Clinical trials: Childhood Leukemia, Acute Lymphoblastic
Leukemia
Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Giving the drugs in different combinations may kill more cancer cells.
- Trial name
- NCT00022126
- Testing
- asparaginase, cyclophosphamide, cyclosporine
- Where
- 51 sites in United States, Australia and 1 more
- Volunteers
- 6 people
- Sponsor
- Children's Oncology Group
Leukemia
Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00430118
- Testing
- asparaginase, cyclophosphamide, cytarabine
- Where
- 76 sites in Austria, Germany and 1 more
- Volunteers
- 4,559 people
- Sponsor
- University Hospital Schleswig-Holstein
Pediatric ALL
Exploring the Minimum Effective Concentration and Volume of Ropivacaine for Sacral Plexus Anesthesia
The goal of this clinical trial is to explore the minimum effective concentration and volume of ropivacaine for sacral plexus anesthesia.
- Trial name
- NCT06711679
- Testing
- Low-dose ropivacaine, Medium-dose of ropivacaine, High-dose ropivacaine
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Yilin Zhao
Acute Lymphoblastic Leukemia (ALL)
A Pilot Study of Allopurinol As A Modifier of 6-MP Metabolism in Pediatric ALL
This research is being done to determine if allopurinol can change the metabolism of the oral chemotherapeutic medication 6-mercaptopurine (6-MP) in children with acute lymphoblastic leukemia (ALL).
- Trial name
- NCT02046694
- Testing
- Allopurinol
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Executive Functioning, Pediatric ALL
Effectiveness of EEG Neurofeedback in Pediatric Occupational Therapy to Improve Executive Functioning
EEG Neurofeedback is a noninvasive way that allows the central nervous system to self regulate and the frontal cortex to be accessed through quieting of the limbic system at the subcortical level.
- Trial name
- NCT04221620
- Testing
- Zengar Electroencephalogram (EEG) Neurofeedback device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northern Arizona University
Leukemia
Filgrastim-Treated Donor Peripheral Stem Cell Transplantation in Treating Patients With Acute Leukemia</p>
RATIONALE: Transplanted peripheral stem cells can sometimes be rejected by the body's tissues. Treating donor peripheral stem cells with filgrastim may increase the number of donor white blood cells.
- Trial name
- NCT00025545
- Testing
- cyclophosphamide, methotrexate, peripheral blood stem cell transplantation
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Anesthesia, Local, Ophthalmopathy
Comparison Between Peribulbar And Sub-tenon Blocks on Oculocardiac Reflex (OCR) During Pediatric Strabismus Surgery
The aim of this study is to compare between peribulbar block and subtenon block as an adjunct to general anesthesia in children undergoing strabismus surgery on oculocardiac reflex (OCR), post-operative analgesia and…
- Conditions
- Anesthesia, Local, Ophthalmopathy, Strabismus, Pediatric ALL
- Trial name
- NCT06293586
- Testing
- peribulbar block, sub-tenon block, Paracetamol
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cardiovascular Disease, Childhood ALL
Statin Therapy in Young Adult Survivors of Childhood Cancer
Adult survivors of childhood cancer are at high risk of developing cardiovascular disease. Therapies used to treat many cancers, such as chemotherapy and radiation, likely cause damage to the surface of the artery wall called the…
- Conditions
- Cardiovascular Disease, Childhood ALL, Childhood NHL
- Trial name
- NCT01733953
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Minnesota
Childhood Acute Lymphoblastic Leukemia in Remission, Recurrent Childhood Acute Lymphoblastic Leukemia
Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia
This phase II trial is studying how well combination chemotherapy with or without donor peripheral stem cell transplant works in treating children with acute lymphoblastic leukemia.
- Trial name
- NCT00022737
- Testing
- filgrastim, asparaginase, cyclophosphamide
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- National Cancer Institute (NCI)
Patient Participation, Pediatric ALL
Inclusion Appeal Videos and Intent to Register for Pediatric Clinical Trials
An informational video about joining a Research Notification Registry is being compared with a version of the video tailored to African/ African American parents, reminding them about the importance of their being included in…
- Trial name
- NCT06138145
- Testing
- Video, Survey
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Fracture Forearm, Pediatric ALL
Taking POSNA's OrthoKids to the People
The objective of this project is to determine the efficacy of a tablet-based educational intervention at improving orthopaedic health literacy amongst families of pediatric patients treated for fractures in an outpatient setting.
- Trial name
- NCT04996745
- Testing
- Tablet-based educational intervention
- Where
- United States
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Childhood Acute Lymphoblastic Leukemia, Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies
Lestaurtinib With or Without Chemotherapy Agents in Samples From Young Patients With Leukemia
This research study is studying lestaurtinib with or with chemotherapy in samples from young patients with leukemia. Studying the effects of lestaurtinib with or without chemotherapy in cell samples from patients with cancer in…
- Trial name
- NCT01150669
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Children's Oncology Group
Primary/Relapsed Acute Lymphoblastic Leukemia (ALL) of Childhood, Adolescents and Young Adults
Patient-individualized Peptide Vaccination Based on Tumor-specific Mutations in Children and Young Adults With Primary/Relapsed ALL
The aim of this clinical study is to evaluate the feasibility and safety of an individualized peptide vaccination approach in patients with acute lymphoblastic leukemia (ALL).
- Trial name
- NCT03559413
- Testing
- Individual peptide vaccination with adjuvant GM-CSF and Imiquimod
- Where
- 5 sites in Germany
- Volunteers
- 30 people
- Sponsor
- University Children's Hospital Tuebingen
Burns Elbows, Pediatric ALL
Effects of Virtual Reality in Pediatric Burn Patients
The aim of this randomized controlled trial is to find the effectiveness of Virtual reality as an adjunctive to transverse friction massage in pediatric burn patients for reducing pain, anxiety and enhancing elbow range of motion.
- Trial name
- NCT05973162
- Testing
- Virtual Realty Training, Transverse friction massage (TFM)
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia
Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children
This phase II trial studies how well T cell depleted donor peripheral blood stem cell transplant works in preventing graft-versus-host disease in younger patients with high risk hematologic malignancies.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia, Acute Leukemia of Ambiguous Lineage, Acute Undifferentiated Leukemia
- Trial name
- NCT01858740
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Fludarabine Phosphate, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Fred Hutchinson Cancer Center
Graft Versus Host Disease, Leukemia
Treatment of Single or Double Umbilical Cord Trans + Graft-versus-host Disease (GVHD) Prophylaxis w/ Tacrolimus & Mycophenolate Mofetil
RATIONALE: Giving chemotherapy and total-body irradiation before a donor umbilical cord blood transplant helps stop the growth of cancer and abnormal cells and helps stop the patient's immune system from rejecting the donor's…
- Conditions
- Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00608517
- Testing
- anti-thymocyte globulin, cyclophosphamide, fludarabine phosphate
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Leukemia
Studying Genes in Samples From Younger Patients With Acute Lymphoblastic Leukemia
RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01653613
- Testing
- DNA analysis, fluorescence in situ hybridization, gene expression analysis
- Volunteers
- 400 people
- Sponsor
- Eastern Cooperative Oncology Group
Surgery, Anesthesia, Local
Regional Anesthesia for Totally Awake Upper Limb Surgery in PEDiatric Population
Peripheral loco-regional anesthesia (LRA) for anesthetic purposes is a technique widely used in adults for upper limb surgery. In pediatrics, LRA is not classically considered on its own.
- Conditions
- Surgery, Anesthesia, Local, Pediatric ALL
- Trial name
- RATAPED (NCT04846855)
- Testing
- local anaesthetic injection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
T-cell Lymphoma, NK-Cell Lymphoma
A Registry for People With T-cell Lymphoma
The purpose of this registry study is to create a database-a collection of information-for better understanding T-cell lymphoma.
- Conditions
- T-cell Lymphoma, NK-Cell Lymphoma, T-cell Prolymphocytic Leukemia, T-cell Large Granular Lymphocytic Leukemia
- Trial name
- NCT05978141
- Testing
- Optional Blood Sample and Nail Sample
- Where
- 26 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Stem Cell Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy and radiation therapy used to kill tumor cells.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00004904
- Testing
- anti-thymocyte globulin, filgrastim, cladribine
- Where
- United States
- Sponsor
- Northwestern University