Clinical trials: Chest--Diseases
Lung Cancer, Lung Lobectomy
Effects of Different I:E Ratio on Intrapulmonary Shunt Fraction and Oxygenation During One Lung Ventilation in the Lateral Decubitus Position
The purpose of this study is to investigate effect of increasing inspiratory time (I:E ratio 1:1) on intrapulmonary shunt fraction and oxygenation during one lung ventilation in the lateral decubitus position.
- Trial name
- NCT01499212
- Testing
- I:E ratio
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Yonsei University
Small Cell Lung Cancer
Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)
The purpose of this randomized, open-label, 2-arm, phase 3 study is to assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic SCLC with high levels of…
- Trial name
- TAHOE (NCT03061812)
- Testing
- Rovalpituzumab tesirine, Topotecan, Dexamethasone
- Where
- 195 sites in United States, Australia and 31 more
- Volunteers
- 444 people
- Sponsor
- AbbVie
Aortic Aneurysm, Thoracic
Neurophysiological Intraoperative Monitoring During Aortic Surgery
The primary objective of this study is to evaluate if the motor-evoked potentials/motor action potential amplitude ratio and motor action potential amplitude measurement are useful in detecting spinal cord ischemia during…
- Trial name
- NIMAS (NCT02644681)
- Testing
- Aortic Aneurysm, Thoracic surgery
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Scientific Institute San Raffaele
Chronic Stable Angina
A Clinical Trial of a Self-Management Education Program for People With Chronic Stable Angina
The purpose of this clinical trial was to determine the effectiveness of a supportive and educational self-management program for improving health-related quality of life (HRQOL), angina symptoms, and self-efficacy and…
- Trial name
- NCT00350922
- Testing
- Psychoeducation
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- University of Toronto
Lung Neoplasm Malignant, Mesothelioma; Lung
Feasibility Trial of a Personalised Nutrition and Activity Programme for People With Lung Cancer Over 65 Years
People with cancer affecting the lungs tend to be older and frailer compared to people with other cancers. As a result, they may have poorer quality of life and are less able to tolerate treatments for their cancer, such as…
- Trial name
- CanBenefitII (NCT05404022)
- Testing
- Tailored nutrition and physical activity programme
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Hull
Lung Cancer, Non-small Cell, Artificial Intelligence
Neoadjuvant Camrelizumab, Nab-paclitaxel and Carboplatin in Stage IB-IIIA NSCLC
This prospective, single-arm, multicenter, phase II trial enrolled 40 patients who underwent surgery after three cycles of neoadjuvant therapy with camrelizumab, nab-paclitaxel, and carboplatin.
- Trial name
- NCT04541251
- Testing
- Camrelizumab + Nab-paclitaxel + Carboplatin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Pneumothorax, Pulmonary Nodule, Solitary
Multi-Reader Retrospective Study Examining Carebot AI CXR 2.0.21-v2.01 Implementation in Everyday Radiology Clinical Practice
The primary objective is to evaluate the performance parameters of the proposed DLAD (Carebot AI CXR) in comparison to individual radiologists.
- Conditions
- Pneumothorax, Pulmonary Nodule, Solitary, Atelectasis, Subcutaneous Emphysema
- Trial name
- NCT05963945
- Testing
- Carebot AI CXR
- Where
- Czechia
- Volunteers
- 956 people
- Sponsor
- Carebot s.r.o.
Carcinoma, Small Cell Lung
Study to Assess Safety,Tolerability,Efficacy of PM01183 and Atezolizumab in Patients w/ Advanced Small Cell Lung Cancer.
Prospective, open-label, uncontrolled and multicenter phase I-II study in SCLC patients with ECOG PS 0-1 who have failed one prior platinum-containing line but no more than one chemotherapy-containing line.
- Trial name
- NCT04253145
- Testing
- PM 01183, Atezolizumab
- Where
- 13 sites in Spain
- Volunteers
- 184 people
- Sponsor
- Fundacion Oncosur
Lung Cancer
Cisplatin, Vinorelbine, and Radiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as cisplatin and vinorelbine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- SOCCAR (NCT00309972)
- Testing
- Control arm (SEQ):, Experimental arm (CON):
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- University College, London
Non Small Cell Lung Cancer, Urothelial Cancer
Study of INCB086550 in Select Solid Tumors
An open-label, nonrandomized study to evaluate the efficacy and safety of INCB086550, a first-in-class oral inhibitor of PD-L1, as initial immune checkpoint inhibitor therapy in participants with select solid tumors
- Conditions
- Non Small Cell Lung Cancer, Urothelial Cancer, Renal Cell Carcinoma, Hepatocellular Carcinoma
- Trial name
- NCT04629339
- Testing
- INCB086550
- Where
- 20 sites in Bulgaria, Hungary and 3 more
- Volunteers
- 16 people
- Sponsor
- Incyte Corporation
Breast Cancer Females
Dextrose Hydrodissection for Post-Breast Cancer Chest Wall and Axillary Tightness.
The goal of this clinical trial (prospective case series) is to evaluate the feasibility, safety, and preliminary clinical outcomes of ultrasound-guided dextrose prolotherapy in female breast cancer survivors with persistent…
- Trial name
- NCT07378319
- Testing
- ultrasound guided dextrose prolotherapy
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Taichung Veterans General Hospital
Non Small Cell Lung Cancer
The Safety and Efficacy of First-line Lazertinib and Locally Ablative Radiotherapy in Patients With Synchronous Oligo-metastatic EGFR-mutant Non-small Cell Lung Cancer
This is based on the observations that disease progression under EGFR(Epidermal Growth Factor Receptor) targeting TKI(Tyrosine Kinase Inhibitor) most frequently occurs at the original sites of metastatic disease and that the…
- Trial name
- NCT05167851
- Testing
- Lazertinib , a combination group of SBRT, Lazertinib single administration group
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Yonsei University
Carcinoma, Non-Small-Cell Lung
Dose Escalation of BIBF 1120 Combined With Pemetrexed in Advanced Non Small Cell Lung Cancer
The primary objective was to determine the safety, tolerability and maximum tolerate dose (MTD) of BIBF 1120 in combination with pemetrexed.
- Trial name
- NCT02182102
- Testing
- BIBF 1120, Pemetrexed
- Volunteers
- 26 people
- Sponsor
- Boehringer Ingelheim
Non Small Cell Lung Cancer
PET/CT-directed Hyperfractionated Radiation Dose Escalation in Stage III Non-small Cell Lung Cancer
The goal of this study is to find the maximum tolerable dose of radiation that can be delivered combined with chemotherapy (carboplatin \& paclitaxel) in patients with stage III non-small cell lung cancer (NSCLC).
- Trial name
- NCT03099577
- Testing
- radiochemotherapy 1, radiochemotherapy 2, radiochemotherapy 3
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
EGFR-mutated Lung Adenocarcinoma, Brain Metastasis
Assess the Efficacy of Whole Brain Radiation Therapy in Lung Cancer Patients With Brain Metastasis
Multicentre randomised (1:1) trial assessing the efficacy of whole brain radiotherapy in addition to Gefitinib for the management of brain metastasis in lung cancer patients with a mutated EGFR.
- Trial name
- ARPEGE (NCT01363557)
- Testing
- whole brain radiotherapy, Gefitinib (IRESSA)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thymoma, Thymic Carcinoma
Carboplatin Combined With Paclitaxel in Treating Patients With Advanced Thymoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug may kill more tumor cells.
- Trial name
- NCT00010257
- Testing
- carboplatin, paclitaxel
- Where
- 67 sites in United States
- Volunteers
- 46 people
- Sponsor
- Eastern Cooperative Oncology Group
Non-Small Cell Lung Cancer
A Study of Bevacizumab Versus Placebo in Combination With Carboplatin/Paclitaxel in Participants With Advanced or Recurrent Non-Squamous Non-Small Cell Lung Cancer Who Have Not Received Previous Chemotherapy
This randomized, double-blind, placebo-controlled study will evaluate the efficacy and safety of bevacizumab (Avastin) versus placebo in combination with carboplatin/paclitaxel in participants with advanced or recurrent…
- Trial name
- NCT01364012
- Testing
- Bevacizumab, Carboplatin, Paclitaxel
- Where
- 17 sites in China
- Volunteers
- 276 people
- Sponsor
- Hoffmann-La Roche
Advanced Solid Tumor, BRAF V600 Mutation
A Study of ABM-1310 in Patients With BRAF V600-Mutant Advanced Solid Tumors
This is a Phase I, Open-Label, Multicenter, Dose Escalation and Expansion Study to evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-cancer activity of ABM-1310 in patients with BRAF V600-Mutant advanced…
- Trial name
- NCT05501912
- Testing
- ABM-1310
- Where
- 10 sites in China
- Volunteers
- 20 people
- Sponsor
- ABM Therapeutics Shanghai Company Limited
Coronary Heart Disease, Unstable Angina
Efficacy and Safety of Xuesaitong Soft Capsule for Coronary Heart Disease Unstable Angina
In this study, typical cases of coronary heart disease are selected. They will be intervened by Xuesaitong soft capsules to investigate efficacy and safety for Coronary Heart disease.
- Trial name
- NCT03083119
- Testing
- Xuesaitong soft capsule
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jie Wang
Tumor Progression
The Role of Protein Tyrosine Kinase 7 (PTK7) in Non-small Cell Lung Cancer
To understand the mechanism and cellular functions of PTK7-associated signaling pathways in promoting lung cancer progression and conferring treatment to epidermal growth factor receptor tysosine kinase inhibitors (EGFR TKIs).
- Trial name
- NCT04018183
- Where
- Taiwan
- Volunteers
- 167 people
- Sponsor
- National Taiwan University Hospital
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