Clinical trials: Chloride Disorder
Atrial Fibrillation
Role of Calcium Chloride Injection in Alleviating Atrial Fibrillation Post CABG
This study hypothesize that injecting calcium chloride (CaCl2) into the major atrial ganglionated plexus (GPs) during on pump Coronary artery bypass graft (CABG) can reduce the incidence of Post operative Atrial fibrillation in…
- Trial name
- NCT06378021
- Testing
- Calcium Chloride, Sodium Chloride 0.9% Inj
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Helwan University
Dentine Hypersensitivity
Instant and Lasting Relief Effects of Strontium Chloride/Potassium Nitrate Dentifrice on Dentin Hypersensitivity
The objective of the present study was to compare the effects of a commercially available dentifrice containing 2% strontium chloride and 5% potassium nitrate in a silica base, versus a control dentifrice, containing exactly the…
- Trial name
- NCT01426360
- Testing
- control dentifrice, strontium chloride/potassium nitrate dentifrice
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Sun Yat-sen University
Sentinel Lymph Node Biopsy, Breast Cancer
A Study to Find the Best Dose of ASP5354 to Show Lymph Nodes in People With Breast Cancer or Melanoma During Surgery
This study was for women with breast cancer and for adults with melanoma. Breast cancer was a type of cancer when cells in the breast turn into cancer cells, which might grow out of control.
- Conditions
- Sentinel Lymph Node Biopsy, Breast Cancer, Melanoma
- Trial name
- NCT05457842
- Testing
- pudexacianinium chloride
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Astellas Pharma Inc
Cutaneous Leishmaniasis
Pilot Study Using a Heat Pack to Treat Cutaneous Leishmaniasis
Current standard therapies with chemotherapy (CT) for Cutaneous Leishmaniasis (CL) are expensive, toxic/allergenic, frequently ineffective, burdensome, and often unavailable.
- Trial name
- HECT (NCT01277796)
- Testing
- Heat pack conduction-heat therapy
- Sponsor
- Universidad Peruana Cayetano Heredia
Hypertension
China Salt Substitute Study in Tibet
The study was a single-blind randomized controlled trial conducted between February and August 2009 in two townships (Yangbajing and Gongtang) of Dangxiong County, an area at 4300 meters altitude in Tibet.
- Trial name
- CSSS-Tibet (NCT01429246)
- Testing
- Regular Salt, Salt Substitute
- Where
- China
- Volunteers
- 282 people
- Sponsor
- The George Institute for Global Health, China
Pulmonary Disease, Chronic Obstructive
Characterization of 24 Hour Spirometry Profiles of Inhaled BI 1744 CL and Inhaled Foradil in Patients With Chronic Obstructive Pulmonary Disease
The study is intended to characterize the lung function profile of BI1744 in COPD patients where patients will perform pulmonary function tests at regular intervals for 24 hours at the end of a 6 week treatment period.
- Trial name
- NCT00931385
- Testing
- BI 1744, bi1744, Foradil
- Where
- 11 sites in United States
- Volunteers
- 99 people
- Sponsor
- Boehringer Ingelheim
Hypertension
CLCNKA (Ka Renal Chloride Channel[ClC-Ka]) Polymorphism Effects on Hypertrophy Regression
This study will consist of middle-aged Caucasian non-failing subjects with high blood pressure who are homozygous for a gene that confers increased risk of developing heart failure, the Glycine 83 variant of the Ka renal chloride…
- Trial name
- NCT01275352
- Testing
- Eplerenone
- Where
- 2 sites in United States
- Sponsor
- Washington University School of Medicine
Cystic Fibrosis
Early Signs of Efficacy Study With Riociguat in Adult Homozygous Delta F508 Cystic Fibrosis Patients
Assessment of the safety, tolerability and early signs of efficacy of three times a day orally administered BAY63-2521 in adult delta F508 homozygous Cystic Fibrosis patients not on treatment with Orkambi
- Trial name
- NCT02170025
- Testing
- Riociguat (Adempas, BAY63-2521)
- Where
- 10 sites in United States, Belgium and 5 more
- Volunteers
- 21 people
- Sponsor
- Bayer
Infertility
PartoSure to Predict Spontaneous Preterm Delivery in Pregnancies After Assisted Reproductive Technology (ART)
To calculate sensitivity (SN), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) of PartoSure TTD test in predicting delivery within 7 or 14 days from testing and to compare it with cervical…
- Trial name
- NCT02576418
- Testing
- Partosure TTD test
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Vietnam National University
Uterine Atony, Uterine Atony With Hemorrhage
Calcium Chloride for Prevention of Uterine Atony During Cesarean
In this pilot study, investigators will administer calcium chloride or placebo to pregnant women undergoing Cesarean delivery who have been identified as high risk for hemorrhage due to poor uterine muscle contraction, or atony.
- Conditions
- Uterine Atony, Uterine Atony With Hemorrhage, Cesarean Section Complications
- Trial name
- NCT03867383
- Testing
- Calcium Chloride
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Hypovolemia
Plasma-Lyte 148® versUs Saline Study
The aim of PLUS is to conduct a multi-centre, blinded, randomised, controlled trial (RCT) to determine whether fluid resuscitation and therapy with a "balanced" crystalloid solution (Plasma-Lyte 148®) decreases 90-day mortality…
- Trial name
- PLUS (NCT02721654)
- Testing
- Plasma-Lyte 148®, 0.9% sodium chloride
- Where
- 51 sites in Australia, New Zealand
- Volunteers
- 5,037 people
- Sponsor
- The George Institute
Dysphagia
Effects of 3% Sodium Chloride on Post-operative Dysphagia Following Anterior Cervical Spine Surgery
Post-operative dysphagia is a significant issue following anterior cervical spine surgery. The investigators are studying the effects of perioperative 3% sodium chloride, given over a period of 24 hours, on post-operative…
- Trial name
- NCT03677310
- Testing
- 3% Sodium Chloride, Normal Saline
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hypokalemia, Arrhythmias, Cardiac
Safety of Continuous Potassium Chloride Infusion in Critical Care
Patients in critical care often require supplemental potassium chloride if levels in their blood are below acceptable level. Common practice is to administer a single dose of potassium chloride under controlled conditions via a…
- Trial name
- ASPIC (NCT00718068)
- Testing
- Sterile Potassium Chloride Concentrate
- Where
- Australia
- Volunteers
- 160 people
- Sponsor
- The Queen Elizabeth Hospital
Gingivitis, Plaque
Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.
Qualified subjects will be enrolled and randomized to one of the two study groups based on their initial Plaque and Gingivitis scores. Subjects will be instructed to use the products according to the instructions provided.
- Trial name
- NCT06244303
- Testing
- manual Tooth Brush + Colgate Total TP (0.454% SnF, 1100 ppm F), manual toothbrush + Colgate dental cream
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Infectious Diseases
Chlorhexidine Against Sodium Hypochlorite as Skin Antiseptics
The physicians have few options for skin antisepsis. Alternatives for common use antiseptics are costly or ineffective. In order to have more options, this study is needed.
- Trial name
- NCT01321125
- Testing
- Bacterial culture of the prepared skin's areas, Preparing skin's areas to be tested, Antiseptic substantivity
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Guanajuato
Acute Heart Failure, Congestion
Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure
The aim of the study is to compare the differences in diuretic, natriuretic and clinical response to decongestion in patients receiving different replacement fluid regimens (0.9% sodium chloride vs 5% glucose) in acute heart…
- Conditions
- Acute Heart Failure, Congestion, Heart Failure
- Trial name
- SOLVRED-AHF (NCT05962255)
- Testing
- Furosemide intravenous infusion, Continous intravenous infusion of 0.9% Sodium Chloride solution, Continous intravenous infusion of 5% Glucose solution
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Wroclaw Medical University
Overactive Bladder
Efficacy of Sanctura XR (Trospium Chloride) for Reducing Overactive Bladder Symptoms in Female Subjects Refractory to Detrol LA (Tolterodine Tartrate Extended Release) Daily
This study will investigate the safety and efficacy of Sanctura XR (trospium chloride) daily in reducing urgency, urinary frequency and urinary urge incontinence in female patients with incontinence refractory to Detrol LA…
- Trial name
- NCT01089751
- Testing
- trospium chloride
- Where
- United States
- Volunteers
- 322 people
- Sponsor
- Allergan
Osteoarthritis of the Knee
A Study on the Efficacy of Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Leaf Extract in Adults With Osteoarthritis of the Knee.
The primary objective of the study is to assess the effectiveness of alpha-D Glucosamine Sulfate/Standardized Extract of Ginkgo Biloba Leaf versus a comparator product on osteoarthritis pain as assessed by the between group…
- Trial name
- 13GOHJ (NCT02604381)
- Testing
- Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Extract
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- KGK Science Inc.
Breast Cancer
Trial of Ra-223 Dichloride in Combination With Hormonal Therapy and Denosumab in the Treatment of Patients With Hormone-Positive Bone-Dominant Metastatic Breast Cancer
The goal of this clinical research study is to learn if Xofigo® (also called Ra-223 dichloride) combined with hormone therapy and denosumab can help to control breast cancer that has spread to the bones and/or bone marrow.
- Trial name
- NCT02366130
- Testing
- Ra-223 dichloride, Denosumab, Hormone Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- M.D. Anderson Cancer Center
Onychomycosis/Onycholysis and Tinea Pedis
Safety and Pharmacokinetics of Terbinafine Hydrogen Chloride (HCl) Nail Lacquer in Patients With Onychomycosis
In this study, the safety and pharmacokinetics of 10 % terbinafine hydrogen chloride (HCl) nail lacquer wre investigated by comparison with vehicle control and 1% terbinafine cream
- Trial name
- NCT00691184
- Testing
- Terbinafine Hydrochloride, Terbinafine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- NexMed (U.S.A.), Inc. (subsidiary of Apricus Biosciences, Inc.)