Clinical trials: Cholesterol; Metabolic Disorder
Hypercholesterolemia
A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Pravastatin for at Least 4 Weeks.
Determine the effect of WelChol tablets on serum lipids, lipoproteins, apolipoproteins, and lipoprotein particle size in patients who were stabilized on pravastatin therapy for at least 4 weeks.
- Trial name
- NCT00755352
- Testing
- pravastatin tablets and Welchol tablets
- Where
- 15 sites in United States
- Volunteers
- 67 people
- Sponsor
- Daiichi Sankyo
Hypercholesterolemia
A Study to Investigate LDL-cholesterol Lowering With Inclisiran Compared to Bempedoic Acid in Patients With Atherosclerotic Cardiovascular Disease.
This study is a phase IV, open-label, randomized study designed to evaluate the efficacy of Inclisiran vs. bempedoic acid (BPA) in 400 adult subjects (≥ 18 years) at very high and high risk for cardiovascular events as defined by…
- Trial name
- NCT06431763
- Testing
- Inclisiran sodium, BPA
- Where
- 55 sites in Germany
- Volunteers
- 402 people
- Sponsor
- Novartis Pharmaceuticals
Dyslipidemia
Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk
The primary objective was to evaluate the effect of treatment with evolocumab, compared with placebo, on the risk for cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary…
- Trial name
- FOURIER (NCT01764633)
- Testing
- Evolocumab
- Where
- 1,284 sites in United States, Argentina and 47 more
- Volunteers
- 27,564 people
- Sponsor
- Amgen
ASCVD, Elevated Cholesterol
Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C
The purpose of this extension study was to evaluate the efficacy, safety, and tolerability of long-term dosing of Inclisiran. The study was a global multicenter study.
- Conditions
- ASCVD, Elevated Cholesterol, Heterozygous Familial Hypercholesterolemia, Homozygous Familial Hypercholesterolemia
- Trial name
- ORION-8 (NCT03814187)
- Testing
- Inclisiran Sodium
- Where
- 238 sites in United States, Canada and 11 more
- Volunteers
- 3,275 people
- Sponsor
- Novartis Pharmaceuticals
Lateral Epicondylitis
Metabolic and Inflammatory Indices in Lateral Epicondylitis
This study aims to investigate whether metabolic and inflammatory indices differ between patients with chronic lateral epicondylitis (tennis elbow) and individuals without the condition.
- Trial name
- NCT07876778
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Mardin Artuklu University
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention
Efficacy of Lipid-Lowering Therapy Based on Apolipoprotein B Versus LDL-Cholesterol Levels in Patients Undergoing Percutaneous Coronary Intervention
This multicenter randomized trial is designed to assess the efficacy of lipid-lowering therapy in patients undergoing percutaneous coronary intervention, comparing an Apolipoprotein B-targeted approach with a Low-Density…
- Conditions
- Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention, LDL-cholesterol, Lipid Metabolism Disorders
- Trial name
- ApoB-guidedLLT (NCT06626126)
- Testing
- ApoB-guided-LLT, LDL-C-guided-LLT
- Where
- Vietnam
- Volunteers
- 1,448 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Cardiovascular Risk Factor, Cholesterol; Lipidosis
Meta-analysis of the Portfolio Dietary Pattern and Cardiometabolic Risk
The European Association for the Study of Diabetes (EASD) guidelines have not made any specific recommendations regarding the Portfolio diet, a dietary pattern that includes nuts, viscous fibre, plant protein, and plant sterols.
- Trial name
- NCT03534414
- Testing
- Portfolio Dietary Pattern, NCEP Based Diet
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Dyslipidemia
LDL-Cholesterol Lowering Effect of KB2115 as Add on to Statin
Thyroid hormones are known to reduce cholesterol levels through regulation of a number of key enzymes involved in synthesis, degradation, and lipid transport.
- Trial name
- NCT00593047
- Testing
- KB2115
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Karo Bio AB
Dyslipidemia
Improving Adherence to Statins Among Minority Populations
Statins are cholesterol lowering medications that reduce the risk of cardiovascular events. However adherence to these medications has been found to be lower among minorities, a group particularly vulnerable for heart disease.
- Trial name
- NCT02037685
- Testing
- Motivational Interviewing (MINT), Usual Care
- Where
- United States
- Volunteers
- 779 people
- Sponsor
- University of Miami
Hypercholesterolaemia, Familial Hypercholesterolaemia
An Observational Study to Evaluate Treatment Patterns in High, Very High and Extreme Cardiovascular Risk Patients With Hypercholesterolemia, Including Familial Hypercholesterolemia
TRAP-HC is a multicenter, observational, longitudinal, prospective study designed to evaluate real-world treatment patterns and lipid-lowering therapy (LLT) management in patients with hypercholesterolemia, including familial…
- Conditions
- Hypercholesterolaemia, Familial Hypercholesterolaemia, CVD Risk
- Trial name
- TRAP-HC (NCT07606118)
- Volunteers
- 2,500 people
- Sponsor
- Fondazione SISA (Societa Italiana per lo Studio della Arteriosclerosi)
Hypercholesterolemia
AEGR-733 and Atorvastatin 20 mg vs. Monotherapy in Moderate Hypercholesterolemia
The purpose of this study is to test the effectiveness of the study drug, AEGR-733 alone and in combination with the medication, atorvastatin (Lipitor), on cholesterol in volunteers with moderately high cholesterol.
- Trial name
- NCT00474240
- Testing
- Atorvastatin 20 mg, AEGR-733 5 mg, AEGR-733 10 mg
- Where
- 17 sites in United States
- Volunteers
- 157 people
- Sponsor
- Aegerion Pharmaceuticals, Inc.
Metabolic Syndrome
Dose Ranging Study of the Effects of Alpha Lipoic Acid on Oxidative Stress
Heart disease is the most common cause of death in the United States and it is commonly found in people with diabetes and high cholesterol.
- Trial name
- Alpha (NCT00857376)
- Volunteers
- 77 people
- Sponsor
- Johns Hopkins University
Hypercholesterolemia
A Study of LY3015014 in Participants With High Cholesterol
This study is designed to define the amount and duration of cholesterol lowering and to assess the safety and tolerability of different dose regimens of LY3015014 in participants with high cholesterol.
- Trial name
- NCT01890967
- Testing
- LY3015014, Statin, Ezetimibe
- Where
- 49 sites in United States, Canada and 6 more
- Volunteers
- 527 people
- Sponsor
- Eli Lilly and Company
Hypercholesteremia
Effects of Limicol on LDL-cholesterol
The principal objective of this study is to investigate the effects of a novel food supplement (Limicol) on LDL-cholesterol levels in healthy subjects with moderate hypercholesterolemia.
- Trial name
- NCT01354327
- Testing
- Limicol
- Where
- France
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Lescuyer Laboratory
Fed
Bioequivalence Study of Bisoprolol Fumarate Tablet 10 mg Under Fed Condition
This is a randomized, open Label, balanced, two-treatment, two-period, two-sequence, single dose, crossover pivotal study. The purpose of this study is to assess the bioequivalence between Test Product and the corresponding…
- Trial name
- NCT01744873
- Testing
- Bisoprolol Fumarate Tablet 10 mg, Bisoprolol
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- IPCA Laboratories Ltd.
To Determine Bioequivalence Under Fed Conditions
Bioequivalence Study of Cabergoline Tablets and Dostinex Under Fed Conditions
To compare the rate and extent of absorption of cabergoline 0.5 mg tablets (test) versus Dostinex (reference)
- Trial name
- NCT00652873
- Testing
- Cabergoline, Dostinex
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Pre-diabetes
A Study for Pre-diabetic Patients With Cholesterol Lowering Drugs
The purpose of this research study is to examine if a combination of a cholesterol lowering-drug, simvastatin, with a sugar-lowering drug called rosiglitazone is more effective in improving vascular inflammation (irritation of…
- Trial name
- SIROCO (NCT00831129)
- Testing
- Rosiglitazone, Simvastatin
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Chicago
HIV Infections, Hyperlipidemia
Antihyperlipidemic Effects of Oyster Mushrooms
The primary goal of this study is to evaluate the short-term safety and potential efficacy of oyster mushrooms (Pleurotus ostreatus) for treatment of hyperlipidemia in HIV-infected patients who are taking Kaletra, a protease…
- Trial name
- NCT00069524
- Testing
- oyster mushroom
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
High Blood Cholesterol
An Observational Study Evaluating Cholesterol Levels in Patients on Cholesterol Lowering Drugs in Jordan and Lebanon
This was a multicenter survey of patients who were on lipid -lowering pharmacological treatment in 2 Levant countries namely Jordan and Lebanon.
- Trial name
- CEPHEUS (NCT01614561)
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Hypertriglyceridemia
Efficacy and Safety of AMR101 (Ethyl Icosapentate) in Patients With Fasting Triglyceride (Tg) Levels ≥ 500 and ≤ 2000 mg/dL
The primary objective is to determine the efficacy of AMR101 (ethyl icosapentate) compared to placebo in lowering fasting triglyceride levels in patients with very high fasting triglyceride levels ≥ 500 and ≤ 2000 mg/dL.
- Trial name
- MARINE (NCT01047683)
- Testing
- AMR101 (ethyl icosapentate) - 4 g/day, AMR101 (ethyl icosapentate) - 2 g/day
- Where
- 60 sites in United States, Denmark and 9 more
- Volunteers
- 229 people
- Sponsor
- Amarin Pharma Inc.
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