Clinical trials: Childhood and Adolescent Cancer
Diffuse Intrinsic Pontine Glioma, DIPG
Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).
This study will evaluate BCB-276, an investigational B7-H3-targeted Chimeric Antigen Receptor (CAR) T cell therapy, in children and young adults with diffuse intrinsic pontine glioma (DIPG).
- Conditions
- Diffuse Intrinsic Pontine Glioma, DIPG, Brain Tumor, CNS Tumor
- Trial name
- NCT07680439
- Testing
- BCB-276
- Where
- 6 sites in United States
- Volunteers
- 75 people
- Sponsor
- BrainChild Bio, Inc
Exercise, Childhood Cancer
POZIKIDS: Exercise and Comprehensive Care to Improve the Quality of Life of Children and Adolescents With Cancer
Objective: To assess the feasibility of a supervised, controlled and personalised physical exercise programme and its potential efficacy in improving functional capacity and quality of life in children and adolescents with…
- Trial name
- PoziKids (NCT06321016)
- Testing
- Physical exercise program, Type of the physical exercise program
- Volunteers
- 45 people
- Sponsor
- Nere Mendizabal
Neuroblastoma, Rhabdomyosarcoma
Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO)
Methodology: Prospective, multicentric, open, non-randomised, non-therapeutic, interventional study
- Conditions
- Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, Osteosarcoma
- Trial name
- MICCHADO (NCT03496402)
- Testing
- Sampling on blood, bone marrow and cerebrospinal fluid
- Where
- 30 sites in France
- Volunteers
- 600 people
- Sponsor
- Institut Curie
Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma
CAYA Cancer Retrospective Cohort Study
Despite advances in cancer treatment, significant disparities in outcomes persist between high-income countries (HICs) and low-and middle-income countries (LMICs).
- Conditions
- Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Young Adult Cancer, Adolescent Cancer
- Trial name
- NCT07246213
- Testing
- Retrospective Medical Record Review
- Where
- 7 sites in Armenia, Egypt and 4 more
- Volunteers
- 18,000 people
- Sponsor
- Resonance, Inc.
Childhood Cancer, Social Behavior
Social Experiences of Adolescents and Young Adults With Cancer
Participants are being asked to take part in this clinical trial, a type of research study, because investigators want to learn more about the social experiences adolescents and young adults who are being treated or have been…
- Conditions
- Childhood Cancer, Social Behavior, Social Competence
- Trial name
- NCT04328350
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- St. Jude Children's Research Hospital
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Mobile Health and Social Media Physical Activity Intervention Among Adolescent and Young Adult Childhood Cancer Survivors, the StepByStep Study
This phase III trial compares a multi-component mobile health and social media physical activity intervention versus wearing a physical activity tracker alone among adolescent and young adult childhood cancer survivors.
- Trial name
- NCT04089358
- Testing
- Educational Intervention, FitBit, Goal Setting
- Where
- 116 sites in United States, Canada
- Volunteers
- 387 people
- Sponsor
- Children's Oncology Group
Solid Tumor, Adult, Solid Tumor, Childhood
Evaluation of the Impact of Chemotherapy on Body Odor in Adolescents and Young Adults in Oncology
The appearance of unpleasant body odors in adolescent Young adult (aya) wille be evaluated undergoing chemotherapy
- Conditions
- Solid Tumor, Adult, Solid Tumor, Childhood, Chemotherapy Effect
- Trial name
- ODORAJA (NCT04899505)
- Testing
- Evaluation on appearance of unpleasant body odors
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Institut Curie
Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)
QUESTIONS AND OBJECTIVES OF ALL-MB 2015 STUDY 1. Will the new risk group stratification (especially of T-ALL) to improve overall and event-free survival? 2.
- Trial name
- ALL-MB 2015 (NCT03390387)
- Testing
- Dexamethasone continuous, Dexamethasone intermittent, Dexamethasone
- Where
- 58 sites in Armenia, Belarus and 3 more
- Volunteers
- 4,000 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Lymphoma
Surgery Alone or With CYC VBL and PRED or CVP Alone in Stage IA or IIA Nodular Lymphocyte-Predominant Hodgkin Lymphoma
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, vinblastine, and prednisolone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EuroNetLP1 (NCT01088750)
- Testing
- cyclophosphamide, prednisolone, vinblastine sulfate
- Where
- Germany
- Volunteers
- 225 people
- Sponsor
- Christine Mauz-Körholz
Primary Central Nervous System Neoplasms
Radiation Therapy or Combination Chemotherapy in Treating Patients With Clinically or Radiologically Progressive Low-Grade Gliomas
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- SIOP-LGG-2004 (NCT00276640)
- Testing
- vincristine, carboplatin, vincristine, carboplatin, etoposide, radiation therapy
- Where
- 13 sites in Austria, Belgium and 10 more
- Volunteers
- 3,417 people
- Sponsor
- Societe Internationale d'Oncologie Pediatrique
Glioma, CNS Tumor, Adult
Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors
This clinical trial is a 2-phase trial designed to evaluate the safety of tarlatamab in combination with a fixed dose of metronomic temozolomide in adolescents and adults with CNS tumors (stratified into two age-based cohorts)…
- Conditions
- Glioma, CNS Tumor, Adult, CNS Tumor, Childhood
- Trial name
- TARLATEM (NCT07243470)
- Testing
- Tarlatamab, Temozolomide (TMZ)
- Where
- 12 sites in France
- Volunteers
- 70 people
- Sponsor
- Centre Leon Berard
Pediatric Cancer, Cancer
UNC Childhood, Adolescent, and Young Adult Cancer Cohort
Purpose: This study aims to create a registry of childhood, adolescent, and young adult patients with cancer (<40 years-old at cancer diagnosis), entitled the 'UNC Childhood, Adolescent, and Young Adult Cancer Cohort'…
- Conditions
- Pediatric Cancer, Cancer, Cancer Metastatic, Survivorship
- Trial name
- UNC-CAYACC (NCT05096923)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Childhood Cancer
ADLs at the End of Acute Treatment for Childhood Leukemia and Non-Hodgkin Lymphoma
Reduced activity levels and reduced muscular strength could severely impair the activities of daily living (ADLs) in pediatric leukemia and Non-Hodgkin lymphoma patients.
- Trial name
- NCT05235633
- Testing
- Assessment of the accomplishment regarding Activities of Daily Living at the end of acute treatment
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Obesity, Childhood, Diabetes Mellitus, Type 2
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort study is a unique and comprehensive longitudinal study of 630 Caucasian children and their parents that was designed to investigate the natural history and…
- Conditions
- Obesity, Childhood, Diabetes Mellitus, Type 2, Cardiovascular Risk Factor, Pediatric ALL
- Trial name
- QUALITY (NCT03356262)
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Cancer, Treatment-Related, Late Effect
Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors
Cancer treatment can affect the testicular function, including sperm and hormonal functions. The aim of this study is to assess the testicular function and semen quality in young men who recover from childhood and adolescent…
- Conditions
- Cancer, Treatment-Related, Late Effect, Semen Analysis
- Trial name
- NCT06587477
- Testing
- Hormonal profile, Semen analysis, Questionnaire
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Childhood Brain Tumor
KEYS to Succeed: Cognitive and Academic Intervention Program for Children and Adolescents Surviving Cancer
The study will examine whether school liaison services and home-based parental tutoring can help with academic difficulties of paediatric brain tumour survivors who received cranial spinal radiation and have returned to school.
- Trial name
- NCT02573441
- Testing
- Jump Math, Cogmed, Liaison Services
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- The Hospital for Sick Children
Childhood Hematopoietic and Lymphatic System Neoplasm, Childhood Malignant Solid Neoplasm
Attention Bias Modification for the Improvement of Anxiety in Adolescent and Young Adult Cancer Survivors
This clinical trial studies how well attention bias modification (ABM) improves anxiety in adolescent and young adult (AYA) cancer survivors.
- Trial name
- NCT06682039
- Testing
- Internet-Based Intervention, Interview, Questionnaire Administration
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Fred Hutchinson Cancer Center
Childhood Cancer
Rehabilitation Including Social and Physical Activity in Children and Teenagers With Cancer
The purpose of this study is to determine whether early rehabilitation intervention including individualized physical training and social activities with a class mate at two weeks intervals at the ped.onc.
- Trial name
- RESPECT (NCT01772862)
- Testing
- Intervention group
- Where
- Denmark
- Volunteers
- 240 people
- Sponsor
- Kjeld Schmiegelow
Recurrent Childhood Neuroblastoma, Recurrent Childhood Osteosarcoma
Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, GD2-CAR PERSIST Trial
This phase I trial investigates the side effects and determines the best dose of an immune cell therapy called GD2CART, as well as how well it works in treating patients with osteosarcoma or neuroblastoma that has come back…
- Conditions
- Recurrent Childhood Neuroblastoma, Recurrent Childhood Osteosarcoma, Recurrent Neuroblastoma, Recurrent Osteosarcoma
- Trial name
- NCT04539366
- Testing
- Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration
- Where
- 6 sites in United States
- Volunteers
- 73 people
- Sponsor
- National Cancer Institute (NCI)
Childhood Cancer Survivors
Physical Activity Post-Cancer for Adolescents and Young Adults
The Physical Activity Post-Cancer for Adolescents and Young Adults (PAPAYA) trial aims to carry out a pilot randomized controlled trial among 10-17 year-old adolescents and young adults, at least 1 year and up to 5 years…
- Trial name
- PAPAYA (NCT04947709)
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milton S. Hershey Medical Center