Clinical trials: Chlorhexidine
Periodontal Diseases
A Comparison of Mouth Rinse Containing Alcohol-free Chlorhexidine With a Cetylpyridinium Chloride in Periodontal Diseases
Aim: clinical effectiveness of 0.05% cetylpyridinium chloride mouth rinse in patients with gingivitis as compared to non-alcoholic chlorhexidine mouth wash.
- Trial name
- NCT02756377
- Testing
- cetylpyridinium chloride mouthwash, Chlorhexidine mouthwash
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Dental Caries
Glass-ionomer Cement Containing Chlorhexidine for ART
This study evaluated the clinical and microbiological long-term effects of 1.25% CHX associated with GIC applied in primary molars using Atraumatic Restorative Treatment (ART) technique.
- Trial name
- NCT02459730
- Testing
- ART with GIC containing 1.25% CHX., ART with GIC.
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Dental Caries Prevention
Silver Nanoparticle vs Chlorhexidine Mouthwashes for Reducing Streptococcus Mutans and Improving Salivary pH in Children
Dental caries remains one of the most common chronic diseases in children, with Streptococcus mutans playing a major role in its development.
- Trial name
- SMILE (NCT07728409)
- Testing
- Silver nanoparticle mouthwash (10 ppm), Chlorhexidine mouthwash (0.2%)
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Assiut University
Dental Erosion
The Effect of Chlorhexidine on the Oral Microbiome and Saliva in Dental Erosion
Dental erosion happens when the teeth lose some of their parts because of acid from the things people eat and/or drink or even from stomach. It can make teeth hurt and become sensitive.
- Trial name
- NCT06171594
- Testing
- Chlorhexidine mouthwash
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Ventilator Associated Pneumonia
The Effectiveness of Oral Care With Chlorhexidine in Medical Intensive Care Unit
Oral care with chlorhexidine was used to be considered an effective way to prevent ventilator-associated pneumonia (VAP). However, recent evidence revealed that oral care with chlorhexidine may associate with higher mortality and…
- Trial name
- NCT05913856
- Testing
- Normal saline, Chlorhexidine
- Where
- Taiwan
- Volunteers
- 141 people
- Sponsor
- National Taiwan University Hospital
Wound Heal, Surgical Wound
Chlorhexidine Plus Hyaluronic Acid Mouthwash in Surgical Wound Healing Following Third Molar Surgery
Evaluation of the response of gingival tissues to the use of mouthwash with chlorhexidine and chlorhexidine + hyaluronic acid in terms of healing of the surgical wound following third molar surgery.
- Conditions
- Wound Heal, Surgical Wound, Impacted Third Molar Tooth
- Trial name
- CLOR_4 (NCT05414253)
- Testing
- Parallel Assignment
- Where
- Italy
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Oral Squamous Cell Carcinoma, Oral Cancer
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
The goal of this phase II single arm clinical study is to evaluate the effect of antibiotics (metronidazole) and oral chlorhexidine (CHX) in reducing the bacteria load within tumors of patients undergoing surgery for oral cancer.
- Conditions
- Oral Squamous Cell Carcinoma, Oral Cancer, Head and Neck Cancer, Head and Neck Carcinoma
- Trial name
- NCT06627270
- Testing
- Metronidazole, Chlorhexidine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
HIV (Human Immunodeficiency Virus), HPV
Feasibility Study Comparing Use of One Or Two Probes for Thermal Ablation Among Screen Positive Women Living With HIV in C1001P-CS2 Kenya
Cervical cancer disproportionately affects women in low- and middle-income countries (LMICs), particularly women living with HIV (WLWH) who have a 6-fold increased risk of cervical cancer compared to women in the general…
- Conditions
- HIV (Human Immunodeficiency Virus), HPV, Cervical Precancer
- Trial name
- NCT07468695
- Testing
- Thermal ablation (TA) with 1 probe, Thermal ablation (TA) with 2 probes
- Where
- Kenya
- Volunteers
- 300 people
- Sponsor
- Fred Hutchinson Cancer Center
Peri-implant Mucositis
Ozoral Pro and Ozoral Gel vs Chlorhexidine Gel 1% for the Management of Peri-implant Mucositis Sites.
This is a randomized controlled clinical trial (RCT) with a split-mouth design. After signing the informed consent, patients satisfying the inclusion criteria will undergo supragingival and subgingival professional oral hygiene…
- Trial name
- NCT05254275
- Testing
- Ozoral Pro and Ozoral gel administration, Curasept chlorhexidine gel 1%
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Neonatal Sepsis, Omphalitis
A Comparative Analysis of 4% Chlorhexidine Versus Methylated Spirit as Prophylaxis of Omphalitis and Sepsis in Newborns
Introduction: Neonatal sepsis in one of the leading cause of death in developing countries. Umbilical cord care is important as it may lead to infection.
- Trial name
- NCT06002295
- Testing
- Chlorhexidine Topical Cream, Methylated Spirit
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Ventilator Associated Pneumonia
Effectiveness of a VAP Prevention Bundle in the PICU
This observational monocentric prospective study aims to evaluate the efficacy of new measures for ventilator associated pneumonia (VAP) management in the pediatric population in the pediatric intensive care unit (PICU) of…
- Trial name
- NCT03763695
- Testing
- Measures for the VAP prevention in the PICU, Evaluation of VAP incidence before the protocol introduction
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Staph Aureus Methicillin Resistant Colonization
Study of 2% Chlorhexidine Gluconate-Impregnated Bath Cloths to Prevent MRSA Colonization in Complex Continuing Care
The purpose of this study is to determine whether daily bathing with 2% chlorhexidine gluconate-impregnated antiseptic cleanser (CHG) significantly reduces incidence of colonization of hospitalized patients with…
- Trial name
- NCT01717690
- Testing
- CHG antiseptic body cleanser
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Baycrest
Caregivers, Community Health Workers
Intervention to Help Orient Men to Excel (IN-HOME) Phase II Study
The goal of the study is to examine the effect of outreach from IN-HOME-trained CHWs on changes in male informal caregiver knowledge/skills, positive attitudes, self-efficacy, and intentions about caregiving topics.
- Conditions
- Caregivers, Community Health Workers, Knowledge, Attitude
- Trial name
- IN-HOME (NCT07704060)
- Testing
- Intervention to Help Orient Men to Excel (IN-HOME), Supplying Useful Perimenopause Through Post-menopause Online Resources and Tools (SUPPORT)
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- KDH Research & Communication
Preterm Birth
Preterm Labor Prevention Using Vaginal Antiseptics Prior to 16 Weeks of Gestation
The aim of this prospective observational study was to evaluate the efficacy of a universal strategy of primary prevention of preterm birth using intravaginal chlorhexidine (CLX) applied before 16 weeks.
- Trial name
- PLUVA (NCT05944094)
- Testing
- Clorhexidine
- Where
- Spain
- Volunteers
- 1,117 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Dental Caries in Children
Evaluation of Glass Ionomer Cement Modified With Chlorhexidine and Titanium Dioxide in Primary Molars (RCT)
to investigate the effect of modifying GIC with different formulations on the antibacterial activity and clinical performance in reference to unmodified glass ionomer restorative materials.
- Trial name
- NCT05645029
- Testing
- glass ionomer-chlorhexidine, glass ionomer-titanium dioxide powder, glass ionomer
- Where
- Egypt
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia, Spinal, Anesthesia, Epidural
Alcohol 70% Versus Chlorhexidine 0.5% in the Spinal Anesthesia Skin Antissepsis
Context: The neuraxial blocks, spinal anesthesia and epidural anesthesia are among the most frequently performed procedures worldwide, and despite the advancements of medical equipment, remain dependent on experience and practice…
- Conditions
- Anesthesia, Spinal, Anesthesia, Epidural, Antisepsis
- Trial name
- NCT02833376
- Testing
- alcohol antisepsis, chlorhexidine antisepsis
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Universidade do Vale do Sapucai
Neonatal Mortality, Omphalitis
Newborn Care Kit to Save Lives in GB, Pakistan
Neonatal deaths account for almost half of all deaths in children under 5 years of age. Pakistan has the world's highest neonatal mortality rate (NMR), and many of these deaths are preventable.
- Conditions
- Neonatal Mortality, Omphalitis, Post-Partum Hemorrhage
- Trial name
- iNCK (NCT04798833)
- Testing
- Integrated Newborn Care Kit (iNCK)
- Where
- 2 sites in Pakistan
- Volunteers
- 19,344 people
- Sponsor
- The Hospital for Sick Children
Halitosis
Effect of Mouth Rinses in Oral Malodor
Bad breath or halitosis is caused by specific gases originating from the mouth or the expired air. In most cases the pathology lies within the mouth and in this case receives the name pathologic halitosis of oral cause or oral…
- Trial name
- MR2012 (NCT01747226)
- Testing
- Fluoride rinse, Halita, Meridol Halitosis
- Where
- Belgium
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Periodontitis
Teh Effect of Subgingival Irrigation Wif Ketorolac and Chlorhexidine in Patients Wif Chronic Periodontist
In this study, 40 patients with a history of Mild- Periodontitis who were diagnosed with clinical and radiographic findings showed that all of the periodontal parameters before the treatment, during the treatment period Then…
- Trial name
- NCT03836781
- Testing
- Ketorolac, Chlorhexidine 2%
- Where
- Iran
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Amirhossein Farahmand
Peri-Implantitis
Surgical Protocol for Peri-Implantitis Treatment-3
Peri-implant diseases are common post-restorative complications in implant rehabilitations and they occur with an incidence of 12-43%.
- Trial name
- NCT03977324
- Testing
- Chlorhexidine, Connective Tissue Graft
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele