Clinical trials: Chlorhexidine
Surgical Skin Preparation
Single Dose CHG Pharmacokinetic Study
A single 2% topical application of ReadyPrep® CHG was applied on either the abdomen (Treatment-1) or the groin (Treatment-2) whereas Treatment-3 consisted of a control treatment where the same procedure as Treatment-1 and -2 was…
- Trial name
- NCT03331263
- Testing
- Chlorhexidine Gluconate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medline Industries
HIV (Human Immunodeficiency Virus), HPV
Feasibility Study Comparing Use of One Or Two Probes for Thermal Ablation Among Screen Positive Women Living With HIV in C1001P-CS2 Kenya
Cervical cancer disproportionately affects women in low- and middle-income countries (LMICs), particularly women living with HIV (WLWH) who have a 6-fold increased risk of cervical cancer compared to women in the general…
- Conditions
- HIV (Human Immunodeficiency Virus), HPV, Cervical Precancer
- Trial name
- NCT07468695
- Testing
- Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes
- Where
- Kenya
- Volunteers
- 300 people
- Sponsor
- Fred Hutchinson Cancer Center
Diabetic Foot
Chlorhexidine Gluconate Solution at 0.125% vs Placebo for the Healing of Grade IIB Ulcers of Diabetic Foot
There is controversy regarding the utility of antiseptics in wound management for diabetic foot ulcer syndrome. The aim of this study is to assess chlorhexidine gluconate at 0.125% vs.
- Trial name
- NCT03209466
- Testing
- Chlorhexidine gluconate at 0.125%
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Universidad de Guanajuato
Oral Complications
Oral Care Frequency in Mechanically Ventilated Patients
Many problems may develop in patients due to mechanical ventilation in intensive care units. These include ventilator-associated pneumonia, decreased cerebral perfusion, venous air embolism, sinus and eye infections…
- Trial name
- NCT05039593
- Testing
- chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Aydin Adnan Menderes University
Non-carious Cervical Lesions
Chlorhexidine as Coadjuvant in Dentin Adhesion of Noncarious Cervical Lesions
This study aims to evaluate the effect of chlorhexidine digluconate (CRX) application in etched dentin on the retention of noncarious cervical lesions restorations.
- Trial name
- NCT01947192
- Testing
- Treatment with chlorhexidine, Water pre-treatment
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Dental Caries
Cinnamon and Ginger in Comparison to Chlorhexidine Gluconate 0.2% on Oral Streptococcus Mutans
Chlorhexidine is the most potent chemotherapeutic agent against mutans streptococci and dental caries, however, the incidence of side effects such as teeth discoloration, staining of restorations, undesirable taste, discoloration…
- Trial name
- NCT03061916
- Testing
- Cinnamon, Ginger, Chlorhexidine Gluconate
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Biofilm, Mouthwash
Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth.
The accumulation and maturation of oral biofilm in the gingival margin is widely recognised to be the primary aetiological factor in the development of chronic gingivitis.
- Conditions
- Oral Biofilm, Mouthwash, Periodontitis
- Trial name
- NCT02124655
- Testing
- Essential oils, 0.2% chlorhexidine, Sterile water
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Stage II Grade B Periodontitis
Active Oxygen Gel vs Chlorhexidine Gel in Stage II Grade B Periodontitis
This randomized controlled clinical trial will evaluate the effectiveness of locally delivered active oxygen gel and chlorhexidine gel as adjuncts to scaling and root planing in the treatment of stage II grade B…
- Trial name
- NCT07840716
- Testing
- Active oxygen gel, Chlorhexidine gel
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Cerebral Palsy, Exercise
A Feasibility Randomised Controlled Trial of an Online Exercise Programme for Adults With Cerebral Palsy
Adults with cerebral palsy (CP) often face challenges in accessing exercise programmes that are appropriate for their needs. Barriers such as limited mobility, a lack of tailored options, and restricted access to physiotherapy…
- Conditions
- Cerebral Palsy, Exercise, Adults, Fitness
- Trial name
- NCT06983782
- Testing
- Exercise and education programme, control group
- Where
- Ireland
- Volunteers
- 47 people
- Sponsor
- Royal College of Surgeons, Ireland
Postoperative Pain, Postoperative Complications
Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction
The purpose of this clinical study is to compare the effects of mouthwashes containing Chlorhexidine and tea tree oil on edema, pain, and trismus after the extraction of impacted third molars.
- Conditions
- Postoperative Pain, Postoperative Complications, Trismus, Periodontal Health
- Trial name
- NCT07180498
- Testing
- Chlorhexidine Gluconate 0.12% Mouthwash, Tea Tree Oil mouthwash
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Harran University
Ventilator Associated Pneumonia
Oral Care Interventions and Ventilator Associated Pneumonia in Critically Ill Children
This experimental study aims to verify the influence of the oral hygiene performance with chlorhexidine digluconate 0.12% in the development of VAP in children.
- Trial name
- NCT01083407
- Testing
- 0.12% Chlorhexidine Digluconate, Toothbrushing
- Volunteers
- 146 people
- Sponsor
- Federal University of São Paulo
Chlorhexidine Gluconate Cloths, Infection; Cesarean Section
STRIPES Study: Study To Reduce Infection Post cEsarean Section
The objective of this study is to determine if the use of chlorhexidine gluconate cloths prior to cesarean section reduce the rate of infectious morbidity (i.e. surgical site infections, endometritis).
- Conditions
- Chlorhexidine Gluconate Cloths, Infection; Cesarean Section, Infectious Morbidity, Surgical Site Infections
- Trial name
- NCT02402907
- Testing
- 2% chlorhexidine gluconate (CHG) cloth
- Where
- United States
- Volunteers
- 1,356 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Severe Neutropenia, Thrombocytopenia
Effect of Supragingival Irrigators Containing Chlorhexidine on Oral Health in Blood Dyscrasia
in this study , effectiveness of supragingival irrigators containing chlorhexidine is compared with routine oral health measures in patients with blood dyscrasia whom can not use effective oral health measures(e.g brushing ) due…
- Conditions
- Severe Neutropenia, Thrombocytopenia, Chemotherapy, Blood Dyscrasia Patients
- Trial name
- NCT01974401
- Testing
- supragingival irrigators containing chlorhexidine
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Dental Caries
Antibacterial Effect of Nano Silver Fluoride vs Chlorhexidine on Occlusal Carious Molars Treated With Partial Caries Removal Technique
The teeth of the patients that meet inclusion criteria will be anesthetized, isolated with a rubber dam. Cavity opened using conventional high-speed rotary instruments.
- Trial name
- NCT03186261
- Testing
- Nano silver fluoride solution, Cavity Cleanser
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mild Gingivitis, Periodontal Diseases
Evaluation of Antiplaque Efficacy of Licorice Extract Mouthrinse & HSS and Their Comparison With EO & CHX Mouthrinse
Periodontal disease is a multifactorial disease caused by mainly bacterial, genetic, immunological, and environmental factors. Chronic periodontitis, one of the widely prevalent forms of periodontal disease, is characterized by…
- Conditions
- Mild Gingivitis, Periodontal Diseases, Plaque
- Trial name
- NCT03550651
- Testing
- Licorice, Hypertonic salt solution, Essential oil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Government College of Dentistry, Indore
Chlorhexidine, Hospital-Acquired Infection
Chlorhexidine Bathing to Prevent Hospital-acquired Infections: the CLEANS Study
Hospital-acquired infections (HAI) have been shown to increase length of hospital stay and mortality. Infections acquired during a hospital stay have been shown to be preventable.
- Conditions
- Chlorhexidine, Hospital-Acquired Infection, Surgery, Intensive Care Unit
- Trial name
- NCT05142969
- Testing
- 2% Chlorhexidine bathing
- Where
- China
- Volunteers
- 247 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Coronary Occlusion, Left Main Coronary Artery Disease
EXCEL Clinical Trial (Universal Registry)
The purpose of the Universal Registry is to assess the proportion and reasons for which subjects with angiographically significant ULMCA disease requiring revascularization during the time course of this study are not randomized…
- Conditions
- Chronic Coronary Occlusion, Left Main Coronary Artery Disease, Stent Thrombosis, Vascular Disease
- Trial name
- EXCEL (NCT01205789)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Chronic Coronary Occlusion, Unprotected Left Main Coronary Artery Disease
EXCEL Clinical Trial
To establish the safety and efficacy of the commercially approved XIENCE Family Stent System (inclusive of XIENCE PRIME, XIENCE V, XIENCE Xpedition and XIENCE PRO [for use outside the United States [OUS] only]) in subjects with…
- Conditions
- Chronic Coronary Occlusion, Unprotected Left Main Coronary Artery Disease, Stent Thrombosis, Vascular Disease
- Trial name
- EXCEL (NCT01205776)
- Testing
- Percutaneous Coronary Intervention, CABG
- Where
- United States
- Volunteers
- 1,905 people
- Sponsor
- Abbott Medical Devices
Skin Microbiota
Comparison of the Permanent Skin Flora of Children Who Had Bathing With Two Different Products
This study was carried out as a randomized controlled experimental study to compare the effect of wiping bath with 2% daily chlorhexidine gluconate and soap-free body wash on the permanent skin flora of children hospitalized in…
- Trial name
- NCT04845672
- Testing
- 2% chlorhexidine gluconate, soap-free body cleaning solution
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Propionibacterium Acnes
BPO vs Hibiclens Soap for Surgical Preparation
This is a randomized trial of benzoyl peroxide soap versus Hibiclens soap for surgical preparation. The objective is to determine whether benzoyl peroxide soap, commonly available in drug stores for over-the-counter acne…
- Trial name
- NCT04021524
- Testing
- Benzoyl Peroxide 10% Bar, Chlorhexidine Gluconate
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Washington