Clinical trials: Child Birth
Allergies, Obesity
Effects of the Mediterranean Diet During Pregnancy on the Onset of Allergies in the Offspring
Allergy prevalence is increasing steadily with some describing as the "epidemic of the twenty-first century". Maternal diet during pregnancy has been linked to offspring allergy risk, so it represents a potential target for…
- Conditions
- Allergies, Obesity, Gestational Complications, Gestational Weight Gain
- Trial name
- PREMEDI (NCT05119868)
- Testing
- Nutritional intervention based on Mediterranean Diet
- Where
- 2 sites in Italy
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Federico II University
Eczema
Barrier Enhancement for Eczema Prevention
The primary objective is to determine whether advising parents to apply emollient (moisturiser) to their child's skin for the first year of life in addition to best practice infant skin care advice can prevent or delay the onset…
- Trial name
- BEEP (NCT04680520)
- Testing
- Experimental (Doublebase Gel® or Diprobase Cream®), Best practice skin care advice booklet
- Where
- 16 sites in United Kingdom
- Volunteers
- 1,394 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Depression, Child Development
Improving Preterm Outcomes by Safeguarding Maternal Mental Health
The investigators' goal is to optimize the developmental outcomes of preterm infants by preventing depression and improving functioning among their mothers during the critical first year of life.
- Trial name
- NCT01892982
- Testing
- Problem Solving Education tailored to NICU
- Where
- 4 sites in United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Health Behavior
Effect of Social Accountability on Improving Service Delivery and Outcomes in the Public Sector in Uttar Pradesh, India
In several low and middle-income countries, Social Accountability (SA) interventions have been introduced as an innovative approach to governance, aiming to improve delivery of public services.
- Trial name
- D0168 (NCT02879708)
- Testing
- Information Only, Information and Facilitation
- Where
- India
- Volunteers
- 105,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Molar Incisor Hypomineralisation
SleeperOne® 5 Intraosseous Anesthesia in MIH
This randomized split-mouth clinical trial evaluates whether computer-controlled intraosseous anesthesia delivered with the SleeperOne® 5 system reduces pain perception and dental anxiety compared with conventional local…
- Trial name
- CCLAD-MIH (NCT07741487)
- Testing
- SleeperOne® 5 Computer-Controlled Intraosseous Anesthesia, Conventional Local Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Ankara University
Vitamin D3 Deficiency, Prematurity
Vitamin D and Health Outcomes in Preterm Born Population
Improved survival of very preterm newborn population during the last decades has challenged us neonatologists to study and improve nutritional practices including vitamin D (VitD) supplementation.
- Conditions
- Vitamin D3 Deficiency, Prematurity, Lung Diseases, Heart Rate Variability
- Trial name
- ViDePrePop (NCT04342078)
- Testing
- Vitamin D
- Where
- Finland
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Mortality, Morbidity
Birth Cohort in Coast Province, Kenya
In 2010, 7.6 million children under the age of five died worldwide and yet the causes of only 2.7% (0.205 million) of these deaths were medically certified.
- Conditions
- Mortality, Morbidity, Child Development, Child Behaviour
- Trial name
- NCT02448615
- Where
- 2 sites in Kenya
- Volunteers
- 283 people
- Sponsor
- The Hospital for Sick Children
Premature Birth
Cardiovascular Health Assessment of Preterm- and TERm-born Children
The purpose of the CHAPTER study is to help understand how complications during pregnancy, such as preterm birth, affect how childrens' hearts and blood vessels develop.
- Trial name
- CHAPTER (NCT05698836)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Vaccination, Education
Manicaland Cash Transfer Trial for Children in Zimbabwe
The purpose of this study is to determine whether cash transfers (conditional and unconditional) can improve health and social outcomes amongst children living in vulnerable households in Manicaland, eastern Zimbabwe.
- Conditions
- Vaccination, Education, Birth Registration, Financial Support
- Trial name
- NCT00966849
- Testing
- Conditional Cash Transfer, Unconditional Cash Transfers, Standard Agricultural Package
- Where
- Zimbabwe
- Volunteers
- 4,043 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Anemia; Drepanocytic
Prognostic Factors of Acute Splenic Sequestration
Acute splenic sequestration is a frequent and life threatening complication occurring in approximately 10 % of homozygous children. Maximal incidence is between 6 and 18 months.
- Trial name
- SSADREPA (NCT01207037)
- Testing
- blood samples and scintigraphy
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Child Overweight
Breastfeeding and Complementary Feeding in Relation to BMI and Overweight
This study examines the associations between different types of infant feeding and BMI and overweight in childhood. The study is based on the Danish National Birth Cohort, established in 1996.
- Trial name
- NCT03334760
- Testing
- Danish National Birth Cohort
- Volunteers
- 100,418 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Diabetes Mellitus, Type 1
The Impact of Hybrid Closed-loop Insulin Delivery in Type 1 Diabetes on Glycemic Control and PROMs
Since February 2019 the first hybrid closed-loop insulin pump, the Medtronic MiniMed 670G system, has been offered to people with type 1 diabetes in Belgium.
- Trial name
- INRANGE (NCT04414280)
- Testing
- Medtronic MiniMed 670G, Medtronic MiniMed 780G, Tandem Control-IQ
- Where
- 38 sites in Belgium
- Volunteers
- 1,600 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Premature Birth
A Cluster Randomized Controlled Trial of FICare At 18 Months
In Alberta, one in every twelve babies is born preterm. Compared with their full term counterparts, preterm infants who survive are at higher risk for respiratory problems, jaundice, infections, feeding problems, behavioural…
- Trial name
- NCT03337659
- Testing
- Family Integrated Care
- Where
- Canada
- Volunteers
- 297 people
- Sponsor
- University of Calgary
Pregnancy, Obesity
An Optimized Programming of Healthy Children (APPROACH)
The Nutrition Research Unit at Copenhagen University Hospital Herlev will during the fall 2013 initiate a randomized and controlled intervention study engaging 390 obese pregnant women.
- Conditions
- Pregnancy, Obesity, Gestational Age and Weight Conditions, Maternal Care for Excessive Fetal Growth
- Trial name
- NCT01894139
- Testing
- High-Protein/Low-GI Diet, Low-protein/High-GI Diet
- Where
- Denmark
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Severe Malaria, Severe Anaemia
Post-discharge Malaria Chemoprevention Implementation Trial in Benin
The proposed research aims to conduct implementation trials in Benin, co-designed with national stakeholders, to evaluate different delivery strategies for optimizing health system delivery of post-discharge malaria…
- Trial name
- PDMC-SL (NCT06601712)
- Testing
- Adherence support strategy A, Adherence support strategy B, Control
- Where
- 2 sites in Benin
- Volunteers
- 648 people
- Sponsor
- Institut de Recherche Clinique du Benin
Parenteral Nutrition, Necrotizing Enterocolitis
Neurodevelopment and Neuroimaging in Parenterally-fed Infants and Young Children
Manganese (Mn) is an essential metal required for normal growth and development. However, exposure to high Mn levels can be toxic to the brain.
- Conditions
- Parenteral Nutrition, Necrotizing Enterocolitis, Digestive System Abnormalities, Cholestasis
- Trial name
- NCT00392730
- Testing
- Remove Mn from PN if evidence of increased brain Mn on MRI
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Dental Phobia, Dental Anxiety
"Study of Pain Perception Using Computer-Controlled Versus Conventional Local Anaesthesia in Children Undergoing Molar Extraction
This clinical trial aims to compare pain perception in children during dental procedures when using a computer-controlled local anesthesia device versus a traditional syringe.
- Conditions
- Dental Phobia, Dental Anxiety, Dental Anesthesia, Dental Anesthesia Efficacy
- Trial name
- CCLAD-Pain (NCT07056101)
- Testing
- A conventional dental syringe, GENI High-Speed Injection, GENI Moderate-Speed Injection
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Tarek MHD kher al saka amini
Pregnancy, HIV
Management and Optimization of Nutrition, Antenatal, Reproductive, Child Health & HIV Care
This study evaluates the impact of a quality improvement (QI) intervention on maternal and child healthcare services in seven primary healthcare (PHC) clinics, in a rural setting of KwaZulu-Natal, South Africa.
- Trial name
- MONARCH (NCT02626351)
- Testing
- Quality Improvement, Baseline data collection (active comparator)
- Where
- South Africa
- Volunteers
- 3,172 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
HIV Infections
Using Nevirapine to Prevent Mother-to-Child HIV Transmission During Breastfeeding
The many benefits of breastfeeding are well documented. However, because of the risk of mother-to-child transmission (MTCT) of HIV from an HIV infected mother to her infant, there is considerable concern over the practice…
- Trial name
- NCT00074412
- Testing
- Nevirapine
- Where
- 5 sites in South Africa, Tanzania and 2 more
- Volunteers
- 2,026 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Premature Birth, Psychological Stress
Parental Stress and Attachment in Preterm Infants
Introduction: Advances in neonatology mean a significant reduction in mortality in premature infants as well as an increase in the risk of morbidity in the medium, short and long term.
- Conditions
- Premature Birth, Psychological Stress, Physiological Stress
- Trial name
- NCT06813560
- Testing
- hair cortisol, salivary cortisol, salivary Oxytocin
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University