Clinical trials: Child Development Disorders, Pervasive
Autism Spectrum Disorder
Mentorship Program for Individuals With Autism Spectrum Disorder (ASD)
The purpose of this pilot project is to evaluate the feasibility of a mentorship program for adolescents with autism spectrum disorder (ASD). Data will be collected from adolescents with ASD and their parents/guardians.
- Trial name
- NCT05300295
- Testing
- Mentoring Program
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Minnesota
Tuberous Sclerosis Complex
Trial of RAD001 and Neurocognition in Tuberous Sclerosis Complex (TSC)
Tuberous Sclerosis Complex (TSC) is a multi-system disease, usually presenting with seizures, mental retardation and autism, and exhibiting a high variability in clinical findings both among and within families.
- Trial name
- TSC (NCT01289912)
- Testing
- RAD001
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Mustafa Sahin
Autism Spectrum Disorder (ASD)
Omega-3 Fatty Acids Monotherapy in Children and Adolescents With Autism Spectrum Disorders
The primary aim of this study is to examine the efficacy and tolerability of short-term omega-3 fatty acids monotherapy in youth with Autism Spectrum Disorders (ASD).
- Trial name
- NCT01248130
- Testing
- Omega-3 Fatty Acid
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorders
Gaming for Autism to Mold Executive Skills Project
The goal of the project is to better understand executive control-how children manage complex or conflicting information in the service of a goal.
- Trial name
- GAMES (NCT02361762)
- Testing
- Computerized executive control training
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Children's Hospital
Autism Spectrum Disorder, Mental Disorders
Physiological Mechanisms of Therapeutic Horseback Riding Intervention Effects in a Psychiatric Population of ASD Youth
This randomized control trial (RCT) seeks to assess the mechanisms underlying Therapeutic Horseback Riding's (THR) previously observed significant positive effects on ASD youth, particularly those with co-occurring psychiatric…
- Trial name
- NCT04606966
- Testing
- Therapeutic Horseback Riding, Barn Activity, Hybrid
- Where
- 2 sites in United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Autism Spectrum Disorder
Providing Accessible Diagnostic Evaluations and Psychoeducation for Autism Spectrum Disorder in Rural Southwest Virginia
This study will be the pilot/feasibility phase of a future clinical trial. The proposed feasibility and pilot study aims to bridge the barriers to diagnosis by providing easy-to-access assessment for free, through a mobile unit…
- Trial name
- NCT05822921
- Testing
- In-person Psychoeducation (IP), Telehealth Psychoeducation (TH), Psychoeducation as Usual (PAU)
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Virginia Polytechnic Institute and State University
Autism Spectrum Disorder
Sulforaphane Treatment of Children With Autism Spectrum Disorder (ASD)
ASD is a diverse disorder starting in early childhood and characterized by social communication impairment as well as restricted interests and repetitive behaviors.
- Trial name
- NCT02561481
- Testing
- Sulforaphane
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Massachusetts, Worcester
Autistic Disorder
An Open-Label Study of N-Acetyl Cysteine in Children With Autism
The purpose of the study is to test the tolerability and efficacy of N-Acetyl Cysteine (NAC) in children with Autism.
- Trial name
- NCT00676195
- Testing
- N-Acetyl Cysteine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Autism Spectrum Disorder, Quality of Life
Essential Oils for Enhancing QOL in ASD
Essential oils (aromatic oils extracted from plant parts) are routinely used by the public and are available on the market. Investigators are conducting this study because it is unknown whether the essential oils formulations…
- Conditions
- Autism Spectrum Disorder, Quality of Life, Sleep, Anxiety
- Trial name
- NCT02543203
- Testing
- Reconnect, Coconut oil Comparator
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Jill Hollway
Attention-deficit/Hyperactivity Disorder, Autism Spectrum Disorder
Methylphenidate ER Liquid Formulation in Adults With ASD and ADHD
The purpose of this study is to determine whether methylphenidate hydrochloride extended release liquid formulation is safe and effective in the treatment of attention-deficit/hyperactivity disorder (ADHD) in high-functioning…
- Trial name
- NCT02096952
- Testing
- Methylphenidate extended-release liquid formulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder
Daily Living Skills Intervention for 9th and 10th Graders With Autism Spectrum Disorders
The current study seeks to develop the first daily living skills (DLS) intervention package for high functioning adolescents with autism spectrum disorder (ASD) and evaluate its effectiveness.
- Trial name
- NCT03984513
- Testing
- Surviving and Thriving in the Real World, Program for the Education and Enrichment of Relational Skills
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Schizophrenia, Autism
Lurasidone Pediatric Pharmacokinetics Study
This is a Phase 1, open-label, multicenter, single and multiple ascending lurasidone dose study in subjects from 6 to 17 years old with schizophrenia spectrum, bipolar spectrum, autistic spectrum disorder, or other psychiatric…
- Trial name
- NCT01620060
- Testing
- Lurasidone
- Where
- 10 sites in United States
- Volunteers
- 105 people
- Sponsor
- Sumitomo Pharma America, Inc.
Autism Spectrum Disorder, Aggression
Nicotinic Cholinergic Modulation as a Novel Treatment Strategy for Aggression Associated With Autism
Some individuals with autism spectrum disorders (ASD) also demonstrate irritability or aggression, which can interfere with functioning.
- Conditions
- Autism Spectrum Disorder, Aggression, Irritability
- Trial name
- NCT02552147
- Testing
- Transdermal nicotine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Autism Spectrum Disorder
Open Label Phase I hCT-MSC in Toddlers With Autism Spectrum Disorder
This is a single site, prospective study of one intravenous infusion of human umbilical cord tissue-derived mesenchymal stromal cells (hCT-MSC) in toddlers with autism spectrum disorder (ASD).
- Trial name
- TACT (NCT04294290)
- Testing
- hCT-MSC infusion
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Autism, Attention Deficit Disorder With Hyperactivity
Methylphenidate for Attention Deficit Hyperactivity Disorder and Autism in Children
This study examined the cognitive and behavioral differences in children who have an autism spectrum disorder (ASD) with or without additional symptoms of ADHD.
- Trial name
- NCT00178503
- Testing
- Methylphenidate-extended release, Methylphenidate-immediate release
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Autism Spectrum Disorders, Pervasive Developmental Disorders
An Open-Label Trial of Oxytocin in Adolescents With Autism Spectrum Disorders
This study is an 8-week open-label trial testing oxytocin nasal spray (Syntocinon) as a treatment for social impairment in adolescents with autism spectrum disorders (ASD).
- Conditions
- Autism Spectrum Disorders, Pervasive Developmental Disorders, ASD, PDD
- Trial name
- NCT01931033
- Testing
- Intranasal Oxytocin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Schizophrenia, Schizoaffective Disorder
Second-Generation Antipsychotic Treatment Indication Effectiveness And Tolerability In Youth (Satiety) Study
The purpose of this study is to get a better understanding of the side effect burden and identify predictors of psychotic, mood and aggressive disorders in children and adolescents.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Psychotic Disorder, Not Otherwise Specified
- Trial name
- SATIETY (NCT01269710)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of North Carolina, Chapel Hill
Autism
Validation of Indiana's Early Evaluation Hub System
The investigators' objective is to test an innovative method of autism diagnosis that integrates clinical evaluation and assessment of biobehavioral markers in a large high-risk community-referral sample of children in the…
- Trial name
- EAER21 (NCT06586788)
- Testing
- Eyelink Portable Duo, Integrated PCP Diagnosis and Eye-tracking Biomarker
- Where
- 7 sites in United States
- Volunteers
- 154 people
- Sponsor
- Indiana University
Autism Spectrum Disorders, Anxiety
An Open-Label Trial of Buspirone for the Treatment of Anxiety in Youth With Autism Spectrum Disorders
The main objective of this exploratory 8-week pilot study is to evaluate the safety and efficacy of buspirone for the treatment of anxiety in youth (ages 6-17 years) with autism spectrum disorders.
- Trial name
- NCT01850355
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
PTEN Gene Mutation, PTEN Hamartoma Tumor Syndrome
RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome
Phosphatase and TENsin homolog (PTEN) gene germline mutations are associated with a spectrum of clinical manifestations characterized by neurocognitive deficits, intellectual disability, autism symptomatology, skin lesions…
- Trial name
- NCT02991807
- Testing
- RAD001
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Boston Children's Hospital