Clinical trials: Child Nutrition Disorders
Hypophosphatasia (HPP)
Safety and Efficacy of Asfotase Alfa in Juvenile Patients With Hypophosphatasia (HPP)
This clinical trial studied the safety and efficacy of asfotase alfa in children with HPP compared to a historical control group.
- Trial name
- NCT00952484
- Testing
- asfotase alfa
- Where
- 2 sites in United States, Canada
- Volunteers
- 13 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Malnutrition, Wasting
Nutritional Impact of Moringa Oleifera Leaf Supplementation in Mothers and Children
Studies to date on the effects of Moringa oleifera in diabetes and anemia and animal studies that examine the utility of moringa for increased milk and litter yield are of small scale, however high-quality large-scale placebo or…
- Conditions
- Malnutrition, Wasting, Growth Failure
- Trial name
- NCT04587271
- Testing
- Moringa oleifera (high dose), Moringa oleifera (low dose)
- Where
- 2 sites in Kenya
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Suzanna L Attia
Obesity, Insulin Resistance
Apelin Levels and G212A Polymorphism of Apelin Receptor (APJ)
The aim of this study is to investigate serum apelin levels as well as their possible association with G212A polymorphism of the apelin receptor in obese children and adolescents.
- Conditions
- Obesity, Insulin Resistance, Diabetes Mellitus Type 2
- Trial name
- NCT01121172
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Pediatric Obesity
NOURISH: Nourishing Our Understanding of Role Modeling to Improve Support and Health
The percentage of overweight children between the ages of 6 and 11 has nearly tripled in the last three decades, and rates are even higher among African Americans.Overweight children are at-risk for numerous health problems, thus…
- Trial name
- NOURISH (NCT00628030)
- Testing
- NOURISH, Wellness Group
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
CLABSI - Central Line Associated Bloodstream Infection
Sodium Citrate 4% Locking Solution for Children Requiring Home Parenteral Nutrition
This study an open label prospective observational cohort study to evaluate the safety and efficacy of sodium citrate 4% locking solution in preventing central line associated blood stream infection in children requiring long…
- Trial name
- NCT04756427
- Testing
- Sodium Citrate 4% Inj Syringe 3Ml
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Bullying, Weight, Body
Cognitive-Behavioral Therapy for Weight-related Bullying (Online Treatment)
This study will perform a clinical trial with adolescents to pilot a new cognitive-behavioral treatment (CBT) for weight-related bullying testing (1) feasibility, (2) acceptability, and (3) initial efficacy.
- Conditions
- Bullying, Weight, Body, Trauma, Psychological
- Trial name
- NCT04587752
- Testing
- CBT for Weight Bullying
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Obesity, Childhood, Eating Behavior
Study of Brain, Reward, and Kids' Eating
Children from rural communities are at greater risk for obesity than children from more urban communities. However, some children are resilient to obesity despite greater exposure to obesogenic influences in rural communities…
- Trial name
- BRAKE (NCT05456516)
- Testing
- Food Rating
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Penn State University
Healthy, Obesity
Break It Up: A Study Evaluating Breaking Up Daily Sedentary Behavior in Youth
Background: Some studies have found that people can better process sugars when they take walking breaks. Studies have also found that children's attention and memory may improve after exercise.
- Conditions
- Healthy, Obesity, Overweight
- Trial name
- NCT03223649
- Testing
- Walking Bouts, Sedentary
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Prader-Willi Syndrome, Hyperphagia
Intranasal Oxytocin vs. Placebo for the Treatment of Hyperphagia in Prader-Willi Syndrome
This study is a phase 2 randomized double blind 8-week treatment trial of intranasal OXT vs. placebo in 50 subjects aged 5 to 17 years with PWS in order to assess IN-OXT's affect on measurements of (1) eating behaviors (2)…
- Trial name
- NCT03197662
- Testing
- Intranasal Oxytocin (IN-OXT)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Eric Hollander
Obesity
For the Health of Our Children--Clinic Based Treatment of Childhood Obesity
Childhood obesity is a major public health problem in the U.S. Currently approximately one in three children is considered overweight or obese. Most overweight children grow to become overweight adults.
- Trial name
- NCT01625910
- Testing
- Behavioral counseling
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Severe Obesity
Enhancing Weight Loss Maintenance With GLP-1RA (BYDUREON™) in Adolescents With Severe Obesity
Long-term weight loss maintenance is seldom achieved by individuals with obesity owing to numerous biological adaptations involving appetite, satiety, and energy expenditure in the post- weight loss setting.
- Trial name
- NCT02496611
- Testing
- Weight loss with pharmacotherapy, Weight loss without pharmacotherapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obesity
Guided Self-help for Families With an Overweight Child
The purpose of this study is to evaluate whether a home based program can teach parents and moderately overweight kids who are of 8-12 years old with a BMI% between 85-97%, how to manage their child's weight.
- Trial name
- GSH (NCT01145833)
- Testing
- Immediate Treatment Group, Delayed Treatment Group
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity, Atherosclerosis
Endothelial Dysfunction in Obese Children
The purpose of this study is to objectify the effect of diet and exercise on early markers of atherosclerosis in obese children.
- Trial name
- EDOC (NCT01461226)
- Testing
- Exercise training, Usual care
- Where
- 3 sites in Belgium
- Volunteers
- 61 people
- Sponsor
- University Hospital, Antwerp
HIV Positive, Malnourished
IMPAACT P1092: Steady State PK in Malnourished HIV Infected Children
Children living with HIV from sub-Saharan Africa often present with severe malnutrition. In severe malnutrition, metabolic and/or gut structural derangement may lead to inadequate antiretroviral (ARV) absorption and/or erratic…
- Trial name
- NCT01818258
- Testing
- ZDV+3TC+LPV/r
- Where
- 5 sites in Malawi, Tanzania and 2 more
- Volunteers
- 52 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Validation Studies
d13C Added Sugar Intake Biomarker: Determining Validity in Children
Added sugars (AS) constitute a significant source (~ 16%) of the total daily calories consumed by youth. The role of AS in health is contentious, and the reliance on self-reported dietary data is an often-cited flaw in existing…
- Trial name
- NCT02455388
- Testing
- High added sugar diet, Low added sugar diet
- Where
- United States
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Weight Change, Body, Behavior, Health
Increased Monitoring of Physical Activity and Calories With Technology
Since severe obesity in youth has been steadily increasing. Specialized pediatric obesity clinics provide programs to aid in reducing obesity.
- Conditions
- Weight Change, Body, Behavior, Health, Obesity, Childhood, Parent-Child Relations
- Trial name
- IMPACT (NCT03961061)
- Testing
- Brenner mFIT (standard care), Brenner mFIT (standard care plus mobile health components)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pediatric Cancer, Nutrition Related Cancer
Pediatric Oncology Nutrition Intervention Trial
Nearly 60% of pediatric patients diagnosed with cancer develop malnutrition caused by a combination of disease burden, side effects of chemotherapy, and the intensity of cancer treatment.
- Conditions
- Pediatric Cancer, Nutrition Related Cancer, Nutrition Aspect of Cancer, Muscle Loss
- Trial name
- POINT (NCT06175273)
- Testing
- Oral Nutrition Supplement, Tube Feed, Cyproheptadine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Corey Hawes
Obesity, Overweight
Children's Use of the Built Environment for Physical Activity
The study aims are to develop and test the feasibility of a pediatric physical activity intervention that incorporates personal information on use of the built environment, and test the intervention's preliminary efficacy at…
- Trial name
- CUBES (NCT01939405)
- Testing
- built environment use counseling
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Pseudohypoparathyroidism, Albright Hereditary Osteodystrophy
Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism
Pseudohypoparathyroidism type 1a (PHP1a) is a rare disease that causes childhood obesity and learning difficulties. This study will investigate eating behaviors and perform cognitive testing on children with PHP1a.
- Trial name
- NCT02411461
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Overweight and Obesity, Adiposity
Healthy Mothers-Healthy Children Nutrition
Using a randomized two-group, repeated measures experimental design, the goal of the proposed study is to investigate the efficacy of a 12-week nutrition and exercise education, physical activity, coping skills training, and…
- Conditions
- Overweight and Obesity, Adiposity, Nutrient; Excess, Physical Activity
- Trial name
- HMHC (NCT03866902)
- Testing
- Nutrition and Physical Activity Intervention, English for Second Language Intervention
- Where
- United States
- Volunteers
- 578 people, healthy volunteers welcome
- Sponsor
- University of Miami