Clinical trials: Childhood Cancer Survivors
Childhood Cancer Survivors
A Study of Time-Restricted Eating in Childhood Cancer Survivors
This study will look at whether motivational sessions (including regular calls with a trained health coach) in combination with time-restricted eating (TRE) is an effective way to achieve weight loss and lower cardiometabolic…
- Trial name
- NCT07009288
- Testing
- Children's Oncology Group Heart Health Link, Monthly weights, Fasting
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Leukemia, Lymphoblastic, Acute, Osteoporosis
A Severity-Adapted Clinical Trial of Diminished Bone Mineral Density in Acute Lymphoblastic Leukemia Survivors
Research studies have shown that children who are long-term survivors of childhood leukemia may be at greater risk for early bone loss called osteoporosis.
- Trial name
- NCT00186901
- Testing
- Calcium carbonate (Tums), vitamin D
- Where
- 3 sites in United States
- Volunteers
- 429 people
- Sponsor
- St. Jude Children's Research Hospital
Childhood Cancer Survivors
Exercise and Pain in CCS
The purpose of this study is to demonstrate that integration of exercise intervention into standard post-cancer directed treatment care will improve patient reported pain, decrease the need for medications to manage chronic pain…
- Trial name
- NCT05562193
- Testing
- Physical activity intervention coupled with standard post-cancer directed treatment care, Standard post-cancer directed treatment care control
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Medulloblastoma, Childhood, Survivorship
Cognitive Rehabilitation for Survivors of Childhood Medulloblastoma Using Real Time Hemodynamic Neurofeedback
This study will evaluate a new way to help childhood medulloblastoma survivors improve their thinking and memory skills. Many survivors experience long term challenges with attention and working memory because of the tumor and…
- Trial name
- NCT07830134
- Testing
- rt fMRI Neurofeedback (DLPFC), rt fMRI Neurofeedback (PAC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- St. Jude Children's Research Hospital
Muscle Weakness, Low Muscle Mass
Muscle Aging Phenotypes in Childhood Cancer Survivors
Childhood cancer survivors experience premature declines in muscle mass, strength, and physical function that contribute to morbidity and early mortality.
- Conditions
- Muscle Weakness, Low Muscle Mass, Sarcopenia
- Trial name
- NCT07531498
- Testing
- Multimodal Muscle Imaging and Functional Assessment, Multimodal Muscle Imaging and Neuromuscular Assessment, Comprehensive Muscle Phenotyping
- Where
- United States
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Cancer
Impact of Resistance Training-Protein Supplementation on Lean Muscle Mass in Childhood Cancer Survivors
This study is being conducted because low lean muscle mass is prevalent among childhood cancer survivors. Lean muscle is the non-fatty muscle tissue that makes up part of the body's lean body mass.
- Trial name
- NCT02501460
- Testing
- Educational handouts, Resistance training, Supplementation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- St. Jude Children's Research Hospital
Brain Tumors
Pediatric Research on Improving Speed, Memory and Attention
Introduction: The aim of this study is to investigate the efficacy of neurofeedback (NFB) to improve attention, memory and processing speed in children treated for a Brain Tumour (BT).
- Trial name
- PRISMA (NCT00961922)
- Testing
- Neurofeedback
- Where
- Netherlands
- Volunteers
- 105 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Childhood Cancer Survivors, Cardiotoxicity
Impact of Exercise Intensity on Cardiac Health in Young Adult Survivors of Childhood Cancer: The PULSE Trial
This trial aims to evaluate the impact of exercise intensity on cardiac health in young adult survivors of childhood cancer previously treated with anthracyclines.
- Conditions
- Childhood Cancer Survivors, Cardiotoxicity, Cardiovascular Diseases, Anthracycline-induced Cardiotoxicity
- Trial name
- PULSE (NCT07442578)
- Testing
- HIIT Exercise Program, MICT Exercise Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dana-Farber Cancer Institute
Childhood Cancer
Study to Education Childhood Cancer Survivors About Survivorship Care
The proposed study is part of a career development award. The first two phases of research involve collaborating with adult survivors of childhood cancer representing both sexes and three ethnic/racial groups (African American…
- Trial name
- SPEAC (NCT01742481)
- Testing
- Education and empowerment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Illinois Chicago
Frailty, Childhood Cancer
An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer
This is a first-in survivor pilot study with the goal of establishing preliminary evidence of efficacy, safety, and tolerability of two senolytic regimens to reduce markers of cellular senescence (primary outcome: p16^INK4a) and…
- Trial name
- NCT04733534
- Testing
- Dasatinib plus Quercetin, Fisetin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- St. Jude Children's Research Hospital
Childhood Cancer Survivor
Assessing the Acceptability of the Use of a Mobile Health App Among Young Adult Female Survivors of Childhood Cancer
The purpose of this research study is to understand if a mobile app is useful to assist young adult female survivors of childhood cancer in the self-management of survivorship-related needs.
- Trial name
- NCT03242200
- Testing
- Mobile Health App
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hypopituitarism, Hypogonadism
Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients
This study will determine the prevalence of endocrine-related side effects in children who have been treated for cancer and establish a database and registry organized according to cancer diagnosis, treatments and endocrine side…
- Conditions
- Hypopituitarism, Hypogonadism, Thyroid Dysfunction, Bone Diseases, Metabolic
- Trial name
- NCT00504218
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Survivors of Childhood Cancer
A Mobile Phone Intervention to Promote Adherence to Survivorship Care Among Adolescent and Young Adult Cancer Survivors
Adolescents and young adults (AYA) survivors of childhood cancer receive inadequate surveillance for treatment-related late effects.
- Trial name
- NCT05000359
- Testing
- text messaging intervention
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Cancer
A Web-Based Physical Activity Intervention in Adolescent Survivors of Childhood Cancer
Five year survival following a diagnosis of childhood cancer has reached 83%, making long term health outcomes among survivors an important concern.
- Trial name
- NCT01778127
- Testing
- Activity Monitor, Interactive Website, Educational Materials
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- St. Jude Children's Research Hospital
Childhood Cancer, Insomnia
eHealth Insomnia Intervention for Adult Survivors of Childhood Cancer
There is evidence that survivors of childhood cancer have a high prevalence of poor sleep, including symptoms of insomnia. Insomnia is highly comorbid and has been associated with impaired cognitive performance, a range of…
- Conditions
- Childhood Cancer, Insomnia, Neurocognitive Impairment, Survivorship
- Trial name
- NCT04317742
- Testing
- Sleep Healthy Using the Internet (SHUTi) Intervention Group, Online Patient Education (PE) Control Group
- Where
- United States
- Volunteers
- 1,554 people
- Sponsor
- St. Jude Children's Research Hospital
Autonomic Dysfunction, Childhood Cancer
Cardiac Autonomic Dysfunction in Childhood Cancer Survivors
This study is being done to evaluate heart rate activity and sleep patterns, among participants in the Long-Term Follow-Up (LTFU) study.
- Trial name
- NCT05132673
- Sponsor
- St. Jude Children's Research Hospital
Acute Lymphoblastic Leukemia, Transcranial Direct Current Stimulation
Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)
Brief Overview: Children and adolescents diagnosed with cancer will experience problems with learning, memory and attention during and after completing their cancer therapy.
- Conditions
- Acute Lymphoblastic Leukemia, Transcranial Direct Current Stimulation, Executive Dysfunction
- Trial name
- NCT04105530
- Testing
- Anodal tDCS treatment, Cathodal tDCS treatment, NIH Toolbox List Sorting Working Memory Test
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- St. Jude Children's Research Hospital
Childhood and Adolescence Cancer (Survivors and Deceased)
Cardiac and Vascular Late Sequelae in Long-term Survivors of Childhood Cancer (CVSS)
Due to remarkable advances in childhood cancer therapy the 10-year survival rate increased to over 80% and late sequelae come to the fore.
- Trial name
- CVSS (NCT02181049)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- CVSS study
Childhood Cancer
Multi-component Remote Assessment in Adult Survivors Using a Connected Technology Platform for Healthcare Delivery
This feasibility study evaluates a 12-week, multi-component remote assessment program for adult survivors of childhood cancer. The study aims to determine the participation and adherence rates to remote monitoring of…
- Trial name
- NCT07222358
- Testing
- Remote Monitoring Program
- Sponsor
- St. Jude Children's Research Hospital
Acute Lymphoblastic Leukemia
Family-Based Behavioral Treatment for Childhood Survivors of Acute Lymphoblastic Leukemia
A single-arm, non-randomized four-month trial of the adapted family-based behavioral weight loss treatment (FBT) intervention will be conducted to evaluate its acceptability, feasibility, and preliminary indications of efficacy…
- Trial name
- NCT05410574
- Testing
- Family-based Behavioral Weight Loss Treatment
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine