Clinical trials: Childhood Neoplasm
Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain
Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain
This phase I/II trial tests the safety, side effects, and best dose of universal donor UD TGFbetai natural killer (NK) cells, and whether UD TGFbetai NK cells with temozolomide works to shrink tumors in patients with stage IV…
- Conditions
- Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Pathologic Stage IV Cutaneous Melanoma AJCC v8
- Trial name
- NCT05588453
- Testing
- Natural Killer Cell Therapy, Temozolomide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Kari Kendra
Leukemia
Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00015873
- Testing
- asparaginase, cytarabine, mercaptopurine
- Where
- 33 sites in United States, Austria and 9 more
- Volunteers
- 350 people
- Sponsor
- Dutch Childhood Oncology Group
Colon Cancer, Lymph Node Metastasis
Italian Study on the Right Hemicolectomy: How the Lymphadenectomy is Performed
The objective of the study is the analysis of lymphadenectomy in the course of right hemicolectomy, in relation to the radicality of the surgical resection that is performed.
- Conditions
- Colon Cancer, Lymph Node Metastasis, Surgical Procedure, Unspecified
- Trial name
- CoDIG-2 (NCT05943951)
- Testing
- Right hemicolectomy
- Where
- 62 sites in Italy
- Volunteers
- 788 people
- Sponsor
- Gabriele Anania
Plasma Cell Neoplasm
Influenza Vaccination for Flu Prevention in Patients With Plasma Cell Disorders
This phase IV trial studies how well influenza vaccination works in preventing infections such as influenza in patients with plasma cell disorders.
- Trial name
- NCT04080531
- Testing
- Pneumococcal 13-valent Conjugate Vaccine, Trivalent Influenza Vaccine
- Where
- 2 sites in United States
- Volunteers
- 165 people
- Sponsor
- Emory University
Advanced or Metastatic Solid Tumor
Phase 1 Study of the Combination of Rogaratinib With Copanlisib in Patients With Fibroblast Growth Factor Receptor (FGFR)-Positive, Locally Advanced or Metastatic Solid Tumors
The primary objective of this study is to determine the safety, tolerability, maximum tolerated dose (MTD) or recommended Phase 2 dose (RP2D) and efficacy of rogaratinib in combination with copanlisib in patients with locally…
- Trial name
- ROCOCO (NCT03517956)
- Testing
- Rogaratinib (BAY1163877), Copanlisib (BAY80-6946)
- Where
- 20 sites in United States, Belgium and 4 more
- Volunteers
- 16 people
- Sponsor
- Bayer
Breast Cancer
Study of Etoposide in Treating Patients With Recurrent or Metastatic Breast Cancer
The purpose of this study is to determine whether Etoposide Monotherapy is effective and safe in the treatment of recurrent or metastatic breast cancer in Chinese female patients.
- Trial name
- NCT01492556
- Testing
- Etoposide
- Where
- 14 sites in China
- Volunteers
- 100 people
- Sponsor
- Chinese Academy of Medical Sciences
Metastatic Malignant Neoplasm to Brain
Safety Evaluation of a Combination of Brain Radiation Therapy and Bevacizumab (Avastin®) for Treatment of Brain Metastasis
This phase I pilot study aims to define the safety of a combined treatment of bevacizumab and whole brain radiation therapy for the treatment of patients with brain metastasis of solid tumors.
- Trial name
- NCT01332929
- Testing
- Bevacizumab
- Where
- 6 sites in France
- Volunteers
- 21 people
- Sponsor
- Centre Francois Baclesse
Leukemia, Lymphoma
Combination Chemotherapy and Bone Marrow Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00002502
- Testing
- busulfan, cyclophosphamide, cytarabine
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Recurrent Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone
Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer
This phase II trial studies how well surgery and radiation therapy work in treating patients with prostate cancer that has come back or spread to other parts of the body.
- Conditions
- Recurrent Prostate Carcinoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Lymph Nodes, Oligometastasis
- Trial name
- SOAR (NCT03796767)
- Testing
- Hypofractionated Radiation Therapy, Intensity-Modulated Radiation Therapy, Metastasectomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Medulloblastoma, Childhood, Recurrent, Atypical Teratoid/Rhabdoid Tumor
Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT
This is a three arm Phase I study within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). This study will look to determine the safety and recommended phase 2 dose of the modified measles virus (MV-NIS) in children and…
- Conditions
- Medulloblastoma, Childhood, Recurrent, Atypical Teratoid/Rhabdoid Tumor, Medulloblastoma Recurrent
- Trial name
- NCT02962167
- Testing
- Modified Measles Virus, Modified Measles Virus Lumbar Puncture
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Sabine Mueller, MD, PhD
Prostate Cancer
Oral VT-464 in Patients With Castration-Resistant Prostate Cancer Previously Treated With Enzalutamide, Androgen Receptor Positive Triple-Negative Breast Cancer Patients, and Men With ER Positive Breast Cancer
The goal of this clinical study is to determine the safety and efficacy of VT-464, a lyase-selective inhibitor of CYP17, in patients with castration-resistant prostate cancer (CRPC) who have been previously treated with…
- Trial name
- NCT02130700
- Testing
- VT-464: given orally twice daily in 28-day cycles, VT-464: given orally once daily in 28-day cycles
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Innocrin Pharmaceutical
Cholesteatoma, Middle Ear, Cholesteatoma, Residual
Comparison of Outcomes of Microscopic Mastoidectomy With and Without Check Endoscopy
Cholesteatoma is a serious otological condition and a major challenge for otolaryngologists worldwide. If left undetected and untreated, it can erode the surrounding bone, ear ossicles, facial nerve canal, bony labyrinth or…
- Trial name
- NCT07896200
- Testing
- Microscopic Mastoidectomy, Check Endoscopy
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Metastatic Neoplasm to the Spine, Metastatic Neoplasm
Spine Radiosurgery for Symptomatic Metastatic Neoplasms
The purpose of this study is to compare three types of radiation therapy for cancer that has spread to the spine. The two types of radiation therapy used in this trial are External Beam Radiation Therapy (EBRT) and Stereotactic…
- Trial name
- SPORTSMEN (NCT05617716)
- Testing
- Conventional external beam radiation therapy dose (EBRT), Spine radiosurgery/stereotactic body radiation therapy standard dose, Spine radiosurgery/stereotactic body radiation therapy high dose
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Oklahoma
Malignant Neoplasm
Multi-Tracer Positron Emission Tomography in Patients With Solid Tumors
This clinical trial studies multi-tracer positron emission tomography in patients with solid tumors. Diagnostic procedures, such as multi-tracer positron emission tomography, may help measure a patient's response to treatment.
- Trial name
- NCT01243333
- Testing
- [F-18]fluorodeoxyglucose, [F-18]fluorothymidine, Positron Emission Tomography
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Utah
Cancer, Cancer, Lung
A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors
The goal of this clinical trial is to test CPO301, a type of drug called an antibody drug conjugate in adult patients with advanced or metastatic solid tumors.
- Trial name
- NCT05948865
- Testing
- CPO301
- Where
- 14 sites in United States, Canada
- Volunteers
- 132 people
- Sponsor
- Conjupro Biotherapeutics, Inc.
Colon Cancer, Minimal Residual Disease
Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery
The aim of this study is to compare the effects of three types of perioperative analgesia on the number of circulating cancer cells (representing minimal residual disease) following radical colon cancer surgery.
- Trial name
- NCT02314871
- Testing
- Epidural analgesia, Piritramide, Morphine
- Where
- 2 sites in Czechia
- Volunteers
- 60 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Fertility Issues, Childhood Cancer
Fertility and Temporality in Pediatric Oncology
Background: When a cancer is diagnosed in a child, the urgency is to take therapeutic actions. Children and their families face the reality of cancer and the reality of the treatments that, in addition to be overwhelming, might…
- Conditions
- Fertility Issues, Childhood Cancer, Psychology, Social
- Trial name
- FERTITOP (NCT05048771)
- Testing
- Questionnaire
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Recurrent Neuroblastoma, Unspecified Childhood Solid Tumor, Protocol Specific
Decitabine, Doxorubicin, and Cyclophosphamide in Treating Children With Relapsed or Refractory Solid Tumors or Neuroblastoma
This phase I trial is studying the side effects and best dose of decitabine when given together with doxorubicin and cyclophosphamide in treating children with relapsed or refractory solid tumors or neuroblastoma.
- Trial name
- NCT00075634
- Testing
- decitabine, doxorubicin hydrochloride, cyclophosphamide
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Neoplasms
A Safety and Effectiveness Study of Aroplatin in Patients With Advanced Colorectal Cancer Resistant to Standard Therapies
To determine the rate of response and duration of reponse following therapy with Aroplatin in subjects with advanced colorectal cancer resistant to standard therapies.
- Trial name
- NCT00043199
- Testing
- Aroplatin (Liposomal NDDP, L-NDDP)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Aronex Pharmaceuticals
Colorectal Cancer
Study of FOLFIRI Plus Cetuximab Plus IMO-2055 in Patients With Colorectal Cancer
Open-label phase 1b trial. Study treatment will be administered in 3 week cycles. There are two distinct parts in this study: Part 1: Dose escalation from IMO-2055 Part 2: Once a recommended phase 2 dose is found additional…
- Trial name
- NCT00719199
- Testing
- IMO-2055, Cetuximab, FOLFIRI
- Where
- 5 sites in United States
- Volunteers
- 21 people
- Sponsor
- EMD Serono
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.