Clinical trials: Chest--Diseases
Carcinoma, Non-Small-Cell Lung
A Study of Pemetrexed and Carboplatin/Cisplatin or Gemcitabine and Carboplatin/Cisplatin With or Without IMC-1121B in Participants Previously Untreated With Recurrent or Advanced Non-Small Cell Lung Cancer (NSCLC)
The purpose of this study is to determine if participants with Stage IV NSCLC have a better outcome when treated with IMC-1121B in combination with pemetrexed + carboplatin/cisplatin or gemcitabine + carboplatin/cisplatin than…
- Trial name
- NCT01160744
- Testing
- IMC-1121B (ramucirumab), Pemetrexed, Carboplatin (AUC 6)
- Where
- 53 sites in United States, Belgium and 4 more
- Volunteers
- 280 people
- Sponsor
- Eli Lilly and Company
Non-small Cell Lung Cancer
Inetetamab in Combination With Pyrotinib in HER2 Mutant or Amplified Advanced Non-small Cell Lung Cancer
This is a Phase 1, open-label study to evaluate the safety and the efficacy of inetetamab in combination with pyrotinib in patients in HER2 mutant or amplified patients with advanced non-small cell lung cancer
- Trial name
- NCT05016544
- Testing
- inetetamab, Pytotinib
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Sun Yat-sen University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Thoracic Aortic Aneurysm
- Trial name
- TURBO (NCT04523909)
- Testing
- Trajectory of neuroinflammatory proteins in CSF and blood
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Smoking, Smoking, Tobacco
DECIDE: Developing Tools for Lung Cancer Screening Discussion Improvement
The purpose of this study is to learn about discussion between clinicians and their patients related to lung screening. Survey answers will be collected from both clinicians and their patients.
- Conditions
- Smoking, Smoking, Tobacco, Smoking, Cigarette, Lung Cancer
- Trial name
- DECIDE (NCT03891602)
- Testing
- Cataldo Lung Cancer Stigma Scale (Smoking-Related Subscale), Patient Trust in the Medical, Decision Conflict Scale (DCS) - Lung Cancer Screening
- Where
- United States
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Non-Small Cell Lung Cancer
Examination of Trends in Non-Small Cell Lung Cancer Patients' Medical Study Experiences
Medical study participation percentages haven't always been fully representative of a given demographic. The goal is to find out which aspects of a clinical trial may make it more difficult for patients to take part or see it…
- Trial name
- NCT05778045
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Stable Angina
Boston Scientific COMET Wire Validation Study
Summary of Study Aims To assess, in a randomised fashion: 1. performance of Boston Scientific Pressure Wire versus St Jude Pressure Wire 2. performance of Boston Scientific Pressure Wire versus Boston Scientific Pressure Wire 3.
- Trial name
- COMET (NCT02578381)
- Testing
- Boston Scientific Pressure Wire, Validation of Boston Scientific pressure wire
- Where
- 2 sites in United Kingdom
- Volunteers
- 106 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
NSCLC, Recurrent, Adenocarcinoma of Lung
Combination Nab-paclitaxel (N-P) and Nintedanib or N-P and Placebo in Relapsed NSCLC Adenocarcinoma
A PHASE I/II TRIAL OF COMBINATION NAB-PACLITAXEL AND NINTEDANIB OR NAB-PACLITAXEL AND PLACEBO IN RELAPSED NSCLC ADENOCARCINOMA
- Trial name
- N3 (NCT03361319)
- Testing
- Vargatef, Abraxane
- Sponsor
- Royal Marsden NHS Foundation Trust
Non-small Cell Lung Cancer
Third-generation EGFR-TKI Plus Anlotinib as Maintenance for NSCLC With Small Cell Transformation After EGFR-TKI Resistance
This study aimed to evaluate the efficacy and safety of third-generation EGFR-TKI plus anlotinib as maintenance after chemotherapy plus immunotherapy in advanced NSCLC with small cell transformation after EGFR-TKI resistance.
- Trial name
- NCT06634667
- Testing
- third-generation EGFR-TKI combined with anlotinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hunan Province Tumor Hospital
Non-small Cell Lung Cancer (NSCLC)
A Safety and Efficacy Trial of Docetaxel With or Without XH1 in Non-small Cell Lung Cancer (NSCLC) Patients
This is a prospective, randomized, multicenter clinical study designed to evaluate its safety and efficacy by using Docetaxel with or without Traditional Chinese Medicine XH1 in patients with Stage ⅢB-Ⅳ Non-small Cell Lung Cancer…
- Trial name
- NCT03407300
- Testing
- Docetaxel, Chinese traditional medicine XH1
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Haining Health-Coming Biotech Co., Ltd.
Adenocarcinoma of Lung, Lung Neoplasm
An Integrated Approach to Treating Recurrent Thoracic Carcinomas Resistant to Tyrosine Kinase Inhibitors
Patients are asked to participate in this study if they have been diagnosed with a thoracic carcinoma which includes lung cancer and have a gene mutation (alteration in the body's genetic instructions) and after undergoing…
- Conditions
- Adenocarcinoma of Lung, Lung Neoplasm, Cancer of Lung, Lung Cancer
- Trial name
- NCT02616211
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Small Cell Lung Cancer
Phase Ib/II Study of M3814 With Etoposide and Cisplatin in Small Cell Lung Cancer (SCLC) Extensive Disease (ED)
M3814 is an investigational drug under evaluation for treatment of lung cancer. The purpose of the study was to assess the Safety and Efficacy of M3814 in combination with chemotherapy with SCLC ED.
- Trial name
- NCT03116971
- Testing
- M3814, Cisplatin, Etoposide
- Where
- 80 sites in United States, Belgium and 11 more
- Volunteers
- 2 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Coronary Artery Disease
Angiomax® or Unfractionated Heparin for Patients Undergoing Percutaneous Coronary Intervention
The objective of the study is to assess the safety and efficacy of Angiomax® (bivalirudin) versus unfractionated heparin (UFH) in patients presenting with stable angina or silent ischemia (positive stress test without chest pain)…
- Trial name
- STATUS PCI (NCT01464671)
- Testing
- Bivalirudin, Heparin
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Stony Brook University
Spinal Cord Injury at T1-T12 Level, Traumatic Thoracic Spinal Cord Contusion
Spinal Cord Stimulation (SCS) for Spinal Cord Injury (SCI)
The purpose of this feasibility study is to compare the impact of Spinal cord stimulation [SCS] for Spinal Cord Injury (SCI) pain and rehabilitation.
- Conditions
- Spinal Cord Injury at T1-T12 Level, Traumatic Thoracic Spinal Cord Contusion, Thoracic Spinal Cord Trauma, Traumatic Thoracic Spinal Cord Laceration
- Trial name
- NCT04894734
- Testing
- EES on, EES off
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Nandan Lad, M.D., Ph.D.
Carcinoma, Non-Small-Cell Lung
A Study of the Efficacy and Safety of Alectinib in Participants With Anaplastic Lymphoma Kinase (ALK)-Rearranged Non-Small Cell Lung Cancer
This study will evaluate the efficacy and safety of alectinib, in selected participants, with anaplastic lymphoma kinase-rearranged (ALK-rearranged) non-small cell lung cancer (NSCLC), after disease progression on prior treatment…
- Trial name
- ATALK (NCT03155009)
- Testing
- Alectinib
- Where
- 16 sites in France
- Volunteers
- 44 people
- Sponsor
- Hoffmann-La Roche
Metastatic Non Small Cell Lung Cancer
Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no…
- Trial name
- NCT05555732
- Testing
- Datopotamab Deruxtecan, Pembrolizumab, Pemetrexed
- Where
- 260 sites in United States, Argentina and 27 more
- Volunteers
- 1,170 people
- Sponsor
- Daiichi Sankyo
Mesotheliomas Pleural
Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM)
The study is a single-arm phase I trial to evaluate the safety, feasibility, and preliminary efficacy of the addition of pembrolizumab and image-guided resection to surgical therapy and chemotherapy for malignant pleural…
- Trial name
- NCT03760575
- Testing
- Pembrolizumab, Indocyanine Green (ICG) Image-Guided Surgery, Cisplatin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Radiation Pneumonitis
Study on the Biological Prediction Models of Radiation Pneumonitis
Radiation pneumonitis is the most common complication and the major dose-limiting toxicity associated with radiotherapy, which can cause poor quality of life or life-threatening symptoms and might hinder the tumor-controlling…
- Trial name
- NCT02490319
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huazhong University of Science and Technology
Diabetes, Diabetes Mellitus, Type 1
The HEADWIND Study - Part 2
To analyse driving behavior of individuals with type 1 diabetes in eu- and progressive hypoglycaemia while driving in a real car.
- Trial name
- HEADWIND (NCT04569630)
- Testing
- Controlled hypoglycaemic state while driving
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Small Cell Lung Cancer
A Study of Paclitaxel Plus Bevacizumab in Patients With Chemosensitive Relapsed Small Cell Lung Cancer
Improvements in therapy for relapsed SCLC are much needed. Paclitaxel has been previously tested and found to have significant single agent activity in relapsed SCLC, including in refractory patients.
- Trial name
- NCT00317200
- Testing
- Paclitaxel, Bevacizumab
- Where
- 17 sites in United States
- Volunteers
- 34 people
- Sponsor
- Hoosier Cancer Research Network
Lung Cancer
Radiation Therapy in Preventing Brain Metastases in Patients With Small Cell Lung Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which regimen of radiation therapy may be more effective in preventing brain metastases.
- Trial name
- NCT00006344
- Testing
- radiation therapy
- Where
- United States
- Sponsor
- Virginia Commonwealth University
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