Clinical trials: Chloroquine
COVID-19
Umifenovir in Hospitalized COVID-19 Patients
The present study is a randomized, double-blind, placebo-controlled, clinical trial, with the approval of the ethics committee will be conducted on patients who have a positive test confirming COVID-19 in Loghman Hakim Medical…
- Trial name
- UAIIC (NCT04350684)
- Testing
- Umifenovir, Interferon-β 1a, Lopinavir / Ritonavir
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
COVID-19
Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19
Rationale: Currently there are no approved treatments for COVID-19. In the Dutch treatment protocol guideline (SWAB) designated treatment is supportive care with the option to add chloroquine base (CQ) or hydroxychloroquine…
- Trial name
- ARCHAIC (NCT04362332)
- Testing
- Chloroquine Sulfate, Hydroxychloroquine, Standard supportive care
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Coronavirus Infection
An Observational Study to Assess the Protocol for the COVID-19 Treatment in Burkina Faso
This is an observational study to evaluate the effectiveness of the combinations Hydroxychloroquine + Azithromycin (HCQ-AZ) and Chloroquine + Azithromycin (CQ-AZ) in the treatment of Coronavirus (Covid-19) infection in Burkina…
- Trial name
- CHLORAZ (NCT04445441)
- Where
- 2 sites in Burkina Faso
- Volunteers
- 153 people
- Sponsor
- Centre Muraz
Proliferative Nephritis, Chloroquine Retinopathy
Proliferative Lupus Nephritis Treatment With Chloroquine and Hydroxychloroquine
Evaluation the efficacy of chloroquine and hydroxychloroquine in the treatment of proliferative lupus nephritis class III and IV in children and adolescents and evaluate the side effects of both drugs .
- Trial name
- NCT03687905
- Testing
- Chloroquine, Hydroxychloroquine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Malaria, Falciparum
Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine or Chloroquine/Azithromycin Prophylaxis
This study will assess the superior protective immunity of the combination of chloroquine and azithromycin prophylaxis under Chemoprophylaxis Sporozoites (CPS) immunization versus a standard chloroquine prophylactic regimen.
- Trial name
- MMV (NCT01783340)
- Testing
- Azithromycin capsules, Immunization with falciparum
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria, Falciparum
Azithromycin in Combination With Chloroquine Versus Chloroquine in the Eradication of Asymptomatic Plasmodium Falciparum
The purpose of this study is to determine if Azithromycin in combination with chloroquine is superior to chloroquine alone in eradicating P. falciparum asexual parasitemia in asymptomatic, semi-immune adults in Western Kenya.
- Trial name
- NCT00082563
- Testing
- Azithromycin/Chloroquine, Chloroquine
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pfizer
Plasmodium Falciparum Infection
Safety and Efficacy of Sanaria's PfSPZ-CVac in Malian Adults
Single site, double-blinded, randomized, placebo-controlled clinical trial of PfSPZ-CVac safety, tolerability, immunogenicity and efficacy against naturally occurring malaria in malaria-exposed Malian adults.
- Trial name
- NCT02996695
- Testing
- Artesunate, Chloroquine, PfSPZ (NF54) Challenge
- Where
- Mali
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Pharmacokinetic Study of Multi-dose Chloroquine
Chloroquine (CQ) remains an alternative cheap, safe and widely available drug. Our previous research has shown that double (50 mg/kg) standard dose CQ given in split doses had a 95% efficacy and was well tolerated and safe.
- Trial name
- NCT01814423
- Testing
- Chloroquine-base 50 mg, Chloroquine-base 70 mg
- Where
- Guinea-Bissau
- Volunteers
- 30 people
- Sponsor
- Bandim Health Project
Toxic Maculopathy
Incidence and Risk Factor of Hydroxychloroquine and Chloroquine Retinopathy
The purpose of this study is to evaluate the incidence and risk factor of toxic maculopathy who treated with hydroxychloroquine or chloroquine due to their autoimmune disease such as rheumatoid arthritis or systemic lupus…
- Trial name
- NCT02550964
- Testing
- Composite Examination
- Where
- South Korea
- Volunteers
- 124 people
- Sponsor
- Asan Medical Center
Malaria
Chloroquine for Malaria in Pregnancy
The purpose of this study is to test prevention strategies for pregnancy-related malaria. Researchers will compare different malaria treatments and treatment schedules which include chloroquine therapy (weekly doses versus being…
- Trial name
- NCT01443130
- Testing
- Chloroquine, Sulfadoxine-pyrimethamine
- Where
- Malawi
- Volunteers
- 900 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Pregnancy
Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women
Malaria in pregnancy is potentially fatal to both the mother and the foetus particularly in the primigravidae. Implementation of appropriate control and preventive measures is challenged by the fact that malaria infection in…
- Trial name
- NCT00131703
- Testing
- Amodiaquine, Sulphadoxine-pyrimethamine, Chloroquine
- Volunteers
- 900 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Coronavirus Infection
Hydroxychloroquine,Hydroxychloroquine,Azithromycin in the Treatment of SARS CoV-2 Infection
This Phase III trial four treatment strategies non-critically ill hospitalized participants (not requiring intensive care unit (ICU) admission and/or mechanical ventilation) with SARS CoV-2 infection, Participants will receive…
- Trial name
- WU352 (NCT04341727)
- Testing
- Hydroxychloroquine Sulfate, Azithromycin, Chloroquine Sulfate
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Glioblastoma Multiforme
The Addition of Chloroquine to Chemoradiation for Glioblastoma
Patients with a glioblastoma (GBM) have a poor prognosis with a median survival of 14.6 months after maximal treatment with a resection and chemoradiation.
- Trial name
- CHLOROBRAIN (NCT02378532)
- Testing
- Chloroquine, Radiotherapy, Temozolomide
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Maastricht Radiation Oncology
Falciparum Malaria, Vivax Malaria
To Evaluate Current Efficacy of Antimalarials Used in Timika, Papua, Indonesia
Multidrug resistant strains of P.falciparum and P.vivax are becoming increasingly prevalent in the Asia Pacific rim. To determine the efficacy of locally recommended antimalarial protocols in Papua, Indonesia, consecutive…
- Trial name
- NCT00157859
- Testing
- Chloroquine and sulphadoxine-pyrimethamine
- Where
- Indonesia
- Volunteers
- 150 people
- Sponsor
- Menzies School of Health Research
Malaria, Vivax Malaria
TES of Chloroquine for Pv in the Philippines in 2016
Chloroquine (CQ) is officially used as a first-line drug of Plasmodium vivax malaria in the Philippines. In this study, the therapeutic efficacy of CQ for the treatment of uncomplicated P.
- Conditions
- Malaria, Vivax Malaria, Recrudescence
- Trial name
- TES (NCT05958797)
- Testing
- Chloroquine, Primaquine
- Volunteers
- 74 people
- Sponsor
- Research Institute for Tropical Medicine, Philippines
Sickle Cell Anemia, Malaria
Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia
Malaria is fatal and increases the risk of death among children with sickle cell anemia. Chemoprophylaxis significantly improves quality of life in these children.
- Trial name
- NCT00399074
- Testing
- sulfadoxine pyrimethamine
- Where
- Uganda
- Volunteers
- 220 people
- Sponsor
- Makerere University
Local Metastatic Melanoma
DNA Repair Inhibitor & Irradiation on Melanoma
Phase I trial will be conducted in patients suffering local metastatic melanoma with relapsed cutaneous/subcutaneous tumors including melanoma-in-transit.
- Trial name
- DRIIM (NCT01469455)
- Testing
- DT01
- Where
- 12 sites in France
- Volunteers
- 27 people
- Sponsor
- DNA Therapeutics
Influenza
The Chloroquine for Influenza Prevention Trial
A randomised controlled trial to determine the efficacy of chloroquine for the prevention of influenza
- Trial name
- CHIP (NCT01078779)
- Testing
- Chloroquine
- Where
- Singapore
- Volunteers
- 1,516 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Covid-19, HIV
Chloroquine Outpatient Treatment Evaluation for HIV-Covid-19
Clinical manifestations of Covid-19 are poorly characterised in HIV co-infection, which may predispose to more severe disease. Reducing hospitalisation and severe illness in this population has important individual and public…
- Trial name
- CQOTE (NCT04360759)
- Testing
- Chloroquine or hydroxychloroquine
- Where
- 2 sites in South Africa
- Sponsor
- University of Cape Town
Malaria, Falciparum
The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau
The National Malaria Programme in Guinea-Bissau recommends paracetamol for all children treated for malaria. We, the investigators of the Bandim Health Project, want to evaluate whether this treatment has any effect on: the…
- Trial name
- NCT00137566
- Testing
- acetaminophen (paracetamol)
- Where
- Guinea-Bissau
- Sponsor
- Bandim Health Project