Clinical trials: Chest--Diseases
Chest Pain, Anxiety
The Effects of Use of Auditory Stimulation Methods on Cardiac Patients' Clinical Outcomes
This study will be used to compare the effects of two auditory stimulation methods on improving vital signs parameters, reducing the severity of chest pain, and improving the sleep quality of cardiac patients.
- Conditions
- Chest Pain, Anxiety, Sleep
- Trial name
- NCT06670027
- Testing
- Family voice, Nature sound
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Non-small Cell Lung Cancer
Asymptomatic Brain Metastasis in Non-small Cell Lung Cancer (NSCLC)
The prognosis of NSCLC patients with asymptomatic brain metastasis, who are not treated with SRS or WBRT has not been fully investigated yet.
- Trial name
- NCT01130766
- Testing
- stereotactic radiosurgery (SRS)
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Samsung Medical Center
NSCLC, Non-small Cell Lung Cancer
Study of Pembrolizumab + Pemetrexed + Platinum Chemotherapy With or Without Zoldonrasib as First Line Treatment in Metastatic Non-squamous RAS G12D-Mutated NSCLC
The purpose of this study is to evaluate the efficacy of an investigational RAS(ON) inhibitor administered in combination with pembrolizumab and platinum-based chemotherapy doublet compared to placebo in combination with…
- Conditions
- NSCLC, Non-small Cell Lung Cancer, Non-Small Cell Lung Cancer NSCLC, Non-Squamous Non Small Cell Lung Cancer
- Trial name
- RASolve 308 (NCT07777822)
- Testing
- zoldonrasib, pembrolizumab, pemetrexed + cisplatin /carboplatin
- Where
- United States
- Volunteers
- 430 people
- Sponsor
- Revolution Medicines, Inc.
Lung Cancer
Increasing Equity in Lung Cancer Screening
The overall objective of this mixed methods study is to: 1) Refine the Emergency Department Lung Cancer Screening (ED-LCS) intervention using qualitative interviews among key stakeholders; 2) pilot test the ED-LCS intervention…
- Trial name
- LUCARE (NCT06360822)
- Testing
- ED-LCS
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Indiana University
NSCLC, ALCL
Crizotinib Continuation Clinical Study
The purpose of this continuation study is to provide continued access to crizotinib treatment for eligible participants from a current Pfizer sponsored crizotinib clinical study that is planned to close.
- Conditions
- NSCLC, ALCL, IMT
- Trial name
- NCT05160922
- Testing
- crizotinib
- Where
- 13 sites in China, Italy and 3 more
- Volunteers
- 27 people
- Sponsor
- Pfizer
Pulmonary Nodule, Solitary, Lung Cancer
Pulmonary Nodule Cohort
The aim of this study is to identify the clinical features of pulmonary nodules and establish a cohort to identify biomarkers for lung cancer.
- Trial name
- liquidNodule (NCT04049422)
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Intra-abdominal Surgery, Anesthesia
Open Lung Protective Extubation Following General Anesthesia
Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development.
- Conditions
- Intra-abdominal Surgery, Anesthesia, Lung Injury, Ventilator-Induced Lung Injury
- Trial name
- OLEXT-3 (NCT06296173)
- Testing
- Protective "open-lung" extubation, Conventional extubation
- Where
- 5 sites in Canada
- Volunteers
- 270 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Asthma
Comparison of Flutter and PEP Mask on Chest Clearance, Dyspnea in Elderly Asthmatic Patients
This study will be a Randomized controlled and will be conducted in Allied Hospital, Faisalabad. The study will be completed within the duration of 10 months. Convenience sampling study technique will be used to collect the data.
- Trial name
- NCT05618873
- Testing
- Flutter device, positive expiratory pressure mask
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Chest Pain, Stenosis
Diagnosis of Myocardial Ischemia With MCG Using SPECT as a Reference Standard
This is a prospective clinical study aiming to investigate the efficacy of Magnetocardiography (MCG) in detecting myocardial ischemia in patients of a suspected non-ST-elevation-acute coronary syndrome (NSTE-ACS) by using Single…
- Conditions
- Chest Pain, Stenosis, Myocardial Ischemia
- Trial name
- NCT06255769
- Testing
- Magnetocardiography, Single photon emission computed tomography (SPECT)
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Qilu Hospital of Shandong University
Non-small Cell Lung Cancer (NSCLC)
Survey of Brigatinib Used To Treat People With Non-Small Cell Lung Cancer
This study is a survey in Japan of Brigatinib tablets used to treat Japanese people with non-small cell lung cancer. The study sponsor will not be involved in how the participants are treated but will provide instructions on how…
- Trial name
- NCT05100069
- Testing
- Brigatinib
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Takeda
Pectus Excavatum, Pectus Carinatum
Physiological Assessments During Non Operative Treatment on the Chest Wall Deformities
The physiological assessment in non-operative treatment on chest wall deformities, are still unclear today. These functional benefits outweigh the aesthetic benefits associated with anatomical improvement.
- Trial name
- PECTUS (NCT02528656)
- Testing
- Vacuum Bell, Dynamic Compression System
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Tobacco Use Disorder, Lung Cancer
Assessing the Link Between Smoke Carcinogen Biomarkers and Lung Cancer Risk - 1
Lung cancer is the leading cause of cancer death in the United States. Currently it remains impossible to predict which smokers will get cancer. Each puff of a cigarette delivers a mixture of over 60 known carcinogens.
- Trial name
- NCT00218179
- Testing
- Non-intervention
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Carcinoma, Pancreatic Ductal, Colorectal Neoplasms
A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.
The purpose of this study is to learn about the safety and effects of the study medicine alone or when given together with other anti-cancer therapies. This study also aims to find the best dose.
- Conditions
- Carcinoma, Pancreatic Ductal, Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT06447662
- Testing
- PF-07934040, Gemcitabine, Nab-paclitaxel
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 64 people
- Sponsor
- Pfizer
KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung
Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
This is a phase Ib/II open label study. The escalation part will characterize the safety and tolerability of JDQ443 single agent and JDQ443 in combination with the other study treatments (TNO155 and tislelizumab) in advanced…
- Conditions
- KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small-Cell Lung, Carcinoma, Colorectal, Cancer of Lung
- Trial name
- KontRASt-01 (NCT04699188)
- Testing
- JDQ443, TNO155, tislelizumab
- Where
- 38 sites in United States, Australia and 14 more
- Volunteers
- 344 people
- Sponsor
- Novartis Pharmaceuticals
Ovarian Cancer, Endometrial Cancer
Topotecan in Combination With Pemetrexed in Patients With Advanced Malignancies
Currently, no data exists regarding the safety and tolerability of a combination regimen utilizing weekly topotecan in combination with pemetrexed.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Cervical Cancer, Lung Cancer
- Trial name
- NCT00315861
- Testing
- pemetrexed, topotecan
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- SCRI Development Innovations, LLC
Lung Cancers, Liver Cancer
AI-Assisted Non-Contrast CT for Multi-Cancer Screening
Cancer poses a major public health challenge in China. Early detection can improve treatment outcomes and survival rates. In this study, we will conduct a large-scale, prospective, multi-center cohort study to evaluate the…
- Conditions
- Lung Cancers, Liver Cancer, Gastric Cancers, Colorectal, Cancer
- Trial name
- NCT06632886
- Testing
- AI-Assisted Non-Contrast CT for Multi-Cancer Screening
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Guo ShiWei
Recurrent Non-small Cell Lung Cancer, Squamous Cell Lung Cancer
Nintedanib in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Failed Up to Two Previous Chemotherapy Regimens
This phase II trial studies how well nintedanib works in treating patients with advanced non-small cell lung cancer who have failed up to two previous chemotherapy regimens.
- Conditions
- Recurrent Non-small Cell Lung Cancer, Squamous Cell Lung Cancer, Stage III Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
- Trial name
- NCT01948141
- Testing
- nintedanib
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Roswell Park Cancer Institute
Breast Cancer, Colon Cancer
Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer
This pilot clinical trial studies copper Cu 64 anti-carcinoembryonic antigen (CEA) monoclonal antibody M5A positron emission tomography (PET) in diagnosing patients with CEA positive cancer.
- Conditions
- Breast Cancer, Colon Cancer, Extrahepatic Bile Duct Cancer, Gallbladder Cancer
- Trial name
- NCT02293954
- Testing
- radionuclide imaging, positron emission tomography, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Head and Neck Cancer, Breast Cancer
Evaluation of Improved Onboard Patient Imaging
The primary objective of radiation therapy is to deliver a therapeutic dose of radiation precisely to the target while minimizing exposure to healthy surrounding tissues.
- Conditions
- Head and Neck Cancer, Breast Cancer, Upper Gastrointestinal Cancer, Lung Cancer
- Trial name
- NCT06187103
- Testing
- HyperSight Imaging
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Varian, a Siemens Healthineers Company
Carotid Artery Disease, Stroke
Natural History of Carotid Atherosclerosis
A prospective study of 700 patients with coronary artery disease will undergo non invasive evaluation of their carotid arteries by ultrasound and microwave radiometry.
- Conditions
- Carotid Artery Disease, Stroke, Myocardial Infarction, Angina Pectoris
- Trial name
- NCT01521351
- Where
- Greece
- Volunteers
- 700 people
- Sponsor
- National and Kapodistrian University of Athens
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