Clinical trials: Child Birth
Dental Anxiety, Pain Management
Wand STA vs SleeperOne for Pediatric Local Anesthesia (WASO-Kids)
This randomized, single-blind, split-mouth trial compares the acceptance of two computer-controlled local anaesthetic delivery (CCLAD) systems - Wand® STA and SleeperOne⑤ - in children aged 4-9 years undergoing comparable…
- Trial name
- WASO-Kids (NCT07754851)
- Testing
- Computer-controlled local anesthetic delivery system (pressure-sensing, single-tooth anesthesia type), Computer-controlled local anesthetic delivery system (corded, pen-style electronic type)
- Where
- Greece
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Invasive Fungal Infection
Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal Infection (MK-5592-127)
This study aims to estimate the pharmacokinetics (PK) of posaconazole (POS, MK-5592) intravenous (IV) and powder for oral suspension (PFS) formulations in pediatric participants <2 years of age with invasive fungal infection…
- Trial name
- NCT04665037
- Testing
- Posaconazole IV 6 mg/kg, Posaconazole PFS 6 mg/kg
- Where
- 26 sites in United States, Belgium and 8 more
- Volunteers
- 40 people
- Sponsor
- Merck Sharp & Dohme LLC
Milk Hypersensitivity
Prevention of Cow's Milk Allergy in Children
Impact of fermented milk in prevention of cow's milk allergy in new born and infants
- Trial name
- NCT00792090
- Testing
- Fermented milk, Standard milk
- Where
- 2 sites in France
- Volunteers
- 142 people
- Sponsor
- Bledina
Parental Anxiety Following Premature Birth
Impact of Preterm Birth on Symptoms of Anxiety and Depression in Parents, and on the Precursors of Cognition, Including Social Cognition in Their Child
In 2018, the World Health Organization (WHO) counted no less than 15 million preterm births each year worldwide, or more than one in ten children.
- Trial name
- PréDANPa (NCT05734768)
- Testing
- State-Trait Anxiety Inventory - Y ou STAI-Y
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Fetal Alcohol Syndrome, HIV
Neighborhood Alcohol & HIV Prevention in South African Townships (Philani)
The purpose of this study is to test a mother-to-mother intervention during pregnancy and after delivery with mothers in South Africa, most of whom are at risk delivering babies with fetal alcohol syndrome, babies that are…
- Conditions
- Fetal Alcohol Syndrome, HIV, Nutrition Disorders
- Trial name
- NCT00996528
- Testing
- Philani Intervention Program
- Where
- South Africa
- Volunteers
- 1,239 people
- Sponsor
- University of California, Los Angeles
Obstetrical Brachial Plexus Palsy
Effectiveness and Safety of Early Intramuscular Botulinum Toxin Injections to Prevent Shoulder Deformity in Babies With Obstetrical Brachial Plexus Palsy
In children population with obstetrical brachial plexus palsy (OBPP), shoulder musculoskeletal deformity is the main cause of morbidity, with a loss of range of shoulder motion, pain and a reduction in social participation.
- Trial name
- POPB-TOX (NCT03198702)
- Testing
- Botulinum toxin type A injection
- Where
- 7 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Brest
Preterm Birth, Parent-Child Relations
Skin-to-skin Contact in Neonatal Intensive Care Unit (NICU), Caregiving Touch and Neural Correlates of Slow Stroking Touch in Preterm Infants
Preterm (PT) infants spend their first weeks of life in Neonatal Intensive Care Unit (NICU) where receive little affective physical contact, which plays a crucial role in brain development.
- Trial name
- NCT04293939
- Testing
- Functional Magnetic Risonance Imaging (fMRI) acquisition
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Congenital Heart Defect
A Feasibility Study of Physical Activity After Surgical or Catheterization Intervention
This feasibility study will assess whether a 6-month, home-based, parent-led physical activity program, completed after surgical or catheterization treatment, enables young children with congenital heart defects (CHD) to achieve…
- Trial name
- NCT04619745
- Testing
- Individualized Home and Play-Based Physical Activity Plans
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Children's Hospital of Eastern Ontario
Motor Skills Disorders, Premature Birth
Premie DCD Imaging Intervention Study
This study will leverage a current longitudinal study of brain development in preterm children. In the Miller/Grunau Trajectories study, preterm children are returning for follow-up at 8-9 years.
- Trial name
- NCT04483401
- Testing
- Cognitive Orientation to Occupational Performance (CO-OP)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Immunizations, Vaccination
School Influenza Vaccine vs Standard of Care With Nested Trial of 2 Parent Notification Intensities
Purpose of the study. The purpose of the project is to evaluate the feasibility, acceptability, and cost effectiveness of providing influenza vaccine in schools to children in grades Kindergarten through 6th grade.
- Conditions
- Immunizations, Vaccination, Influenza, School Health
- Trial name
- MCSkipp (NCT01224301)
- Testing
- School based flu vaccine: Low intensity, School based flu vaccine: High intensity
- Where
- United States
- Volunteers
- 25,366 people
- Sponsor
- Monroe County Department of Public Health
Premature, Breast Feeding
Effect of Teach-Back Education on Breastfeeding and Bonding in Mothers of Preterm Infants
The aim of this randomized controlled experimental study is to contribute to the standardization of nursing interventions for premature mothers and to establish a scientific basis for breastfeeding education models in our…
- Conditions
- Premature, Breast Feeding, Mother-Child Relationship
- Trial name
- TEACH-PRE (NCT07371845)
- Testing
- Teach-Back Education
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Preterm Infant
Executive Functions and Preterm Children in 11 to 12 Year Old
Preterm children have a high risk for neurodevelopmental impairments. The impact on motor functions and neurosensory functions is demonstrated but the incidence of executive functions is not described for preterm infants.
- Trial name
- NCT03700619
- Testing
- BRIEF parental survey
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Nantes University Hospital
Pregnancy, Pain
Safety of Epidural Fentanyl and Adrenalin During Childbirth
Investigation of pharmacokinetic effects of combining fentanyl and adrenalin in the epidural solution given to women in childbirth
- Trial name
- NCT00685672
- Testing
- adrenalin
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Parent-Child Relations, Behavioral Intervention
Mobile Health (mHealth) Tools to Improve Delivery Quality of a Family Home Visiting Intervention
This study will pilot a family-focused, behavioral health intervention while also developing and piloting mHealth tools to support Community Health Workers (CHWs) in Sierra Leone.
- Conditions
- Parent-Child Relations, Behavioral Intervention, Exposure to Violent Event, Child Development
- Trial name
- NCT04481399
- Testing
- Family Strengthening Intervention for Early Childhood Development, Community Health Worker Routine
- Where
- Sierra Leone
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Boston College
Early Intervention (Education)
Early Support From Birth Onwards: ZEPPELIN
ZEPPELIN (Zurich Equity Prevention Project with Parents Participation and Integration) is a longitudinal, randomized controlled intervention study.
- Trial name
- ZEPPELIN (NCT02882763)
- Testing
- Parents As Teachers (PAT)
- Where
- Switzerland
- Volunteers
- 213 people
- Sponsor
- University of Applied Sciences of Special Needs Education
Cerebral Palsy
Trends in Prevalence and Comorbidities of Children With Cerebral Palsy in Norway
Many studies have reported that the prevalence of cerebral palsy (CP) has been relatively stable and is mainly due to events before birth and therefore cannot be prevented.
- Trial name
- NCT03413566
- Testing
- Clinical diagnosis
- Volunteers
- 707,916 people
- Sponsor
- Sykehuset i Vestfold HF
HIV Infections, HIV Seronegativity
A Study of the Effects of Giving Two Anti-HIV Vaccines to Babies of HIV-Positive Mothers
The purpose of this study is to see if giving the ALVAC vCP1452 anti-HIV vaccine alone or with another vaccine called AIDSVAX B/B to babies of HIV-positive mothers is safe.
- Trial name
- NCT00000879
- Testing
- ALVAC(2)120(B,MN)GNP (vCP1452), MN rgp120/HIV-1 and GNE8 rgp120/HIV-1, ALVAC-HIV MN120TMG (vCP205)
- Where
- 17 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Exposure to Secondhand Smoke in Neonatal Infants
Motivational Incentives to Reduce Secondhand Smoke in NICU Infants' Homes
A randomized, controlled, parallel group design will be used to test whether a Secondhand Smoke Exposure program initiated in the hospital and completed in the home using motivational interviewing plus motivational incentives…
- Trial name
- NCT01726062
- Testing
- Motivational Interviewing plus Incentives, Conventional Care (CC)
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cerebral Palsy Infantile, Pre-Term
Motor-voice Assessment in Infants (MAMI)
The goal of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants..
- Conditions
- Cerebral Palsy Infantile, Pre-Term, Motor Delay, Neurodevelopmental Disorders
- Trial name
- MAMI (NCT06807203)
- Testing
- Behavioral observation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Ohio State University
Kangaroo Mother Care Method
Effect of Kangaroo Position on Electromyographic Activity, Macrocirculation and Microcirculation of Preterm Newborns
Growing evidences indicates that the Kangaroo Mother Method is associated with health benefits for the child and her mother. Improvements have been found in physiological parameters of the preterm infants assisted by the method.
- Trial name
- NCT03611088
- Testing
- Kangaroo Position.
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute