Clinical trials: Chlorhexidine
Alveolar Osteitis
Comparative Efficacy of Amoxicillin, Metronidazole, and Chlorhexidine in Preventing Alveolar Osteitis
This study will compare the effectiveness of amoxicillin, metronidazole, and chlorhexidine in preventing alveolar osteitis (dry socket) following lower third molar extraction.
- Trial name
- NCT07833176
- Testing
- Amoxicillin, Metronidazole, Chlorhexidine
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Traumatic Oral Ulceration, Orthodontic Treatment
Comparison of Hyaluronic Acid and Chlorhexidine Gels for Traumatic Oral Ulcers During Fixed Orthodontic Treatment
This randomized controlled trial aims to compare the effectiveness of topical hyaluronic acid gel and chlorhexidine gel in the management of traumatic oral ulcers that develop following placement of fixed orthodontic appliances.
- Conditions
- Traumatic Oral Ulceration, Orthodontic Treatment, Orthodontic Appliances, Fixed, Oral Mucosal Ulceration
- Trial name
- HYCHO-TOU (NCT07709455)
- Testing
- Hyaluronic Acid gel, Chlorhexidine gel
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Dow University of Health Sciences
Periodontitis, Type 2 Diabetes Mellitus (T2DM)
Para-Probiotic Oral Care in Periodontal Patients With Type 2 Diabetes
This randomized controlled clinical trial aims to evaluate the effectiveness of a para-probiotic-based oral care protocol in improving periodontal health and glycemic control in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- PPDM2 (NCT07069166)
- Testing
- Para-probiotic oral care, Chlorhexidine oral care
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Mucositis
Efficacy of 0.12% Chlorhexidine Gluconate for Peri-implant Mucositis
The purpose of this study is to analyze the efficacy of 0.12% chlorhexidine gluconate as a chemical adjuvant for the treatment of peri-implant mucositis, in a non-surgical treatment protocol with a six-month follow-up.
- Trial name
- NCT02605382
- Testing
- Chlorhexidine gluconate
- Volunteers
- 37 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Peri-implant Mucositis
Chlorhexidine Gel and Peribioma Periogel Use in Peri-implant Mucositis Sites: a Split-mouth Randomized Clinical Trial.
The aim of this study is to evaluate the efficacy of non-surgical periodontal therapy with supportive home oral care for the treatment of peri-implant mucositis.
- Trial name
- NCT04899986
- Testing
- Chlorhexidine and Biorepair gel and toothpaste application, Standard oral hygiene
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Pavia
Oral Mucosa; Ulcer
Comparison of the Effects of Oral Ulceration Healing in Patients Wearing a Removable Denture
The aim of the study was comparing the effectiveness of oral mucosa healing properties of different preparations: CHX=0,2% chorhexidine digluconate, CHS=8,7% choline salicylate, CON=control group, in patients with delivered…
- Trial name
- MUCOSA HEALING (NCT06531720)
- Testing
- Chlorhexidine Gluconate, Choline Salicylate 8.7 % Oral Gel, control group
- Where
- Poland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Catheter-Associated Infections
Effect of Chlorhexidine Solution in Preventing Peripheral Venous Catheter Associated-Infection
This research aims to determine the most effective chlorhexidine concentration to be used in preventing peripheral venous catheter-associated infections.
- Trial name
- NCT05441605
- Testing
- Effects of Chlorhexidine Solutions with Different Concentrations in Preventing Peripheral Venous Catheter-Associated Infections
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Aydin Adnan Menderes University
Infection
Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA)
Continuous femoral nerve block (CFNB) techniques continue to be increasingly used in the management of postoperative pain after total knee arthroplasty.
- Trial name
- NCT00896402
- Testing
- Skin antisepsis with chlorhexidine, povidone-iodine
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Intratracheal Intubation, Surgery
Efficacy of Pre-intubation Chlorhexidine Oral Care on Health Outcomes
This single-centre, single-blind, randomised controlled study with parallel-group design was conducted in Yun Ling, Taiwan between May 2019 and August 2019.
- Conditions
- Intratracheal Intubation, Surgery, Anesthesia
- Trial name
- NCT04252469
- Testing
- Oral care
- Where
- Taiwan
- Volunteers
- 210 people
- Sponsor
- National Taiwan University Hospital
Penile Prosthesis; Complications
Urethral Sterilization With Chlorhexidine Digluconate to Facilitate Primary Repair & Same-Session Implantation
The introduction of penile implants has revolutionized the management of male erectile dysfunction. However, a number of intraoperative complications may occur, which have a major impact on clinical outcomes and patient…
- Trial name
- NCT03614429
- Testing
- Chlorhexidine gel will be prepared according to an international product Instillagel®
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Caries, Dental, Risk Reduction
Using a Mouthwash Containing Propolis, Clove Oil and Chlorhexidine to Improve the Caries Risk of High Risk Patients
This study is conducted to determine if using a mouthwash containing propolis, clove oil and chlorhexidine will improve the caries risk of high risk patients in comparison to using a mouthwash containing chlorhexidine only.
- Trial name
- NCT03553628
- Testing
- Chlorhexidine, Propolis and Clove Oil mouthwash, Chlorhexidine mouthwash
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Moataz Gamal Ali Abdul-Maksoud Konsouh
Preterm Premature Rupture of Membrane
Vaginal Cleansing With Chlorhexidine Gluconate in Women With Preterm Pre-labor Rupture of Membranes
Randomized controlled trial studying the use of vaginal cleansing with chlorhexidine gluconate for pregnant women with PPROM (preterm pre labor rupture of membranes). The primary outcome will be pregnancy latency.
- Trial name
- NCT04516226
- Testing
- Vaginal cleansing with chlorhexidine gluconate solution
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Traumatic Ulcer of Oral Mucosa
Evaluation of Low Level Laser Therapy and Lidocaine Versus Chlorhexidine for the Management of Traumatic Oral Ulcers in Children
the goal of the study was to evaluate the pain reduction and healing efficiency of traumatic oral ulcers in children using low-level laser therapy with diode laser 980 nm, lidocaine oral gel and chlorhexidine mouthwash
- Trial name
- NCT07138586
- Testing
- low level laser therapy group, Lidocaine gel group, Chlorhexidine mouthwash group (positive control group).
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- National Research Centre, Egypt
Plaque, Dental, Dental Plaque Induced Gingivitis
The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients
This randomized controlled trial will be conducted on 40 orthodontic patients at the Department of Orthodontics, University Hospital Centre Zagreb, Croatia. Respondents will be randomly allocated into 4 groups (n=10).
- Conditions
- Plaque, Dental, Dental Plaque Induced Gingivitis, White Spot Lesion
- Trial name
- NCT06331442
- Testing
- Photodynamic therapy, Tricalcium phosphate (TCP) varnish with 5% NaF, Chlorhexidine varnish
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Abscess
The Effect Of Wound Irrigation With Irrisept™ Delivery System On Abscess Healing In Patients Presenting To The Emergency Department
The purpose of this study is to determine if wound cleansing and irrigation using the IRRISEPT Chlorhexidine Gluconate(CHG)solution, applying a given volume with a pressurized stream, will improve the outcome for infected…
- Trial name
- NCT01302548
- Testing
- IRRISEPT, Usual Care
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Florida
Oral Complications
Oral Care Frequency in Mechanically Ventilated Patients
Many problems may develop in patients due to mechanical ventilation in intensive care units. These include ventilator-associated pneumonia, decreased cerebral perfusion, venous air embolism, sinus and eye infections…
- Trial name
- NCT05039593
- Testing
- chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Aydin Adnan Menderes University
Ventilator Associated Pneumonia
Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX
This was a single-centered, randomized, placebo-controlled double-blind clinical trial conducted in the pediatric intensive care unit (PICU), in patients who were aged 1 month to 18 years, needing MV for at least 48 hours, to…
- Trial name
- NCT04527276
- Testing
- Oral care with 0,12% Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul Medeniyet University
Dental Caries, Dental Caries in Children
The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries
This study aims to compare salivary IL-6, MMP-8, MMP-9, and TIMP-1 levels between healthy children and caries-active children, and to evaluate the effects of 5% sodium fluoride (NaF) varnish and 2% chlorhexidine (CHX) used in…
- Trial name
- DentalCaries (NCT07609797)
- Testing
- 5% Sodium Fluoride Varnish, 2% Chlorhexidine Pre-Treatment + 5% NaF Varnish, Standard Oral Hygiene Education
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gül Keskin
Periodontal Diseases, Diabetes Mellitus Type 2
Microbiological Effect of 0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs Probiotics (Lactobacillus Reuteri Prodentis) on Porphyromonas Gingivalis.
This randomized non-inferiority clinical trial aims to evaluate the microbiological effect of 0.12% chlorhexidine and 0.05% cetylpyridinium vs.
- Trial name
- NCT07489924
- Testing
- Mouthwash with chlorhexidine and cetylpyridine chloride, Probiotic (Lactobacillus reuteri Prodentis
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Universidad de Colima
Surgical Site Infections
PVP Iodine vs Chlorhexidine in Alcohol for Disinfection of the Surgical Site
Prospective cluster-randomized multicenter cross-over trial to prove non-inferiority of PI compared to CHX in preoperative skin antisepsis
- Trial name
- PICASSo (NCT03685604)
- Testing
- CHX disinfection, PI Disinfection
- Where
- 3 sites in Switzerland
- Volunteers
- 3,321 people
- Sponsor
- University Hospital, Basel, Switzerland