Clinical trials: Childhood and Adolescent Cancer
Adolescent Cancer Survivors, Childhood Cancer Survivors
IMpact of Mind-body Therapies (HYpnosis and Relaxation) on Anxiety in Children, Adolescents and Young Adults Who Had Been Treated in ONcology. Multicenter Study.
In France today, it is estimated that one in 850 people aged between 20 and 45 has been cured of cancer in childhood. Some descriptive studies have established that cancer diagnosis and treatment can affect psychological health…
- Conditions
- Adolescent Cancer Survivors, Childhood Cancer Survivors, Anxiety
- Trial name
- HARMONY-Impact (NCT07380672)
- Testing
- 10 mind-body therapy sessions (hypnosis or relaxation, depending on the patient's choice), 9 sessions of standard psychological care
- Where
- 5 sites in France
- Volunteers
- 558 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ototoxicity, Drug-Induced, Ototoxicity, Radiation-Induced
Analysis of Risk Factors for Hearing Loss in Survivors of Cancer Occurred During Childhood, Adolescence or Young Adulthood
This study is aimed at people treated for cancer before the age of 25, who have been followed for at least 5 years, and who are now aged between 18 and 50. It is a prospective, multicenter, non-randomized study.
- Conditions
- Ototoxicity, Drug-Induced, Ototoxicity, Radiation-Induced, Pediatric Cancer
- Trial name
- RISP-OTOTOX (NCT06957132)
- Testing
- Audiogram
- Where
- 3 sites in France
- Volunteers
- 500 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study
This clinical trial tests the impact of a culturally-tailored home-based physical activity program on physical fitness in Hispanic or Latino/Latina adolescent and young adult (AYA) childhood cancer survivors.
- Trial name
- NCT06410209
- Testing
- Discussion, Goal Setting, Interview
- Where
- 77 sites in United States, Puerto Rico
- Volunteers
- 190 people
- Sponsor
- Children's Oncology Group
Acute Lymphoblastic Leukemia
Hemostasis During Asparaginase Treatment in Acute Lymphoblastic Leukemia(ALL)
Asparaginase is an important drug in the treatment of childhood leukemia. One of the rare but severe side effects to the treatment is thrombosis in or outside the central nervous system.
- Trial name
- NCT01094392
- Where
- 4 sites in Denmark
- Volunteers
- 65 people
- Sponsor
- Aarhus University Hospital
Childhood Solid Tumor
Nivolumab in Combination With Metronomic Chemotherapy in Paediatrics Refractory / Relapsing Solid Tumors
The study is a two-stage trial: 1. First stage (closed - 16 patients recruited in France): Phase I feasibility trial to evaluate the safety of the combination of Nivolumab + metronomic chemotherapy considering three possible…
- Trial name
- Metro-PD1 (NCT03585465)
- Testing
- Vinblastine, Cyclophosphamide, Capecitabine
- Where
- 11 sites in Belgium, France
- Volunteers
- 63 people
- Sponsor
- Centre Oscar Lambret
Leukemia
AT9283 in Treating Young Patients With Relapsed or Refractory Acute Leukemia
RATIONALE: AT9283 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I/IIa clinical trial is studying the side effects and best dose of AT9283 in treating young…
- Trial name
- NCT01431664
- Testing
- multikinase inhibitor AT9283, laboratory biomarker analysis, pharmacological study
- Where
- 5 sites in United Kingdom
- Volunteers
- 7 people
- Sponsor
- Cancer Research UK
Childhood Cancer, Childhood Solid Tumor
PRecISion Medicine for Children With Cancer
This is a multicentre prospective study of the feasibility and clinical value of a diagnostic service for identifying therapeutic targets and recommending personalised treatment for children and adolescents with high-risk cancer.
- Conditions
- Childhood Cancer, Childhood Solid Tumor, Childhood Brain Tumor, Childhood Leukemia
- Trial name
- PRISM (NCT03336931)
- Testing
- Molecular profiling and drug testing
- Where
- 8 sites in Australia
- Volunteers
- 550 people
- Sponsor
- Sydney Children's Hospitals Network
Pediatric Cancer
ATOMIC Mobile App to Increase Physical Activity (PA) Levels in Survivors of Childhood Cancer
Development and Usability Testing of the ATOMIC Mobile App to Increase Physical Activity (PA) Levels in Children, Adolescent and Young Adults (AYA) survivors of childhood cancer
- Trial name
- NCT05792566
- Testing
- Atomic app
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Connecticut Children's Medical Center
Lymphoma
Combination Chemotherapy in Treating Pediatric Patients With Advanced-Stage Large Cell Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Giving the drugs in different doses may kill more cancer cells.
- Trial name
- NCT00002618
- Testing
- filgrastim, cytarabine, doxorubicin hydrochloride
- Where
- 10 sites in United States, Puerto Rico and 1 more
- Volunteers
- 242 people
- Sponsor
- Children's Oncology Group
Childhood Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2019 Pilot
THE PURPOSE OF THE STUDY is to optimize the therapy of patients with primary B-cell precursor acute lymphoblastic leukemia (BCP-ALL) by including monoclonal bispecific antibodies in post-induction treatment with simultaneous…
- Trial name
- NCT04723342
- Testing
- Blinatumomab
- Where
- 4 sites in Russia
- Volunteers
- 180 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Sarcoma, Central Nervous System Tumor
Dendritic Cell-based Immunotherapy for Advanced Solid Tumours of Children and Young Adults
Phase I/II, open, prospective clinical trial, historically controlled. The objective is to evaluate the safety and, as a secondary measure, the efficacy of an experimental treatment based on a cellular therapy (vaccination with…
- Trial name
- DEND/TIA (NCT02496520)
- Testing
- dendritic cells, Surgery as needed by the patient´s tumor and stage, Chemotherapy as needed by the patient´s tumor and stage
- Where
- Spain
- Volunteers
- 6 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Generalized Anxiety, Introspective & Anxiety-Prone Patient
Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study.
In France today, it is estimated that one in every 850 people aged between 20 and 45 is a childhood cancer survivor (CCS), equivalent to around 40,000 to 50,000 people.
- Conditions
- Generalized Anxiety, Introspective & Anxiety-Prone Patient, Depression, Anxiety, Survivors of Childhood Cancer
- Trial name
- HARMONY-Tool (NCT07117058)
- Testing
- New rapid screening tool for anxiety and depressive disorders, SCARED-R-51 (Screen for Child Anxiety Related Emotional Disorders-Revised), HADS (Hospital Anxiety and Depression Scale)
- Where
- 7 sites in France
- Volunteers
- 545 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sarcoma
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Metastatic Rhabdomyosarcoma or Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003955
- Testing
- dactinomycin, filgrastim, pegfilgrastim
- Where
- 237 sites in United States, Australia and 5 more
- Volunteers
- 77 people
- Sponsor
- Children's Oncology Group
Oral Mucositis, Chemotherapeutic Toxicity
Comparison of Prophylactic Photobiomodulation Protocols in Chemoinduced Oral Mucositis in Oncology Patients
Childhood cancers represent less than 1% of the malignant diseases diagnosed worldwide. Treatment modalities for childhood malignancies will differ depending on the diagnosis.
- Conditions
- Oral Mucositis, Chemotherapeutic Toxicity, Childhood Cancer
- Trial name
- NCT05811195
- Testing
- Diode Semiconductor, Duo, Gemini laser
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Federal University of Rio Grande do Sul
Childhood Brain Tumor
International HIT-MED Registry (I-HIT-MED)
The I-HIT-MED registry registers clinical of children and adults with medulloblastoma, ependymoma, pineal tumours, or choroid plexus tumours in Germany and other countries that fulfil national ethic requirements for participation…
- Trial name
- NCT02417324
- Where
- 57 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Brain and Central Nervous System Tumors
Carboplatin Plus Vincristine in Treating Children and Adolescents With Low Grade Glioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003015
- Testing
- carboplatin, vincristine sulfate, conventional surgery
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 200 people
- Sponsor
- Societe Internationale d'Oncologie Pediatrique
Childhood and Adolescence Cancer (Survivors and Deceased)
Cardiac and Vascular Late Sequelae in Long-term Survivors of Childhood Cancer (CVSS)
Due to remarkable advances in childhood cancer therapy the 10-year survival rate increased to over 80% and late sequelae come to the fore.
- Trial name
- CVSS (NCT02181049)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- CVSS study
Brain and Central Nervous System Tumors
Tumor Tissue, Blood Samples, and Family History in Predicting Tumor Development and Response to Treatment in Young Patients With Low-Grade Glioma
RATIONALE: Studying samples of tumor tissue and blood in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00891722
- Testing
- biologic sample preservation procedure, laboratory biomarker analysis, questionnaire administration
- Where
- United Kingdom
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Children's Cancer and Leukaemia Group
Childhood Fibrolamellar Carcinoma, Recurrent Childhood Fibrolamellar Carcinoma
Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma
This phase I/II trial tests the safety, side effects and best dose of DT2216 in combination with irinotecan and how well it works in treating children, adolescents and young adults with solid tumors and fibrolamellar cancer that…
- Conditions
- Childhood Fibrolamellar Carcinoma, Recurrent Childhood Fibrolamellar Carcinoma, Recurrent Childhood Malignant Solid Neoplasm, Recurrent Fibrolamellar Carcinoma
- Trial name
- NCT06620302
- Testing
- Bcl-XL Proteolysis Targeting Chimera DT2216, Biospecimen Collection, Irinotecan
- Where
- 21 sites in United States
- Volunteers
- 81 people
- Sponsor
- Children's Oncology Group
Brain and Central Nervous System Tumors
Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00278278
- Testing
- cisplatin, etoposide, ifosfamide
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- German Society for Pediatric Oncology and Hematology GPOH gGmbH