Clinical trials: Children, Adolescents
Headache Disorders, Migraine Disorders
Intervention for Sleep and Pain in Youth
This study tests the feasibility, acceptability, and preliminary efficacy of a seven-session cognitive-behavioral therapy intervention to treat sleep and pain problems in youth ages 11-17 with co-morbid headache and insomnia.
- Conditions
- Headache Disorders, Migraine Disorders, Insomnia
- Trial name
- I-SPY (NCT03137147)
- Testing
- Intervention for Sleep and Pain in Youth
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Seattle Children's Hospital
Autism, Attention Deficit Hyperactivity Disorder
Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD
An open label trial to assess the safety and efficacy of transcranial photobiomodulation (tPBM) in improving autistic traits in ADHD youth.
- Trial name
- NCT04569058
- Testing
- Transcranial Photobiomodulation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Massachusetts General Hospital
Cognitive Behavioral Therapy, Autism Spectrum Disorder
Internet-Based, Parent-Led Cognitive-Behavioral Therapy for Anxiety in Youth With ASD
This study compares the effectiveness of two levels of therapist support for an internet-based, parent-led cognitive behavioral therapy for youth with anxiety and ASD.
- Conditions
- Cognitive Behavioral Therapy, Autism Spectrum Disorder, Anxiety Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT05284435
- Testing
- Cognitive Behavioral Therapy-Email (iCBT-E), Cognitive Behavioral Therapy-Email and Videoconferencing (iCBT-EV)
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Baylor College of Medicine
Duchenne Muscular Dystrophy
An Open-Label, Long-Term Extension Study to Evaluate the Safety and Tolerability Deflazacort
This is an open label, long-term extension study in approximately 24 male DMD subjects consisting of children (ages 4-12, inclusive) and adolescents (ages 13-16, inclusive) who participated in the MP-104-CL-005 PK study.
- Trial name
- NCT02295748
- Testing
- Deflazacort
- Where
- 4 sites in United States
- Volunteers
- 24 people
- Sponsor
- PTC Therapeutics
Asperger's Disorder, Pervasive Developmental Disorder
A Study of Aripiprazole in Children and Adolescents With Aspergers and Pervasive Developmental Disorder.
The purpose of this study is to develop a better tolerated and more effective pharmacologic treatment for individuals with Asperger's Disorder and Pervasive Developmental Disorder.
- Trial name
- NCT00198055
- Testing
- aripiprazole
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Indiana University
Shigella Infection
Safety and Immunogenicity Study of IP-QSV Vaccine in Healthy Adults/Adolescents, Children and Infants
The goal of this phase 1/2a, randomized, observer-blind, age-descending, dose-finding trial is to evaluate the safety and immunogenicity of a quadrivalent synthetic oligosaccharide-based Shigella vaccine (adjuvanted IP-QSV) in…
- Trial name
- NCT07666750
- Testing
- 30μg IP-QSV, 10μg IP-QSV, 2μg IP-QSV
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Bipolar Spectrum Disorder
Open-Label Comparative Study of Risperidone Versus Olanzapine Versus Quetiapine for Mania in Children and Adolescents With Bipolar I and Bipolar II Disorder
The objective of this study is to compare the safety and effectiveness of Risperidone, Olanzapine, and Quetiapine in the treatment of mania in children and adolescents with Bipolar disorder over 8 weeks and then over an extension…
- Trial name
- NCT00182013
- Testing
- Risperidone, Olanzapine, Quetiapine
- Volunteers
- 106 people
- Sponsor
- Massachusetts General Hospital
Adverse Bone Health, HIV Infection
Calcium and High-dose Vitamin D Supplementation on Bone Mineral Density Among HIV-infected Children and Adolescents
Since there is no cure for HIV, therefore antiretroviral therapy must be taken life-long. Some of the HIV medications can negatively impact the health of the bone and is even more exacerbated in perinatally HIV-injected children…
- Trial name
- CAL-D (NCT02426840)
- Testing
- High dose vitamin D and calcium, Normal dose vitamin D and calcium
- Where
- 5 sites in Thailand
- Volunteers
- 200 people
- Sponsor
- Chiang Mai University
Fibrodysplasia Ossificans Progressiva, FOP
A Study to Investigate the Safety, Pharmacokinetics (PK), and Efficacy of Garetosmab in Children and Adolescents With Fibrodysplasia Ossificans Progressiva (FOP)
This study is researching an experimental drug called garetosmab, referred to as "study drug". The study is focused on children and adolescent participants with FOP.
- Trial name
- OPTIMA-2 (NCT07559513)
- Testing
- garetosmab
- Volunteers
- 18 people
- Sponsor
- Regeneron Pharmaceuticals
Obesity, Childhood, Pediatric Obesity
Treatment Efforts Addressing Child Weight Management by Unifying Patients, Parents & Providers
The US Preventive Services Task Force (USPSTF) recommends that providers screen children aged 6 years and older for obesity and offer or refer them to a comprehensive behavioral intervention (≥26 hours over a period of up to 12…
- Conditions
- Obesity, Childhood, Pediatric Obesity, Childhood Obesity, Adolescent Obesity
- Trial name
- TEAM UP (NCT03843424)
- Testing
- eSOC program, FBT program
- Where
- 7 sites in United States
- Volunteers
- 1,460 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Malaria, Falciparum
Chlorproguanil-Dapsone-Artesunate (CDA) Versus Chlorproguanil-Dapsone (LAPDAP) For Uncomplicated Malaria
CDA is a combination of chlorproguanil, dapsone and artesunate, being developed in a public-private partnership with the Medicines for Malaria Venture (MMV), World Health Organisation (WHO-TDR) and academic partners from the…
- Trial name
- NCT00371735
- Testing
- chlorproguanil-dapsone-artesunate, chlorproguanil-dapsone
- Where
- 7 sites in Burkina Faso, Ghana and 2 more
- Volunteers
- 900 people
- Sponsor
- GlaxoSmithKline
Migraine Disorders
A Pilot Clinical Trial of a New Neuromodulation Device for Acute Attacks of Migraine in Children and Adolescents
Migraine is a neurological disease characterized by severe and recurrent headaches. Children and adolescents with migraine often present to the emergency department (ED) with acute attacks, where migraine accounts for up to ~30%…
- Trial name
- NCT05102591
- Testing
- Ketorolac, Metoclopramide, Active Remote Electrical Neuromodulation Device
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Calgary
Eating Disorder, Anorexia
Adaptive Treatment for Adolescent Anorexia Nervosa
The investigators are conducting a randomized controlled trial using an adaptive design for adolescents (ages 12-18) with anorexia nervosa to compare standard Family Based Treatment (FBT) to adaptive FBT with an Intensive…
- Conditions
- Eating Disorder, Anorexia, Anorexia Nervosa, Anorexia in Adolescence
- Trial name
- NCT03097874
- Testing
- Family Based Treatment, Family Based Treatment + Intensive Parental Coaching
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Stanford University
Cerebral Palsy, Acquired Brain Injury
Proof of Concept of Pediatric and Adolescent EXPLORER V2 Exoskeleton in Children With Neurological and Neuromuscular Disease
The goal of this clinical trial is to analyze the usability and safety of the prototype gait exoskeleton EXPLORE V2 in children with neurological and neuromuscular disease.
- Conditions
- Cerebral Palsy, Acquired Brain Injury, Neuromuscular Diseases in Children
- Trial name
- NCT05914818
- Testing
- EXPLORER V2
- Where
- 5 sites in Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- MarsiBionics
Autism Spectrum Disorder, Attention-deficit Hyperactivity Disorder
Autism Spectrum Disorder or Attention Deficit Hyperactivity Disorder in Covid-19 Outbreak
In response to the coronavirus disease 2019 (covid-19) outbreak, the home confinement of the population ordered by governments in many countries raise questions about its impact on individuals' physical and mental health in the…
- Trial name
- CLIECO (NCT04416360)
- Testing
- Interview by psychologists
- Where
- 5 sites in France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Toulouse
Lead Poisoning
Early Exposure to Lead and Adolescent Development
This prospective cohort study examines the role of prenatal and early postnatal lead exposure on the neuropsychological status and social adjustment of adolescents enrolled in the Cincinnati Lead Study.
- Trial name
- NCT00011674
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Autism Spectrum Disorder (ASD)
TeleABA for Hospitalized Adolescents and Young Adults With Autism Spectrum Disorder
This study is evaluating whether a telehealth-based applied behavior analysis (ABA) program can improve the care of adolescents and young adults with autism spectrum disorder (ASD) who are hospitalized because of severe…
- Trial name
- NCT07701915
- Testing
- Standard Hospital Care, Telehealth Applied Behavior Analysis (TeleABA)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Caring Technologies, Inc.
Visual Impairments
Effects of Reformer Pilates and Vestibular Exercise Programs on Balance and Gait in Children With Visual Impairment
This study looks at whether Reformer Pilates can help children and adolescents with visual impairment improve their balance, walking patterns, and muscle strength. Participants are between 10 and 17 years old.
- Trial name
- NCT07789691
- Testing
- Equipment-Based Pilates Exercise (Reformer), Vestibular Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Cerebral Palsy, Ankle Foot Orthosis (AFO)
3D Printed Orthotics in Children Adolescents
PRINT is a prospective mixed methods study exploring the feasibility and acceptability of providing 3-D printed orthotics specifically an ankle foot orthosis (AFO) to children and adolescents with cerebral palsy.
- Trial name
- PRINT (NCT03770949)
- Testing
- 3-D Printed Orthotic (Ankle Foot Orthosis)
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Barts & The London NHS Trust
Cerebral Palsy (CP)
Promotion of a Physically Active Lifestyle in Cerebral Palsy
There is increasing evidence that physical activity during childhood and adolescence has an important impact on health and behavior outcomes.
- Trial name
- NCT00940706
- Testing
- TreadMill, Physical activity in groups, Monitoring physical activity
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Assaf-Harofeh Medical Center
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