Clinical trials: Chest--Diseases
Lung Cancer
Gold Sodium Thiomalate in Treating Patients With Advanced Non-Small Cell Lung Cancer
RATIONALE: Gold sodium thiomalate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying the side effects and best dose of gold sodium thiomalate in…
- Trial name
- NCT00575393
- Testing
- gold sodium thiomalate, gene expression analysis, fluorine F 18 fluorothymidine
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Small Cell Lung Cancer
Panomic Approach to Immune-Connected Assays in Small Cell Lung Cancer
The scope of the PICASSO project is to apply an innovative patient-based pan-omic approach to immune-assays, that will include multi-omics tumour characterization (genome, proteome, transcriptome), blood immune-cells and cytokine…
- Trial name
- PICASSO (NCT05797493)
- Testing
- Atezolizumab
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Non STEMI, Angina Pectoris
Time Gain in the Diagnosis Myocardial Infarction by Troponin Point of Care Testing in the Emergency Room
The investigators prospectively want to compare 3 clinical tests for measuring blood troponin levels in patients presenting to the emergency room with thoracic pain probably related to a myocardial infarction with regard to the…
- Conditions
- Non STEMI, Angina Pectoris, Angina, Stable, Angina, Unstable
- Trial name
- T-POCT (NCT02972814)
- Testing
- Laboratory based troponin test, Point of care based troponin test 1, Point of care based troponin test 2
- Where
- Belgium
- Volunteers
- 66 people
- Sponsor
- Ziekenhuis Oost-Limburg
Angina, Stable
Artificial Intelligence in ANOCA
Angina pectoris is diagnosed in >180.000 people in the Netherlands each year. Diagnosis in angina pectoris focuses on epicardial coronary stenosis, the identification of which may lead to guideline-directed medical therapy or…
- Trial name
- (AI)NOCA (NCT06387693)
- Testing
- Holter monitoring, intracoronary ECG
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- UMC Utrecht
Non-small Cell Lung Cancer
A Study to Evaluate the Efficacy of Anti-emetic Drug Upon the Combination Chemotherapy for Non-small Cell Lung Cancer
The purpose of this study is to evaluate the efficacy of anti-emetic drug Aprepitant upon the combination chemotherapy of nedaplatin and docetaxel for non-small cell lung cancer (NSCLC).
- Trial name
- NCT02364804
- Testing
- Aprepitant
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Shiga University
Non-small Cell Lung Cancer
SH-1028 Tablets Versus Placebo as Adjuvant Therapy in Resected Stage II-IIIB NSCLC With Sensitizing EGFR Mutations
To assess the efficacy and safety of SH-1028 tablets versus placebo in stage II-IIIB non-small cell lung cancer (NSCLC) patients with sensitizing epidermal growth factor receptor (EGFR) mutations, following complete tumor…
- Trial name
- NCT06080776
- Testing
- SH-1028 tablets
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Nanjing Sanhome Pharmaceutical, Co., Ltd.
Carcinoma, Non-Small-Cell Lung, Brain Metastases
Circulating Tumor DNA and T Cell Repertoire Predict Radiotherapeutic Outcomes in NSCLC Patients With Brain Metastasis
Collection of ctDNA and TCR data to predict the efficacy and prognosis of brain radiotherapy in patients with brain metastases from non-small cell lung cancer (NSCLC) in a comprehensive manner
- Trial name
- NCT05737589
- Testing
- Whole-brain radiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xiaorong Dong
Non Small Cell Lung Cancer
Reolysin in Previously Treated Advanced/Metastatic, Non Small Cell Lung Cancer Receiving Standard Salvage Therapy
The purpose of this study is to find out if giving reolysin in combination with docetaxel or pemetrexed can offer better results than standard therapy with docetaxel or pemetrexed alone.
- Trial name
- NCT01708993
- Testing
- Pemetrexed and Reolysin (and safety run-in), Pemetrexed, Docetaxel and Reolysin
- Where
- 12 sites in Canada
- Volunteers
- 166 people
- Sponsor
- Canadian Cancer Trials Group
Coronary Artery Disease, Chest Pain
Coronary Obstruction Detection by Molecular Personalized Gene Expression (Corus CAD or ASGES)
To validate the use of Corus CAD (Age/Sex/Gene Expression score - ASGES) blood assay in subjects who are referred for the work-up of coronary artery disease.
- Conditions
- Coronary Artery Disease, Chest Pain, Cardiovascular Diseases, Coronary Heart Disease
- Trial name
- COMPASS (NCT01117506)
- Testing
- Corus CAD (ASGES)
- Where
- 7 sites in United States
- Volunteers
- 581 people
- Sponsor
- CardioDx
SCLC, Extensive Stage
Utidelone in Third-line and Above Treatment of Small Cell Lung Cancer
SCLC has a very high degree of malignancy, and 60% to 70% of patients are diagnosed as extensive stage. The median survival of patients with limited-stage disease is about 15-20 months, and the median OS of patients with…
- Trial name
- NCT05299255
- Testing
- Utidelone
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Cancer Hospital
Tako-Tsubo Cardiomyopathy, Stress-induced Cardiomyopathy
The TAKO-TSUBO And Cancer Registry
Prospective, multicenter, observational registry collecting data from subjects with Tako-Tsubo (stress-induced) cardiomyopathy (TTC).
- Conditions
- Tako-Tsubo Cardiomyopathy, Stress-induced Cardiomyopathy, Acute Coronary Syndrome
- Trial name
- TTAC (NCT01944826)
- Testing
- Registry of patients with Tako-Tsubo cardiomyopathy
- Where
- Germany
- Volunteers
- 800 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell
Concurrent Nab-P/Carboplatin and Thoracic Radiotherapy in Squamous Cell Lung Cancer
Nab-paclitaxel and carboplatin showed better treatment response compared with cremophor-based paclitaxel and carboplatin as first-line therapy in advanced non-small cell lung cancer, especially for squamous cell cancer.
- Trial name
- NCT01494415
- Testing
- Paclitaxel for Injection（Albumin Bound）, carboplatin, thoracic radiation therapy
- Where
- 2 sites in China
- Volunteers
- 21 people
- Sponsor
- First People's Hospital of Hangzhou
Lung Cancer
Characterization of Methylation Patterns in Lung Cancer
In this study the investigators will collect Blood,sputum and saliva samples for Characterization of Methylation Patterns in lung Cancer.
- Trial name
- NCT02373917
- Where
- Israel
- Volunteers
- 683 people
- Sponsor
- Nucleix Ltd.
Squamous Cell Lung Cancer
Dasatinib in Advanced Squamous Cell Lung Cancer
Dasatinib is a drug that has been shown to stop some cancer cells from growing. This drug has been used in treatment for other types of cancer and information from other research studies suggests that dasatinib may help to stop…
- Trial name
- NCT01491633
- Testing
- Dasatinib
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Dana-Farber Cancer Institute
Lung Cancer
ZD 1839 Plus Chemotherapy in Treating Patients With Non-Small Cell Lung Cancer
RATIONALE: Some tumors need growth factors produced by the body's white blood cells to keep growing. ZD 1839 may interfere with the growth factor and stop the tumor from growing.
- Trial name
- NCT00006049
- Testing
- carboplatin, gefitinib, paclitaxel
- Where
- United States
- Sponsor
- AstraZeneca
Paraquat Poisoning, Lung Injury
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Paraquat Poisoning Induced Lung Injury
Phase I-II Clinical Trial-Safety and efficacy of umbilical-cord-derived mesenchymal stem cell (UC-MSC) in patients with paraquat poisoning induced lung injury, randomized,single blind, controlled prospective study.
- Trial name
- UCMSC-PQLI (NCT02444858)
- Testing
- UCMSC group, Control group(Normal saline)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Carcinoma, Non-Small-Cell Lung
LUX Lung 2 Phase II Single Arm BIBW 2992 "Afatinib" in NSCLC With EGFR Activating Mutations
The primary objective of this open-label, single arm Phase II trial is to explore the efficacy of BIBW 2992 defined by the objective response rate (CR, PR) as determined by RECIST criteria in patients with advanced NSCLC Stage…
- Trial name
- NCT00525148
- Testing
- BIBW 2992
- Where
- 30 sites in United States, Taiwan
- Volunteers
- 129 people
- Sponsor
- Boehringer Ingelheim
Thoracic Aortic Aneurysm
Effects of Exercise on Thoracic Aneurysms
Thoracic aneurysm incidence is estimated to 4.5 cases per 100 000. The manifestation as well as natural history of thoracic aneurysm depend on many factors such as its localisation, its diameter, presence of collagen disease and…
- Trial name
- EXTRA (NCT04197648)
- Testing
- Exercise group
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Lung Cancer, Lung Cancer Metastatic
ANET Electrosurgery Applicator Pilot Evaluation Study
Evaluate the preliminary safety and performance of the Electrosurgery Applicator (ANET device) during and after bronchoscopic ablation of a target pulmonary nodule/tumor.
- Trial name
- NCT03400748
- Testing
- RF Ablation
- Where
- 4 sites in United States, Canada
- Volunteers
- 6 people
- Sponsor
- Olympus Corporation of the Americas
Non-small Cell Lung Cancer
Understanding Non-small Cell Lung Cancer Patient Characteristics, Treatment Patterns and Outcomes
This is a retrospective, cross-sectional, non-interventional, multi-country survey-based chart audit study to evaluate real-world treatment patterns, patient clinical profiles, and clinical outcomes among a NSCLC patients…
- Trial name
- UNCOVER (NCT07215026)
- Where
- India
- Volunteers
- 833 people
- Sponsor
- AstraZeneca
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