lips Breathing, Quiet Breathing
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal de Pernambuco
Pectus Excavatum, Pectus Carinatum
Psychological Assessment of Patients With Chest Wall Deformities
The study aims to investigate the most frequent psychological outcomes associated to chest wall deformities and patients' quality of life.
- Trial name
- NCT04362878
- Where
- Italy
- Volunteers
- 209 people
- Sponsor
- University of Florence
Amyotrophic Lateral Sclerosis, Respiratory Infection
HFCWO Vest Plus Mechanical Cough Assist Versus Cough Assist Alone on Respiratory Infections in ALS: a Pilot Trial
This pilot randomised single-blind trial evaluated whether adding high-frequency chest wall oscillation (HFCWO) via chest vest (ComfortCough II) to mechanical cough assist improves respiratory outcomes and reduces respiratory…
- Trial name
- NCT07656714
- Testing
- High-frequency chest wall oscillation (HFCWO) vest, Mechanical cough assist
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Hospital Universitario Virgen Macarena
Cerebral Palsy
Study Assessing High-Frequency Chest Wall Oscillation (HFCWO) in Preventing Pulmonary Exacerbations
To asssess efficacy of airway clearance provided by Vest therapy (HFCWO) in the reduction of respiratory exacerbations requiring hospitalization or antibiotic utilization in patients with muscle weakness and restrictive lung…
- Trial name
- NCT00739310
- Testing
- Vest Treatment (high frequency chest wall oscillation)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Hill-Rom
Acute Respiratory Distress Syndrome
Artificial Increase in Chest Wall Elastance as an Alternative to Prone Positioning in Moderate-to-severe ARDS.
During moderate to severe ARDS, sessions of prone positioning lead to lung and chest wall mechanics changes that modify regional ventilation, with a final redistribution of tidal volume and PEEP towards dependent lung regions…
- Trial name
- ALTERPRONE (NCT03719937)
- Testing
- weight on the anterior chest of the patient
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Catholic University of the Sacred Heart