Clinical trials: Chest Wall Disorders
Late Effects of Hypofractionated Radiotherapy in Breast Cancer
Late-term Effects of Hypofractionated Chest Wall and Regional Nodal Irradiation in Patients With Breast Cancer
Survival of breast cancer patients has improved with multimodality treatment. Hypofractionated radiotherapy (RT) is rapidly emerging as one of the options for breast cancer patients after breast conservation surgery (BCS) but…
- Trial name
- LEHR (NCT04175821)
- Testing
- Hypofractionated radiotherapy
- Volunteers
- 1,770 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pectus Excavatum
Quantification of Chest Wall Changes After Nuss Bar Removal Utilizing Three-dimensional Optical Surface Scans
Pectus excavatum is the most common anterior chest wall deformity that affects up to 1:400 of newborns. If an operative correction is indicated, patients are often operated via the Ravitsch or Nuss bar procedure. The latter (i.e.
- Trial name
- CHEST (NCT04052321)
- Testing
- 3D optical surface scan
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Acute Respiratory Distress Syndrome
Artificial Increase in Chest Wall Elastance as an Alternative to Prone Positioning in Moderate-to-severe ARDS.
During moderate to severe ARDS, sessions of prone positioning lead to lung and chest wall mechanics changes that modify regional ventilation, with a final redistribution of tidal volume and PEEP towards dependent lung regions…
- Trial name
- ALTERPRONE (NCT03719937)
- Testing
- weight on the anterior chest of the patient
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Catholic University of the Sacred Heart
Breast Cancer
2-weeks of Adjuvant Radiotherapy in Patients With Breast Cancer
The investigators at PGIMER have been practicing hypofractionation radiotherapy with a dose of 35Gy/15#/3wks to the chest wall in post mastectomy and 40Gy/16#/3wks in breast conservation in breast cancer patients for the last 4…
- Trial name
- NCT02460744
- Testing
- Hypofractionation
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Atelectasis
What is the Effective Pulmonary Physiotherapy Method in Critically Care Patients?
Effects of the high frequent chest wall oscillation technique applied on the patients who were intubated in intensive care unit were investigated.
- Trial name
- NCT02645695
- Testing
- routine pulmonary rehabilitation, chest wall vibration technique
- Volunteers
- 30 people
- Sponsor
- ILKE KUPELI
Neuromuscular Diseases
Non-invasive Ventilation and Physical Activity
As fatigue and daytime sleepiness are typical symptoms of alveolar hypoventilation in patients with neuromuscular disorders and thoracic deformations, we hope, by starting non-invasive ventilation and improving these symptoms, to…
- Trial name
- NCT02951572
- Testing
- NIV
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tumor of Bone, Chest Wall Tumor
3D Printed Implants for the Defect Reconstruction in Patients With Chest Wall Tumors
A patient with a tumor lesion of the chest wall undergoes CT scan with a step width of less than 1 mm, then engineers design an individual model to replace the defect.
- Conditions
- Tumor of Bone, Chest Wall Tumor, Chest Wall Sarcoma, Sarcoma of Bone
- Trial name
- NCT05057143
- Testing
- Implants, Plates
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Breast Cancer
Veliparib With Radiation Therapy in Patients With Inflammatory or Loco-regionally Recurrent Breast Cancer
The purpose of this study is to determine the maximum tolerated dose of veliparib that can be given while a patient is receiving radiation therapy.
- Trial name
- NCT01477489
- Testing
- Veliparib, Standard radiation treatment
- Where
- 5 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Michigan Rogel Cancer Center
Malignant Chest Wall Neoplasm, Recurrent Breast Carcinoma
Talimogene Laherparepvec in Treating Patients With Recurrent Breast Cancer That Cannot Be Removed by Surgery
This phase II trial studies how well talimogene laherparepvec works in treating patients with breast cancer that has come back and cannot be removed by surgery.
- Conditions
- Malignant Chest Wall Neoplasm, Recurrent Breast Carcinoma, Recurrent Inflammatory Breast Carcinoma, Stage IV Breast Cancer AJCC v6 and v7
- Trial name
- NCT02658812
- Testing
- Laboratory Biomarker Analysis, Talimogene Laherparepvec
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Recurrent Disease
Safety of Omitting Axillary Surgery in Breast Cancer Patients With Isolated Chest Wall Recurrence
The axillary management of breast cancer patients with operable isolated chest wall recurrence after mastectomy is unclear. We aim to determine if axillary restaging surgery can be safely omitted with no increased recurrences in…
- Trial name
- NCT06088719
- Testing
- axillary surgery
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- KK Women's and Children's Hospital
Chronic Obstructive Pulmonary Disease
High Frequency Chest Wall Oscillation in Chronic Obstructive Pulmonary Disease (COPD)
Patients with Chronic obstructive pulmonary disease (COPD) tend to have cough, excess mucus production and breathlessness as cardinal features.
- Trial name
- NCT00863616
- Testing
- HFCWO - SmartVest
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- East and North Hertfordshire NHS Trust
Pectus Excavatum
Non-invasive Negative Pressure Treatment for Pectus Excavatum
The purpose of this study is to determine whether the non-invasive negative pressure treatment with the use of the device Vacuum Bellfor is effective for the pectus excavatum treatment
- Trial name
- NCT01816373
- Testing
- Vacuum Bell
- Where
- 2 sites in Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Palliation of Congenital Heart Diseases, Cardiopulmonary Bypass
Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure
This study aims to describe chest wall mechanics during delayed sternal closure (DSC) in neonates following cardiopulmonary bypass or palliation of congenital heart diseases.
- Conditions
- Palliation of Congenital Heart Diseases, Cardiopulmonary Bypass, Chest Wall Mechanics, Neonatal Delayed Sternal Closure
- Trial name
- NCT05257525
- Testing
- Esophageal manometry catheter at various PEEP levels and tidal volumes
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis
Airway Clearance Using High Frequency Chest Wall Oscillation
High frequency chest wall oscillation (HFCWO) has been shown to increase tracheal mucous clearance compared with control. These observations led to the development of 'The Vest' which is a non-stretchable jacket connected to an…
- Trial name
- NCT00817947
- Testing
- High frequency chest wall oscillation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pectus Carinatum, Chondromanubrial
Chest Compressor for Conservative Treatment of Pectus Carinatum: a Multicenter Study
Pectus carinatum (PC) is a congenital deformity of the chest wall whose prevalence is 0.6% of the population and although it does not cause cardio respiratory physiological damage, it has profound psychological effects on young…
- Trial name
- NCT04171063
- Testing
- Thoracic compressor
- Where
- 4 sites in Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Obstructive Pulmonary Disease, Neuromuscular Disease
Telemedicine and Ventilator Titration in Chronic Respiratory Patients Initiating Non-invasive Ventilation
The critical nature of respiratory diseases, the continuously increasing prevalence of these conditions, and the subjective perception of patients vis-à-vis their pulmonary function and health status underscore the importance of…
- Conditions
- Chronic Obstructive Pulmonary Disease, Neuromuscular Disease, Chest Wall Disorders, Obesity Hypoventilation Syndrome
- Trial name
- TeleMotiNIV (NCT01560741)
- Testing
- Telemonitoring tools, Usual Care
- Where
- Portugal
- Volunteers
- 128 people
- Sponsor
- Hospital Sao Joao
Funnel Chest
Cardiorespiratory Assessment and Quality of Life After Surgical Correction of Congenital Wall Malformations
The main objective of this study is to characterize the cardiorespiratory functional gain in patients with pectus excavatum following corrective surgery.
- Trial name
- HeartSoar (NCT03770390)
- Testing
- Surgical correction of pectus excavatum
- Where
- France
- Volunteers
- 43 people
- Sponsor
- University Hospital, Montpellier
ARDS, COVID-19
Paradoxical Response to Chest Wall Loading in Mechanically Ventilated Patients
The purposes of our study are to: 1) determine the incidence of paradoxical response to chest wall loading in mechanically ventilated patients; 2) identify sub-populations in which it is most likely to occur (e.g., severe ARDS)…
- Conditions
- ARDS, COVID-19, Mechanical Ventilation Pressure High, Ventilator-Induced Lung Injury
- Trial name
- NCT06093958
- Testing
- Manual loading of the chest wall
- Where
- United States
- Sponsor
- HealthPartners Institute
Restrictive Lung Disease
Relation Between Pulmonary Function Tests and Ultrasonographic Chest Joints
Ultrasonography can detect different changes in anterior chest wall (ACW) joints in patients with Rheumatoid arthritis (RA) even before being clinically manifested.
- Trial name
- Ultrasound (NCT05119491)
- Testing
- uitrasonography and spirometry
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Zagazig University
Cystic Fibrosis
Long-term Study, Comparing Vest Therapy to Positive Expiratory Pressure (PEP) Therapy in the Treatment of Cystic Fibrosis
This study is a preliminary study designed to determine the safety and effectiveness of HFCWO using the InCourage vest system as an airway clearance technique for the treatment of CF.
- Trial name
- NCT00817180
- Testing
- Positive Expiratory Pressure (PEP), High Frequency Chest Wall Oscillation (HFCWO) using InCourage Vest System
- Where
- 13 sites in Canada
- Volunteers
- 107 people
- Sponsor
- University of British Columbia