Clinical trials: Chloroquine
SARS-CoV-2 Infection, COVID-19
The Vietnam Chloroquine Treatment on COVID-19
COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. There is currently no vaccine to prevent COVID-19 or therapeutic agent to treat COVID-19.
- Trial name
- VICO (NCT04328493)
- Testing
- Chloroquine phosphate
- Where
- 5 sites in Vietnam
- Volunteers
- 10 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Proliferative Nephritis, Chloroquine Retinopathy
Proliferative Lupus Nephritis Treatment With Chloroquine and Hydroxychloroquine
Evaluation the efficacy of chloroquine and hydroxychloroquine in the treatment of proliferative lupus nephritis class III and IV in children and adolescents and evaluate the side effects of both drugs .
- Trial name
- NCT03687905
- Testing
- Chloroquine, Hydroxychloroquine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Plasmodium Vivax Malaria Without Complication, Plasmodium Falciparum Malaria (Uncomplicated)
Ethiopian Antimalarial Therapeutic Efficacy Study 2026
Background: The WHO recommends monitoring the efficacy of antimalarial drugs at least once every two years after implementation.
- Trial name
- TES2026 (NCT07840898)
- Testing
- Artemether-Lumefantrine + Primaquine and Chloroquine + Primaquine
- Where
- Ethiopia
- Volunteers
- 1,200 people
- Sponsor
- Ethiopian Public Health Institute
Plasmodium Falciparum Infection
Chloroquine Alone or in Combination for Malaria in Children in Malawi
Malaria is a sickness caused by a germ that can get into a person's body when a mosquito bites them. It can cause fever, headache, body aches and weakness. It can even cause death, especially in children.
- Trial name
- NCT00379821
- Testing
- Atovaquone-proguanil, Artesunate, Azithromycin
- Where
- Malawi
- Volunteers
- 640 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uncomplicated Plasmodium Knowlesi Malaria
P. Knowlesi Trial of Artesunate-mefloquine Versus Chloroquine
Preliminary studies have supported the background efficacy of local standard anti-malarial medications in the treatment of uncomplicated knowlesi malaria, however this has not been tested systematically and there are no current…
- Trial name
- ACT KNOW (NCT01708876)
- Testing
- Artesunate-mefloquine, Chloroquine, Primaquine
- Where
- 3 sites in Malaysia
- Volunteers
- 250 people
- Sponsor
- Menzies School of Health Research
COVID
Hydroxy Chloroquine and Covid in RA Patients
evaluation of the clinical course of COVID-19 in a cohort of patients with rheumatoid arthritis treated with or without hydroxychloroquine.
- Trial name
- Covid-19 (NCT04471649)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
HIV
Daily Trimethoprim-sulfamethoxazole or Weekly Chloroquine Among Adults on ART in Malawi
The purpose of this study is to determine if there is a benefit to taking trimethoprim-sulfamethoxazole (TS) as prophylaxis among HIV positive adults who have viral load suppression and a good clinical response on anti-retroviral…
- Trial name
- TSCQ (NCT01650558)
- Testing
- Standard of Care prophylaxis, Chloroquine (CQ) prophylaxis
- Where
- 2 sites in Malawi
- Volunteers
- 1,499 people
- Sponsor
- University of Maryland, Baltimore
Malaria, Malaria in Pregnancy
Prevention of Intrauterine Growth Retardation in Burkina Faso: the Malaria Component
Our objective was to investigate the importance of malaria infection/disease during pregnancy and more particularly during the first trimester; we also looked at the maternal-foetal interactions and their influence on the…
- Trial name
- NCT00680732
- Testing
- Multiple micronutrients supplements (MMS), Iron and folic acid (IFA), Chloroquine (CQ)
- Where
- Burkina Faso
- Volunteers
- 1,370 people
- Sponsor
- Institute of Tropical Medicine, Belgium
P Vivax, Malaria, Vivax
Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P. Vivax Malaria, Cruzeiro do Sul, Acre, Brazil
We plan to assess the efficacy of 3 different regimens of chloroquine and primaquine for the treatment of P. vivax infections in Cruzeiro do Sul, Acre, Brazil.
- Trial name
- NCT03610399
- Testing
- Primaquine
- Where
- Brazil
- Volunteers
- 257 people
- Sponsor
- Centers for Disease Control and Prevention
Vivax Malaria
Comparison Between 7 and 14 Day Primaquine Combined With Dihydroartemisinin-piperaquine or 3 Day Chloroquine Radical Cure of P. Vivax (BPD)
In Southeast Asia, Plasmodium vivax (Pv) infection reaches 50-80% and bears a greater burden of disease than Plasmodium falciparum (Pf).
- Trial name
- NCT01640574
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine
- Where
- Thailand
- Volunteers
- 680 people
- Sponsor
- University of Oxford
Sars-CoV2, Symptomatic Condition
PRophylaxis of Exposed COVID-19 Individuals With Mild Symptoms Using choloroquinE Compounds
To treat Pakistani patients with non-life threatening symptomatic SARS-CoV-2 infection with an intent to reduce burden on institutional healthcare services by determining efficacy of different chloroquine and hydroxychloroquine…
- Conditions
- Sars-CoV2, Symptomatic Condition, Covid-19
- Trial name
- PRECISE (NCT04351191)
- Testing
- Hydroxychloroquine Sulfate Regular dose, Hydroxychloroquine Sulfate Loading Dose, Chloroquine
- Where
- 4 sites in Pakistan
- Volunteers
- 137 people
- Sponsor
- Government of Punjab, Specialized Healthcare and Medical Education Department
Covid19
Prevention With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19) (TS-COVID)
The purpose of this study is to assess the efficacy and safety of chloroquine prophylaxis on the incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in healthcare workers exposed to patients with…
- Trial name
- TS-COVID (NCT04627467)
- Testing
- Chloroquine
- Where
- Colombia
- Volunteers
- 3,217 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinica Valle del Lili
Malaria, Falciparum
Extended-dose Chloroquine (ECQ) for Resistant Falciparum Malaria Among Afghan Refugees in Pakistan
The purpose of this study was to provide stronger evidence for extended-dose chloroquine treatment of falciparum-positive Afghan refugees in Northwest Frontier Province (NWFP), Pakistan or justification for discontinuation of the…
- Trial name
- ECQNWFP (NCT01019408)
- Testing
- Chloroquine
- Where
- 3 sites in Pakistan
- Volunteers
- 163 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Vivax Malaria
Assessment of Plasmodium Vivax Chloroquine Resistance in Cambodia:
The investigators propose to leverage the unique infrastructures and expertise of National Centre for Parasitology Entomology and Malaria Control and the Pasteur Institute in Cambodia and combine modern fieldwork, including a…
- Trial name
- CRePViCam (NCT02118090)
- Testing
- Chloroquine sulfate, DHA-PP
- Where
- Cambodia
- Volunteers
- 73 people
- Sponsor
- Institut Pasteur, Cambodia
Resistance, Disease, Prolactinoma
Cabergoline Combined Hydroxychloroquine/Chloroquine to Treat Resistant Prolactinomas
The purpose of this study is to preliminarily evaluate the safety and efficacy of cabergoline combined hydroxychloroquine/chloroquine(HCQ/CQ) therapy for cabergoline-Resistant Prolactinomas
- Trial name
- NCT03400865
- Testing
- HCQ/CQ and CAB combined treatment
- Where
- 9 sites in China
- Volunteers
- 30 people
- Sponsor
- Zhebao Wu
Malignant Neoplasm, Solid Tumors
Chloroquine in Combination With Carboplatin/Gemcitabine in Advanced Solid Tumors
The purpose of this research study is to test the safety of chloroquine in combination with carboplatin and gemcitabine and see what effects (good and bad) it has on advanced solid tumors.
- Trial name
- NCT02071537
- Testing
- Chloroquine, Carboplatin, Gemcitabine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Cincinnati
Corona Virus Infection
Norwegian Coronavirus Disease 2019 Study
In the current proposal, the investigators aim to investigate the virological and clinical effects of chloroquine treatment in patients with established COVID-19 in need of hospital admission.
- Trial name
- NO COVID-19 (NCT04316377)
- Testing
- Hydroxychloroquine Sulfate
- Where
- Norway
- Volunteers
- 53 people
- Sponsor
- University Hospital, Akershus
Malaria, Falciparum Malaria
TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014
An antimalarial drug efficacy trial was conducted for artemether-lumefantrine (AL) and chloroquine (CQ) in the three (3) municipalities (Bataraza, Brookes and Rizal) of Palawan.
- Conditions
- Malaria, Falciparum Malaria, Vivax Malaria, Malaria Recrudescence
- Trial name
- TES (NCT04222088)
- Testing
- Arthemeter-lumefantrine, Chloroquine, Primaquine
- Volunteers
- 159 people
- Sponsor
- Research Institute for Tropical Medicine, Philippines
COVID-19
Interferon Beta 1a in Hospitalized COVID-19 Patients
The present study is a randomized, double-blind, placebo-controlled, clinical trial, with the approval of the ethics committee will be conducted on patients who have a positive test confirming COVID-19 in Loghman Hakim Medical…
- Trial name
- IB1aIC (NCT04350671)
- Testing
- Interferon Beta-1A, Lopinavir / Ritonavir, Single Dose of Hydroxychloroquine
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Brain Metastasis
Study of Whole-brain Irradiation With Chloroquine for Brain Metastases
Background and purposes:Chloroquine (CLQ), an antimalarial drug, has a lysosomatrophic effect associate with increase the sensibility of Radiation through leakage of hidroliticenzimes, increase of apoptosis, autophagy mediated by…
- Trial name
- CLQ (NCT01894633)
- Testing
- Chloroquine, Total brain radiotherapy
- Where
- Mexico
- Volunteers
- 73 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico