Clinical trials: Chest--Diseases
Non Small Cell Lung Cancer, Brain Metastasis
VEGFRs Predict Bevacizumab Benefit in Advanced Non Small Cell Lung Cancer
a. VEGFRs may be the biomarker which can predict the effect of bevacizumab in non small cell lung cancer
- Trial name
- NCT01891708
- Testing
- bevacizumab, standard chemotherapy and radiation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Li Liu
Palliation of Congenital Heart Diseases, Cardiopulmonary Bypass
Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure
This study aims to describe chest wall mechanics during delayed sternal closure (DSC) in neonates following cardiopulmonary bypass or palliation of congenital heart diseases.
- Conditions
- Palliation of Congenital Heart Diseases, Cardiopulmonary Bypass, Chest Wall Mechanics, Neonatal Delayed Sternal Closure
- Trial name
- NCT05257525
- Testing
- Esophageal manometry catheter at various PEEP levels and tidal volumes
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Lung Cancer (Diagnosis), Hypoxemia
The Effect of Semi-recumbent Position on Hypoxemia After Lung Segment/Lobe Surgery
Thoracoscopic surgery is the most common surgical approach in thoracic surgery, which reduces surgical trauma and postoperative pain compared with open thoracotomy, but postoperative complications should not be overlooked, with…
- Trial name
- NCT07060625
- Testing
- Semi-reclining position
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Patients Are Recruited From One Thoracic and Cardiac Surgery ICU
Study of Safety and Efficacy on Neuromyopathy of Early Standing With the Assistance of Tilt Table in Critically Patients
Critically ill patients frequently develop muscle weakness due to critical illness-related acute neuropathy and/or myopathy. This disorder is associated with difficulties in weaning from mechanical ventilation, prolonged…
- Trial name
- TILT (NCT02047617)
- Testing
- the standard physiotherapy group, standing table group
- Where
- France
- Volunteers
- 145 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Fear, Anxiety
The Effect of 360° Virtual Reality Movies on Fear and Anxiety
To assess the effect of web-based 360° Virtual Reality movies on fear and anxiety, The investigators would like to assess the patient-perceived level of fear and anxiety quantitatively, making use of several questionnaires.
- Conditions
- Fear, Anxiety, Breast Cancer, Lung Cancer
- Trial name
- ENGAGE (NCT06199050)
- Testing
- Questionnaire: SPIRIT, Questionnaire: HADS, Questionnaire: QSC-R23
- Where
- Netherlands
- Volunteers
- 292 people
- Sponsor
- Maastricht Radiation Oncology
Non-Small Cell Lung Cancer
Phase II Trial of Dose-dense Paclitaxel and Cisplatin as Neo-adjuvant Chemotherapy for Operable Stage II and IIA NSCLC
A single arm, open-label phase II is appropriate to evaluate the efficacy and safety of dose - dense combination of paclitaxel with cisplatin supported by pegfilgrastim for neo-adjuvant chemotherapy in this patient population.
- Trial name
- NCT00291850
- Testing
- Paclitaxel, Cisplatin, Pegfilgrastim
- Where
- 5 sites in Austria, Hungary and 1 more
- Volunteers
- 50 people
- Sponsor
- Central European Cooperative Oncology Group
Non Small Cell Lung Cancer
Detection of Circulating Tumor DNA After Stereotactic Ablative Radiotherapy in Patients With Unbiopsied Lung Tumors
The goal of this observational study is to determine if liquid biopsies from patients with stage I non-small cell lung cancer (NSCLC) can add to the diagnosis of a small lung cancer, or can better detect recurrent lung cancer…
- Trial name
- SABR-DETECT (NCT05921474)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Artery Disease, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
First-in-Human Study Using the SiroMax™ Sirolimus-Coated Balloon Catheter as a Percutaneous Transluminal Coronary Angioplasty (PTCA) Balloon Catheter to Treat Subjects Who Have Coronary Artery Disease (CAD) Involving In-Stent Restenosis (ISR) or an Unstented Lesion in a Small Coronary Vessel (DNSV).
The goal of this clinical trial is to learn if the SiroMax™ drug-coated balloon catheter is safe and works to treat stenotic coronary lesions in adults.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), In-Stent Restenosis or De Novo Coronary Artery Lesions, In-Stent Stenosis (Restenosis) of Coronary Artery Stent
- Trial name
- SMART-I (NCT07811024)
- Testing
- Sirolimus-coated balloon catheter
- Where
- 2 sites in Uzbekistan
- Volunteers
- 60 people
- Sponsor
- Tonic Medical, Inc.
Advanced NSCLC
Study of REGN5093-M114 (METxMET Antibody-Drug Conjugate) in Adult Patients With Mesenchymal Epithelial Transition Factor (MET) Overexpressing Advanced Cancer
This study is researching an experimental drug called REGN5093-M114 by itself and in combination with cemiplimab. The study is focused on advanced non-small cell lung cancer (NSCLC) that produces too much of a protein called…
- Trial name
- NCT04982224
- Testing
- REGN5093-M114, Cemiplimab
- Where
- 11 sites in United States
- Volunteers
- 30 people
- Sponsor
- Regeneron Pharmaceuticals
Carcinoma, Non-Small-Cell Lung
Biodistribution Study With 186 Re-labelled Humanised Monoclonal Antibody BIWA 4 in Patients With Non-small Cell Lung Cancer
The primary objectives of this study is to assess the safety and tolerability of intravenously (i.v.) administered 186 Rhenium-isotope (186Re)-labelled bivatuzumab and to investigate the biodistribution and pharmacokinetics of…
- Trial name
- NCT02204059
- Testing
- hMAb BIWA 4
- Volunteers
- 9 people
- Sponsor
- Boehringer Ingelheim
Respiratory Monitoring, Thoracic Surgery
AirGo™ Respiratory Monitoring in Lung Resection
Patients undergoing lung resection surgery may experience changes in respiratory function during the perioperative period. Current monitoring methods provide important clinical information but are often limited to specific time…
- Conditions
- Respiratory Monitoring, Thoracic Surgery, Lung Resection Surgery, Respiratory Function
- Trial name
- NCT07838025
- Testing
- AirGoTM system
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Lung Cancer, Surgery
Development and Clinical Validation of Early-stage Lung Cancer Prognostic Kit
Lung cancer is the leading cause of cancer mortality worldwide in spite of the advanced progresses in medication and low-dose CT screening.
- Conditions
- Lung Cancer, Surgery, Recurrence
- Trial name
- NCT05557474
- Testing
- Early-stage lung cancer prognostic kit -- ELISA, Early-stage lung cancer prognostic kit -- IHC
- Where
- 2 sites in Taiwan
- Volunteers
- 236 people
- Sponsor
- Chung Shan Medical University
Abdominal Aortic Aneurysm, Coronary Heart Disease
Ethnicity and Onset of Cardiovascular Disease: A CALIBER Study
Specific cardiovascular diseases, such as stroke and heart attack, have been shown to vary by ethnic group. However, less is known about differences between ethnic groups and a wider range of cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease, Sudden Cardiac Death, Intracerebral Haemorrhage
- Trial name
- NCT02176174
- Volunteers
- 1,068,318 people, healthy volunteers welcome
- Sponsor
- University College, London
Advanced or Metastatic Solid Tumors Irrespective of Gene Alterations, Non-Small Cell Lung Cancer
Phase 1b/2 Study of Futibatinib in Combination With Binimetinib in Patients With Advanced KRAS Mutant Cancer
Phase 1b/2 study to evaluate the FGFRi futibatinib in combination with the MEKi binimetinib in patients with advanced KRASmt tumors.
- Conditions
- Advanced or Metastatic Solid Tumors Irrespective of Gene Alterations, Non-Small Cell Lung Cancer, KRAS Gene Mutation
- Trial name
- NCT04965818
- Testing
- Futibatinib and Binimetinib
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Taiho Oncology, Inc.
Heart Diseases, Ischemic, Coronary Artery Disease
Power Walking in Cardiac Patients Who Underwent Post-coronary Angioplasty
The risk and prevalence of cardiovascular disease in United Arab Emirates (UAE) is high with ischemic heart disease ranks first in terms of major cause of mortality.
- Conditions
- Heart Diseases, Ischemic, Coronary Artery Disease, Coronary Arteriosclerosis, Coronary Syndrome
- Trial name
- PowerWalk (NCT04610060)
- Testing
- Power walking, Standardised outpatient cardiac rehabilitation
- Where
- United Arab Emirates
- Volunteers
- 24 people
- Sponsor
- Gulf Medical University
Lung Cancer
Tumor Response to Pemetrexed Disodium in Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Enrolled in Clinical Trial MCCRC-RC0524
RATIONALE: Studying samples of blood in the laboratory from patients receiving pemetrexed disodium may help doctors learn more about the effects of pemetrexed disodium on cells.
- Trial name
- NCT00898820
- Testing
- gene expression analysis, polymorphism analysis, protein expression analysis
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Atrial Fibrillation, Coronary Artery Disease
Edoxaban Versus Edoxaban With antiPlatelet Agent In Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease
This study evaluates the efficacy and safety of Edoxaban with the combination of edoxaban and antiplatelet in patients with stable CAD (coronary artery stenosis ≥50% on medical treatment or revascularized stable CAD [≥ 12 months…
- Conditions
- Atrial Fibrillation, Coronary Artery Disease, Stable Angina, Stable Chronic Angina
- Trial name
- EPIC-CAD (NCT03718559)
- Testing
- Edoxaban Monotherapy, Edoxaban plus Single Antiplatelet Agent
- Where
- 18 sites in South Korea
- Volunteers
- 1,040 people
- Sponsor
- Gi-Byoung Nam
Stage IV NSCLC
Harnessing Allo-immunity to Enhance Immune Checkpoint Inhibitor Responses in Advanced NSCLC
Veterans with advanced lung cancer may benefit from recent advances in technologies that is designed to change the activities of their own white blood cells and help kill tumors.
- Trial name
- HAITEN-ICI (NCT06064279)
- Testing
- Poly ICLC, IVIG
- Where
- United States
- Sponsor
- VA Office of Research and Development
Breast Cancer, Colon Cancer
EXoPERT EMERALD Clinical Study
The purpose of this study is to establish a multi-center clinical repository of blood samples to support the development and evaluation of an artificial intelligence-based in vitro diagnostic software.
- Conditions
- Breast Cancer, Colon Cancer, Pancreatic Cancer, Ovarian Cancer
- Trial name
- NCT07186296
- Testing
- EXoPred
- Where
- 9 sites in United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- EXoPERT
Pectus Excavatum
Hemodynamic Repercussions of the Correction (Surgical and Non Surgical) of Pectus Excavatum-type Thoracic Deformities
this non-randomized prospective study of 2 longitudinal cohorts (surgical treatment group or orthopedic treatment group), will evaluate the hemodynamic repercussions of the correction (surgical and non surgical) of pectus…
- Trial name
- PECTUS (NCT02174796)
- Testing
- surgical treatment, orthopedic treatment
- Where
- 5 sites in France
- Volunteers
- 41 people
- Sponsor
- Centre Jean Perrin
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