Clinical trials: Childhood Cancer, open to volunteers
Anthracycline Related Cardiotoxicity in Childhood Cancers, Chemotherapeutic Toxicity
Evaluation of Cardiac and Endothelial Function in Children and Adolescents Treated With Anthracycline
In recent decades, the survival rate of children with cancer has increased significantly thanks to personalized treatments and the adoption of international therapeutic protocols.
- Conditions
- Anthracycline Related Cardiotoxicity in Childhood Cancers, Chemotherapeutic Toxicity, Childhood Cancer Survivors
- Trial name
- CARDIO-PED (NCT07253077)
- Testing
- Biomarker detection
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Brain Tumor, Childhood Cancer
Biomarkers of Brain Injury in Children With Brain Tumors
The goal of this observational study is to identify biomarkers of treatment-induced brain injury in children treated for primary brain tumors.
- Conditions
- Brain Tumor, Childhood Cancer, Childhood Brain Tumor
- Trial name
- BiomarkCBT (NCT07381959)
- Where
- Sweden
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Pediatric Cancer
Food is Medicine in Survivorship: Examining the Feasibility and Impact of a Scalable Food Delivery and Culinary Medicine Program (FoodiiS) Among Pediatric Cancer Survivors and Their Families
The goal of this research study is to learn if the FoodiiS-Kids intervention is useful to parents and guardians of pediatric cancer survivors.
- Trial name
- NCT07218328
- Testing
- FoodiiS plus Culinary Essentials Food Delivery, Culinary Essentials Food Delivery Only, Waitlist control
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Obesity, Childhood, Obesity
Reach Through Equitable Implementation of Turtle Island Tales
Reach Through Equitable Implementation of Turtle Island Tales is a family-level obesity prevention intervention that aims to reinforce AI cultural values of family interaction and holistic wellness.
- Conditions
- Obesity, Childhood, Obesity, Cancer
- Trial name
- NCT06298149
- Testing
- Turtle Island Tales
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Montana State University
Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity
Investigating Cognitive Impairment in Young Patients With Cancer Prospectively
The MyBrain study investigates the brain function of children, adolescents and young adults during and after chemo treatment for cancer.
- Conditions
- Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity, Chemo-brain, Cancer
- Trial name
- MyBrain (NCT05840575)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
CNS Tumor, Childhood
Whole Body Metabolism in Children Before and After Treatment of CNS Tumor
At the center of pediatric oncology in Copenhagen the investigators experience that the children with brain tumor, more or less have a healthy body with normal skeletal muscle mass and are physical active to the same level as…
- Trial name
- NCT06380387
- Testing
- Meal
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Melanoma (Skin Cancer), Artificial Intelligence (AI)
Artificial Intelligence Based Melanoma Early Diagnosis and Risk Prediction in Children, Adolescents and Young Adults
The goal of this study is to develop supportive diagnostic artificial intelligence algorithms to distinguish melanoma from nevi or other benign pigmented skin lesions, especially in younger patients (below the age of 30).
- Conditions
- Melanoma (Skin Cancer), Artificial Intelligence (AI), Pediatric Cancer
- Trial name
- AI-MEL (NCT06621810)
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center
Cancer
Metacognitive Intervention in Youth With Oncological Disease - the Mio Study
The aim of the Mio-Study is to address the current lack of effective treatment options to reduce cognitive and physical long-term problems in children and adolescents with cancer.
- Trial name
- Mio (NCT06464237)
- Testing
- Mio-App
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Childhood Cancer Survivors, Fertility
Fertility and Ovarian Reserve in Female Childhood Cancer Survivors
Ovarian function impairment affects the quality of life of the survivors of paediatric cancer by impacting fertility, bone quality and mental and cognitive health.
- Conditions
- Childhood Cancer Survivors, Fertility, Ovarian Reserve, CED
- Trial name
- PRINCESS (NCT06626282)
- Where
- 3 sites in Belgium
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Acute Lymphatic Leukemia, Lymphoma
More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls.
- Trial name
- MaximALL (NCT07705178)
- Testing
- QOL assessment, Neuropsychological, Spirometry, DLCO measurement
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Sarcoma, Bone, Sarcoma, Soft Tissue
Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients
The goal of DEEPGAIT study is to determine how serious walking problems are for pediatric cancer patients who have had orthopedic surgery, how they change over time, and what can be done to help.
- Conditions
- Sarcoma, Bone, Sarcoma, Soft Tissue, Gait Disorder
- Trial name
- NCT07502885
- Testing
- Lab based 3D Gait Assessment, Wearable Inertial Sensors (In Lab and Remote), Functional Testing & Patient Reported Outcomes
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Leukemia (Both ALL and AML), Brain Tumors
Efficacy of a Smart Holistic Health Care Platform Intervention on Cancer Children and Parents' Bio-Psycho-Social and Spiritual Health
This multicenter randomized controlled trial aims to develop and evaluate two Smart Holistic Health Care Platforms (SHHCPs) for families of children with cancer in Taiwan: the Parent Smart Holistic Health Care Platform (P-SHHCP)…
- Trial name
- NCT07805096
- Testing
- Parent Smart Holistic Health Care Platform (P-SHHCP), Child Smart Holistic Health Care Platform (C-SHHCP)
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Defense Medical University, Taiwan
Pediatric Cancer
Multisite Implementation of COMPRENDO
COMPRENDO (ChildhOod Malignancy Peer Research NavigatiOn) is a multi-site randomized clinical trial (RCT) that uses a Hybrid Type 1 design, to test the effects of a clinical intervention on patient-level outcomes, while exploring…
- Trial name
- COMPRENDO (NCT06055296)
- Testing
- COMPRENDO Peer Navigation Intervention
- Where
- 4 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Childhood Cancer
COMUNICAR: Community-Led Family-Centered Communication for Cancer Survivorship Care
This study will test a novel intervention to facilitate family-centered communication among Hispanic/Latino (H/L) young adult childhood cancer survivors (YA-CCS), their support persons, and their clinicians through collaboration…
- Trial name
- NCT07606443
- Testing
- Family-Centered Communication Intervention
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Stanford University
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pediatric Cancer, Survivorship
Beat Childhood Cancer Specimen Banking and Data Registry
This is an observational data registry study of pediatric cancer patients at participating Beat Childhood Cancer Consortium sites involving specimen banking and data collection.
- Trial name
- NCT04715178
- Testing
- No intervention- registry only
- Where
- 18 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Giselle Sholler
Childhood Cancers, Caregiver Social Support
Assessing and Addressing Health-Related Social Needs Among Families of Children With Cancer
The purpose of this study is to design Community Enhancing Resources for Childhood cAncer support (CERCA) and refine intervention procedures to target Health-related Social Needs (HRSN) in families of children with cancer.
- Conditions
- Childhood Cancers, Caregiver Social Support, Caregiver Distress, Social Needs
- Trial name
- NCT07278414
- Testing
- Community Enhancing Resources for Childhood cAncer support (CERCA)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pediatric Cancer, Palliative Care
Integration of Palliative Care in Pediatric Onco-hematology
PALONCOPED is a multicentre, interregional, observational and qualitative study aiming to better understand the early integration of palliative care in children with cancer.
- Trial name
- PALONCOPED (NCT07838168)
- Testing
- PALONCOPED semi-structured interview
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Childhood Cancer, Childhood Cancers
Examination of the Relationship Between Quality of Life and Caregiving Burden Among Caregivers of Pediatric Oncology Patients
Primary Aim The primary aim of this study is to determine the quality of life and caregiving burden levels of caregivers of pediatric oncology patients and to examine the relationship between these two variables.
- Conditions
- Childhood Cancer, Childhood Cancers, Caregiver Subjective Burden, Primary Caregivers of Children Newly Diagnosed With Cancer
- Trial name
- NCT07308301
- Testing
- Assessment of caregiver quality of life and burden
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Fatma Beyza Akdeniz
Acute Lymphoid Leukemia, Acute Myeloid Leukemia in Children
Study of the Medullary Microenvironment in Acute Childhood Leukemia
Acute leukemia (AL) is the most common cancer in children. Despite the optimization of chemotherapy treatments and the development of supportive care, a certain number of LAs relapse and/or progress to death of the child.
- Trial name
- MILA (NCT05792007)
- Testing
- Biological sampling in patients, Biological sampling in control patients
- Where
- 3 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours