Clinical trials: Children, Adolescents
Hemorrhagic Cystitis
Evaluation of the Safety and Efficacy of LB-DTK-BKV in Patients With BK Virus-Associated Hemorrhagic Cystitis Following Allogeneic Hematopoietic Stem Cell Transplantation
The goal of this clinical trial is to assess efficacy of BK virus specific T cells (LB-DTK-BKV) to treat pediatric, adolescent, and adult patients with BK virus-associated hemorrhagic cystitis after allogenic hematopoietic stem…
- Trial name
- NCT07638332
- Testing
- LB-DTK-BKV, Standard-of-care
- Where
- 9 sites in South Korea
- Volunteers
- 42 people
- Sponsor
- LucasBio
Seasonal Allergic Rhinitis, Seasonal Allergic Conjunctivitis
Safety and Efficacy of Ectoin Allergy Nasal Spray and Ectoin Allergy Eye Drops in the Treatment of Seasonal Allergic Rhinitis (SAR) in Children and Adolescents
Ectoin acts on membranes by forming an Ectoin-Hydro-Complex therewith providing a protection against external agents like aeroallergens.
- Trial name
- NCT01342601
- Testing
- ect4allergy Nasal Spray (ANS01) and Eye Drops (AAT01)
- Where
- 8 sites in Germany
- Volunteers
- 72 people
- Sponsor
- Bitop AG
Conduct Disorders in Adolescence, Oppositional Defiant Disorder
Is Mentalization-based Therapy More Effective Than Treatment-as-usual for Adolescents With Dissocial Disorders?
The goal of this clinical trial is to investigate if Mentalization-based therapy (MBT) is superior to enhanced usual care (treatment-as-usual-plus (TAU-plus)) for adolescents with disruptive behavior or dissocial disorders.
- Trial name
- MEDAL (NCT07181928)
- Testing
- Mentalization-Based Therapy (MBT), Treatment-as-usual-plus (TAU-plus)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Heidelberg
Myopia, Esophoria
Bifocal Soft Contact Lenses and Their Effect on Myopia Progression in Children and Adolescents.
The purpose of this study is to determine whether bifocal soft contact lenses are effective in controlling the progression of myopia in children and adolescents that exhibit a tendency to excessively cross their eyes while…
- Conditions
- Myopia, Esophoria, Fixation Disparity
- Trial name
- NCT00214487
- Testing
- Bifocal Contact Lenses
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Aller, Thomas A., OD
Celiac Disease, Celiac Disease in Children
Effects of A2 Dairy Consumption in Celiac Adolescents
The goal of this clinical trial is to evaluate the effect of A2 β-casein-containing milk and dairy product consumption on nutritional status, gastrointestinal symptoms, quality of life, sleep quality, and selected biochemical…
- Conditions
- Celiac Disease, Celiac Disease in Children, A2 β-casein-containing Milk and Dairy Products
- Trial name
- NCT07815821
- Testing
- A2 β-casein milk and dairy products, Standard milk and dairy products
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Halic University
Cough, Acute
Bromelin, a Compound Prepared With Ananas Comocus Extract and Honey, for Acute Cough
Cough is the most bothersome symptom for patients with the common cold. The objective of the study is to compare the phytotherapic "Bromelin", a compound preparation of honey from the bee apis mellifera with the extract of the…
- Trial name
- BROMETOSS (NCT01356693)
- Testing
- Bromelin
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- Universidade Federal de Pernambuco
Irritability Associated With Autism Spectrum Disorder
Brexpiprazole in Treatment of Children and Adolescents With Irritability Associated With Autism Spectrum Disorder for Subjects That Have Completed Participation in 331-201-00148
The purpose of this study is to evaluate the long-term safety and tolerability of brexpiprazole in children and adolescent participants, aged 5 to 17, with irritability associated with autism spectrum disorder.
- Trial name
- NCT04258839
- Testing
- Brexpiprazole
- Where
- 28 sites in United States
- Volunteers
- 95 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Virtual Reality, Children and Adolescents
Evaluation of the Efficacy of a Virtual Reality When Placing a Needle on an Implantable Venous Access Device in Children With Leukemia
Main objective: Evaluate the effectiveness of the repeated use of interactive or hypnotic virtual reality compared to standard treatment, on pain, during each needle placement on PAC for 3 months on children or adolescents (6 to…
- Conditions
- Virtual Reality, Children and Adolescents, Acute Leukemia, Anxiety and Fear
- Trial name
- LEAVE (NCT06697275)
- Testing
- Hypnotic Virtual reality, Interactive virtual reality, Standard method
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Essential Hypertension
A Phase III Clinical Study of Valsartan Oral Solution for the Treatment of Hypertension in Children and Adolescents
This study was an randomized, double-Blind, placebo-controlled, multicenter Phase II/III study.
- Trial name
- NCT06863987
- Testing
- Valsartan Oral Solution
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Child Malnutrition, Behavior, Maternal
Mobile Gaming App to Improve Child Nutrition in Nigeria
Undernutrition among children born to teenage mothers deserves urgent attention in Nigeria, where 27.2% of girls (15-19 years) living in rural areas have begun childbearing.
- Trial name
- NCT05181293
- Testing
- Mobile Gaming App for Nutrition Intervention
- Where
- Nigeria
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Nocturnal Hypoglycemia, Type 1 Diabetes
Prevalence of Nocturnal Hypoglycemia in Children on a Type 1 Diabetes (TID) Insulin Regimen Using a Continuous Glucose Monitoring System (CGMS)
This study will help determine the frequency and magnitude of nocturnal hypoglycemia (low blood sugar at night during sleep), in children with type 1 diabetes who are on a standard insulin regimen, by using a Continuous Glucose…
- Trial name
- NCT00542334
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Eastern Ontario
Chronic Pain, Chronic Pain Syndrome
Shiatsu for Chronic Non-Inflammatory Pain in Children and Adolescents
The goal of this clinical trial is to learn if adding Shiatsu therapy to standard treatment can improve quality of life in children and adolescents with chronic pain that is not caused by inflammation.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain and Comorbid Emotional Problems, Chronic Pain, Psychogenic
- Trial name
- ShiQoL (NCT06929598)
- Testing
- Shiatsu Therapy
- Where
- 2 sites in Israel
- Volunteers
- 40 people
- Sponsor
- Tel Aviv University
Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
The BIOMEDE 2.0 study is the second stage of the BIOMEDE multi-arm, multistage rolling programme (adaptive platform protocol). It is a multicenter, randomized, open-label, controlled phase-3 trial evaluating efficacy of ONC201 in…
- Conditions
- Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant, Diffuse Midline Glioma, H3K27-altered
- Trial name
- BIOMEDE 2 (NCT05476939)
- Testing
- Everolimus, ONC201, Radiotherapy
- Where
- 56 sites in Belgium, Denmark and 6 more
- Volunteers
- 433 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Complex Post-Traumatic Stress Disorder (CPTSD), Borderline Personality Disorder (BPD)
Symptom Assessment in Adolescents Placed on Child Welfare
This study aims to characterize emotional dysregulation in complex post-traumatic stress disorder (cPTSD) and to determine the extent to which it can promote the distinction with borderline personality disorder (BPD) and…
- Conditions
- Complex Post-Traumatic Stress Disorder (CPTSD), Borderline Personality Disorder (BPD), Post-Traumatic Stress Disorder, PTSD
- Trial name
- PePsAdoTND (NCT07794332)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Heterozygous Familial Hypercholesterolemia (HeFH)
Long-Term Efficacy and Safety of Lerodalcibep in Children and Adolescents With Familial Hypercholesterolemia
The goal is to assess the long term efficacy (LDL cholesterol reduction) and safety over 3 years of lerodalcibep (Lerochol) SC 300 mg QM administered by auto-injector (AI)/pre-filled pen (PFP) in male and female pediatric…
- Trial name
- NCT07775339
- Testing
- Lerodalcibep
- Where
- 5 sites in India, Israel and 3 more
- Volunteers
- 150 people
- Sponsor
- LIB Therapeutics LLC
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Pediatric Atorvastatin in Diabetes Intervention Trial (PADIT)
The purpose of this study is to determine if Atorvastatin can improve blood vessel stiffness and blood vessel function in children 10-18 years old with Type 1 and Type 2 diabetes.
- Trial name
- NCT00130481
- Testing
- Atorvastatin 20 mg daily for 3 months
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Physical Therapy, Cerebral Palsy
Physical Therapy for Improving Functionality, Gait and Participation in Cerebral Palsy
Cerebral Palsy is a non-progressive nature lesion of the Central Nervous System, with a wide spectrum of impairments at body structure and function, which has a great impact at activity and participation in the environment.
- Conditions
- Physical Therapy, Cerebral Palsy, Therapeutic Education, Telehealth
- Trial name
- FIMAPACE (NCT04778930)
- Testing
- Physical Therapy, THERAPEUTIC EDUCATION PROGRAM
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- University of Alcala
Delay in Sexual Debut Among Adolescents, Knowledge About Condom Use
Parenting Styles and Parent-Offspring Communication on Sexuality Issues
The main objective of the study was to develop a novel intervention method which could reduce the spread of Sexually Transmitted Infections (including HIV) and unwanted pregnancies by improving parent-child communication using…
- Conditions
- Delay in Sexual Debut Among Adolescents, Knowledge About Condom Use, Parent-child Communication, Frequency and Quality
- Trial name
- PREPARE (NCT01772628)
- Testing
- Classroom-based component, STI/HIV prevention education, Homework assignment component
- Where
- Uganda
- Volunteers
- 1,700 people
- Sponsor
- Child Health & Development Centre
Generalized Anxiety Disorder, Separation Anxiety Disorder
Transdisciplinary Studies of CBT for Anxiety in Youth: Child Anxiety Treatment Study
The purpose of this study is to investigate neurobehavioral, affective, and social processes that may influence and predict treatment response in pediatric anxiety disorders.
- Conditions
- Generalized Anxiety Disorder, Separation Anxiety Disorder, Social Phobia
- Trial name
- CATS (NCT00774150)
- Testing
- Cognitive Behavioral Therapy, Client Centered Therapy
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Tourette Syndrome
Safety and Efficacy Study of NBI-98854 in Children and Adolescents With Tourette Syndrome
Phase 2, double-blind, placebo-controlled study to assess the safety and efficacy of NBI-98854 administered once daily (qd) for a total of 6 weeks of treatment.
- Trial name
- NCT02679079
- Testing
- NBI-98854
- Where
- 44 sites in United States
- Volunteers
- 98 people
- Sponsor
- Neurocrine Biosciences
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