Clinical trials: Cholera
Vibrio Cholerae, Cholera
Bridging Study for Killed Oral Cholera Vaccine in Ethiopia
This is a randomized, double blind, placebo controlled trial to confirm the safety and determine the immune response of the killed oral cholera vaccine in healthy adults and children in Ethiopia.
- Trial name
- NCT01524640
- Testing
- Killed Bivalent (O1 and O139) whole cell oral cholera vaccine
- Where
- Ethiopia
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Diarrhea
A Post-marketing Observational Study of Oral Cholera Vaccine
Chinese survey data indicate that the incidence rate of diarrhea in the general population ranges from 0.17 to 0.70 episodes per person-year, whereas among children under five years of age, the rate is significantly higher…
- Trial name
- NCT07300462
- Testing
- Recombinant subunit B/bacterial cholera vaccine (enteric-coated capsules)
- Where
- 5 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Shanghai United Cell Biotechnology Co., Ltd
Vaccine Reaction
Immunogenicity of Co-administered Oral Polio Vaccine and Oral Cholera Vaccine
Concomitant administration of multiple vaccines, including live attenuated immunizations, is safe and effective. Some restrictions apply for live vaccines; administering a live-virus vaccine within 4 weeks after administration of…
- Trial name
- NCT03581734
- Testing
- Oral Polio Vaccine, Oral Cholera Vaccine
- Where
- Bangladesh
- Volunteers
- 579 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Cholera, Diarrhea
Evaluation of a Pilot Program to Introduce Cholera Vaccine in Haiti as Part of Global Cholera Control Efforts
The investigators aim to evaluated a public health program in Haiti that introduced an oral cholera vaccine as part of comprehensive control efforts for a major cholera epidemic.
- Trial name
- NCT02864433
- Where
- Haiti
- Volunteers
- 2,207 people
- Sponsor
- Brigham and Women's Hospital
Cholera
Simulation Based Training In Medical Students
Transferring classroom learning to real-life situations is a challenge. Tabletop simulation exercises offer a low-cost and context-specific approach for educating students on appropriate responses during health emergencies.
- Trial name
- NCT06929312
- Testing
- Tabletop simulation based teaching, conventional class room teaching
- Where
- Pakistan
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry
Typhoid and/or Cholera Vaccination
CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera
This is an open-label, non-randomized study. The purpose of this study is to better understand how vaccines against typhoid fever and cholera affect the normal immune system and bacteria in the intestine.
- Trial name
- NCT03705585
- Testing
- Vivotif Typhoid Oral Vaccine, Vaxchora
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cholera
Immunologic Responses to a Live Attenuated Oral Cholera Vaccine
The primary objective of this study is to evaluate the antibody response to the cholera vaccine, Vaxchora®, in healthy subjects.
- Trial name
- NCT03251495
- Testing
- Vaxchora
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Emory University
Adverse Reaction to Cholera Vaccine, Cholera Vaccination Reaction
Extended Dose Intervals With Oral Cholera Vaccine in Cameroon
The primary aim of this project is to determine changes in the vibriocidal geometric mean titers (GMT) in subjects who receive the second dose of oral cholera vaccine (OCV) at different intervals: 2 weeks, 6 months, or 11 months…
- Trial name
- NCT03719066
- Testing
- killed whole cell oral cholera vaccine
- Where
- Cameroon
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cholera Vaccination Reaction
Phase 1b Ascending Dose Study of PanChol in Healthy Volunteers
Cholera is a serious diarrheal disease that can be fatal within hours of onset. The current available cholera vaccines to prevent the disease are not very effective.
- Trial name
- PanChol (NCT07107516)
- Testing
- PanChol
- Where
- Zambia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Cholera
Safety and Immunogenicity of Locally Manufactured New (HL-OCV) Oral Cholera Vaccine
Cholera, a rapidly dehydrating watery diarrheal disease transmitted through water or food contaminated with the bacterium, Vibrio cholerae, is a major cause of morbidity and mortality in low income countries like Bangladesh.
- Trial name
- NCT02823899
- Testing
- HL-OCV, Shanchol
- Where
- Bangladesh
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Diarrhea Infectious, Cholera
Testing a Scalable Model of the Cholera Hospital-Based Intervention for 7 Days (CHoBI7)
The findings from previous recent randomized controlled trials of The Cholera Hospital Based Intervention for 7 Days (CHoBI7) demonstrated that this intervention was effective in significantly reducing symptomatic cholera…
- Trial name
- CHoBI7 (NCT06498817)
- Testing
- Standard Recommendation, CHoBI7 Scale-Up Program
- Where
- Bangladesh
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cholera, Diarrhea
Safety and Immunogenicity of a Killed Oral Cholera Vaccine in Infants
In order to assess whether the bivalent killed oral cholera vaccine may be used safely among infants who are most at risk for cholera, the investigators need to determine the safety and immunogenicity of the killed oral cholera…
- Conditions
- Cholera, Diarrhea, Vibrio Infections
- Trial name
- NCT00548054
- Testing
- Bivalent killed oral cholera vaccine
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Cholera
Ciprofloxacin Multiple Dose for Adult Cholera
Cholera is an important diarrhoeal disease and an important cause of death, particularly during epidemic outbreaks, in Bangladesh and many other developing countries.
- Trial name
- NCT00741052
- Testing
- Ciprofloxacin, Azithromycin
- Where
- Bangladesh
- Volunteers
- 218 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Cholera
Cholera Anti-Secretory Treatment Trial
This trial was designed to assess safety and preliminary efficacy of oral doses of iOWH032 on diarrhea output and clinical symptoms after a cholera challenge in healthy adult participants.
- Trial name
- CAST (NCT04150250)
- Testing
- iOWH032, V. cholerae Challenge, Antibiotics
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- PATH
Cholera Vaccination Reaction
Dose Escalation Study to Evaluate the Safety and Immunogenicity of the Cholera Conjugate Vaccine in Healthy Adults
This Phase I, first-in-human study is intended to primarily determine the safety of the dose range with or without Aluminum phosphate adjuvant expected to be needed for later clinical studies, to determine the nature of adverse…
- Trial name
- NCT05559983
- Testing
- OSP:rTTHc Cholera Conjugate Vaccine Cohort A, OSP:rTTHc Cholera Conjugate Vaccine with Aluminum phosphate adjuvant Cohort A, OSP:rTTHc Cholera Conjugate Vaccine Cohort B
- Where
- 3 sites in South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Cholera (Disorder)
Ondansetron to Prevent Oral Rehydration Failure in Children With Cholera
This Phase IIa randomized controlled trial will evaluate whether a single oral dose of ondansetron can reduce oral rehydration failure in children and adolescents with suspected or confirmed cholera and active vomiting.
- Trial name
- NCT07795060
- Testing
- Ondansetron, Standard Cholera Care
- Where
- Republic of the Congo
- Volunteers
- 120 people
- Sponsor
- Public Interest Science Center
Vibrio Infections
Epidemiology Non-cholera Vibrio Infections
The purpose of this study is to identify the epidemiological and clinical characteristics of patients diagnosed with non-cholera Vibrio infection in Western France from 2000 to 2019.
- Trial name
- INFECTIVE (NCT04451707)
- Testing
- non-cholera Vibrio infection
- Where
- 7 sites in France
- Volunteers
- 67 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Cholera
Safety and Immunogenicity of a New Formulation of Euvichol®
Number of doses and intervals: Two doses, 2 weeks apart Method of administration: Oral administration Volume of vaccine to be administered: 1.5 mL/dose Observational period: 4 weeks (2 weeks after each dose) Number of visits: 3…
- Trial name
- NCT02502331
- Testing
- Test Oral Cholera Vaccine, Euvichol®
- Volunteers
- 442 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Safety of the Oral O1 / O139 Cholera Vaccine (Enteric Capsules)
Safety of An Oral O1 / O139 Cholera Vaccine (Enteric Capsules)
Cholera is an acute enteric infectious disease caused by the bacterium Vibrio cholera, leading to watery diarrhea and loss of fluids from the small intestines.
- Trial name
- NCT03237663
- Testing
- The oral O1 / O139 cholera vaccine (enteric capsules)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Cholera, Diarrhea
Immunogenicity of One Versus Two Doses of Killed Oral Cholera Vaccine
The purpose of this study is to compare the safety and immunogenicity of one and two doses of the killed oral cholera vaccine.
- Conditions
- Cholera, Diarrhea, Vibrio Infections
- Trial name
- NCT00419133
- Testing
- Killed bivalent whole cell oral cholera vaccine
- Where
- India
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute