Clinical trials: Child Cancer Brain, open to volunteers
Brain Tumor
Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors
The objective of this study is to estimate the feasibility and acceptability of cognitive training in the virtual reality setting with children undergoing radiotherapy for brain tumors.
- Trial name
- NCT05947045
- Testing
- Cognitive training via iPad, Cognitive training via virtual reality
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- St. Jude Children's Research Hospital
High Grade Glioma, Diffuse Intrinsic Pontine Glioma
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion
This is a pilot study that will evaluate disease status in children that have been newly diagnosed high-grade glioma with TRK fusion. The evaluation will occur after 2 cycles of the medication (Larotrectinib) have been given.
- Trial name
- NCT04655404
- Testing
- Larotrectinib, Larotrectinib surgical
- Where
- 21 sites in United States, Australia and 3 more
- Volunteers
- 15 people
- Sponsor
- Nationwide Children's Hospital
Cancer Childhood, Brain Tumor
Musical Training: Promoting Brain Function in Children Who Have Survived Brain Tumours
This study aims to understand whether learning music can help improve brain function and quality of life in children who have recovered from brain tumours. A total of 236 children will join the study.
- Trial name
- NCT07769099
- Testing
- Musical Training Program
- Where
- Hong Kong
- Volunteers
- 236 people
- Sponsor
- The Hong Kong Polytechnic University
Haematological Malignancy, Malignancy
DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.
This clinical trial is looking at a drug called entrectinib. Entrectinib is approved as standard of care treatment for adult patients with non-small cell lung cancer (NSCLC) which have a particular molecular alteration called…
- Conditions
- Haematological Malignancy, Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders
- Trial name
- DETERMINE (NCT05770544)
- Testing
- Entrectinib
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Ependymoma of Brain, Pediatric Solid Tumor
Multiomic Approach to Radioresistance of Ependymomas in Children and Adolescents
Treatment of childhood ependymoma, the second most frequent pediatric brain tumor, is based on surgery and radiation therapy. However, 50% relapse, mainly locally.
- Trial name
- EPENDYMOMICS (NCT05151718)
- Where
- France
- Volunteers
- 370 people
- Sponsor
- Institut Claudius Regaud
Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
The BIOMEDE 2.0 study is the second stage of the BIOMEDE multi-arm, multistage rolling programme (adaptive platform protocol). It is a multicenter, randomized, open-label, controlled phase-3 trial evaluating efficacy of ONC201 in…
- Conditions
- Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant, Diffuse Midline Glioma, H3K27-altered
- Trial name
- BIOMEDE 2 (NCT05476939)
- Testing
- Everolimus, ONC201, Radiotherapy
- Where
- 56 sites in Belgium, Denmark and 6 more
- Volunteers
- 433 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Congenital Portosystemic Shunt, CPSS (Congenital Portosystemic Shunt)
International Registry of Congenital Portosystemic Shunt (IRCPSS)
Congenital Portosystemic Shunt (CPSS) is a rare condition important by the multiplicity and severity of associated complications.
- Trial name
- IRCPSS (NCT06041906)
- Testing
- Shunt Closure
- Where
- 26 sites in United States, Australia and 14 more
- Volunteers
- 500 people
- Sponsor
- Prof. Valérie Mc Lin
Medulloblastoma, Childhood, Cognitive Impairment
Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
The efficacy of treatment with metformin for promoting cognitive recovery and brain growth in children/adolescents treated for a brain tumour will be investigated in a multi-site Phase III randomized double-blind…
- Trial name
- Met Med Can (NCT05230758)
- Testing
- Metformin hydrochloride (HCl) 500mg tablet
- Where
- 20 sites in Australia, Canada
- Volunteers
- 140 people
- Sponsor
- Donald Mabbott
Posterior Fossa Tumor
Intensive Physiotherapy in Children Affected by Posterior Fossa Tumors
The objective of the current study is to describe the effectiveness of conventional and intensive physiotherapeutic intervention in improving gross motor skills (i.e.
- Trial name
- NCT06832384
- Testing
- intensive physiotherapy
- Where
- 3 sites in Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Eugenio Medea
Hemianopsia, Virtual Reality
Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour
Evaluate the efficiency of audiovisual stimulation in virtual reality for improving the visual perception of children, adolescents, and young adults with hemianopia resulting from pediatric brain tumors.
- Conditions
- Hemianopsia, Virtual Reality, Visual Rehabilitation, Pediatric Brain Tumor
- Trial name
- REVIIH-BT (NCT07558395)
- Testing
- Visual Stimulation, standard of care
- Where
- 8 sites in Austria, Denmark and 5 more
- Volunteers
- 120 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cancer, Pediatric Cancer
Study of Zanzalintinib in Children and Adolescents With Relapsed or Refractory Solid Tumors
The primary purpose of this study is to determine the pediatric maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D), and to evaluate the safety and tolerability of zanzalintinib.
- Trial name
- NCT07773454
- Testing
- Zanzalintinib
- Volunteers
- 18 people
- Sponsor
- Exelixis
Low-Grade Glioma, Recurrent Low-Grade Glioma
SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma
This is an open-label, multi-center, Phase 1/2 study of the brain-penetrant MEK inhibitor, mirdametinib (PD-0325901), in patients with pediatric low-grade glioma (pLGG).
- Conditions
- Low-Grade Glioma, Recurrent Low-Grade Glioma, Progressive Low-Grade Glioma
- Trial name
- NCT04923126
- Testing
- Mirdametinib
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- St. Jude Children's Research Hospital
Central Nervous System Neoplasms, Brain Tumor
B7-H3.CD28Z.CART in CNS Neoplasms
The purpose of this research study is to test the safety and effectiveness of a cell therapy at different doses for children and young adults with recurrent or progressive brain tumors.
- Conditions
- Central Nervous System Neoplasms, Brain Tumor, Brain Tumor, Recurrent, Brain Tumor, Pediatric
- Trial name
- NCT07390539
- Testing
- B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Robbie Majzner
Epilepsy, Intracranial Tumors
Magnetoencephalography in Children
This study is a single-center observational clinical study, which evaluates the diagnostic value of magnetoencephalography (MEG) in the diagnosis of neurodevelopmental diseases in children, such as the localization of epileptic…
- Conditions
- Epilepsy, Intracranial Tumors, Cerebrovascular Disease, Autism
- Trial name
- NCT06668519
- Testing
- Magnetoencephalography
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Children's Hospital of Fudan University
Childhood Cancer, Childhood Solid Tumor
Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer
A companion platform trial to test novel targeted agents based on the patient's tumor profile.
- Conditions
- Childhood Cancer, Childhood Solid Tumor, Childhood Brain Tumor, Recurrent Cancer
- Trial name
- NCT06208657
- Testing
- Paxalisib, Opdualag, Irinotecan (drug)
- Where
- 14 sites in Australia, Canada
- Volunteers
- 90 people
- Sponsor
- Australian & New Zealand Children's Haematology/Oncology Group
Brain Tumor, Pediatric
Utility of PET-MRI in Surveillance of Paediatric Brain Tumours
This is a pilot project to explore the utility of PET-MRI in the post-treatment surveillance of high-grade gliomas or medulloblastomas in children in our institution.
- Trial name
- PET-MRI (NCT05553899)
- Testing
- PET-MRI
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
Combination Therapy for the Treatment of Diffuse Midline Gliomas
This phase II trial determines if the combination of ONC201 with different drugs is effective for treating participants with diffuse midline gliomas (DMGs).
- Conditions
- Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant, Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Diffuse Midline Glioma, H3 K27M-Mutant
- Trial name
- PNOC022 (NCT05009992)
- Testing
- ONC201, Radiation Therapy, Paxalisib
- Where
- 32 sites in United States, Australia and 4 more
- Volunteers
- 360 people
- Sponsor
- University of California, San Francisco
Infratentorial Neoplasms, Mutism
Cerebellar Mutism Syndrome Study
The purpose of this study is to determine why up to 25% of the pediatric patients who have surgery for a tumor in the posterior fossa develops the Cerebellar Mutism Syndrome (CMS).
- Trial name
- NCT02300766
- Where
- 32 sites in Austria, Belgium and 12 more
- Volunteers
- 2,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Primary Brain Tumor
Neurocognitive Function After Proton Therapy in Children and Adolescents
Brain tumors are the second most frequent malignant diseases in children and adolescents. In the study the short and medium term consequences of proton therapy on cognitive processes in particular on executive functions in…
- Trial name
- ELBE-ProKids (NCT04066465)
- Where
- 3 sites in Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Brain Tumor, Pediatric, Cancer-related Fatigue
Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related Fatigue
Cancer-related fatigue is a common and debilitating late effect in pediatric brain tumor survivors. Currently, evidence-based recommendations to ameliorate this condition are lacking.
- Conditions
- Brain Tumor, Pediatric, Cancer-related Fatigue, Methylphenidate
- Trial name
- EMBRAIN (NCT06905587)
- Testing
- Methylphenidate (MPH)
- Where
- 4 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Odense University Hospital