Clinical trials: Child Mortality
Metabolic Acidosis, Acid-Base Imbalance
Frequency of Metabolic Acidosis in the Pediatric Intensive Care Unit
Metabolic acidosis is one of the most common acid-base disturbances encountered in critically ill children and often reflects underlying disease severity.
- Conditions
- Metabolic Acidosis, Acid-Base Imbalance, Critical Illness in Children
- Trial name
- NCT07803263
- Volunteers
- 140 people
- Sponsor
- Assiut University
Malaria, All-cause Mortality
Effects of Insecticide Treated Bednets on Child Morbidity and Mortality
Insecticide-impregnated bed nets and curtains (ITN) have been shown to be effective against malaria. However, given that most ITN studies were of limited length, researchers have postulated the hypothesis that in areas of intense…
- Trial name
- NCT00225368
- Testing
- Insecticide treated bednets
- Where
- Burkina Faso
- Sponsor
- Heidelberg University
Sepsis
Smart Discharges for Older Children
This study is an observational multi-country cohort study that aims to build algorithms that can identify children between 5 and 16 years of age admitted for proven or suspected sepsis who are at risk of mortality after they are…
- Trial name
- NCT07629154
- Testing
- No Intervention: Observational Cohort
- Where
- 7 sites in United States, Canada and 3 more
- Volunteers
- 4,000 people
- Sponsor
- University of British Columbia
Asphyxia Neonatorum
First Breath: Neonatal Resuscitation in Developing Countries
In developing countries, neonatal death from birth asphyxia is a major problem. This study will be conducted in several countries to determine if the combined Neonatal Resuscitation Program/Essential Newborn Care Program compared…
- Trial name
- NCT00136708
- Testing
- Neonatal Resuscitation
- Where
- 7 sites in Argentina, Guatemala and 4 more
- Volunteers
- 120,009 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Congenital Heart Disease
Mortality Among Children With Congenital Heart Defects in Norway
To describe mortality among children with congenital heart defects in Norway
- Trial name
- NCT02026557
- Volunteers
- 15,000 people
- Sponsor
- Sorlandet Hospital HF
Acquired Immunodeficiency Syndrome
Chinese Network of Pediatric Antiretroviral Therapy
This is an observational cohort in pediatric HIV patients in China. Children who receive antiretroviral drugs will be recruited in this study. The main objectives are as follows: 1.
- Trial name
- CN-PART (NCT01210924)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- National Center for AIDS/STD Control and Prevention, China CDC
Death, Death, Infant
Coupons for Safe Water Project
Guaranteeing access to safe drinking water is still a challenge in rural households in developing countries, and unsafe water sources are responsible for millions of deaths each year around the world.
- Conditions
- Death, Death, Infant, Diarrhea, Diarrhea, Infantile
- Trial name
- Coupons (NCT05766826)
- Testing
- Coupons for safe water program: Treatment, Coupons for safe water program: Control
- Where
- 2 sites in Kenya
- Volunteers
- 3,468 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Plasmodium Falciparum Malaria
Malaria Prevalence in Children
The purpose of this pilot study is to evaluate the use of (1) 'malaria prevalence', (2) 'malaria incidence' and (3) 'malaria mortality' as a measure of malaria transmission in The Gambia, while mosquito insecticides (larvicides)…
- Trial name
- NCT00322816
- Where
- The Gambia
- Volunteers
- 2,552 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pregnancy
Routine Iron Prophylaxis During Pregnancy
Comparison of two policies of iron administration during pregnancy in regard to health and program feasibility in an area with endemic malaria and high prevalence of HIV infection.
- Trial name
- PROFEG (NCT00488579)
- Testing
- Two policies of iron prophylaxis
- Where
- Mozambique
- Volunteers
- 4,326 people, healthy volunteers welcome
- Sponsor
- National Istitute For Health and Welfare, Finland
Shock, Septic
Significance of Disseminated Intravascular Coagulation Score in Mortality for Children With Shock
Evaluates whether the DIC score, as defined according to the International Society of Thrombosis and Hemostasis guidelines is associated with mortality in Children with shock and DIC
- Trial name
- NCT06581172
- Testing
- D_dimer
- Volunteers
- 80 people
- Sponsor
- Assiut University
Neonatal Vitamin A Supplementation
Efficacy of Newborn Vitamin A Supplementation Versus Placebo in Improving Child Survival (NeoVitA Trial)
The study is a large randomized controlled trial to assess the efficacy and safety of neonatal vitamin A supplementation administered to neonates once orally either on the day of birth or in the next 2 days in improving infant…
- Trial name
- NCT01138449
- Testing
- Vitamin A
- Where
- India
- Volunteers
- 44,984 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Bacterial Pneumonia, Viral Pneumonia
Inhaled Corticosteroids in U-5 Children With Acute Respiratory Infection in Uganda: A Randomised Trial
The purpose of this study is to find out whether adjunct treatment with inhaled corticosteroids lead to faster improvement and reduce mortality of children under 5 years of age admitted to hospital with ALRI.
- Conditions
- Bacterial Pneumonia, Viral Pneumonia, Acute Asthma
- Trial name
- ICS (NCT01868113)
- Testing
- Inhaled corticosteroid
- Where
- Uganda
- Volunteers
- 1,010 people
- Sponsor
- Makerere University
Hypertension in Pregnancy, Hypertension
Enhancing Intergenerational Health in Nigeria: Peripartum as Critical Life Stage for Cardiovascular Health
The purpose of the ENHANCE-CVH study is to promote intergenerational cardiovascular health (CVH) of women and children in Abuja and the surrounding Federal Capital Territory of Nigeria.
- Conditions
- Hypertension in Pregnancy, Hypertension, Obesity and Overweight, Maternal Morbidity and Mortality
- Trial name
- ENHANCE-CVH (NCT06773299)
- Testing
- PAT+HEALTH curriculum - Nigeria
- Where
- Nigeria
- Volunteers
- 1,000 people
- Sponsor
- Washington University School of Medicine
Cirrhosis
Validation of Child-Turcotte-Pugh-Kumar (CTPK) Score in Predicting Short Term Mortality in Patients With Liver Cirrhosis
The CTP score is one of the best proved severity score in predicting mortality in patients with cirrhosis. Portal hypertension and variceal bleed are significant causes of morbidity and mortality in patients with cirrhosis.
- Trial name
- NCT01863121
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Sir Ganga Ram Hospital
Malaria
Revaccination of Young Children With Bacille Calmette Guerin (BCG) Vaccine
BCG has marked immune stimulatory effects in both animal and human studies and observational studies suggest that BCG is associated with a non-specific reduction in mortality in areas with high infant and child mortality.
- Trial name
- NCT00126217
- Testing
- Bacille Calmette Guerin (BCG)
- Where
- Guinea-Bissau
- Volunteers
- 2,871 people
- Sponsor
- Bandim Health Project
Stillbirth and Neonatal Mortality, Perinatal Mortality
Perinatal Mortality Outcomes Through Household Infection Pathways
The goal of this trial is to learn if replacing household soil floors with concrete floors can prevent deaths of infants around the time of birth, including stillbirths and deaths in the first month of life in rural Bangladesh.
- Conditions
- Stillbirth and Neonatal Mortality, Perinatal Mortality, Infant Mortality, Child Mortality
- Trial name
- POTH (NCT07620613)
- Testing
- Concrete household floor
- Where
- Bangladesh
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acute Respiratory Tract Infections, Diarrhea
Home Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT
Melghat is poorly developed tribal area in India with very high child mortality \& malnutrition prevalence (grossly inadequate medical facilities). Important health problems.
- Conditions
- Acute Respiratory Tract Infections, Diarrhea, Malaria, Neonatal Sepsis
- Trial name
- HBCC (NCT02473796)
- Testing
- Home based child care
- Where
- India
- Volunteers
- 7,594 people
- Sponsor
- MAHAN Trust
Pregnancy, Neonatal Mortality
Scalable Public Health Empowerment, Research, and Education Sites (SPHERES)
SPHERES is a health service research trial in the Indonesian primary care system designed to improve health system performance using a structured data-driven action model.
- Conditions
- Pregnancy, Neonatal Mortality, Tuberculosis, Hepatitis B
- Trial name
- SPHERES (NCT07126041)
- Testing
- Prescription for Action (SPHERES Model)
- Where
- 2 sites in Indonesia
- Volunteers
- 1,750,000 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Mortality
Lufwanyama Neonatal Survival Project
We seek to determine whether we can reduce day 28 mortality in Zambian newborns by training traditional birth attendants a modified version of the neonatal resuscitation protocol (NRP) and by improving their abiltiy to identify…
- Trial name
- LUNESP (NCT00518856)
- Testing
- Neonatal resuscitation protocol, Standard of care
- Volunteers
- 3,559 people, healthy volunteers welcome
- Sponsor
- Boston University
Maternal Morbidity and Mortality, Stillbirth and Neonatal Mortality
Emergency Obstetric and Neonatal Care: The EmONC Trial
The objective of this cluster randomized controlled trial is to reduce maternal and neonatal mortality by increasing access to and improving the quality of obstetric and neonatal care for pregnant women in study clusters.
- Trial name
- EmONC (NCT01073488)
- Testing
- Community Mobilization, HBLSS and facility improvement
- Where
- 7 sites in Argentina, Guatemala and 4 more
- Volunteers
- 267,181 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health