Clinical trials: Child Malnutrition
Sickle Cell Anemia, Severe Acute Malnutrition
Management of Severe Acute Malnutrition in SCD, in Northern Nigeria
Except for children with HIV, all recommendations for treatment of childhood malnutrition are for children < 5 years of age. The overall goal of this randomized controlled nutrition feasibility trial is to identify whether…
- Trial name
- NCT03634488
- Testing
- hydroxyurea (20mg/kg/day), Ready-to-use therapeutic food
- Where
- 3 sites in United States, Nigeria
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Congenital Heart Disease, Malnutrition
Preoperative Nutritional Intervention and Outcomes of Children Submitted to Heart Surgery for Congenital Heart Diseases
The hypothesis of this study is a nutrition preoperatively in infants and children undergoing elective cardiac surgery with cardiopulmonary bypass leads to improvement in nutritional status, intervention, and that this results in…
- Trial name
- NCT02647541
- Testing
- Nutritional intervention
- Where
- Brazil
- Volunteers
- 11 people
- Sponsor
- University of Sao Paulo
Depression, Postpartum, Malnutrition, Child
Decreasing Stunting by Reducing Maternal Depression in Uganda: A Cluster Randomized Controlled Trial (CRCT) for Improved Nutrition Outcomes
The project seeks to test the integration of Interpersonal Psychotherapy for Groups within Care Group projects and investigate whether the treatment of maternal depression with Interpersonal Psychotherapy for Groups improves the…
- Trial name
- NCT03573713
- Testing
- Care Groups, IPT-G
- Where
- Uganda
- Volunteers
- 1,248 people
- Sponsor
- Food for the Hungry
Malnutrition in Pregnancy, Preterm Birth
Improving Cognition and Gestational Duration With Targeted Nutrition
The goal of this clinical trial is to test (1) a novel maternal ready-to-use supplementary food and (2) a novel cognitive behavioral therapy intervention in undernourished Sierra Leonean women.
- Conditions
- Malnutrition in Pregnancy, Preterm Birth, Child Development, Postpartum Depression
- Trial name
- COGENT (NCT05949190)
- Testing
- M-RUSF+ (Maternal Ready-to-Use Supplementary Food + DHA/EPA/choline), M-RUSF (Maternal Ready-to-Use Supplementary Food), Azithromycin
- Where
- 10 sites in Sierra Leone
- Volunteers
- 1,660 people
- Sponsor
- Washington University School of Medicine
Newborn Resuscitation, Severe Malnutrition
Enhancing Pediatric Acute Care Through Adaptive E-Learning and In-Person Skills Practice in Tanzania
The goal of this clinical trial is to evaluate whether the integration of in-person skills practice (ISP) with an adaptive e-learning platform can improve refresher learning progress (RLP) among healthcare providers in pediatric…
- Conditions
- Newborn Resuscitation, Severe Malnutrition, Severe Malaria, Severe Pneumonia
- Trial name
- PACE (NCT06635733)
- Testing
- Rhapsode Capable™ Platform (Intervention Group), Paper-based ISP (Control Group)
- Where
- Tanzania
- Volunteers
- 100 people
- Sponsor
- Stanford University
Complementary Feeding
Improving Growth and Cognitive Development of the Disadvantaged Young Children in Resource Poor Setting
1. Burden: The period from birth to two years of age is the "critical window" for the promotion of optimal growth, health, and development.
- Trial name
- NCT05805514
- Testing
- Animal source of food and psychosocial stimulation, Animal source of food, Control
- Where
- Bangladesh
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Low Birthweight, Preterm Birth
Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Ethiopia
The ENAT study will test the impact of packages of antenatal interventions to enhance maternal nutrition and manage pregnancy infections on the outcomes of infant birth size, gestational length, and infant growth in the first 6…
- Conditions
- Low Birthweight, Preterm Birth, Maternal; Malnutrition, Affecting Fetus, Sexually Transmitted Diseases
- Trial name
- ENAT (NCT04171388)
- Testing
- Azithromycin 500 mg, Multiple Micronutrient or Fortified Balanced Energy Protein Supplement, Enhanced Infection Management Package (EIMP)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Severe Acute Malnutrition, HIV
An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM
Malnutrition underlies 45% of child deaths, and has far-reaching educational, economic and health consequences. Severe acute malnutrition (SAM) affects 17 million children globally and is the most life-threatening form of…
- Conditions
- Severe Acute Malnutrition, HIV, Comorbidities and Coexisting Conditions, Child Malnutrition
- Trial name
- Co-SAM (NCT05994742)
- Testing
- Rifampicin, Azithromycin, Isoniazid
- Where
- 9 sites in Kenya, Zambia and 1 more
- Volunteers
- 674 people
- Sponsor
- Queen Mary University of London
Nutrition in Cancer Survival and Treatment
Delivery of Nutritional Services in Nicaragua
This study investigates nutritional status, at predefined points in therapy, and the association with outcomes in children and adolescents undergoing treatment for cancer in institutions under Asociación de Hemato-Oncología…
- Trial name
- NCT04031586
- Where
- Nicaragua
- Volunteers
- 50 people
- Sponsor
- Columbia University
Malnutrition, Malnutrition, Child
Double Duty Interventions and Its Impact on Double Burden of Malnutrition in Children Under Five Years
Background: Double burden of malnutrition is an emerging public health problem among children under-five years due to the inevitable consequences of nutritional transition.
- Conditions
- Malnutrition, Malnutrition, Child, Obesity, Undernutrition
- Trial name
- DBM (NCT05791305)
- Testing
- double duty intervention packages
- Where
- 2 sites in Ethiopia
- Volunteers
- 456 people
- Sponsor
- Debre Berhan University
Uncomplicated Severe Acute Malnutrition
Effects of Three Feeding Regimens on Recovery of Uncomplicated Severely Acute Malnourished Children
This project aims to assess the efficacy of three options under consideration in India for home management of Severe Acute Malnutrition (SAM).
- Trial name
- SAMPOORNA (NCT01705769)
- Testing
- Ready to Use Therapeutic Food-Centrally produced, Ready to Use Therapeutic Food-Locally produced, High energy and micronutrient rich foods
- Where
- 3 sites in India
- Volunteers
- 911 people
- Sponsor
- Society for Applied Studies
Malnutrition
Effect of Vitamins on Academic Performance of School Children
The purpose of this clinical trial is to determine if administration of a daily chewable multivitamin-mineral supplement (Monday - Friday when school is in session) given to children (third through sixth graders) during the…
- Trial name
- NCT00418990
- Testing
- Multivitamin/Mineral supplements
- Where
- United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Child Malnutrition, Child Allergy
The UFIM (Ultraprocessed Foods In Breast Milk) Project
In last decades, a change in dietary habits has been observed in industrialized countries characterized by a drastic increase in the consumption of ultra-processed foods (UPF, Ultra-Processed Foods).
- Conditions
- Child Malnutrition, Child Allergy, Maternal Exposure
- Trial name
- UFIM (NCT05889520)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Federico II University
Child Malnutrition
Intervention on Development and Growth at Children in Poverty
Children in extreme poverty lack adequate care and face increased health risks. The earlier poverty strikes in the developmental process, the more deleterious and long-lasting its effects.
- Trial name
- RAI (NCT02988180)
- Testing
- basic services, the play-based developmental stimulation
- Where
- 2 sites in Belgium, Ethiopia
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Anemia, Undernutrition
Effect of Iron Versus Multiple Micronutrient Supplementation on Anemia in Preschool Children of Malaria-Endemic Area
Some micronutrients are likely to interact with malaria parasite, leading to either synergistic or antagonist effect on malaria morbidity and therefore on hemoglobin response.
- Trial name
- NCT00628459
- Testing
- micronutrient supplementation
- Where
- Burkina Faso
- Volunteers
- 297 people
- Sponsor
- Centre National de la Recherche Scientifique et Technologique
Malnutrition
Acceptability of LNS for Infants and Young Children in Guatemala
This study aims to assess the acceptability of lipid-based nutrient supplements (LNS) for use as nutritional supplements for infants and young children in Guatemala. The study was conducted in three phases.
- Trial name
- NCT01148641
- Testing
- LNS
- Where
- Guatemala
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Child Malnutrition
Effects of Prebiotics on Metagenomic Diversity and Abundance in Young Children With Acute Malnutrition
Malnutrition is a major global public health issue, contributing to poor health and early morbidities in children under five, particularly in developing countries.
- Trial name
- P-MAM (NCT06155474)
- Testing
- Prebiotic galacto-oligosaccharide (GOS) Powder, Starch Only, RUTF + Starch
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of the Punjab
Severe Acute Malnutrition, Health Care Associated Infection
Prevention of Nosocomial Infections (CleanKids)
While the standardization of treatment protocols for Severe Acute Malnutrition (SAM) has helped to reduce historically high mortality, mortality in inpatient settings remains substantial, likely due to the severity of…
- Conditions
- Severe Acute Malnutrition, Health Care Associated Infection, Multi Drug Resistant Organisms
- Trial name
- CleanKids (NCT03360877)
- Testing
- Health-care associated infection (HCAI)
- Volunteers
- 4,944 people
- Sponsor
- Epicentre
Hypophosphatasia
Open-Label Study of Asfotase Alfa in Infants and Children ≤ 5 Years of Age With Hypophosphatasia (HPP)
This clinical trial was conducted to study hypophosphatasia (HPP), a bone disorder caused by gene mutations or changes. These gene mutations cause low levels of an enzyme needed to harden bone.
- Trial name
- NCT01176266
- Testing
- asfotase alfa
- Where
- 23 sites in United States, Australia and 10 more
- Volunteers
- 69 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Obesity, Vitamin D Deficiency
Vitamin D and Vascular Health in Children
In this study, we will test the central hypothesis that enhancement of vitamin D status in obese and overweight children will improve their vascular health and their cardiovascular disease (CVD) and metabolic syndrome risk…
- Trial name
- NCT01797302
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh