Clinical trials: Cholesterol, HDL
Diet Modification, Cardiology
A Whole Food Plant Diet and Its Lipidemic Effects on Primary Prevention in a Free-range Population
This study seeks to determine the effects of a whole-food, plant-based diet on lipid, metabolic, and inflammatory biomarkers. Eligible participants will have had either an LDL-C >100 mg/dL or non-HDL-C >130 mg/dL without a…
- Trial name
- WholeLIFE (NCT03523247)
- Testing
- whole food, plant based diet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Lancaster General Hospital
Diabetes Mellitus, Type II
´Sit Less, Move More' at Work: mHealth Intervention on Office Employees With Diabetes Type 2.
The objective of the study is measuring the impact of a ´sit less, move more' mHealth intervention at work on the glycaemic control and anthropometric profile of office employees with diabetes type 2 (DT2) at short, mid and long…
- Trial name
- Walk@Work (NCT04092738)
- Testing
- Walk@WorkApp-Diab
- Where
- Spain
- Volunteers
- 368 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Insulin Sensitivity, Lipoproteins Metabolism
Metabolic Effects of an 8 Week Niaspan Treatment in Patients With Abdominal Obesity and Mixed Dyslipidemia
Nicotinic acid (Niacin) has been used for many years for the treatment of dyslipidemia. Indeed Niacin decreases triglycerides (TG) and low density lipoprotein cholesterol (LDL-c) but more importantly increases high density…
- Conditions
- Insulin Sensitivity, Lipoproteins Metabolism, Non Esterified Fatty Acid Kinetics, Lipid Profile
- Trial name
- NCT01216956
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe
Poorly Controlled Diabetes Mellitus
Changes in Hematological Parameters With Glycemia Control in Type 2 Diabetes
There is a systemic low-grade chronic inflammation in diabetes, and research suggests that this inflammation plays a vital role in the development of diabetic complications.
- Trial name
- NCT06228898
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Healthy
Ginger and Plasma Cholesterol Efflux Capacity
In light of the findings from experimental studies examining the effects of ginger-derived compounds on cholesterol efflux pathways, this study aims to investigate the impact of oral ginger supplementation on high-density…
- Trial name
- NCT06662695
- Testing
- Ginger-based supplement
- Where
- Iran
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Cardiovascular Diseases, Heart Diseases
HDL-C in Cardiac Syndrome X
High density lipoprotein cholesterol (HDL-C) is in the centrum of the process of reverse cholesterol transport from peripheral cells to the liver[10].
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Ischaemia, Unstable Angina
- Trial name
- HIRICS-X (NCT02095964)
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Laparoscopic Sleeve Gastrectomy, Cardiovascular Risk Factor
Impact of Sleeve Gastrectomy on Monocyte-to-High-Density Lipoprotein Cholesterol Ratio
The present study hypothesized that significant weight loss is associated with a reduction in the inflammatory markers, leading to diminished cardiovascular risks in patients undergoing laparoscopic sleeve gastrectomy (LGS).
- Conditions
- Laparoscopic Sleeve Gastrectomy, Cardiovascular Risk Factor, Obesity
- Trial name
- NCT04439851
- Volunteers
- 125 people
- Sponsor
- Umraniye Education and Research Hospital
Acute Coronary Syndrome
Function of High Density Lipoproteins in Acute Coronary Syndromes
High density lipoproteins (HDL) have many effects that protect against cardiovascular diseases. In an acute heart attack (acute coronary syndrome -ACS), HDL change in composition and structure, reflecting the inflammatory…
- Trial name
- HDL_ACS (NCT01278875)
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hypercholesterolemia, Cardiovascular Risk Factor
The Effect of Psyllium Fibre on LDL-C, Non-HDL-C, and Apolioprotein-B: A Systematic Review and Meta-analysis
Serum cholesterol is a major modifiable risk factor for cardiovascular disease, which despite considerable reduction in prevalence, remains the leading cause of premature mortality worldwide.
- Trial name
- NCT03346733
- Testing
- Psyllium Fibre
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Dyslipidemia, Atherosclerosis
Safety, Pharmacokinetic Study of RVX000222 in Healthy Subjects and Subjects With Low HDL Cholesterol
The purpose of this study is to investigate an oral formulation of RVX000222 for safety, pharmacokinetic and efficacy in healthy subjects.
- Conditions
- Dyslipidemia, Atherosclerosis, Acute Coronary Syndrome, Cardiovascular Disease
- Trial name
- NCT00768274
- Testing
- RVX000222
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Resverlogix Corp
Insulinemic Response, Type 2 Diabetes (Adult Onset)
Impact of High-Oleic Palm Oil Consumption on Cardiovascular Biomarkers in Adults in Bogotá
This randomized clinical trial aims to evaluate the effects of refined high-oleic palm oil consumption on cardiovascular risk biomarkers and insulin resistance in healthy adults.
- Conditions
- Insulinemic Response, Type 2 Diabetes (Adult Onset), Hyperglycaemia (Diabetic), Hyperlipidaemia
- Trial name
- EDCHOPA-CRB (NCT07748559)
- Testing
- High-oleic palm oil
- Where
- Colombia
- Volunteers
- 52 people
- Sponsor
- Ruby Alejandra Villamil
Type 2 Diabetes
Measuring Cholesterol in the Fasting and Postmeal State in Patients With Type 2 Diabetes
Many patients with type 2 diabetes have difficulty attaining cholesterol goals, partly due to the recommendations for fasting measurements that may not be practical in the typical clinical setting.
- Trial name
- NCT00287404
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina
Kidney Failure Chronic, Cardiovascular Disease
Fish Oil and HDL Function in Patients on Maintenance Hemodialysis
Patients who receive maintenance hemodialysis have a very high risk of cardiovascular disease, and standard cholesterol-lowering treatments such as statins have not been shown to reduce cardiovascular events in this group.
- Conditions
- Kidney Failure Chronic, Cardiovascular Disease, HDL Cholesterol
- Trial name
- EFFLUX-HD (NCT07730385)
- Testing
- n-3 PUFA (fish oil)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Diabetes
Effect of Rosuvastatin on Function of High Density Lipoprotein Cholesterol in Type 2 Diabetes
The patients who have achieved LDL-C levels below the currently recommended targets may still experience cardiovascular events. To reduce further the risk of coronary heart disease (CHD), raising HDL-C and lowering TG may be the…
- Trial name
- NCT02185963
- Testing
- Rosuvastatin
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Bundang Hospital
Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy
DMD Gene Variants and Cardiac Dysfunction in Young Males With Dystrophinopathies
The goal of this observational study is to investigate whether the type, location, and extent of pathogenic variants in the DMD gene are associated with cardiac dysfunction in male children, adolescents, and young adults with…
- Conditions
- Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy, Cardiomyopathy
- Trial name
- NCT07515235
- Where
- Greece
- Volunteers
- 65 people
- Sponsor
- Aristotle University Of Thessaloniki
Type 2 Diabetes
Effects of Cranberry Extractive on the Lipid Profiles in Subjects With Type 2 Diabetes
Cranberry, containing flavonoids, is effective on improvement of lipid profiles in non-diabetic subjects. The Hypothesis of is to assess the effect of cranberry on lipid profiles in type 2 diabetic patients using oral…
- Trial name
- NCT00695526
- Testing
- cranberry
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taichung Veterans General Hospital
Dyslipidemia, Healthy Volunteers
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAP311 in Healthy Subjects and Dyslipidemic Patients
This study will assess the safety, tolerability, and effect of TAP311 on blood lipids in healthy subjects and in patients who have dyslipidemia.
- Trial name
- NCT01487460
- Testing
- TAP311
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Weight Change, BMI
Childhood Obesity Prevention Project in Gran Canaria
Given the alarming rates of obesity and overweight in our child population, the investigators have developed an intervention strategy, based on a multidisciplinary, school-centered approach, which addresses nutritional education…
- Conditions
- Weight Change, BMI, Activity Level, Cholesterol (total and HDL)
- Trial name
- POI (NCT06607159)
- Testing
- Implementation of healthy habits teaching protocol
- Where
- Spain
- Volunteers
- 557 people, healthy volunteers welcome
- Sponsor
- Complejo Hospitalario Universitario Insular Materno Infantil
HDL, Drug Safety
Safety, Immunogenicity and Dose Response of ATH03, a New Vaccine Against the Cholesterol Ester Transfer Protein (CETP)
Phase 1 Study :Safety, Immunogenicity and Dose response of ATH03, a new vaccine against the cholesterol ester transfer protein (CETP), in healthy male subjects with high density lipoprotein cholesterol (HDLc) blood concentrations…
- Trial name
- NCT01284582
- Testing
- ATH03
- Where
- Austria
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Affiris AG
Atherosclerosis, Cardiovascular Disease
High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly
The purpose of this study is to investigate the added benefits of increased high-density lipoprotein (HDL) cholesterol serum levels over and above those achieved by lipid lowering therapy guided by current guidelines, in older…
- Trial name
- NIA-Plaque (NCT00127218)
- Testing
- any statin, niacin
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Johns Hopkins University